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Dynamic microphysiological system chip platform for high-throughput,customizable,and multi-dimensional drug screening

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Bioactive Materials 2024年第9期39卷 59-73页

作者： Yuxuan Zhu Deming Jiang yong Qiu Xin Liu Yuhan Bian Shichao Tian Xiandi Wang k.Jimmy Hsia Hao Wan Liujing Zhuang Ping Wang Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Ministry of EducationDepartment of Biomedical EngineeringZhejiang UniversityHangzhouZhejiang310027China Schools of Mechanical&Aerospace Engineering of Chemical&Biomedical EngineeringNanyang Technological University639798Singapore Cancer Center Binjiang Institute of Zhejiang UniversityHangzhou310027China The MOE Frontier Science Center for Brain Science&Brain-machine Integration Zhejiang UniversityHangzhou310027China State key Laboratory of Transducer Technology Chinese Academy of SciencesShanghai200050China

Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug *** employing diverse types of spheroids or organoids,it is feasible to establish microphysiological systems that enhance the precision of disease modeling and offer more dependable and comprehensive drug ***-throughput microphysiological systems that support optional,parallel testing of multiple drugs have promising applications in personalized medical treatment and drug ***,establishing such a system is highly challenging and requires a multidisciplinary *** study introduces a dynamic Microphysiological System Chip Platform(MSCP)with multiple functional microstructures that encompass the mentioned *** developed a high-throughput lung cancer spheroids model and an intestine-liverheart-lung cancer microphysiological system for conducting parallel testing on four anti-lung cancer drugs,demonstrating the feasibility of the *** microphysiological system combines microscale and macroscale biomimetics to enable a comprehensive assessment of drug efficacy and side ***,the microphysiological system enables evaluation of the real pharmacological effect of drug molecules reaching the target lesion after absorption by normal organs through fluid-based physiological *** MSCP could serves as a valuable platform for microphysiological system research,making significant contributions to disease modeling,drug development,and personalized medical treatment.

关键词： Microphysiological system Organ-on-a-chip Biomimetics High throughput Multidimensional drug screening

ZERO NET ENERGY TEST HOUSE

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Journal of Green Building 2011年第2期6卷 36-48页

作者： Timothy L.Hemsath James D.Goedert Avery D.Schwer yong k.Cho University of Nebraska LincolnNE

INTRODUCTION This paper describes the first phase of a residential research program to reduce the impact of new construction on the environment through research and education using a Zero Net Energy Test House as a *** four bedrooms,three and a half baths,the 1,800 square foot house,1,000 square foot basement,is located in Omaha,*** is being used to validate several research projects and provides a platform for applications research of a number of technological *** photovoltaic solar panels,a wind turbine,and an occupant monitoring energy control system are some of the sustainable design innovations *** features are described that detail the application for LEED Platinum *** into several University of Nebraska courses,the house has reached more than 200 students in the past *** teaching has involved design,construction,research,monitoring and energy *** opportunities have reached k-12 students,industry professionals,and public through tours and presentations.

关键词： residential energy efficiency sustainability LEED

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3k-Akt,HIF-1,NF-κB,MAPk,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Endocrine aberrations of human nonobstructive azoospermia

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Asian Journal of Andrology 2022年第3期24卷 274-286页

作者： yong Tao Ottawa Fertility Center 955 Green Valley CrescentOttawaON K2C 3V4Canada

Nonobstructive azoospermia(NOA)refers to the failure of spermatogenesis,which affects approximately 1%of the male population and contributes to 10%of male *** has an underlying basis of endocrine imbalances since proper human spermatogenesis relies on complex regulation and cooperation of multiple hormones.A better understanding of subtle hormonal disturbances in NOA would help design and improve hormone therapies with reduced risk in human fertility *** purpose of this review is to summarize the research on the endocrinological aspects of NOA,especially the hormones involved in hypothalamic–pituitary–testis axis(HPTA),including gonadotropin-releasing hormone,follicle-stimulating hormone,luteinizing hormone,prolactin,testosterone,estradiol,sex hormone binding globulin,inhibin B,anti-Müllerian hormone,and *** the NOA men associated with primary testicular failure,the quality of currently available evidence has not been sufficient enough to recommend any general hormone optimization *** other NOA patients,especially those with hypogonadotropic hypogonadism,could be treated with hormonal *** these approaches have succeeded in resuming the fertility in many NOA patients,the prudent strategies should be applied in individuals according to specific NOA etiology by balancing fertility benefits and potential *** review also discusses how NOA can be induced by immunization against hormones.

关键词： endocrine follicle-stimulating hormone gonadotropin-releasing hormone inhibin B nonobstructive azoospermia prolactin sperm retrieval testosterone

Extremal P_(8)-Free/P_(9)-Free Planar Graphs

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Journal of the Operations Research Society of China 2023年第3期11卷 451-457页

作者： yong-Xin Lan yong-Tang Shi School of Science Hebei University of TechnologyTianjin300401China Center for Combinatorics and LPMC Nankai UniversityTianjin300071China

An H-free graph is a graph not containing the given graph H as a *** is well known that the Turán number ex(n,H)is the maximum number of edges in an H-free graph on n *** on this definition,we define ex_(P)(n,H)to restrict the graph classes to planar graphs,that is,ex_(P)(n,H)=max{|E(G)|:G∈G,where G is a family of all H-free planar graphs on n ***,we have ex_(P)(n,H)=3n−6 if the graph H is not a planar *** study is initiated by Dowden(J Graph Theory 83:213–230,2016),who obtained some results when H is considered as C_(4)or C_(5).In this paper,we determine the values of ex_(P)(n,Pk)with k∈{8,9},where Pk is a path with k vertices.

关键词： Turán number Extremal graph Planar graph

Lightweight fault localization combined with fault context to improve fault absolute rank

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Science China(Information Sciences) 2017年第9期60卷 178-193页

作者： yong WANG Zhiqiu HUANG yong LI Bingwu FANG College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics College of Computer and Information Anhui Polytechnic University

Lightweight fault localization(LFL), which outputs a list of suspicious program entities in descending order based on their likelihood to be a root fault, is a popular method used by programmers to assist them in debugging. However, owing to the nature of program structures, it is impossible for LFL to always rank the root faulty program entity at the top of a ranking list. Recently, Xia et al. noted in their study that programmers inspect the first top-k-ranked program entities outputted by an LFL tool in sequence. Therefore,it is of practical significance to further improve the absolute rank of those buggy programs by using LFL if the root fault is ranked higher. To solve this issue, we propose a new LFL combined with a fault context to improve the fault absolute rank. We conduct experiments in which we apply our proposed approach to seven Siemens benchmark programs. The results show that by combining the suspiciousness scores of program entities with their fault-context suspiciousness scores that are based on an LFL called Dstar, our approach can improve the fault absolute rank with an effectiveness rate of 35.7% for 129 faulty versions from the seven benchmark programs. It should be noted that our approach can obtain an average improvement of 65.18% for those improved programs to which LFL can be effectively applied, and that there were improvements to seven top-ranked root faults of buggy programs.

关键词： fault context fault localization program spectrum absolute rank debugging

Adenoid cystic carcinoma of breast: Recent advances

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World Journal of Clinical Cases 2014年第12期2卷 732-741页

作者： kosuke Miyai Mary R Schwartz Mukul k Divatia Rose C Anton yong Wook Park Alberto G Ayala Jae Y Ro Department of Pathology and Genomic Medicine Houston Methodist Hospital Weill Medical College of Cornell UniversityHouston TX 77030 United States Department of Basic Pathology National Defense Medical College Saitama 359-0042 Japan Department of Pathology Hanyang University Guri Hospital 153 Gyeongchun-ro Guri Gyeonggi-do 471-701 South Korea

Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features.

关键词： Adenoid cystic carcinoma Breast Triplenegative and basal-like phenotype Histology Molecular genetic features

Magnesium cationic cue enriched interfacial tissue microenvironment nurtures the osseointegration of gamma-irradiated allograft bone

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Bioactive Materials 2022年第4期7卷 32-47页

作者： Wenhao Wang Jie Shen Yuan Meng Miaoman Ye Shaozhang Lin Qi Zhao Le Wang kenneth M.C.Cheung Shuilin Wu Yufeng Zheng Xuanyong Liu Paul k.Chu kelvin W.k.Yeung Zhi-yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Department of Orthopaedics and Traumatology The University of Hong KongHong Kong999077PR China Shenzhen key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053PR China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Shenzhen key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen518036PR China Ministry of Education key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials&EngineeringHubei UniversityWuhan430062PR China Ministry of Education key Laboratory for Advanced Ceramics and Machining Technology School of Materials Science&EngineeringTianjin UniversityTianjin300352PR China State key Laboratory for Turbulence and Complex System Department of Materials Science and EngineeringCollage of EngineeringPeking UniversityBeijing100871PR China State key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Department of Materials Science and Engineering City University of Hong KongHong Kong999077PR China

Regardless of the advancement of synthetic bone substitutes,allograft-derived bone substitutes still dominate in the orthopaedic circle in the treatments of bone ***,the stringent devitalization process jeopardizes their osseointegration with host bone and therefore prone to long-term ***,improving osseointegration and transplantation efficiency remains *** alteration of bone tissue microenvironment(TME)to facilitate osseointegration has been generally ***,the concept of exerting metal ionic cue in bone TME without compromising the mechanical properties of bone allograft is *** address this concern,an interfacial tissue microenvironment with magnesium cationc cue was tailored onto the gamma-irradiated allograft bone using a customized magnesium-plasma surface *** formation of the Mg cationic cue enriched interfacial tissue microenvironment on allograft bone was verified by the scanning ion-selective electrode *** cellular activities of human TERT-immortalized mesenchymal stem cells on the Mg-enriched grafts were notably *** the animal test,superior osseointegration between Mg-enriched graft and host bone was found,whereas poor integration was observed in the gamma-irradiated controls at 28 days ***,the bony in-growth appeared on magnesium-enriched allograft bone was significant *** mechanism possibly correlates to the up-regulation of integrin receptors in mesenchymal stem cells under modified bone TME that directly orchestrate the initial cell attachment and osteogenic differentiation of mesenchymal stem ***,our findings demonstrate the significance of magnesium cation modified bone allograft that can potentially translate to various orthopaedic procedures requiring bone augmentation.

关键词： Osseointegration Allograft bone Bone tissue microenvironment Bone-implant interface Magnesium

Propagation of Light in an Ensemble of Tripod Level Atoms

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Communications in Theoretical Physics 2006年第1X期46卷 135-140页

作者： LI yong Institute of Theoretical Physics the Chinese Academy of Sciences Beijing 100080 China Interdisciplinary Center of Theoretical Studies the Chinese Academy of Sciences Beijing 100080 China Department of Physics Hunan Normal University Changsha 410081 China

We study the propagation of a quantum probe light in an ensemble of tripod level atoms when the atoms are coupled to two other classical control fields. First we calculate the dispersion properties, such as susceptibility and group velocity, of the probe light within such an atomic medium under the case of three-photon resonance via the dynamical algebra method of collective atomic excitations. Then we calculate the dispersion of the probe light in the case that two classical control fieMs have the different detunings to the relative atomic transitions. Our results show that in both cases the phenomenon of electromagnetically induced transparency can occur. Especially under the second case, we can find two transparency windows for the probe light.

关键词： group velocity collective excitation electromagnetically induced transparency