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Bacteriological Profile of Effusion Fluids Infections at Charles De Gaulle University Pediatric Hospital from 2017 to 2020

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Open Journal of Medical Microbiology 2024年第2期14卷 146-163页

作者： Kambiré Dinanibè Ouédraogo Oumarou Tiendrebéogo Salam Tondé Issa Tamboura Mamadou Zida Sylvie Kpoda Dissinviel Sagna Tani compaoré T. rebeca Zouré Abdou-Azaque Soubeiga R. Serge Théophile Sawadogo Stanislas Ilboudo Maïmouna Rouamba Hortense Ouédraogo Wenkouni Henri Gautier Ouédraogo-Traoré Rasmata Sanou Mahamoudou Institut de Recherche en Sciences de la Sant Ouagadougou Burkina Faso Centre Hospitalier Universitaire Pdiatrique Charles De Gaulle Ouagadougou Burkina Faso Centre Universitaire de Ziniar Ziniar Burkina Faso Universit Joseph Ki-Zerbo Ouagadougou Burkina Faso Universit Ouaga 3S Ouagadougou Burkina Faso Centre Mdical Urbain de Samandin Ouagadougou Burkina Faso

Introduction: Microbiology of effusion fluids in children in Burkina Faso is characterized by the scarcity of data. This work aimed to study the bacteriological and antibiotics susceptibility profile of bacteria involved in effusion fluid infections in paediatrics in order to improve the choice of probabilistic antibiotics therapy. Methods: A cross-sectional, descriptive study was used in children aged 0 to 15 years from 2017 to 2020 at the Charles De Gaulle Pediatric University Hospital Center (CHUP-CDG) in Ouagadougou. Classical bacteriology methods such as macroscopy, Gram staining, identification galleries and antibiotics susceptibility testing were used. Results: Of 231 samples, 64 bacteria were isolated. The most common bacterial strains of pleural fluid were Staphylococcus aureus (25%) and 40% for Enterobacteriaceae. Of the peritoneal fluid, 77% were Enterobacteriaceae with 57% Escherichia coli;and from joint fluid, 33% were S. aureus and 22% for P. aeruginosa. The overall susceptibility profile showed 29% extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL), 10% methicillin-resistant S. aureus (MRSA), and 8% carbapenemases. Conclusion: Bacteriological profile is characterized by ESBL-producing Enterobacteriaceae and MRSA. The most active antibiotics were macrolides, aminoglycosides, and cefoxitin (methicillin) for Gram-positive cocci, carbapenems, and aminoglycosides for Gram-negative bacilli. Then, the monitoring of antibiotics resistance must be permanent.

关键词： Bacteriological Profile Effusion Fluid Infections

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G6PD Deficiency and COVID-19 in Burkina Faso: A Possible Link?

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Journal of Biosciences and Medicines 2023年第1期11卷 57-69页

作者： Abdoul Karim Ouattara Lassina Traoré Tégwendé rebeca compaoré Théodora Mahoukèdè Zohoncon Jacques Simporé Université Norbert Zongo/Centre Universitaire de Manga Koudougou Burkina Faso Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE) UFR/SVT Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Département Biomédical et de Santé Publique Institut de Recherche en Sciences de la Santé (CNRST/IRSS) Ouagadougou Burkina Faso Faculté de Médecine Université Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso

Burkina Faso is a malaria-endemic country, with a high incidence of G6PD deficiency (G6PDd), which recorded its first case of COVID-19 in March 2020. G6PDd leads to a decrease in the efficiency of erythrocytes to combat oxidative stress, while SARS-CoV-2 infection induces massive production of Reactive Oxygen Species (ROS) in patients. In the present review, we discuss a possible link between G6PDd and SARS-CoV-2 infection. The mean prevalence of G6PDd in Burkina Faso is estimated at 16.6% among males and 6.5% among females. A total of 21,128 cases of COVID-19 have been recorded in Burkina Faso with 387 deaths reported (with a mortality rate of 1.15% among diagnosed cases) as of August 30, 2022. To our knowledge, no association study between G6PDd and SARS-CoV-2 infection has been conducted to date in Burkina Faso. However, several case reports around the world have described elevated risks of hemolysis and thrombosis, and other complications among G6PD-deficient patients infected with SARS-CoV-2. The use of Hydroxychloroquine (HCQ) has also been deemed unsafe by some authors for the treatment of COVID-19 among patients with G6PDd. Although HCQ has been shown to be well tolerated in COVID-19 patients in Burkina Faso, the drug could induce hemolytic crises in people with G6PD deficiency. G6PD is important in regulating ROS and maintaining erythrocyte homeostasis. In view of its high prevalence in Burkina Faso, determination of the G6PD status is required in COVID-19 patients for adequate management such as identifying a subset of COVID-19 patients for whom close monitoring and supportive care may be essential and to restrict treatment with HCQ.

关键词： G6PD Deficiency COVID-19 CQ/HCQ Hemolysis Burkina Faso

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Bacteriological Profile of Effusion Fluids Infections at Charles De Gaulle University Pediatric Hospital from 2017 to 2020

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Open Journal of Medical Microbiology（医学微生物学） 2024年第2期 146页

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ST of Streptococcus pneumonia Circulating in Burkina Faso before the Introduction of PCV-13, 2013

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Advances in Microbiology 2023年第5期13卷 237-248页

作者： Kambiré Dinanibè Tamboura Mamadou Ouédraogo Oumarou Tondé Issa Ouédraogo W. H. Gautier Sanou Mahamoudou Zouré Abdou Azaque compaoré rebeca Sagna Tani Soubeiga R. S. Théophile Zida Sylvie Aké Flavien Abdoul-Salam Ouédraogo Sangaré Lassana Méda Isaïe Kouanda Séni Ouédraogo-Traoré Rasmata Centre Hospitalier Universitaire Pédiatrique Charles De Gaulle Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé Ouagadougou Burkina Faso Davycas International Ouagadougou Burkina Faso Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso Centre Hospitalier Universitaire Sanon Sourô Bobo-Dioulasso Burkina Faso Direction Générale de la Santé Publique Ouagadougou Burkina Faso

Introduction: Burkina Faso experiences regular cases of Streptococcus pneumoniae meningitis. As part of the strategy to reduce cases of meningitis, the 13-valent pneumococcal conjugate vaccine (PCV-13) has been introduced in the Expanded Programme on Immunisation (EPI). Despite these efforts, there are some cases of pneumococcal meningitis including both vaccine and non-vaccine serotypes. The objective of this study was to describe the pneumococcal sequence types (ST) circulating in Burkina Faso before the introduction of the 13-valent pneumococcal conjugate vaccine (PCV-13). Methods: It was a descriptive cross-sectional study that took place from 27th October 2013 to 7th January 2014. S. pneumoniae strains were collected in Burkina Faso and Multi Locus Sequence Typing (MLST) was performed at the Pneumococcal Laboratory at the Centers for Disease Control and Prevention (CDC) in the USA (United States of America). MLST consists of 4 steps: amplification, purification, sequencing and interpretative reading of the results. The amplification used 7 primers consisting of sequences of aroe, gdh, gki, recP, spi, xpt, ddl genes. Results: Of 37 strains tested, 10 serotypes were identified. Serotype 1 was prevalent in 48.7% (18/37) followed by serotype 25F in 10.8% (4/37). Serotypes 5 and 12F/12A/12B/44/46 were 8.1% (3/37) each. Serotype 1 contained 5 STs including ST303 24.3% (9/37), ST217 8.1% (3/37) and ST618 8.1% (3/37);followed by serotype 25F with ST105 10.8% (4/37), serotype 5 with ST289 8.1% (3/37) and serogroup 12F/12A/12B/44/46 with ST 989 8.1% (3/37). Conclusion: Pneumococci are characterised by their great variability both in number of serotypes and in ST within the same serotype. Thus, 10 serotypes have been identified. Also, within serotype 1, 5 different STs have been described. These data indicate the complexity of the pneumococcus which is strongly involved in purulent bacterial meningitis at national level. This requires continuous surveillance of pneumococc

关键词： Streptococcus pneumoniae Burkina Faso PCV-13 Sequence Types

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Meningitis Outbreak Caused by Neisseria meningitidis Serogroup C ST 10217 in 2019 in Diapaga, Burkina Faso

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Advances in Infectious Diseases 2023年第1期13卷 66-76页

作者： Kambiré Dinanibè Tondé Issa Ouédraogo W. H. Gautier Sanou Mahamoudou Ouédraogo L. S. L. Wilfrid Savadogo Mahamoudou Tamboura Mamadou Zongo Moumouni Ouédraogo Oumarou Zouré Abdou Azaque compaoré rebeca Sagna Tani Zida Sylvie Soubeiga R. S. Théophile Aké Flavien Sangaré Lassana Méda Isaïe Kouanda Séni Ouédraogo-Traoré Rasmata Centre Hospitalier Pédiatrique Universitaire Charles De Gaulle Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé Ouagadougou Burkina Faso Direction de la protection de la Santé de la Population Ouagadougou Burkina Faso Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso Davycas International Ouagadougou Burkina Faso Direction Générale de la Santé Publique Ouagadougou Burkina Faso

Introduction: Meningitis caused by Neisseria meningitidis constitutes a burden for the countries in the meningitis belt of sub-Saharan in general and particularly for Burkina Faso. In 2019 the Diapaga health district experienced a meningitis epidemic due to N. meningitidis serogroup C. Methods: This is a cross-sectional study with a descriptive aim in the health district of Diapaga where all cases of meningitis were included in this work. Rapid diagnostic tests (RDTs), culture as well as real-time PCR were used for the biological analysis of cerebral spinal fluid (CSF) samples. Results: Of 155 CSF samples analysed, 42% (65/155) were tested positve. Of them, N. meningitidis C accounted for 83% of all positive cases. Likewise, all thirteen (13) NmC strains were susceptible to oxacillin, ceftriaxone, penicillin and chloramphenicol. All strains of NmC belonged to the sequence type (ST) 10 217 and to the clonal complex (CC) 10 217. These CCs belonged to the same variant PorA type: P1.21-15.16;FetA type: F1-7;PorB type: 3-463. Conclusion: Burkina Faso had known an epidemic of meningitis caused by NmC in 2019 in the health district of Diapaga. This outbreak was contained in time due to the performance of the epidemiological surveillance system which made it possible to investigate on time and introduce the vaccine against the pathogen NmC.

关键词： Meningitis Neisseria meningitidis VS Diapaga Burkina Faso

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Meningitis Outbreak Caused by Neisseria meningitidis Serogroup C ST 10217 in 2019 in Diapaga, Burkina Faso

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Advances in Infectious Diseases（传染病进展） 2023年第1期

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