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Chinese Journal of Chemical Engineering 2016年第11期24卷 1533-1540页

作者： Zhuan Yi Fa-dong Wu Yong Zhou cong-jie gao Department of Ocean Zhejiang University of Technology Hangzhou 310014 China Water Treatment Technology Development Center Hangzhou 310012 China

Microstructure in selective layer has played a decisive role in permselectivity of nanofiltration(NF) membranes,and nanomaterials were well-known additives that had been applied to mediate the microstructure and permeability of polyamide NF membranes. However, nanoadditives generally displayed a poor dispersion in membranes or in fabrication process. To solve this problem, we showed an interesting concept that novel NF membranes with hybrid selective layer consisting of flexible polyisobutylene(PIB) and rigid polyamide could be fabricated from well-defined interfacial polymerization. The hydrophobic polymer mediated phase separation and microdomains formation in polyamide layer were found. The immiscibility between the rigid polyamide and flexible PIB as well as the resultant interface effect was interpreted as the reason for the polymer enhanced permselectivity, which was similar with the well-known thin film nanocomposite(TFN) membranes that nanoparticles incorporated contributed significantly to membrane permeability and rejection *** results have demonstrated that novel NF membranes with enhanced performance can be prepared from immiscible polymers, which is a new area that has not been extensively studied before.

关键词： Nanofiltration membranes Interfacial polymerization Polymer additive Hydrophobicity Fabrication

Synthesis and Characterization of the Polyacrylonitrile-block- poly(methyl acrylate) by RAFT Technique

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Chinese Chemical Letters 2006年第3期17卷 365-368页

作者： Quan Fu AN Jin Wen QIAN cong jie gao Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 The Development Center of Water Treatment Technology State Oceanic Administration Hangzhou 310012

Polyacrylonitrile-block-poly（methyl acrylate）（P（AN-b-MA）） was synthesized by reversible addition-fragmentation chain transfer （RAFT） polymerization employing macro-RAFT agent （PAN-RAFT） as the chain transfer agent and azobis（isobutyronitrile）（AIBN） as the initiator. A linear relationship between ln（[M]0/[M]1） and reaction time was observed. The molecular structure of P（AN-b-MA） was characterized by ^1H-NMR, element analysis, FTIR and SEC. The molecular weight distribution （MWD） was less than 1.40, the Mn could be controled from 0.733 to 4.834×10^4, and the molar content of MA in P（AN-b-MA） were from 15.6 to 75.0 percentage, respectively.

关键词： RAFT acrylonitrile methyl acrylate block polymer.

Recent advances in nanofiltration,reverse osmosis membranes and their applications in biomedical separation field

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Chinese Journal of Chemical Engineering 2022年第9期35卷 76-99页

作者： Kai Zhang Huan-Huan Wu Hui-Qian Huo Yan-Li Ji Yong Zhou cong-jie gao Center for Membrane and Water Science&Technology Zhejiang University of TechnologyHangzhou 310014China

In the face of human society's great requirements for health industry,and the much stricter safety and quality standards in the biomedical industry,the demand for advanced membrane separation technologies continues to rapidly grow in the ***(NF)and reverse osmosis(RO)as the highefficient,low energy consumption,and environmental friendly membrane separation techniques,show great promise in the application of biomedical separation *** chemical compositions,microstructures and surface properties of NF/RO membranes determine the separation accuracy,efficiency and operation cost in their ***,recent studies have focused on tuning the structures and tailoring the performance of NF/RO membranes via the design and synthesis of various advanced membrane materials,and exploring universal and convenient membrane preparation strategies,with the objective of promoting the better and faster development of NF/RO membrane separation technology in the biomedical separation *** paper reviews the recent studies on the NF/RO membranes constructed with various materials,including the polymeric materials,different dimensional inorganic/organic nanomaterials,porous polymeric materials and metal coordination polymers,***,the influence of membrane chemical compositions,interior microstructures,and surface characteristics on the separation performance of NF/RO membranes,are comprehensively ***,the applications of NF/RO membranes in biomedical separation field are systematically ***,the perspective for future challenges of NF/RO membrane separation techniques in this field is discussed.

关键词： Nanofiltration Reverse osmosis Membrane Separation Biomedical

Recent developments in polymeric nano-based separation membranes

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Fundamental Research 2022年第2期2卷 254-267页

作者： Yan-Li Ji Ming-jie Yin Quan-Fu An cong-jie gao Center for Membrane and Water Science&Technology Zhejiang University of TechnologyHangzhou 310014China Bejing Key Laboratory for Green Catalysis and Separation Department of Envronmental and Chemical Engineering Bejing University of TechnologyBeijing 100124China

Polymeric nanomaterials,which have tuneable chemical structures,versatile functionalities,and good compatibility with polymeric matrices,have attracted increasing interest from researchers for the construction of polymeric nano-based separation *** their distinctive nanofeatures,polymeric nano-based membranes show great promise in overcoming bottlenecks in polymer membranes,namely,the trade-off between permeability and selectivity,low stability,and fouling ***,recent studies have focused on tuning the structures and tailoring the surface properties of polymeric nano-based membranes via exploitation of membrane fabrication techniques and surface modification strategies,with the objective of pushing the performance of polymeric nano-based membranes to a new *** this review,first,the approaches for fabricating polymeric nano-based mixed matrix membranes and homogeneous membranes are summarized,such as surface coating,phase inversion,interfacial polymerization,and self-assembly ***,the manipulation strategies of membrane surface properties,namely,the hydrophilicity/hydrophobicity,charge characteristics,and surface roughness,and interior microstructural properties,namely,the pore size and content,channel construction and regulation,are comprehensively ***,the separation performances of liquid ions/molecules and gas molecules through polymeric nano-based membranes are systematically ***,we conclude this review with an overview of various unsolved scientific and technical challenges that are associated with new opportunities in the development of advanced polymeric nano-based membranes.

关键词： Polymeric nanomaterial Polymeric nano-based membrane Mixed matrix membrane Homogeneous membrane Separation application

Precursor solution prepared by evaporation deamination complex method for solvent separation of Mo and W by H_2O_2-complexation

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Transactions of Nonferrous Metals Society of China 2013年第4期23卷 1139-1146页

作者：关文娟张贵清高从堦中南大学冶金科学与工程学院长沙410083 中南大学稀有金属冶金与材料制备湖南省重点试验室长沙410083

An novel method on preparation of precursor solution for solvent separation of molybdenum （Mo） and tungsten （W） by hydrogen peroxide （H2O2）-complexation from the ammonium tungstate solution containing high Mo was studied. The precursor solution was obtained via evaporation deamination and H202-complex transformation processes. Then it was extracted with a mixture extractant of tri-alkyl phosphine oxide （TRPO） and tributyl phosphate （TBP） to separate Mo and W. The results indicated that the evaporation deamination complex method reduced the acid consumption by more than 90% in comparison with the traditional directly acid regulation complex method. The transformation rates of W and Mo were higher than 95% and the decomposition rate of H202 was less than 15% at a 1.8-1.9 times H202 dosage, 45-50 ℃, initial pH of 1.80-1.90, and transformation volume ratio of 100% for 60 min in the H2O2-complexation transformation process. The minimum extraction rate of W was 2%, the maximum extraction rate of Mo was 82.6% and the highest separation coefficient was 76.7 in a single-stage extraction.

关键词： tungsten molybdenum solvent extraction separation precursor solution H202

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu jie gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

氧化还原引发接枝—填充聚合制备pH响应型分离膜

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化学工程与装备 2007年第1期 1-3+11页

作者：汪锰吴礼光莫剑雄高从堦浙江大学材料与化学工程学院国家海洋局杭州水处理中心

由全反射红外光谱和场发射电子显微镜证实,利用氧化还原可成功地引发甲基丙烯酸在酚酞型聚醚砜膜表面的接枝聚合。继而,接枝膜在不同pH下的水通量测定实验表明,该接枝膜膜孔径的变化具有着显著、快速、可逆的pH响应性。

关键词： pH响应性接枝聚合多孔膜

Recent progress on the mechanics of sharply bent DNA

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Science China(Physics,Mechanics & Astronomy) 2016年第8期59卷 1-8页

作者： PeiWen cong jie Yan Mechanobiology Institute National University of Singapore Singapore-MIT Alliance National University of Singapore Department of Physics National University of Singapore BioSystems and Micromechanics IRG Singapore-MIT Alliance for Research and Technology Centre Centre for BioImaging Sciences National University of Singapore

Despite extensive studies on the mechanics of DNA under external constrains, such as tension, torsion, and bending, several important aspects have remained poorly understood. One biologically important example is the mechanics of DNA under sharp bending conditions, which has been debated for a decade without thorough comprehension. The debate is about the interesting phenomenon raised from a series of different experiments: sharply bent DNA has a surprisingly high apparent bending flexibility that deviates from the canonical bending elasticity of DNA. This finding has motivated various theoretical models, which mainly incorporate the excitation of mechanical defects inside severely bent DNA molecules. Here, we review the recent progress on the understanding of the mechanics of sharply bent DNA and provide our view on this important question by interrogating the theoretical foundation of these experimental measurements.

关键词： DNA mechanics DNA elasticity DNA nicks molecular dynamics simulation

Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

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Oncology research 2025年第1期33卷 171-184页

作者： Gengyun Sun Yiping Zheng Jianfeng Cai jie gao Lie Dong Xiangbin Zhang Yinghui Huang Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Anhui Medical University Hefei 230022 China. Department of Respiratory and Critical Care Medicine Nanping First Hospital Affiliated to Fujian Medical University Nanping 353006 China.

Background:Long noncoding RNA, LINC01106 exhibits high expression in lung adenocarcinoma (LUAD) tumor tissues, but its functional role and regulatory mechanism in LUAD cells remain unclear.Methods:LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was assessed. LUAD cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor growth. The downstream transcription factors and molecular mechanism were determined using the Human transcription factor database (TFDB) database and Gene Expression Profiling Interactive Analysis (GEPIA) database. Additionally, the impact of linc01106 on autophagy was analyzed by determining the expression of autophagy-related genes (ATGs) in LUAD cells.Results:Our results showed that LINC01106 exhibited upregulation in both LUAD tissues and cell lines. The silencing of LINC01106 demonstrated a suppressive effect on tumorigenesis in a xenograft mouse model of LUAD. Additionally, LINC01106 was found to recruit TATA-binding protein-associated factor 15 (TAF15), an RNA-binding protein, thereby enhancing the mRNA stability of TEA domain transcription factor 4 (TEAD4). In turn, TEAD4 served as a transcription factor that bound to the LINC01106 promoter and regulated its expression. Further assays indicated that LINC01106 promoted autophagy in LUAD cells by upregulating the expression of autophagy-related genes (ATGs). The silencing of LINC01106 in LUAD cells inhibited autophagy, and cell proliferation, and promoted apoptosis, which all were effectively reversed by ATG5 overexpression.Conclusions:Overall, LINC01106, transcriptionally activated by TEAD4, interacts with TAF15 to promote the stability of TEAD4 and upregulates the expression of ATGs, promoting malignancy of LUAD cells.

关键词： ATG5 LINC01106 Lung adenocarcinoma (LUAD) Non-small cell lung cancer (NSCLC) TAF15 TEAD4