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Blood Count Abnormalities Associated with Death in Patients Infected with SARS-COV-2 at the Ziguinchor EpidemicTreatment Center (ETC)

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Open Journal of Internal Medicine 2023年第4期13卷 304-312页

作者： coly mame ngoné Diallo Kalilou Sarr Habibou Diop Abdoulaye Manga Noel Magloire Diatta Alassane Medical Analysis Laboratory The Ziguinchor Peace Hospital Ziguinchor Senegal Health Sciences Training and Research Unit The Assane Seck University of Ziguinchor Ziguinchor Senegal Infectious Diseases Department The Ziguinchor Peace Hospital/Ziguinchor Epidemic Treatment Center Ziguinchor Senegal Medical Analysis Laboratory The Ziguinchor Regional Hospital Ziguinchor Senegal

Introduction: SARS-COV-2 infection is a real public health challenge for the World Health Organization and for our country. It is responsible for numerous hematological abnormalities in infected patients. Objectives: To describe the haemogram abnormalities in patients infected with SARS-COV-2 and to determine which ones are associated with death. Material and Method: We conducted a retrospective, descriptive, analytical, cross-sectional study from March 2020 to September 2021. The study included all patients hospitalized with RT-PCR-confirmed COVID-19 who performed a blood count. We evaluated the blood count profile, the pathologies found and the associated blood count abnormalities. Results: A total of 263 patients were included. The mean age of the patients was 63.77 years (range 12 - 90 years). The male sex represented 54.75% (n = 144) while the female sex was 45.25% (n = 119) (sex ratio = 1.21). The most common pathologies were: diabetes: 30.03% (n = 79), high blood pressure: 41.04% (n = 108), and Chronic kidney disease: 7.98 (n = 21). The abnormalities of the haemogram found were essential: anaemia 28.13% (n = 121), hyperleukocytosis with neutrophilic predominance: 29.3% (126), lymphopenia: 34.41% (n = 148), thrombocytopenia: 8.16% (n = 35). The search for hematological factors associated with death in patients showed a significant difference between hyperleukocytosis (p = 0.000) and lymphopenia (p = 0.0001). Conclusion: SARS-COV-2 disease was a mortality factor when associated with lymphopenia and hyperleukocytosis in our series.

关键词： SARS-COV-2 Infection Abnormalities Blood Count Death

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Profile of the Blood Count among People Living with HIV Monitored at the Institute of Social Hygiene and the Aristide Le Dantec Hospital in Dakar

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Open Journal of Blood Diseases 2022年第4期12卷 133-141页

作者： Faye Cheikh Ibrahima coly mame ngoné Makalou Demba Sène Abdoulaye Sall Abibatou Touré Awa Oumar Ly Fatouamata Hematology Laboratory of the Aristide le Dantec Hospital Dakar Senegal Health Sciences Training and Research Unit Hematology Laboratory of the Ziguinchor Peace Hospital Assane Seck University of Ziguinchor Ziguinchor Senegal Training and Research Unit in Health Sciences Hematology Laboratory of the Sickle Cell Disease Control Center of Saint Louis Gaston Berger University of Saint Louis Dakar Senegal Pharmacy and Odontostomatology Faculty of Medicine Cheikh Anta Diop University of Dakar Dakar Senegal Dermatology Department of the Social Hygiene Institute of Dakar Dakar Senegal

Introduction: The human immunodeficiency virus (HIV) is a pandemic of concern to the World Health Organization. It is all the more worrisome because if not properly managed, it can be responsible for several complications, including abnormal blood counts. These abnormalities may also be related to treatment. Objectives: The main objective of this study is to show that adequate antiretroviral therapy can correct various abnormalities exerted by HIV on patients’ blood counts. The specific objective is to determine all the abnormalities we can see in blood count before and during HIV treatment. Materials and Methods: Our study was conducted in the hematology laboratory and the dermatology departments of the Aristide Le Dantec Hospital and the Institute of Social Hygiene. It took place from December 2009 to October 2011. It is a retrospective descriptive and analytical study involving HIV-positive patients (HIV 1 and 2) and under antiretroviral treatment (at least six months of treatment). We included 110 patients in the study. Blood counts were performed at the hematology laboratory of the Aristide le Dantec hospital using a KX21 automaton. Each patient received three blood counts during the first six months of treatment (M0, M3 and M6). A univariate analysis was performed to determine the profile of the abnormalities of the blood count and the chi 2 test was used and a threshold of p 0.05 was considered significant. Results: The mean age of the patients was 38.6 ± 8.6 years (extremes of 18 and 64 years) with a sex ratio of 0.42 (77 females and 33 males). The prevalence of anemia was 80% (n = 88) at M0, 53, 63% at M3 (n = 59), and 38.20% at M6 (n = 42) (p = 0.02). We noted a favorable evolution with treatment. For the other abnormalities, the evolution was favorable for leukopenia (p = 0.011) and thrombocytopenia (p = 0.007). Conclusion: Our study showed a correction of blood count abnormalities in PLHIV with antiretroviral treatment.

关键词： Blood Count Abnormalities Antiretroviral Treatment PLHIV

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Blood Count Abnormalities Associated with Death in Patients Infected with SARS-COV-2 at the Ziguinchor Epidemic Treatment Center (ETC)

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Open Journal of Internal Medicine（内科学期刊） 2023年第4期

作者： coly mame ngoné Diallo Kalilou Sarr Habibou Diop Abdoulaye Manga Noel Magloire Diatta Alassane

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