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Mismatch repair enzyme expression in primary and castrate resistant prostate cancer

Asian Journal of Urology 2016年第4期3卷 223-228页

作者： Belinda Nghiem Xiaotun Zhang Hung-Ming Lam Lawrence DTrue Ilsa Coleman Celestia SHigano Peter SNelson Colin CPritchard colm morrissey Department of Urology University of WashingtonSeattleWAUSA State Key Laboratory of Quality Research in Chinese Medicine Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao(SAR)China Department of Pathology University of WashingtonSeattleWAUSA Divison of Human Biology Fred Hutchinson Cancer Research CenterSeattleWAUSA Department of Medicine University of WashingtonSeattleWAUSA Department of Laboratory Medicine University of WashingtonSeattleWAUSA

Objective:Although the utility of immunohistochemistry(IHC)for assessing mismatch repair(MMR)protein expression has been demonstrated in solid tumors including primary prostate cancer(PCa),its utility has not been assessed in castration-resistant PCa(CRPC).Methods:Tissue microarrays were constructed from 127 radical prostatectomies and 155 CRPC metastases from 50 ***(MLH1,MSH2,MSH6,and PMS2)expression was assessed by IHC and gene expression *** between MMR protein expression in PCa and CRPC and biochemical recurrence(BCR)or time from diagnosis to death respectively were ***:There was no correlation between levels of MMR protein and *** of MSH2 and MSH6 was the most pronounced at 15%and 22%in PCa and 17.8%and 16%in CRPC patients,***2 and MSH6 protein were absent in 9.4%and 8%of PCa and CRPC *** of individual MMR proteins did not correlate with BCR or time from diagnosis to *** absent MSH2/MSH6 in CRPC was associated with shorter time to death(pZ0.0006).Loss of MSH2 was verified at the gene expression *** finding correlated with microsatellite instability previously reported in this CRPC cohort.

关键词： Mismatch repair Castration resistant prostate cancer MLH1 MSH2 MSH6 PMS2

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