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Comparison Study of Funduscopic Exam of Pediatric Patients Using the D-EYE Method and Conventional Indirect Ophthalmoscopic Methods

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Open Journal of Ophthalmology 2017年第3期7卷 145-152页

作者： Drew Dickson Samiksha Fouzdar-Jain collin macdonald Helen Song Daniel Agraz Linda Morgan Donny Suh University of Nebraska Medical Center Omaha Nebraska USA Children’s Hospital and Medical Center Omaha Nebraska USA

Purpose: The D-EYE device, a new fundoscopic smartphone lens, has demonstrated its utility in a clinical setting to detect and document ocular pathology, but has not been tested in the pediatric population. A prospective study was performed to explore the application of D-EYE in pediatric fundus examinations. Methods: Patients ages 3 - 18 years old underwent dilated fundus examinations by masked examiners using the video function of the D-EYE, while indirect ophthalmoscopy was performed by apediatric ophthalmologist. The examiners independently analyzed the D-EYE videos for the presence or absence of abnormalities, cup-to-disc (c/d) ratios and optic nerve size and color. The D-EYE video findings were compared to indirect ophthalmoscopy findings. Results: The study included 172 eyes from 87 patients. In comparing D-EYE to indirect ophthalmoscopy for detecting fundus abnormalities, the sensitivity was 0.72, specificity was 0.97, positive predictive value (PPV) was 0.77, negative predictive value (NPV) was 0.97, positive likelihood ratio (LR) was 27.8, and negative LR was 0.29. The agreement rate between the D-EYE video graders for the c/d ratio within a value of 0.1 was 97.0%. Multiple, distinct abnormalities were discovered using the D-EYE device, including nystagmus, optic nerve hypoplasia, optic disc edema, peripapillary atrophy, disc pallor, and optic disc drusen. Conclusion: Fundoscopic imaging using the D-EYE smartphone lens reliably detects the presence of fundus abnormalities and has good reliability in assessing c/d ratios. The video capability is useful in patients with nystagmus or those who are poorly compliant with the examination and allowed for effective teaching by the pediatric ophthalmologist.

关键词： D-EYE Fundoscopic Imaging Pediatric Ophthalmologist

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Grow-light smart monitoring system leveraging lightweight deep learning for plant disease classification

Artificial Intelligence in Agriculture

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Artificial Intelligence in Agriculture 2024年第2期12卷 44-56页

作者： William macdonald Yuksel Asli Sari Majid Pahlevani Department of Electrical&Computer Engineering Queen's UniversityKingstonON K7L 3N6Canada The Robert M.Buchan Department of Mining Queen's UniversityKingstonON K7L 3N6Canada

This work focuses on a novel lightweight machine learning approach to the task of plant disease classification,posing as a core component of a larger grow-light smart monitoring *** the extent of our knowledge,this work is the first to implement lightweight convolutional neural network architectures leveraging down-scaled versions of inception blocks,residual connections,and dense residual connections applied without pre-training to the PlantVillage *** novel contributions of this work include the proposal of a smart monitor-ing framework outline;responsible for detection and classification of ailments via the devised lightweight net-works as well as interfacing with LED grow-light fixtures to optimize environmental parameters and lighting control for the growth of plants in a greenhouse *** adaptation of dense residual connections achieved the best balance of minimizing model parameters and maximizing performance metrics with accuracy,precision,recall,and F1-scores of 96.75%,97.62%,97.59%,and 97.58%respectively,while consisting of only 228,479 model *** results are further compared against various full-scale state-of-the-art model architectures trained on the PlantVillage dataset,of which the proposed down-scaled lightweight models were capable of performing equally to,if not better than many large-scale counterparts with drastically less com-putational requirements.

关键词： Plant disease classification Smart monitoring Deep learning Residual connections Inception Dense residual connections

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Nearest Neighbor Sampling of Point Sets Using Rays

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1131-1174页

作者： Liangchen Liu Louis Ly Colin B.macdonald Richard Tsai Department of Mathematics The University of Texas at Austin2515 SpeedwayAustinTX 78712USA Oden Institute for Computational Engineering and Sciences The University of Texas at Austin201 E24th StAustinTX 78712USA Department of Mathematics University of British Columbia1984 Mathematics RdVancouverBCV6T1Z2Canada

We propose a new framework for the sampling,compression,and analysis of distributions of point sets and other geometric objects embedded in Euclidean *** approach involves constructing a tensor called the RaySense sketch,which captures nearest neighbors from the underlying geometry of points along a set of *** explore various operations that can be performed on the RaySense sketch,leading to different properties and potential *** information about the data set can be extracted from the sketch,independent of the ray *** integrals on point sets can be efficiently computed using the *** also present several examples illustrating applications of the proposed strategy in practical scenarios.

关键词： Point clouds Sampling Classification Registration Deep learning Voronoi cell analysis

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Development of an experimental method for well-controlled blast induced traumatic limb fracture in rats

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Defence Technology（防务技术） 2024年第4期34卷 168-176页

作者： Luyang Xu Xiancheng Yu Clement DFavier Ibidumo Igah Thuy-Tien Nguyen Warren macdonald Anthony MJ.Bull Centre for Blast Injury Studies Imperial College LondonLondonUnited Kingdom Department of Bioengineering Imperial College LondonLondonUnited Kingdom Dyson School of Design Engineering Imperial College LondonLondonUnited Kingdom Department of Trauma and Orthopaedics Royal Free London National Health Service Foundation TrustLondonUnited Kingdom

Heterotopic ossification(HO)is a consequence of traumatic bone and tissue damage,which occurs in 65%of military casualties with blast-associated ***,the mechanisms behind blast-induced HO remain *** models are used to study blast-induced HO,but developing such models is challenging,particularly in how to use a pure blast wave(primary blast)to induce limb fracture that then requires an *** studies,including our recent study,have developed platforms to induce limb fractures in rats with blast loading or a mixture of blast and impact ***,these models are limited by the survivability of the animal and repeatability of the *** this study,we developed an improved platform,aiming to improve the animal's survivability and injury repeatability as well as focusing on primary blast *** platform exposed only one limb of the rat to a blast wave while providing proper protection to the rest of the rat's *** obtained very consistent fracture outcome in the tibia(location and pattern)in cadaveric rats with a large range of size and ***,the rats did not obviously move during the test,where movement is a potential cause of uncontrolled *** further conducted parametric studies by varying the features of the design of the *** factors,such as how the limb is fixed and how the cavity through which the limb is placed is sealed,significantly affect the resulting *** platform and test setups enable well-controlled limb fracture induced directly by pure blast wave,which is the fundamental step towards a complete in vivo animal model for blast-induced HO induced by primary blast alone,excluding secondary and tertiary blast *** addition,the platform design and the findings presented here,particularly regarding the proper protection of the animal,have implications for future studies investigating localized blast injuries,such as blast induced brain and lung injuries.

关键词： Blast injury Biomechanics Heterotopic ossification Limb fracture Blast wave Animal model

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Microglial dysfunction and genetic risk for neurodegenerative disease

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra S.macdonald Jay Penney Department of Biomedical Sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

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工程尺度缓冲材料热-水-力多场耦合数值模拟研究

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岩土工程学报 2024年第8期46卷 1712-1722页

作者：赵敬波曹胜飞李杰彪陈亮 collin Frederic 刘月妙张奇核工业北京地质研究院国家原子能机构高放废物地质处置创新中心北京100029 哈尔滨工业大学环境学院黑龙江哈尔滨150090 南方科技大学环境科学与工程学院广东深圳518055 Departement GeomaC University of LiegeSartTilman B52/3Chevreuils Road1B-4000 Liege

缓冲材料作为填充在废物罐与地质体之间重要的人工屏障,对高放废物处置库的长期安全至关重要。以工程尺度缓冲材料热-水-力多场耦合大型模型试验系统(China-Mock-up)为研究对象,采用有限元数值模拟软件LAGAMINE,考虑试验过程中复杂的边... 详细信息

缓冲材料作为填充在废物罐与地质体之间重要的人工屏障,对高放废物处置库的长期安全至关重要。以工程尺度缓冲材料热-水-力多场耦合大型模型试验系统(China-Mock-up)为研究对象,采用有限元数值模拟软件LAGAMINE,考虑试验过程中复杂的边界条件与材料属性,实现了近5 a试验数据的定量模拟。模拟结果可准确预测试验系统内部不同特征点温度随室温周期性波动及线性增长这一动态变化规律;能够较好反映不同特征点相对湿度随时间的行为演化趋势,在加热器附近区域呈现出先干燥后饱和的现象,远离加热器区域则逐渐增大;模拟的总应力与实测试验数据间表现较好地一致性,能够反映试验台架内部不同特征点的总应力随时间逐渐增大这一演化过程。揭示了多场耦合条件下缓冲材料(膨润土)温度、湿度及应力的相互作用关系,为深入认识处置库环境下缓冲材料行为演化特征提供了重要的参考依据。

关键词：缓冲材料 China-Mock-up试验热-水-力多场耦合模拟高庙子膨润土

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Two-dimensional atomically thin Pt layers on MXenes: The role of electronic effects during catalytic dehydrogenation of ethane and propane

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Nano Research 2024年第3期17卷 1251-1258页

作者： Zhe Li Tobias K.Misicko Fan Yang Xiaopeng Liu Zhenwei Wu Xiaoyang Gao Tao Ma Jeffrey T.Miller Daniela S.Mainardi collin D.Wick Zhenhua Zeng Yang Xiao Yue Wu Department of Chemical and Biological Engineering Iowa State University618 Bissell RoadAmesIA 50011USA Institute for Micromanufacturing Louisiana Tech University505 Tech DriveRustonLA 71272USA Davidson School of Chemical Engineering Purdue University480 Stadium Mall DriveWest LafayetteIN 47907USA Michigan Center for Materials Characterization University of Michigan2800 Plymouth RdAnn Arbor MI 48109USA College of Engineering and Science Louisiana Tech UniversityRustonLA 71272USA

Atomically thin Pt nanolayers were synthesized on the surface of Mo2TiC2 MXenes and used for the catalytic dehydrogenation of ethane and propane into ethylene and propylene,two important chemicals for the petrochemical *** compared with Pt nanoparticles,the atomically thin Pt nanolayer catalyst showed superior coke-resistance(no deactivation for 24 h),high activity(turnover frequencies(TOFs)of 0.4–1.2 s^(-1)),and selectivity(>95%)toward ethylene and *** unique Pt nanolayer has a similar geometric surface to Pt nanoparticles,enabling the investigations of the electronic effect on the catalytic performance,where the geometric effect is *** is found that the electronic effect plays a critical role in dehydrogenative product selectivity and catalyst *** metal–support interaction is found dependent on the substrate and metal components,providing wide opportunities to explore high-performance MXene-supported metallic catalysts.

关键词： MXene catalysis alkane dehydrogenation nanolayers

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Modified Atmospheric Packaging and Its Effect on Postharvest Cannabis Quality

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American Journal of Plant Sciences 2024年第3期15卷 222-234页

作者： Luke L. MacLaughlin Mason T. macdonald Department of Plant Food and Environmental Sciences Faculty of Agriculture Dalhousie University Halifax NS Canada

Cannabis sativa L. is used as fiber, food, and medicine in several countries. Though it is illegal for recreational use in most of the world, there are some countries that have legalized production and sale. There is a lot of research on production of cannabis, but less so on storage technologies. Cannabis contains several high value compounds, such as cannabinoids and terpenoids, that are susceptible to degradation via light, temperature, and oxygen. Several studies have explored temperature and light, and industry has adjusted accordingly. However, less is known about oxygen-induced degradation. Biochemical studies have demonstrated oxidative degradation of high value compounds, and many producers use some form of modified atmospheric packaging (MAP) for storage. However, the efficacy of MAP is unclear. The objective of this paper is to review our current understanding of MAP in postharvest cannabis storage and identify avenues where additional research is needed.

关键词： Cannabinoids Cannabis sativa Marijuana Nitrogen Packaging Oxidation Postharvest Terpenoids THC

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Bilateral nephrolithiasis and upper tract transitional cell carcinoma in horseshoe kidney

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Current Urology 2024年第3期18卷 247-249页

作者： Jacob M.Gaines Eric J.macdonald Arun Rai David Hoenig Arthur Smith Zeph Okeke Tareq Aro The Smith Institute for Urology Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellLake SuccessNYUSA

Nephroureterectomy is currently the criterion-standard treatment for high-grade upper tract urothelial carcinoma(UTUC).Current guidelines and expert opinions propose some exceptions to this approach based on patient characteristics,disease status,and function of the contralateral *** present a rare case of a patient with horseshoe kidney,bilateral large nephrolithiasis,high-grade UTUC in one moiety,and relative parenchymal thinning of the contralateral *** patient was treated with a percutaneous,minimally invasive,nephron sparing *** patient also had intracollecting system instillations of gemcitabine and *** invasive percutaneous resection of high-grade UTUC is a safe procedure in select *** guidelines may not apply to all patients;unique scenarios with UTUC may require personalized decision-making and treatment at specialized centers.

关键词： Upper tract urothelial cancer Percutaneous resection Horseshoe kidney Nephrolithiasis

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Evaluating implicit gender bias at Canadian otolaryngology meetings through use of professional title

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 12-17页

作者： Kylen Van Osch Agnieszka Dzioba Khadija Ahmed Andrew macdonald Jamila Skinner Harley Williams Julie E.Strychowsky M.Elise Graham Department of Otolaryngology-Head&Neck Surgery Schulich School of Medicine&DentistryWestern UniversityLondonOntarioCanada Department of Otolaryngology London Health Sciences Centre Children's HospitalLondonOntarioCanada Faculty of Medicine Schulich School of Medicine&DentistryWestern UniversityLondonOntarioCanada

Objectives:Increasing numbers of women enter medical school *** number of female physicians in leadership positions has been much slower to *** are also well‐documented differences in the treatment of women as compared to men in professional *** presenters are less likely to be introduced by their professional title(“Doctor”)for grand rounds and conferences,especially with a man performing the *** study reviewed the Canadian Society of Otolaryngology–Head and Neck Surgery(CSOHNS)meetings from 2017 to 2020 to determine the proportion of presenters introduced by their professional title and whether this varied by ***:Recordings from CSOHNS meetings were reviewed and coded for introducer and presenter demographics,including leadership positions and ***‐squared tests of proportion and multivariate logistic regression was used to compare genders and identify factors associated with professional versus unprofessional forms of ***:No significant association was found between professional title use and introducer or presenter *** presenters were introduced with professional title 69.6%of the time,while male presenters were introduced with professional title 67.6%of the time(P=0.69).Residents were introduced with a professional title with the most frequency(75.8%),while attending staff were introduced with a professional title with the least frequency(63.0%)(P=0.02).Conclusions:The lack of gender bias in speaker introductions at recent CSOHNS meetings demonstrates progress in achieving gender equity in *** efforts should continue to define additional forms of unconscious bias that may be contributing to gender inequity in leadership positions.

关键词： attitude of health personnel gender identity Otolaryngology women

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