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P2X7 receptor blockade decreases inflammation,apoptosis,and enteric neuron loss during Clostridioides difficile toxin A-induced ileitis in mice

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World Journal of Gastroenterology 2022年第30期28卷 4075-4088页

作者： Ana A Q A santos Deiziane V s Costa Danielle A Foschetti Antoniella s G Duarte conceicao s martins Pedro M G soares Patricia Castelucci Gerly A C Brito Department of Morphology School of MedicineFederal University of CearaFortaleza 60430-170CearaBrazil Department of Physiology and Pharmacology School of MedicineFederal University of CearáFortaleza 60430-170CearaBrazil Department of Pathology and Legal Medicine School of MedicineFederal University of CearaFortaleza 60430-170CearaBrazil Department of Morphology(UFC) Federal University of CearaFortaleza 60430-170CearaBrazil Department of Anatomy Institute of Biomedical SciencesUniversity of São PauloSao Paulo 05508-270Brazil Department of Morphology Federal University of CearaFortaleza 60140-170CearaBrazil

Clostridioides difficile(***)is the most common pathogen causing health care-associated *** TcdA and TcdB have been shown to activate enteric neurons;however,what population of these cells is more profoundly influenced and the mechanism underlying these effects remain *** To characterize a specific population of TcdA-affected myenteric neurons and investigate the role of the P2X7 receptor in TcdA-induced ileal inflammation,cell death,and the changes in the enteric nervous system in *** swiss mice were used to model TcdA-induced ileitis in ileal loops exposed to TcdA(50μg/Loop)for 4 *** investigate the role of the P2X7 receptor,Brilliant Blue G(50 mg/kg,i.p.),which is a nonspecific P2X7 receptor antagonist,or A438079(0.7μg/mouse,i.p.),which is a competitive P2X7 receptor antagonist,were injected one hour prior to TcdA *** samples were collected to analyze the expression of the P2X7 receptor(by quantitative real-time polymerase chain reaction and immunohistochemistry),the population of myenteric enteric neurons(immunofluorescence),histological damage,intestinal inflammation,cell death(terminal deoxynucleotidyltransferasemediated dUTP-biotin nick end labeling),neuronal loss,and s100B synthesis(immunohistochemistry).REsULTs TcdA upregulated(Pssion of the P2X7 receptor gene in the ileal tissues,increasing the level of this receptor in myenteric neurons compared to that in control *** with the control mice indicated that TcdA promoted(Pss of myenteric calretinin+(Calr)and choline acetyltransferase+neurons and increased the number of nitrergic+and Calr+neurons expressing the P2X7 *** of the P2X7 receptor decreased TcdAinduced intestinal damage,cytokine release[interleukin(IL)-1β,IL-6,IL-8,and tumor necrosis factor-α],cell death,enteric neuron loss,and s100B synthesis in the mouse *** Our findings demonstrated that TcdA induced the upregulation of the P

关键词： Clostridioides difficile Clostridioides difficile toxin A P2X7 receptor Enteric nervous system Enteric neuron Enteric glia

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King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

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World Journal of Transplantation 2025年第1期15卷 124-134页

作者： Bruno da silva Athanasio Antonio Marcio de Faria Andrade Vivian Vasconcelos Costa Juliano Felix Castro silverio Leonardo Macedo Garcia Mauro martins Teixeira Daniele da Gloria souza Paula Vieira Teixeira Vidigal Cristiano Xavier Lima Department of surgery Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Liver Transplantation Unit Felicio Rocho HospitalBelo Horizonte 30110-934Minas GeraisBrazil Department of Morphology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil Department of Pathology Federal University of Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Acute liver failure(ALF)is a severe condition characterized by rapid deterioration of liver function in individuals without preexisting liver *** transplantation(LT)is the most impactful *** fever(YF)is an infectious disease that primarily affects the liver and has a high mortality ***,LT can be a viable option for treating rare cases with extensive liver ***,the criteria for assessing the severity of ALF and determining the indications for transplantation have not been specifically validated for cases caused by *** To present necessary adjustments to established scoring systems for ALF secondary to *** This was an observational,retrospective,single-center *** consecutive patients with confirmed ALF due to YF were monitored in the intensive care unit by a specialized liver transplant team during a three-month epidemic outbreak in *** hospitalization,general supportive therapeutic measures were implemented,and the patients were regularly assessed using the King's College criteria and the Clichy-Villejuif criteria to determine the severity of liver *** is considered a viable measure for patients with signs of end-stage liver *** Eight of 14(57%)patients developed severe neurological alterations within the first 96 hours after hospital *** patients underwent emergency LT,and despite a moderate viral infection of the graft after transplantation,the 5-year survival rate was 50%.Although the King's College criteria and the Clichy-Villejuif criteria are the main scoring systems for ALF,they are insufficient for predicting the risk of mortality in this context,primarily because of low serum bilirubin levels in the final stage of the disease and significant disparities between coagulation abnormalities and patient *** To ensure good applicability in cases of YF-induced ALF,the authors suggest adaptations to the King's College and Clichy-Vill

关键词： Yellow fever Acute liver failure Liver transplantation King's College criteria Clichy-Villejuif criteria

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Computerized geochemical modeling of burial diagenesis of the Eocene turbidite reservoir elements：Urucutuca Formation,Espirito santo Basin,southeastern Brazil passive margin

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Journal of Palaeogeography 2018年第4期7卷 363-377页

作者： Marcos Antonio Klunk sudipta Dasgupta Rommulo Vieira conceicao Institute of Isotope Geology Federal University of Rio Grande do SulPorto AlegreBrazil Department of Earth sciences Indian Institute of Technology (IIT) BombayMumbai India

The computerized geochemical modeling, a useful tool to understand the diagenetic processes influencing the quality of hydrocarbon reservoirs, is performed by using different modules of computer codes based on the thermodynamic and chemical kinetic principles and their associated parameters. As observed in the reservoir lithofacies deposited from the marine sediment-gravity flows, a case study of diagenesis is presented here from the Espírito santo Basin in southeastern Brazil. The study uses the Geochemist＇s Workbench（GWB～（TM））, PHREEQC～（TM） and TOUGHREACT～（TM） computation packages. The comparison of performances of these packages demonstrates the convergence of results from the software-based geochemical modeling with the petrographic observation of dissolution, albitization, kaolinization, and the precipitation of calcite and dolomite. Moreover, with limited data points, e.g., the sedimentary petrographic data acquired from limited number of boreholes, the computer simulation establishes itself to be a powerful quantitative method estimating the degree and type of diagenetic alteration of turbidite reservoir bodies in contact with a source of saline-water influx associated with salt ***, using the limited petrographic data points, the geochemical computer-simulation method can even be utilized and extrapolated for areas where similar geological context is interpreted but no borehole data are available. Hence, porosity of turbidite reservoir lithofacies can be predicted in relation to the spatial distribution of dissolution, kaolinization, and albitization of feldspars and authigenic carbonate precipitation.

关键词： sandstone diagenesis Computerized diagenetic modeling Turbidite reservoir GWB PHREEQC TOUGHREACT

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DAYLIGHT IN A CIsTERCIAN HERITAGE CHURCH IN LIsBON,FROM RURAL TO URBAN CONTEXT

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Journal of Green Building 2014年第3期9卷 116-130页

作者： Jorge s.Carlos Ana M.T.martins Centre of Materials and Building Technologies University of Beira InteriorCalçada Fonte do Lameiro6201-001 CovilhãPortugal Department of Civil Engineering and Architecture University of Beira Interior/CITADResearch Centre in TerritoryArchitecture and DesignLisbonPortugalCalçada Fonte do Lameiro6201-001 CovilhãPortugal.

Light levels in the churches of the Cistercian Order are mostly related to the fulfilment of liturgical *** compound building of Bernardas’Convent includes a church at the utmost southern corner that dates back to the 17th *** only has one façade facing due *** paper analyses the relationship between daylight conditions within the building before and after the urbanisation of the surrounding area;taking into account the relationship between the church,its main activities,and solar trajectory.A comparative analysis of the relationship between the actual surrounding context and the initial period after it was built(open field)is *** highest reflectance of the street canyon has augmented the levels of available daylight.

关键词： sun-path Daylight factor Vertical daylight factor Urban canyon Cistercians Heritage

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Bioaccessibility of phenolic compounds from Brazilian grape juices using a digestion model with intestinal barrier passage

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Food Bioscience 2023年第2期52卷 1343-1351页

作者： Maria da conceicao Prudencio Dutra Ana Beatriz martins da silva Ederlan de souza Ferreira Ana Julia de Brito Araujo Carvalho Marcos dos santos Lima Aline Camarao Telles Biasoto Graduate Program in Food science Faculty of PharmacyFederal University of BahiaSalvadorBahiaBrazil Federal Institute of Education Science and Technology of Sertao PernambucanoLiquid Chromatography LaboratoryCampus IndustrialPetrolinaPernambucoBrazil Brazilian Agricultural Research Corporation Embrapa Semi-arid RegionPetrolinaPernambucoBrazil Brazilian Agricultural Research Corporation Embrapa EnvironmentJaguariunaSao PauloBrazil

Grape juices are rich in bioactive compounds;however,for these compounds to exert their functionality,they must be ***,the present study evaluated a simulated digestion process on the main bioactive compounds of monovarietal grape juices of five Brazilian hybrid cultivars(*** x ***).Characterization of the chemical profiles in liquid chromatography(HPLC-DAD-RID),behaviour of phenolics in the stages of digestion and bioaccessibility through the INFOGEsT protocol plus intestinal barrier passage were carried *** the 24 polyphenols identified in the grape juice samples,11 were bioaccessible,with emphasis on the class of *** B2(101-426%),(+)-catechin(169-370%)and gallic acid(61-230%)stood out in all juices,showing that these compounds are key to the functionality of these *** were observed to differ between juices,demonstrating that factors such as the cultivar should be explored more extensively in studies on functional *** study also suggests that quality components such as sugars and organic acids influence the bioaccessibility of beverages.

关键词： Grape cultivars Functional beverages Phytochemicals Digestion simulation Bioactivity

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structural Optimization of Metal and Polymer Ore Conveyor Belt Rollers

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Computer Modeling in Engineering & sciences 2022年第12期133卷 601-618页

作者： Joao Pedro Ceniz Rodrigo de sá martins Marco Antonio Luersen Tiago Cousseau Department of Mechanical Engineering Federal University of Technology-Parana(UTFPR)Curitiba81280-340Brazil

Ore conveyor belt rollers operate in harsh environments,making them prone to premature *** service lives are highly dependent on the stress field and bearing misalignment angle,for which limit values are defined in a *** this work,an optimization methodology using metamodels based on radial basis functions is implemented to reduce themass of twomodels of *** a structural point of view,one of the rollers ismade completely of metal,while the other also has some components made of polymeric *** objective of this study is to develop and apply a parametric structural optimization methodology to minimize the mass of the two models of *** represent the mechanical behavior of the rollers,simulations were performed using the finite element *** the numerical optimization process,the variable parameters were the dimensions of the shaft and external *** geometric configuration that corresponded at the same time to the lowest mass and acceptable ranges for the stress and bearingmisalignment angle was *** the proposed methodology,a 32.3% reduction in mass was obtained for a metal roller design and an 18.9% reduction for a polymer *** both cases,the constraints were not *** the all-metal roller,the safety factors for the maximum stress and bearingmisalignment angle were 1.44 and 1.75,respectively,while for the polymer roller the corresponding figures were 1.50 and *** work describes a low-computational-cost optimization methodology for roller designs that have been little studied in the ***,the methodology could be adapted for use with other types of rollers and rollers made of different materials.

关键词： Conveyor belt rollers structural optimization surrogate models radial basis functions

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Do vegetative and reproductive phenophases of deciduous tropical species respond similarly to rainfall pulses?

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Journal of Forestry Research 2013年第4期24卷 643-651页

作者： A.P.silveira F.s.Araújo F.R.martins Itapipoca Faculty of Education Av.Monsenhor Tabosa s/ no.Ceará State University -- UECE Graduate Course of Ecology and Natural Resources Department of BiologyBuilding 906Federal University of Ceará-UFC Department of Plant Biology Institute of BiologyP.O.Box 610University of Campinas – UNICAMP

Deciduous trees with high-density wood that occur in dry seasonal tropical regions respond to rainfall seasonality with synchrony in phenophases. However, they may exhibit interannual differences in synchrony and intensity of phenophases, as strategy for large variations in duration and intensity of rainfall pulses. Nevertheless, it remains unknown how phenophases of deciduous trees of the Brazilian semi-arid region respond to rainfall variations. The phenology of Cordia oncocalyx was monitored in deciduous thorny woodland （Caatinga）, from April 2009 to March 2011, and was correlated with rainfall, soil humidity, temperature, and photoperiod. The rainy years 2009 and 2011 exhibited higher duration of rainfall pulses and lower frequency of interpulses, but in 2010 pulse duration and total rainfall were lower. Circular statistics showed leaf flush followed by flowering and fruiting in the rainy season, and leaf fall and seed dispersal in the dry season.

关键词： asynchrony circular analysis deciduous phenology riskspreading seasonality.

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Ischemic colitis with small-vessel occlusion,simultaneous total colectomy and liver transplantation:A case report

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World Journal of Transplantation 2025年第2期15卷 337-343页

作者： Leonardo Yuri Kasputis Zanini Fabiana Roberto Lima Michel Ribeiro Fernandes Paola sofia Espinoza Alvarez Marcello de souza silva Antônio Paulo Ramos martins Filho Tomazo Antonio Prince Franzini Lucas souto Nacif Department of surgery Federal University of São PauloSão Paulo 04023-062Brazil Department of Liver and Gastrointestinal Transplant Hospital 9 de JulhoSão Paulo 01409-002Brazil Department of Pathology University of São Paulo School of MedicineSão Paulo 05403-900Brazil Department of surgical Pathology Hospital 9 de JulhoSão Paulo 01409-002Brazil Department of Gastrointestinal Endoscopy Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Department of Endoscopy Hospital 9 de JulhoSão Paulo 01409-002Brazil

BACKGROUND The colon is the hollow viscera that proportionally has the lowest vascular supply and is more predisposed to ischemic *** the context of end-stage liver disease,various components may explain this group's greater predisposition to colonic ischemic ***,portal hypertension generates a process of coagulopathy,impairing local *** case report describes a case of ischemic colitis with small-vessel occlusion found during liver transplantation in a patient with decompensated end-stage liver *** sUMMARY A 64-year-old man with liver cirrhosis due to non-alcoholic steatohepatitis and hepatocellular *** patient underwent liver transplantation due to hepatic *** donor was a 53-year-old man who had died of a hemorrhagic *** examination revealed diffuse ischemic colitis with significant distention and *** to the condition of the colon,a subtotal colectomy was *** transplantation with warm ischemia time of 35 minutes,cold ischemia of 6 hours 30 minutes and total ischemia time of 7 hours 5 *** patient improved clinically with oral tract function and physiotherapy,but unfortunately,he developed a bloodstream infection,a new septic shock and died six months after *** simultaneous total colectomy and orthotopic liver transplantation represent a rare *** events have a high mortality rate in the general population and are particularly important in cirrhotic patients.

关键词： Ischemic colitis Liver transplantation End-stage liver disease Acute-on-chronic liver failure Case report

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A new approach to pedestal differentiation for soil loss estimation-a case study from a burnt area in north-central Portugal

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Journal of Forestry Research 2024年第3期35卷 45-54页

作者： Frank G.A.Verheijen Martinho A.s.martins sergio A.Prats Jan J.Keizer Centre for Environmental and Marine studies(CEsAM) Department Environment and PlanningUniversity of Aveiro3810-193 AveiroPortugal Mediterranean Institute for Agriculture Environment and Development(MED-CHANGE)Institute for Advanced Studies and ResearchUniversity of EvoraPolo da MitraAp.947006-554 EvoraPortugal GeoBiociencias Geotecnologias E Geoengenharias(GEOBIOTEC)Department Environment and PlanningUniversity of Aveiro3810-193 AveiroPortugal

soil pedestals have long been used as qualitative indicators of soil splash *** rangelands,plant-capped pedestals,generally grass tussocks,have also been used to quantitatively estimate soil loss since the first half of the twentieth *** agricultural lands,forests,and bad-lands,stone-capped pedestals have been used as qualitative and semi-quantitative indicators of active,'extreme'*** work has been reported on using capstone pedestal data for quantifying soil *** postulate that three distinct capstone pedestal types may be present in any given location and that a detailed analysis of a pedestal height histogram may be used to recognize their *** analysis can subsequently inform if soil loss can be reliably estimated and if so,which of the existing methods using pedestal height data will provide more accurate *** three proposed capstone pedestal types are:(1)neo-pedestals formed underneath surface stones exposed by(partial)removal of the soil surface cover;(2)endo-pedestals formed underneath stones that were buried in the soil but have been exposed by erosion;and(3)phoenix-pedestals formed underneath stones from collapsed *** the pedestal height histogram of any given location,a skew to smaller heights may indicate the existence of endo-and/or phoenix-pedestals,which may be revealed as a bi-(or tri)modal distribution when using a smaller bin *** concept was applied to a case study where soil loss had been monitored for control plots and mulched plots during a 5-year period following wildfire in a eucalypt *** measured pedestal heights and used methods to quantitatively assess soil loss from soil pedestal data in the available *** pedestal data at the end of the 5-year period under or overestimated soil loss in the control treatment,with results ranging from 60 to 115%of measured soil loss,depending on the *** is postulated that phoenix-and endo-pedestals may be a driving fact

关键词： soil pedestals Mulch Wildfire soil erosion Char

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A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast

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Neural Regeneration Research 2020年第10期15卷 1931-1936页

作者： Prashant Bharadwaj Ralph martins Centre of Excellence for Alzheimer’s Disease Research and Care School of Medical and Health SciencesEdith Cowan UniversityWestern AustraliaAustralia school of Pharmacy and Biomedical sciences Curtin Health and Innovation Research Institute(CHIRI)Faculty of Health SciencesCurtin UniversityWestern AustraliaAustralia school of Psychiatry and Clinical Neuroscience.University of Western Australia Western AustraliaAustralia school of Biomedical science Macquarie UniversitySydneyNSWAustralia

Multiple lines of evidence show that soluble oligomer forms of amyloidβprotein(Aβ42)are the most neurotoxic species in the brain and correlates with the degree of neuronal loss and cognitive deficit in Alzheimer’s *** many studies have used mammalian cells to investigate oligomer Aβ42 toxicity,the use of more simple eukaryotic cellular systems offers advantages for large-scale screening *** have previously established and validated budding yeast,saccharomyces cerevisiae to be a simple and a robust model to study the toxicity of Aβ.Using colony counting based methods,oligomeric Aβ42 was shown to induce dose-dependent cell death in *** have adapted this method for high throughput screening by developing an absorbance-based growth *** further validated the assay with treatments previously shown to protect oligomer Aβ42 induced cell death in mammalian and yeast *** assay offers a platform for studying underlying mechanisms of oligomer Aβ42 induced cell death using gene deletion/overexpression libraries and developing novel agents that alleviate Aβ42 induced cell death.

关键词： Alzheimer’s disease amyloid toxicity autophagy Aβ42 oligomer high-throughput screening latrepirdine neuroprotection yeast model

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