检索结果-南通市图书馆

Investigation of wide-angle thin metamaterial absorber at infrared region

在线全文

学校读者我要写书评

暂无评论

Optoelectronics Letters 2021年第11期17卷 669-672页

作者： HUANG Xiutao ZHANG Chunbo cong lin FAN Jun YUAN Hang Aerospace Institute of Advanced Materials&Processing Technology Beijing 100074China

In the practical application,a wide-angle absorption with simple structure is still crucial property of metamaterial absorbers(MAs).A single-band infrared MA is introduced to analyze the angle insensitive *** simulation reveals that a perfect absorption peak with 99.9%(7.55μm)is achieved at normal incidence,as well as the absorptivity is respectively 69.7%(7.46μm)and 93.5%(7.46μm)for transverse electric(TE)and transverse magnetic(TM)modes at 70°*** changing substrate thickness,the absorption ratio at 70°is increased to 91%(7.46μm)for TE *** design can also keep the good absorption stability for the geometric *** E z-field distributions for different incident angles are given to investigate the physical *** designed MA can realize good wide-angle *** MA owns great applications,including infrared spectroscopy,solar harvester and plasmonic sensors.

关键词： Investigation of wide-angle thin metamaterial absorber at infrared region

Antimicrobial resistance characteristics and phylogenetic relationships of pleuromutilin-resistant Enterococcus isolates from different environmental samples along a laying hen production chain

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 195-205页

作者： cong lin Yuxuan Feng Xianjun Xie Haoyu Zhang Jie Wu Yixiao Zhu Jing Yu Jingyi Feng Wen Su Shanming Lai Anyun Zhang Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province Key Laboratory of Bio-Resource and Eco-Environment of Ministry of EducationCollege of Life SciencesSichuan UniversityChengdu 610065China

Antimicrobial resistance in the laying hen production industry has become a serious public health *** antimicrobial resistance and phylogenetic relationships of the common conditional pathogen Enterococcus along the laying hen production chain have not been systematically clarified.105 Enterococcus isolates were obtained from 115 environmental samples (air,dust,feces,fies,sewage,and soil) collected along the laying hen production chain (breeding chicken,chick,young chicken,and commercial laying hen).These Enterococcus isolates exhibited resistance to some clinically relevant antibiotics,such as tetracycline (92.4%),streptomycin (92.4%),and erythromycin (91.4%),and all strains had multidrug resistance *** genome sequencing characterized 29 acquired antibiotic resistance genes (ARGs) that conferred resistance to 11 classes of antibiotics in 51pleuromutilin-resistant Enterococcus isolates,and lsa(E),which mediates resistance to pleuromutilins,always co-occurred with lnu(B).Alignments with the Mobile Genetic Elements database identified four transposons (Tn554,Tn558,Tn6261,and Tn6674) with several ARGs(erm(A),ant(9)-la,fex(A),and optrA) that mediated resistance to many clinically important ***,we identified two new transposons that carried ARGs in the Tn554 family designated as Tn7508 and Tn7492.A complementary approach based on conventional multi-locus sequence typing and whole genome single nucleotide polymorphism analysis showed that phylogenetically related pleuromutilin-resistant Enterococcus isolates were widely distributed in various environments on different production *** results indicate that environmental contamination by antimicrobial-resistant Enterococcus requires greater attention,and they highlight the risk of pleuromutilin-resistant Enterococcus and ARGs disseminating along the laying hen production chain,thereby warranting effective disinfection.

关键词： Antimicrobial resistance Enterococcus Laying hen production chain Pleuromutilin

Fungus induces the release of IL- 8 in human corneal epithelial cells, via Dectin-1-mediated protein kinase C pathways

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2015年第3期8卷 441-447页

作者： Xu-Dong Peng Gui-Qiu Zhao Jing lin Nan Jiang Qiang Xu Cheng-Cheng Zhu Jian-Qiu Qu lin cong Hui Li Department of Ophthalmology the Affiliated Hospital of Qingdao University

AIM: To identify whether Aspergillus fumigatus(***) hyphae antigens induced the release of interleukin-8(IL-8) in anti-fungal innate immunity of cultured human corneal epithelial cells(HCECs) and determine the involvement of intracellular signalling pathways. METHODS: HCECs were treated with A. fumigatus hyphae antigens with different concentrations and *** cytoplasmic calcium of HCECs were assessed by fluorescence imaging. Western blot was used to detect the expression of Ca2 +-dependent protein kinase C(PKC). The IL-8 levels were determined by specific human IL-8 enzyme-linked immunosorbent assay(ELISA) and reverse transcriptase polymerase chain reaction(RT-PCR). Using a series of pharmacological inhibitors, we examined the upstream signalling pathway responsible for IL-8 expression in response to *** hyphae antigens. RESULTS: Cells exposed to A. fumigatus hyphae antigens showed higher level of IL-8 m RNA expression and protein production. We demonstrated here that stimulation of HCECs with A. fumigatus hyphae triggers an intracellular Ca2 +flux and results in the activation of Ca2 +-dependent PKC(α, βⅠ and βⅡ) which can be attenuated by pre-treatment of cells with laminarin,suggesting that Dectin-1 signals pathway induced cytoplasmic calcium and influence the activation of PKC in HCECs. Inhibitors of Ca2 +-dependent PKC(Ro-31-8220 and Go6976) significantly abolished hyphae-induced expression of ***: Our findings suggest that A. fumigatushyphae-induced IL-8 expression was regulated by the activation of Dectin-1-mediated Ca2 +-dependent PKC in HCECs.

关键词： Dectin-1 Ca 2+ protein kinase C interleukin-8 corneal epithelium Aspergillus fumigatus

Effect of icariin on ubiquitination of amyloid precursor protein in Alzheimer′s disease mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理学与毒理学杂志 2023年第7期37卷 519-520页

作者： HE Chengfen lin cong CHEN Xia GONG Qihai LI Fei Department of Pharmacology Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Guizhou Province School of Pharmacy Zunyi Medical University

OBJECTIVE To investigate the effect of icariin (ICA) on the ubiquitination modification of β-amyloid precursor protein (APP) in Alzheimer′s disease *** In vitro,(1) HEK 293 cells stably overexpressing human APP695 (OE-h APP) were treated with different concentrations of ICA (10-100μmol·L-1) for 24 h and the cell viability was detected by MTT assay.(2) CHX(50 mg·L-1) was used to block protein synthesis and MG132 (20μmol·L-1) inhibits proteasome activity, then the level of APP in different time (0, 0.5, 1, 2, 3 and 4 h) and the ubiquitination were tested by Western blotting.(3) E3ubiquitin ligases HMG-Co A reductase degradation protein 1 (HRD1) protein expression in OE-h APP was tested by Western blotting, as well as the level and ubiquitination of APP were tested under HRD1 silent condition by Co-IP and Western blotting. In vivo,(1) male APP/PS1 mice and wild type (WT) mice were randomly divided into 5groups:WT, WT+ICA, APP/PS1, APP/PS1+ICA, and APP/PS1+donepezil (DPZ) groups. ICA (60 mg·kg-1·d-1)and DPZ (1 mg·kg-1·d-1) were treated for 3 months by gavage from 6 months of age, and WT mice were given equal volume of distilled water.(2) Morris water maze and Y-maze experiments were used to detect the alteration of spatial learning memory function.(3) After then, the brain tissues were collected, total proteins were extracted,APP antibodies were subjected to Co-IP, and total ubiquitination (Ub), K48-linked polyubiquitination (Ub K48) and K63-linked polyubiquitination of APP level, APP and HRD1 proteins were detected by Western *** In vitro results showed that ICA significantly enhanced APP degradation (vs control, P<0.01), up-regulated HRD1 expression (vs control, P <0.05; vs OE-h APP, P<0.05), elevated the level Ub and Ub K48 of APP, as well as increased APP degradation. Moreover,silenced HRD1 gene abolished abovementioned effects of ICA (vs control-si RNA, P<0.05; vs HRD1-si RNA, P<0.05). In vivo results showed that ICA improved the spatial learn

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

爆破震动对土质边坡动力稳定性影响研究

岩土力学 2005年第9期26卷 1499-1501页

作者：张林林从谋华侨大学岩土工程研究所福建泉州362021

采用拟静力化的惯性力法,利用改进了的条分法来计算主动土压力,并考虑爆破地震的时程效应,提出了已有边坡在爆破过程中的动力稳定性系数的新的计算方法。实例证明,所得计算结果综合考虑了爆破震动波传播过程的衰减、频谱结构及相位差等... 详细信息

采用拟静力化的惯性力法,利用改进了的条分法来计算主动土压力,并考虑爆破地震的时程效应,提出了已有边坡在爆破过程中的动力稳定性系数的新的计算方法。实例证明,所得计算结果综合考虑了爆破震动波传播过程的衰减、频谱结构及相位差等因素的影响,因此该方法在土质边坡稳定分析中与拟静力法相比更具理论基础,其结果也更接近工程实际。

关键词：爆破震动边坡动力稳定分析拟静力法时程效应

TCP-1,a novel peptide to diagnose early colon cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第3期35卷 226-233页

作者： Hang Yu Baoying Wen Min Huang Ru Feng Libin Pan Manyi Xu Hao lin lin cong Sen Zhang Yan Li Chi-Hin Cho Chongjing Zhang Xiaoguang Chen Yan Wang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesBeijing 100050China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina

A nine cyclic peptide(TCP-1)showed excellent specificity for colon ***-1 binds with human tumor tissues at early stages and mice tumor with diameters of 1-4 mm,suggesting that TCP-1 may be used for early diagnosis of colon *** mechanism of the targeted binding of TCP-1 to colon cancer was also studied using immunoprecipitation,LC-MS and *** screening and identifying of the possible binding target proteins of TCP-1,keratin,typeⅡcytoskeletal 5 was speculated to be the specific binding target protein of TCP-1 in human tumor *** studies were conducted to investigate the target-mediated drug disposition of the new tumor-specific peptide by LC-MS/*** tissue distribution study showed that TCP-1 was found only in colon tumors(the target site)in tumor mice did not bind to any other *** TCP-1 to tumor markedly increased its removal rate from blood circulation but mildly extended its staying time in *** tumor mice,a lower AUC of TCP-1(reduced by almost 35%)and 2-fold higher clearance were found compared to that of normal *** proposed metabolic pathway of TCP-1 in the kidney was also determined using LC-MS^(n)-*** high specificity and low toxicity of the peptide may be caused by its extremely tight binding to the *** applications for future clinical use,including MRI and PET/CT were also explored,and this research may promote the development of colon cancer diagnostic technology research and provide new ideas and technical routes for tumor diagnostic technology.

关键词： Colon cancer TCP-1 Peptide Cytokeratin 5 Pharmacokinetics/pharmacodynamics(PK/PD)

在线全文

学校读者我要写书评

暂无评论

中国交通运输业能源效率及其影响因素研究

交通运输系统工程与信息 2016年第1期16卷 19-25页

作者：宋震丛林福州大学经济与管理学院福州350108 福建省人大法制委福州350001

交通运输业能耗强度与各行业平均水平的差距逐步扩大,使得交通运输业逐步成为节能环保的短板之一.在此背景下,利用随机前沿模型,以中国30省区为样本,测算1995—2012年各地区交通运输业全要素能源效率并进行影响因素分析.结果表明,全要... 详细信息

交通运输业能耗强度与各行业平均水平的差距逐步扩大,使得交通运输业逐步成为节能环保的短板之一.在此背景下,利用随机前沿模型,以中国30省区为样本,测算1995—2012年各地区交通运输业全要素能源效率并进行影响因素分析.结果表明,全要素视角下的中国交通运输业能源效率总体呈扁平W型走势波动上升,平均有56.3%的节能潜力;东中西部地区差异明显,呈现自东向西逐步下降的空间格局;全要素评价结果比单要素能源效率更加稳健;各省区交通运输业能源效率在2004—2012年以年均9.6%的速度发散,其中西部地区年均发散速率达到10.7%;对外开放、工业化进程、人力资本显著促进交通运输业能源效率的提升,制度因素与政府干预抑制作用明显,基础设施水平的影响不显著.

关键词：综合交通运输能源效率随机前沿模型交通运输业收敛分析影响因素

Electrochemical Catalytic Properties of Pt/FeSnO(OH)_5 towards Methanol Oxidation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2018年第10期37卷 1585-1595页

作者： ZHAN Xia-Dan ZHAN Ying-Xu DU Chang-Chao LI Chang-Rong YU Han lin cong State Key Laboratory of Photocatalysis on Energy and Environment Key Laboratory of Eco-materials Advanced Technology (Fuzhou University)Fujian Province UniversityCollege of Materials Science and EngineeringFuzhou UniversityFuzhou 350108，China

The Pt/FeSnO（OH）_5 catalyst has been prepared by depositing Pt nanoparticles on the synthesized FeSnO（OH）_5 nanoboxes and demonstrates excellent performance towards methanol oxidation reaction（MOR） in direct methanol fuel cells（DMFCs）.The Pt/FeSnO（OH）_5 catalyst exhibits a higher mass activity（1182.35 mA/mgPt） compared with Pt/C（594.57 mA/mgPt） *** X-ray powder diffraction,field emission scanning electron microscope,field emission transmission electron microscopy,X-ray photoelectron spectroscopy and electrochemical experiments have been employed to explore the relationships between the crystal structure and electrochemical *** increased activity and resistance of CO poisoning for Pt/FeSnO（OH）_5 catalyst can be attributed to the strong interaction between the transition metal in the hydroxide and Pt and the bifunctional *** higher relative concentration of Pt^0 in Pt/FeSnO（OH）_5 also contributes to the MOR ***,the charge transfer resistance of Pt/FeSnO（OH）_5 is lower than that of Pt/***,Pt/FeSnO（OH）_5 has great application prospect as a high-performance electrocatalyst in DMFCs.

关键词： Pt/FeSnO(OH)5 direct methanol fuel cell metal-support interaction

在线全文

学校读者我要写书评

暂无评论

环境约束下中国交通运输业能源效率研究

交通运输系统工程与信息 2016年第4期16卷 39-45页

作者：宋震丛林福州大学经济与管理学院福州350108 福建省人大法制委福州350001

交通运输业能耗强度、碳排放强度的上升趋势,与其他行业稳步下降的趋势相悖,使得交通运输业逐步成为节能环保的短板之一.本文在考虑CO2排放约束的前提下,构建超效率非期望Min DS模型,评价1995—2013年中国30省份交通运输业能源效率,并利... 详细信息

交通运输业能耗强度、碳排放强度的上升趋势,与其他行业稳步下降的趋势相悖,使得交通运输业逐步成为节能环保的短板之一.本文在考虑CO2排放约束的前提下,构建超效率非期望Min DS模型,评价1995—2013年中国30省份交通运输业能源效率,并利用Global Malmquist-Luenberger指数,动态分析效率的变化情况.研究表明,各地区交通运输业能源效率总体呈反N型波动下降;东部、西部地区各省表现出较大差异性;中部、东北地区内各省表现出一致性,但整体水平较低;超效率非期望Min DS模型有效克服了非期望SBM模型无法完全排序和低估效率结果的问题;造成交通运输业能源效率下降的主要因素是技术效率的下降,但这一状况将在未来得到改善.

关键词：综合交通运输能源效率 MinDS模型交通运输业 GML指数环境约束