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Fecal immunochemical test accuracy in average-risk colorectal cancer screening

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World Journal of Gastroenterology 2014年第4期20卷 1038-1047页

作者： Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias concepción Rivera M Begoa Iglesias Lucía cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators Department of Gastroenterology Complexo Hospitalario Universitario de Vigo Department of Gastroenterology Complexo Hospitalario Universitario de Ourense Department of Clinical Analysis Complexo Hospitalario Universitario de Vigo Department of Pathology Complexo Hospitalario Universitario de Vigo Department of Gastroenterology Donostia Hospital Biodonostia Institute University of the Basque Country UPV/EHU

AIM: To assess the fecal immunochemical test (FIT) accuracy for colorectal cancer (CRC) and advanced neoplasia (AN) detection in CRC screening.

关键词： Colorectal neoplasms Early detection of cancer Sensitivity and specificity Adenoma Occult blood Cost-benefit analysis

Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection

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World Journal of Gastroenterology 2008年第47期14卷 7149-7159页

作者： Juan R Larrubia Selma Benito-Martínez Miryam Calvino Eduardo Sanz-de-Villalobos Trinidad Parra-cid Department of Gastroenterology Guadalajara University HospitalUniversity of AlcaláDonante de Sangre st.19002 GuadalajaraSpain Guadalajara University Hospital University of AlcaláDonante de Sangre st.19002 GuadalajaraSpain

Chemokines produced in the liver during hepatitis C virus(HCV) infection induce migration of activated T cells from the periphery to infected *** milieu of chemokines secreted by infected hepatocytes is predominantly associated with the T-helper cell/Tc1 T cell(Th1/Tc1) *** chemokines consist of CCL3(macrophage inflammatory protein-1α;MIP-1α),CCL4(MIP-1β),CCL5(regulated on activation normal T cell expressed and secreted;RANTES),CXCL10(interferon-γ-inducible protein-10;IP-10),CXCL11(interferon-inducible T-cell α chemoattractant;I-TAC),and CXCL9(monokine induced by interferon γ;Mig) and they recruit T cells expressing either CCR5 or CXCR3 chemokine *** and peripheral blood levels of these chemokines are increased during chronic hepatitis *** interaction between chemokines and their receptors is essential in recruiting HCV-specific T cells to control the *** the adaptive immune response fails in this task,non-specific T cells without the capacity to control the infection are also recruited to the liver,and these are ultimately responsible for the persistent hepatic *** modulation of chemokine receptor expression and chemokine secretion could be a viral escape mechanism to avoid specific T cell migration to the liver during the early phase of infection,and to maintain liver viability during the chronic phase,by impairing non-specific T cell *** chemokines and their receptors correlate with liver damage,and CXCL10(IP-10) and CXCR3 levels have shown a clinical utility as predictors of treatment response *** regulation of chemokines and their receptors could be a future potential therapeutic target to decrease liver inflammation and to increase specific T cell migration to the infected liver.

关键词： Chemokines Chemokine receptors Hepatitis C virus Viral hepatitis pathogenesis Persistentinfection Viral escape mechanism

Costimulatory molecule programmed death-1 in the cytotoxic response during chronic hepatitis C

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World Journal of Gastroenterology 2009年第41期15卷 5129-5140页

作者： Juan Ramón Larrubia Selma Benito-Martínez Joaquín Miquel Miryam Calvino Eduardo Sanz-de-Villalobos Trinidad Parra-cid Translational Hepatology Unit Guadalajara University Hospital University of Alcalá

Hepatitis C virus（HCV）-specific CD8^＋ T cells play an important role in the resolution of HCV infection. Nevertheless, during chronic hepatitis C these cells lack their effector functions and fail to control the virus. HCV has developed several mechanisms to escape immune control. One of these strategies is the upregulation of negative co-stimulatory molecules such us programmed death-1 （PD-1）. This molecule is upregulated on intrahepatic and peripheral HCV-specific cytotoxic T cells during acute and chronic phases of the disease, whereas PD-1 expression is low in resolved infection. PD-1 expressing HCV-specific CD8^＋ T cells are exhausted with impairment of several effector mechanisms, such as： type-1 cytokine production, expansion ability after antigen encounter and cytotoxic ability. However, PD-1 associated exhaustion can be restored by blocking the interaction between PD-1 and its ligand （PD-L1）. After this blockade, HCV-specific CD8^＋ T cells reacquire their functionality. Nevertheless, functional restoration depends on PD-1 expression level. High PD-l-expressing intrahepatic HCV-specific CD8^＋ T cells do not restore their effector abilities after PD-1/ PD-L1 blockade. The mechanisms by which HCV is able to induce PD-1 up-regulation to escape immune control are unknown. Persistent TCR stimulation by a high level of HCV antigens could favour early PD-1 induction, but the interaction between HCV core protein and gClq receptor could also participate in this process. The PD-1/PD-L1 pathway modulation could be a therapeutic strategy, in conjunction with the regulation of others co-stimulatory pathways, in order to restore immune response aclainst HCV to succeed in clearing the infection.

关键词： Chronic hepatitis Exhaustion Hepatitis C virus core Hepatitis C virus Programmed death-1 Programmed death-1 ligand

Nonlinear optical characterization of single β-barium-borate nanocrystals using second-harmonic confocal microscopy

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Chinese Optics Letters 2018年第4期16卷 81-85页

作者： Rodrigo G.dos Santos Lauro J.Q.Maia cid B.de Araújo Leonardo de S.Menezes Departamento de Fisica Universidade Federal de PernambucoRecife-PE 50670-901Brazil Instituto de Fisica Universidade Federal de CoiasCoiania-CO 74001-970Brazil

The confocal microscopy technique was applied for nonlinear optical characterization of single β-barium-borate（β-BBO） nanocrystals. The experimental setup allows measurements of the laser polarization-selective secondharmonic（SH） generation, and the results can be used to determine the nanocrystals＇ c-axis orientation, as well as to obtain information about their second-order susceptibility χ^（2）. The dependence of the SH signal on the laser polarization allowed the discrimination of individual particles from aggregates. The data were fitted using a model that takes into account the BBO properties and the experimental setup characteristics considering（i） the electrostatic approximation,（ii） the effects of the microscope objective used to focus the light on the sample in an epi-geometry configuration, and（iii） the symmetry of χ^（2） for the β-BBO nanocrystals. A signal at the third-harmonic frequency was also detected, but it was too weak to be studied in detail.

关键词： SH BBO HR barium-borate nanocrystals using second-harmonic confocal microscopy Nonlinear optical characterization of single

ThMn12-Type Alloys for Permanent Magnets

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Engineering 2020年第2期6卷 141-147页

作者： G.C.Hadjipanayis A.M.Gabay A.M.Schonhobel A.Martin-cid J.M.Barandiaran D.Niarchos Department of Physics and Astronomy University of DelawareNewarkDE 19716USA BCMaterials Leioa 48940Spain NCSR Demokritos Agia Paraskevi 15341Greece

Iron-rich compounds with the tetragonal ThMn12-type structure have the potential to meet current demands for rare-earth-lean permanent magnets with high energy density and operating temperatures of 150-200℃.However,while it is normal for magnet technology to lag behind the development of underlying magnetic material,this gap has always been unusually large for ThMn12-type *** gap has widened further in recent years,as excellent combinations of intrinsic magnetic properties have been obtained in compounds synthesized with a smaller amount of structure-stabilizing elements(e.g.,SmFe11V or Sm0.8Zr0.2Fe9.2Co2.3Ti0.5)or with no such elements(i.e.,SmFe9.6Co2.4 thin films).The search for promising compounds continues-with increasing help coming from theoretical ***,progress in the development of magnets beyond polymer-bonded interstitially modified powders remains *** introduction of lanthanum(La)was found to stabilize low-meltingtemperature minority phases in Sm(Fe,Ti)12 alloys,thus allowing for liquid-phase sintering for the first *** high reactivity of La,however,has apparently undermined the development of coercivity(Hc).A controlled crystallization of the initially suppressed ThMn12-type phase makes"bulk"magnetic hardening possible,not only in Sm-Fe-V alloys(in which it has been known since the 1990s),but also is in La-added(Ce,Sm)(Fe,Ti)12 *** properties of the bulk-hardened alloys,however,remain *** synthesized(Sm,Zr)(Fe,Si)12 and(Sm,Zr)(Fe,Co,Ti)12 powders may become suitable for sintering into powerful fully dense magnets,although not before a higher degree of anisotropy in both alloys and a higher Hc in the latter alloy have been developed.

关键词： Permanent magnets Rare earths permanent magnets ThMn12 structure

Single atom Cu-N-C catalysts for the electro-reduction of CO_(2) to CO assessed by rotating ring-disc electrode

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Journal of Energy Chemistry 2024年第1期88卷 169-182,I0004页

作者： S.Pérez-Rodríguez M.Gutiérrez-Roa C.Giménez-Rubio D.Ríos-Ruiz P.Arévalo-cid M.V.Martínez-Huerta A.Zitolo M.J.Lázaro D.Sebastián Instituto de Carboquímica(CSIC) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de Catálisis y Petroleoquímica(CSIC) Marie Curie 228049 MadridSpain Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190France

The electrochemical CO_(2) reduction reaction(CO_(2)RR) to controllable chemicals is considered as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based on copper-nitrogendoped carbon xerogel(Cu-N-C) are successfully developed varying the copper amount and the nature of the copper precursor, for the efficient CO_(2)RR. The electrocatalytic performance of Cu-N-C materials is assessed by a rotating ring-disc electrode(RRDE), technique still rarely explored for CO_(2)RR. For comparison, products are also characterized by online gas chromatography in a H-cell. The as-synthesized Cu-NC catalysts are found to be active and highly CO selective at low overpotentials(from -0.6 to -0.8 V ***) in 0.1 M KHCO_(3), while H_(2) from the competitive water reduction appears at larger overpotentials(-0.9 V vs. RHE). The optimum copper acetate-derived catalyst containing Cu-N_(4) moieties exhibits a CO_(2)-to-CO turnover frequency of 997 h^(-1) at -0.9 V vs. RHE with a H_(2)/CO ratio of 1.8. These results demonstrate that RRDE configuration can be used as a feasible approach for identifying electrolysis products from CO_(2)RR.

关键词： Cu-N-C Carbon xerogel Rotating ring disc electrode Carbon dioxide reduction reaction Carbon monoxide

Three Uncommon Seaweeds of the Pacific Coast of Mexico

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American Journal of Plant Sciences 2015年第19期6卷 3187-3192页

作者： A. Catalina Mendoza-González Luz Elena Mateo-cid Deisy Yazmín García-López Departamento de Botánica Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Campus Santo Tomás México City México

This report describes a new record and two unusual and rare species of marine algae collected from Oaxaca, Michoacán, Jalisco and Baja California Sur at Mexican Pacific coast. Boodleopsis verticillata is the first record in the Pacific shore of Mexico, in the case of Melobesia polystromatica, this is the sixth record at tropical Pacific while Litholepis sonorensisis reported for the third time in the Gulf of California. These results suggest that the taxonomic inventory of seaweed in the Pacific coast of Mexico is not yet complete, so attention must be given to the epiphytes, and other small and delicate species that inhabit the coast of Mexico. Morphological descriptions, distributional range, reproductive stage and samples examined are included.

关键词： Bryopsidales Corallinales Distribution New Records Seaweeds

The Pattern of Sediment Dispersion in the Front Sector of the Stenhouse and Ajax Glaciers, Visca Anchorage, King George Island, Antarctica

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International Journal of Geosciences 2014年第12期5卷 1509-1520页

作者： Beatriz Ferraz Scigliano Kátia Kellem da Rosa Ana Teresa Cordeiro cid Bastos Elisabete de Santis Braga Instituto Oceanográfico da Universidade de Sao Paulo Laboratório de Nutrientes Micronutrientes e Elementos Traco nos Oceanos—Praca do Oceanográfico 191 CEP 055-8-120 Cidade Universitária Sao Paulo Brazil Universidade Federal do Rio Grande do Sul UFRGS Centro Polar e Climático—CPC Departamento de Geografia—Instituto de Geociências Av. Bento Goncalves 9500 Porto Alegre Brazil

This study investigated the dispersal pattern of suspended sediment in the areas near the Stenhouse and Ajax glaciers, Visca Anchorage, Martel Inlet, King George Island, Antarctica. This study was conducted using visible band processing of Quickbird high-resolution spatial images obtained in October 2006. The methodology was also based on the collection and interpretation of data obtained from water samples collected in Admiralty Bay in December 2004. The digital processing of satellite images was performed using a classification method based on the reflectance characteristics of water. The classified images improved visual identification of the dispersion pattern of suspended sediments in the study area. These data were related to the interpretation of analyses conducted on suspended particulate matter (SPM) in the water. The sediment dispersal pattern observed may be associated with glacial erosion processes, their input of meltwater from the front of the glaciers into the study area, detritus flow processes and glaciomarine circulation in the region.

关键词： Remote Sensing Glaciomarine Circulation Suspended Sediment

Occurrence and Distribution of the Genus Jania J. V. Lamouroux (Corallinales, Rhodophyta) in the Pacific Coast of Baja California and Gulf of California, Mexico

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American Journal of Plant Sciences 2013年第12期4卷 1-13页

作者： Luz Elena Mateo-cid A. Catalina Mendoza-González Luis E. Aguilar-Rosas Raúl Aguilar-Rosas Facultad de Ciencias Marinas Universidad Autónoma de Baja California Ensenada Baja California México Instituto de Investigaciones Oceanológicas Universidad Autónoma de Baja California Ensenada Baja California México Instituto Politécnico Nacional Escuela Nacional de Ciencias Biológicas Departamento de Botánica Ciudad de México México

This paper provides a description of the articulated species of the Tribe Janieae (Corallinales, Rhodophyta) in the Pacific coast of Baja California and Gulf of California, Mexico. This taxonomic report is based on newly collected data in the study area and material currently housed at several herbaria. As a result of the present study, the record of the tribe Janieae is represented at the Pacific coast of Mexico for one genus: Jania J. V. Lamouroux with nine species. Morphological, reproductive and anatomical descriptions are provided in detail. In addition, keys for determination are included, as well as habitat, nomenclature, comparisons with other species and information on distribution. Instead of eleven species of Jania currently recorded for the study area, we recognize only nine. Jania verrucosa is restricted to the occidental coast from the Peninsula of Baja California. The remainder of the species commonly occurs in the Gulf of California and the Pacific coast of Baja California’s Peninsula. On the other hand, the gametangial thalli of J. adhaerens and tetrasporangial conceptacle in J. longiarthra are reported for the first time in Mexico.

关键词： Janieae Morphology Distribution Pacific Mexico