检索结果-南通市图书馆

Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

引用

World Journal of Gastrointestinal Oncology 2024年第1期16卷 30-50页

作者： Yu-Hua Du Jian-Jun Zhao Xia Li shi-cong Huang Na Ning Guo-Qing Chen Yi Yang Yi Nan Ling Yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Ningxia Chinese Medicine Research Center Manufacturing LaboratoryYinchuan 750004Ningxia Hui Autonomous RegionChina College of Foundation Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Pachymic acid(PA)is derived from Poria cocos.PA has a variety of pharmacological and inhibitory effects on various tumors.However,the mechanism of action of PA in gastric cancer(GC)remains unclear.AIM To investigate the mechanism of PA in treating GC via the combination of network pharmacology and experimental verification.METHODS The GeneCards and OMIM databases were used to derive the GC targets,while the Pharm Mapper database provided the PA targets.Utilizing the STRING database,a protein-protein interaction network was constructed and core targets were screened.The analyses of Gene Ontology,Kyoto Encyclopedia of Genes and Genomes(KEGG),and gene set enrichment analysis were conducted,and molecular docking and clinical correlation analyses were performed on the core targets.Ultimately,the network pharmacology findings were validated through in vitro cell assays,encompassing assessments of cell viability,apoptosis,cell cycle,cloning,and western blot analysis.RESULTS According to network pharmacology analysis,the core targets were screened,and the PI3K/AKT signaling pathway is likely to be the mechanism by which PA effectively treats GC,according to KEGG enrichment analysis.The experimental findings showed that PA could control PI3K/AKT signaling to prevent GC cell proliferation,induce apoptosis,and pause the cell cycle.CONCLUSION Network pharmacology demonstrated that PA could treat GC by controlling a variety of signaling pathways and acting on a variety of targets.This has also been supported by in vitro cell studies,which serve as benchmarks for further research.

关键词： Pachymic acid Gastric cancer Network pharmacology Enrichment analysis Cell proliferation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

To explore the mechanism of Yigong San anti-gastric cancer and immune regulation

引用

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1965-1994页

作者： Dou-Dou Lu Ling Yuan Zhao-Zhao Wang Jian-Jun Zhao Yu-Hua Du Na Ning Guo-Qing Chen shi-cong Huang Yi Yang Zhe Zhang Yi Nan School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Chinese Medical Gastrointestinal China-Japan Friendship HospitalBeijing 100029China Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 years.However,the mechanism of its anti-gastric cancer and regulate immunity are still remains unclear.AIM To explore the mechanism of YGS anti-gastric cancer and immune regulation.METHODS Firstly,collect the active ingredients and targets of YGS,and the differentially expressed genes of gastric cancer.Secondly,constructed a protein-protein interaction network between the targets of drugs and diseases,and screened hub genes.Then the clinical relevance,mutation and repair,tumor microenvironment and drug sensitivity of the hub gene were analyzed.Finally,molecular docking was used to verify the binding ability of YGS active ingredient and hub genes.RESULTS Firstly,obtained 55 common targets of gastric cancer and YGS.The Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6,EGFR,MMP2,MMP9 and TGFB1 as the hub genes.The 5 hub genes were involved in gastric carcinogenesis,staging,typing and prognosis,and their mutations promote gastric cancer progression.Finally,molecular docking results confirmed that the components of YGS can effectively bind to therapeutic targets.CONCLUSION YGS has the effect of anti-gastric cancer and immune regulation.

关键词： Gastric cancer Yigong San Mechanism Immune

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16-F10,MC38 and Hep1-6 Tumor Models

引用

Chinese Journal of Integrative Medicine 2024年第4期30卷 348-358页

作者： FU Yu-bing LIU Chen-feng WANG Jin-jia JI Xiao-lin TANG Rong-han LIAO Kun-yu CHEN Ling-yue HONG Ya-zhen FAN Bin-bin WANG shi-cong LIU Wen-Hsien State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life ScienceXiamen UniversityXiamenFujian Province(361102)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian Province(363000)China

Objective To investigate the anti-tumor effects of Pien Tze Huang(PZH)in mouse models of B16–F10 melanoma,MC38 colorectal cancer,Hep1-6 hepatocellular carcinoma and chemically induced hepatocellular carcinoma model.Methods Various tumor models,including B16–F10,MC38 and Hep1-6 tumor hypodermic inoculation models,B16–F10 and Hep1-6 pulmonary metastasis models,Hep1-6 orthotopic implantation model,and chemically induced hepatocellular carcinoma model,were utilized to evaluate the anti-tumor function of PZH.Tumor growth was assessed by measuring tumor size and weight of solid tumors isolated from C57BL/6 mice.For cell proliferation and death of tumor cells in vitro,as well as T cell activation markers,cytokine production and immune checkpoints analysis,single-cell suspensions were prepared from mouse spleen,lymph nodes,and tumors after PZH treatment.Results PZH demonstrated significant therapeutic efficacy in inhibiting tumor growth(P0.05).Nevertheless,PZH exhibited a remarkable ability to enhance T cell activation and the production of interferon gamma,tumor necrosis factor alpha,and interleukin 2 in CD4^(+)T cells in vitro(P<0.01 or P<0.05).Importantly,PZH substantially inhibited T cell exhaustion and boosted cytokine production by tumor-infiltrating CD8^(+)T cells(P<0.01 or P<0.05).Conclusion This study has confirmed a novel immunomodulatory function of PZH in T cell-mediated anti-tumor immunity,indicating that PZH holds promise as a potential therapeutic agent for cancer treatment.

关键词： Pien Tze Huang metastasis anti-tumor immunity T cell activation T cell exhaustion immune checkpoints Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects and evaluation of biogas slurry/water integrated irrigation technology on the growth,yield and quality of tomatoes

引用

International Journal of Agricultural and Biological Engineering 2022年第5期15卷 123-131页

作者： Jian Zheng Xingyun Qi Shaohong Yang cong shi Zhengjiang Feng College of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China Key Laboratory of Complementary Energy System of Biomass and Solar Energy Gansu ProvinceLanzhou 730050China Western China Energy&Environment Research Center Lanzhou University of TechnologyLanzhou 730050China

Reasonable techniques and methods in biogas slurry application are significant for the promotion of biogas slurry and the improvement of crop quality in agricultural production.To investigate the impacts of different biogas slurry application techniques on the water use efficiency,growth,yield,and quality of tomatoes,three irrigation techniques,and two application methods were considered in this study.The three irrigation techniques are alternate partial root-zone irrigation(APRI),fixed partial root-zone irrigation(FPRI),and two sides root-zone irrigation(TSRI).Two application methods refer to applying the biogas slurry with hole irrigation and surface irrigation.In addition,principal component analysis(PCA)and technique for order preference by similarity to ideal solution(TOPSIS)methods were adopted to evaluate the comprehensive quality and comprehensive indicators of tomatoes among different treatments.There are three hole irrigation treatments,T1(APRI),T2(TSRI),T3(FPRI),and three surface irrigation treatments,T4(APRI),T5(TSRI),and T6(FPRI)were set in two-season pot experiments.The results show that the plant height,dry matter accumulation,fruit yield,and water use efficiency present a similar descending trend for APRI,TSRI,and FPRI under the same methane irrigation method,yet show that the hole irrigation treatment was higher than the surface irrigation treatment for the same irrigation technique.These indicate that the coupling of APRI technique and hole irrigation is more conducive to the increase of plant production and water use efficiency.Meanwhile,T1 treatment can significantly improve the soluble sugar,sugar-acid ratio,VC content,soluble protein,soluble solid content,and firmness of tomato fruits,which are better for the taste,storage,and transportation of tomato fruit.The titratable acid content in tomato fruit is the highest in T2 treatment,followed by T5 treatment,indicating that TSRI technique may result in an accumulation of titratable acid and is not conducive to the taste of the tomato.The compre

关键词： biogas slurry irrigation technique coupling quality evaluation comprehensive index evaluation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ethylenediurea(EDU)spray effects on willows(Salix sachalinensis F.Schmid)grown in ambient or ozone-enriched air:implications for renewable biomass production

引用

Journal of Forestry Research 2022年第2期33卷 397-422页

作者： Evgenios Agathokleous Mitsutoshi Kitao cong shi Noboru Masui Shahenda Abu-ElEla Kyohsuke Hikino Fuyuki Satoh Takayoshi Koike Department of Ecology School of Applied MeteorologyNanjing University of Information Science and Technology(NUIST)Nanjing 210044People’s Republic of China School of Agriculture Hokkaido UniversitySapporoHokkaido 060-8589Japan Hokkaido Research Center Forestry and Forest Products Research Institute(FFPRI)Sapporo 062-8516Japan School of Environmental Science and Engineering Tiangong UniversityTianjin 300387People’s Republic of China Department of Entomology Faculty of ScienceCairo UniversityGiza 12613Egypt TUM School of Life Sciences Technical University of Munich(TUM)Hans-Carl-von-Carlowitz Platz 285354 FreisingGermany Field Science Center for Northern Biosphere Hokkaido UniversitySapporo 060-0809Japan Research Center for Eco-Environmental Science Chinese Academy of ScienceBeijing 100085People’s Republic of China

Ground-level ozone(O_(3)) is a widespread air pollutant causing extensive injuries in plants.However,its effects on perennial energy crops remain poorly under-stood due to technical difficulties in cultivating fast-growing shrubs for biomass production under O_(3) treatment on the field.Here we present the results of a two-year evaluation in the framework of which willow(Salix sachalinensis F.Schmid)shrubs were exposed to ambient(AOZ)or elevated(EOZ)O_(3) in two successive growing seasons(2014,2015)and treated with 0(EDU0)or 400 mg L^(−1)(EDU400)eth-ylenediurea spray in the second growing season.In 2014,EOZ altered the chemical composition of both top young and fallen leaves,and a novel mechanism of decreasing Mg in fallen leaves while highly enriching it in young top leaves was revealed in shrubs exposed to EOZ.In 2015,EDU400 alleviated EOZ-induced decreases in leaf fresh mass to dry mass ratio(FM/DM)and leaf mass per area(LMA).While EDU400 protected against EOZ-induced suppression of the maximum rate at which leaves can fix carbon(A_(max))in O_(3)-asymptomatic leaves,it did not alle-viate EOZ-induced suppression of the maximum rates of carboxylation(VCmax)and electron transport(J_(max))and chlorophylls a,b,and a+b in the same type of leaves.In O_(3)-symptomatic leaves,however,EDU400 alleviated EOZ-induced suppression of chlorophylls a and a+b,indicating different mode of action of EDU between O_(3)-asymptomatic and O_(3)-symptomatic leaves.Extensive herbivory occurred only in AOZ-exposed plants,leading to suppressed biomass production,while EOZ also led to a similar suppression of biomass production(EDU0×EOZ vs.EDU400×EOZ).In 2016,carry-over effects were also evaluated following cropping and transplantation into new ambient plots.Effects of EOZ in the preceding growing seasons extended to the third growing season in the form of suppressed ratoon biomass production,indicating carry-over effect of EOZ.Although EDU400 protected against EOZ-induced suppression of biomass production when applied in 2015,there was no

关键词： Air pollution Ethylenediurea(EDU) Hormesis Plant protection Tropospheric ozone(O_(3))

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low-cost real-time VLSI system for high-accuracy optical flow estimation using biological motion features and random forests

引用

Science China(Information Sciences) 2023年第5期66卷 301-302页

作者： cong shi Junxian HE Shrinivas PUNDLIK Xichuan ZHOU Nanjian WU Gang LUO School of Microelectronics and Communication Engineering Chongqing University Schepens Eye Research Institute Massachusetts Eye and Ear Harvard Medical School State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences

This study proposes a low-cost, real-time, very large-scale integration (VLSI) architecture for optical flow estimation.The architecture adopts parallel spatiotemporal filters to extract bio-inspired motion features at each pixel location and uses hardware random forests to infer the motion speed.Our system achieves higher estimation accuracy at low computational hardware costs under real-time constraint than previous biological motion estimation systems.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Spectrophotometric analyses of hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX) in water

引用

Journal of Environmental Sciences 2015年第7期27卷 39-44页

作者： cong shi Zhonghou Xu Benjamin L.Smolinski Per M.Arienti Gregory O'Connor Xiaoguang Meng Center for Environmental Systems Stevens Institute of Technology US Army RDECOM-ARDEC

A simple and accurate spectrophotometric method for on-site analysis of royal demolition explosive（RDX） in water samples was developed based on the Berthelot reaction. The sensitivity and accuracy of an existing spectrophotometric method was improved by：replacing toxic chemicals with more stable and safer reagents; optimizing the reagent dose and reaction time; improving color stability; and eliminating the interference from inorganic nitrogen compounds in water samples. Cation and anion exchange resin cartridges were developed and used for sample pretreatment to eliminate the effect of ammonia and nitrate on RDX analyses. The detection limit of the method was determined to be 100 μg/L. The method was used successfully for analysis of RDX in untreated industrial wastewater samples. It can be used for on-site monitoring of RDX in wastewater for early detection of chemical spills and failure of wastewater treatment systems.

关键词： Berthelot reaction Exchange resins RDXS pectrophotometric method Water

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

门限密码技术及其标准化进展

引用

密码学报（中英文） 2024年第1期11卷 227-254页

作者：荆继武张世聪王平建中国科学院大学密码学院北京100190 中国科学院信息工程研究所北京100085

信息技术的发展,加剧了信息终端的多样性和复杂性,使得单个终端的安全保障变得更加脆弱,能抵御"单点故障"的门限密码需求就变得更加重要.本文从门限密码的基础元素和框架入手,首先介绍门限密码的方案组成和安全定义、门限密码设计中常... 详细信息

信息技术的发展,加剧了信息终端的多样性和复杂性,使得单个终端的安全保障变得更加脆弱,能抵御"单点故障"的门限密码需求就变得更加重要.本文从门限密码的基础元素和框架入手,首先介绍门限密码的方案组成和安全定义、门限密码设计中常用的多方联合秘密生成技术和门限联合计算方法以及门限密码方案的评价指标.然后总结了门限密码学领域不同算法的门限方案研究进展,旨在介绍门限密码学在各类算法中安全性、效率等方面的研究重点和进展及在实践中的应用,并让读者了解门限密码学研究的最新动态.众多门限密码方案的实现以秘密分享为基础,目前多采用简单加法或者多项式加法类型的秘密分享,这种方式在门限密码实现时面临的重要问题是秘密的乘积和求逆的安全联合计算,现有方案主要采用同态加密等较重的技术来解决这个问题,使得方案的效率较低.最后介绍了美国国家标准技术研究院(NIST)和互联网工程任务组(IETF)等机构的门限密码标准化工作.尽管门限密码各类算法层出不穷,标准化工作推进较快,但产业跟进却相对迟缓.相较之下,较为简单的(2,2)门限签名方案,即协同签名方案,在产业界得到了较为成熟的应用,为软件密码产品提供了可靠的安全保障.

关键词：门限密码门限签名门限加密秘密分享

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

碳配额与交易监管下基于区块链技术的平台供应链网络运营决策

引用

山东大学学报（理学版） 2024年第1期59卷 100-114,123页

作者：史聪张桂涛张萧林帅成青岛大学商学院山东青岛266071

在碳配额与交易监管下,基于Nash非合作博弈与变分不等式理论,考虑碳排放权初始分配环节中供应商存在谎报碳配额行为与绿色信息敏感型消费者对产品核实需求,构建应用与未应用区块链技术的2种平台供应链网络均衡模型,对比研究应用区块链... 详细信息

在碳配额与交易监管下,基于Nash非合作博弈与变分不等式理论,考虑碳排放权初始分配环节中供应商存在谎报碳配额行为与绿色信息敏感型消费者对产品核实需求,构建应用与未应用区块链技术的2种平台供应链网络均衡模型,对比研究应用区块链技术前后各平台供应链成员的均衡决策及区块链应用阈值。利用修正收缩投影算法对模型进行求解,并通过数值算例可得:应用区块链技术可避免碳交易量不一致的情况,进一步减少资源的浪费并提高供应链利润;供应商谎报碳配额的行为在一定程度上能提高供应链整体利润,但抑制了供应链获得更高利润的能力;在一定的区块链运营成本阈值内,供应链成员才有采用区块链技术的动机。

关键词：区块链技术碳配额与交易政策碳配额谎报行为绿色信息敏感平台供应链网络均衡

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

标准数字化平台建设机制与发展路径研究

引用

标准科学 2024年第1期 64-71页

作者：狄矢聪上海市质量和标准化研究院

建设标准数字化平台是推进标准数字化转型的重要载体。本文系统分析了新形势下标准数字化平台建设的必要性,收集和整理平台建设典型需求和国内外先进标准数字化平台建设案例,归纳总结特点和优势,从基本原则、建设目标、参考架构、核心... 详细信息

建设标准数字化平台是推进标准数字化转型的重要载体。本文系统分析了新形势下标准数字化平台建设的必要性,收集和整理平台建设典型需求和国内外先进标准数字化平台建设案例,归纳总结特点和优势,从基本原则、建设目标、参考架构、核心系统、主要功能5个维度形成标准数字化平台建设机制初探。结合技术演进和工作举措,深入探究标准数字化平台建设的发展路径。围绕充分调研、过程监督、动态调整、人才物资4个方面提出了平台建设的保障性建议,以期为我国开展相关工作提供参考借鉴。

关键词：标准数字化平台建设机制发展路径

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：