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Tumor necrosis factor-alpha, transforming.g.ow.h factor-b.ta, deg.ee of low.r urinary tract symptoms as predictors of erectile dysfunction in b.nig. prostatic hyperplasia patients

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Asian Journal of Urolog. 2024年第2期11卷 280-285页

作者： g.de w.K.Duarsa Yeremia g.Kusumah Ronald Sug.anto Pande M.w.Tirtayasa Tjokorda g.b.Mahadew. Department of Urolog. Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia Department of g.neral Surg.ry Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia Medical Doctor Study Prog.am Faculty of MedicineUniversitas UdayanaBaliIndonesia Department of Urolog. Faculty of MedicineUniversitas UdayanaUniversitas Udayana Teaching HospitalBaliIndonesia Department of Neurosurg.ry Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia

Ob.ective: Erectile dysfunction (ED) is a condition of insufficient penile erection, consistently or recurrently, for sexual activity. Tumor necrosis factor-alpha (TNF-α) induces transforming.g.ow.h factor-b.ta (Tg.-β), w.ich causes the transition of epithelial cells into mesenchymal cells that affect ED. This study aimed to evaluate the roles of TNF-α, Tg.-β, deg.ee of low.r urinary tract symptoms, and prostatic volume for the presence of ED in b.nig. prostatic hyperplasia (b.H) patients.Methods: Our study performed an analytic ob.ervational retrospective cohort study using.secondary data from four hospitals in b.li, Indonesia, including.medical records and other administrative data. The sample w.s b.H patients w.th several history qualifications.Results: Our sample w.s 83 respondents, rang.ng.from 50 years to 80 years, 61 respondents w.th ED and 22 w.th non-ED. The International Prostate Symptom Score show.d a sig.ificant result, w.ich indicates that ED is more common in patients w.th hig.er International Prostate Symptom Score (p=0.002). Moreover, the TNF-α of ≥43.9 pg.mg.and Tg.-β of ≥175.8 pg.mL w.re sig.ificantly associated w.th the presence of ED in b.H patients (pg.ificant w.th ED (p=0.947).Conclusion: TNF-α, Tg.-β, and low.r urinary tract symptoms severity can predict the occurrence of ED in b.H, w.ile prostatic volume w.s not sig.ificant.

关键词： Prostate enlarg.ment b.omarker Erectiledysfunction Riskfactor

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The g.eat catastrophe: causes of the Permo-Triassic marine mass extinction

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National Science Review 2024年第1期11卷 37-50页

作者： Paul b.w.g.all David P.g.b.nd School of Earth & Environment University of Leeds School of Environmental Sciences University of Hull

The marine losses during.the Permo-Triassic mass extinction w.re the w.rst ever experienced. All g.oups w.re b.dly affected, especially among.t the b.nthos(e.g. b.achiopods, corals, b.yozoans, foraminifers,ostracods). Planktonic populations underw.nt a fundamental chang. w.th eukaryotic alg.e b.ing.replaced b. nitrog.n-fixing.b.cteria, g.een-sulphur b.cteria, sulphate-reducing.b.cteria and prasinophytes. Detailed studies of b.undary sections, especially those in South China, have resolved the crisis to a ～55 kyr interval straddling.the Permo-Triassic b.undary. Many of the losses occur at the b.g.nning.and end of this interval painting.a picture of a tw.-phase extinction. Improved know.edg. of the extinction has b.en supported b. numerous g.ochemical studies that allow.diverse proposed extinction mechanisms to b. studied. A transition from oxyg.nated to anoxic-euxinic conditions is seen in most sections g.ob.lly, althoug. the intensity and timing.show. reg.onal variab.lity. Decreased ocean ventilation coincides w.th rapidly rising.temperatures and many extinction scenarios attrib.te the losses to b.th anoxia and hig. temperatures.Other kill mechanisms include ocean acidification for w.ich there is conflicting.support from g.ochemical proxies and, even less likely, siltation(b.rial under a massive influx of terrig.nous sediment) w.ich lacks sub.tantive sedimentolog.cal evidence. The ultimate driver of the catastrophic chang.s at the end of the Permian w.s likely Sib.rian Trap eruptions and their associated carb.n dioxide emissions w.th consequences such as w.rming. ocean stag.ation and acidification. Volcanic w.nter episodes stemming.from Sib.rian volcanism have also b.en linked to the crisis, b.t the short-term nature of these episodes(w.elming.evidence for rapid w.rming.during.the crisis makes this an unlikely cause. Finally, w.ilst the extinction is w.ll studied in equatorial latitudes, a different history is found in northern b.real latitudes including.an earlier crisis w.ich merits furthe

关键词： ocean anoxia ocean acidification siltation productivity collapse volcanic w.nter

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Study of hyb.id nanofluid flow.in a stationary cone-disk system w.th temperature-dependent fluid properties

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Applied Mathematics and Mechanics(Eng.ish Edition) 2024年第4期45卷 677-694页

作者： A.S.JOHN b.MAHANTHESH g.LORENZINI Center for Mathematical Needs Department of MathematicsCHRIST(Deemed to be University)Karnataka 560029India School of Mathematical and Statistical Sciences The University of Texas Rio Grande ValleyTexas 78539U.S.A. Department of Eng.neering.and Architecture University of ParmaParma 43124Italy

Cone-disk systems find frequent use such as conical diffusers,medical devices,various rheometric,and viscosimetry applications.In this study,w. investig.te the three-dimensional flow.of a w.ter-b.sed Ag.Mg.O hyb.id nanofluid in a static cone-disk system w.ile considering.temperature-dependent fluid properties.How.the variab.e fluid properties affect the dynamics and heat transfer features is studied b. Reynolds's linearized model for variab.e viscosity and Chiam's model for variab.e thermal conductivity.The sing.e-phase nanofluid model is utilized to describ. convective heat transfer in hyb.id nanofluids,incorporating.the experimental data.This model is developed as a coupled system of convective-diffusion equations,encompassing.the conservation of momentum and the conservation of thermal energ.,in conjunction w.th an incompressib.lity condition.A self-similar model is developed b. the Lie-g.oup scaling.transformations,and the sub.equent self-similar equations are then solved numerically.The influence of variab.e fluid parameters on b.th sw.rling.and non-sw.rling.flow.cases is analyzed.Additionally,the Nusselt numb.r for the disk surface is calculated.It is found that an increase in the temperature-dependent viscosity parameter enhances heat transfer characteristics in the static cone-disk system,w.ile the thermal conductivity parameter has the opposite effect.

关键词： hyb.id nanofluid cone-disk system laminar flow variab.e fluid property Nusselt numb.r

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The mag.etosheath at hig. spectral resolution

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Earth and Planetary Physics 2024年第1期8卷 234-246页

作者： K.D.Küntz D.Koutroumpa w.R.Dunn A.Foster F.S.Porter D.g.Sib.ck b.w.lsh The Henry A.Row.and Department of Physics and Astronomy Johns Hopkins University3701 San Martin DriveBaltimoreMD21218USA NASA g.ddard Space Flig.t Center 8800 Greenbelt RoadGreenbeltMD 20771USA LATMOS-OVSQ CNRSUVSQ Paris-SaclaySorbonne Université11 Boulevard d’Alembert78280GuyancourtFrance Department of Physics and Astronomy University College LondonLondonUK The Centre for Planetary Science at UCL/b.rkb.ck Gower StreetLondon WC1E 6BTUK Center for Astrophysics Harvard University&Smithsonian Institution60 Garden StreetCambridgeMA 02138USA Center for Space Physics Boston University110 Cummington MallBostonMAUSA

w.ile w. eag.rly anticipate SMILE’s(Solar w.nd Mag.etosphere Ionosphere Link Explorer)unprecedented X-ray ob.ervations of the Earth’s mag.etosheath and the initiation of a new.era of mag.etospheric research,it seems appropriate to look ahead to the ab.lities of the next g.neration of astrophysics missions.Of these,the Line Emission Mapper(LEM),a larg. aperture micro-calorimeter b.sed mission,is currently planned to b. ab.e to ob.erve the mag.etosheath at hig. spectral resolution(~2 eV).w.th a field of view.of~30′,LEM w.ll allow.hig.er spatial resolution and hig.er cadence measurement of the motion of a very small portion of the mag.etopause over relatively short periods of time(multiple hours),complementing.SMILE’s g.ob.l mapping.LEM’s streng.h is its spectral resolution.It w.ll b. ab.e to measure the ab.ndance of a b.oad rang. of elements and ionization states,many of w.ich are inaccessib.e to current in situ instruments,and w.ll b. ab.e to separate the emission from the mag.etosheath from the emission from the cosmic X-ray b.ckg.ound using.the difference in their relative velocities.

关键词： mag.etosheath charg. exchang. solar w.nd ab.ndances

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Optimal Control of Service Rates of Discrete-Time(s,Q)Queueing.Inventory Systems w.th Finite b.ffer

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Journal of Systems Science and Systems Eng.neering 2024年第3期33卷 261-280页

作者： L.Iniya b.Sivakumar g.Arivarig.an School of Mathematics Madurai Kamaraj UniversityMaduraiTamilnaduIndia Department of Statistics Manonmaniam Sundaranar UniversityTirunelveliTamilnaduIndia

This article,w. develop an optimal policy to control the service rate of a discrete time queueing.inventory system w.th finite b.ffer.The customers arrive according.to a b.rnoulli process and the service time for the customers are g.ometric.w.enever the b.ffer size attains its maximum,any arriving.new.customers are considered to b. lost.The customers are served one b. one according.to FCFS rule and each customers request random numb.r of items.The inventory is replenished according.to a(s,Q)inventory policy w.th g.ometric lead time.The main ob.ectives of this article are to determine the service rates to b. employed at each slot so that the long.run expected cost rate is minimized for fixed inventory level and fixed b.ffer size and to minimize the expected w.iting.time for a fixed inventory level and fixed b.ffer size.The prob.ems are modelled as Markov decision prob.em.w. estab.ish the existence of a stationary policy and employ linear prog.amming.method to find the optimal service rates.w. provide some numerical examples to illustrate the b.haviour of the model.

关键词： Queueing.inventory system discrete time b.tch demand-Markov decision process

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Collisionless shock acceleration of protons in a plasma slab.produced in a g.s jet b. the collision of tw. laser-driven hydrodynamic shockw.ves

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Matter and Radiation at Extremes 2024年第2期9卷 12-25页

作者： J.-R.Marquès L.Lancia P.Loiseau P.Forestier-colleoni M.Tarisien E.Atukpor V.b.g.oud C.b.ab.tz F.Consoli J.Domang. F.Hannachi P.Nicolaï M.Salvadori b.Zielb.uer LULI CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance CEA DAMDIF91297 Arpajon CedexFrance UniversitéParis-Saclay CEALMCE91680 Bruyères-le-ChatelFrance CENb. CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance g.I Helmholtzzentrum für Schw.rionenforschung.g.b. Planckstraße 164291 DarmstadtGermany University of Darmstadt Schloßgartenstr.764289 DarmstadtGermany ENEA Fusion and Technolog.es for Nuclear Safety Department C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly CELIA Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance UniversitéParis-Saclay CEALIDYL91191 Gif-sur-YvetteFrance

w. have recently proposed a new.technique of plasma tailoring.b. laser-driven hydrodynamic shockw.ves g.nerated on b.th sides of a g.s jet[Marquès et al.,Phys.Plasmas 28,023103(2021)].In a continuation of this numerical w.rk,w. study experimentally the influence of the tailoring.on proton acceleration driven b. a hig.-intensity picosecond laser in three cases:w.thout tailoring.b. tailoring.only the entrance side of the picosecond laser,and b. tailoring.b.th sides of the g.s jet.w.thout tailoring.the acceleration is transverse to the laser axis,w.th a low.energ. exponential spectrum,produced b. Coulomb.explosion.w.en the front side of the g.s jet is tailored,a forw.rd acceleration appears,w.ich is sig.ificantly enhanced w.en b.th the front and b.ck sides of the plasma are tailored.This forw.rd acceleration produces hig.er-energ. protons,w.th a peaked spectrum,and is in g.od ag.eement w.th the mechanism of collisionless shock acceleration(CSA).The spatiotemporal evolution of the plasma profile is characterized b. optical shadow.0}aphy of a prob. b.am.The refraction and ab.orption of this b.am are simulated b. post-processing.3D hydrodynamic simulations of the plasma tailoring.Comparison w.th the experimental results allow. estimation of the thickness and near-critical density of the plasma slab.produced b. tailoring.b.th sides of the g.s jet.These parameters are in g.od ag.eement w.th those required for CSA.

关键词： acceleration hydrodynamic collision

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b.oad Hormonal Responses Induced b. Aluminum in Roots of Dw.rf Transg.nics of Solanum lycopersicum L. cv “Micro-Tom”

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American Journal of Plant Sciences 2024年第5期15卷 349-358页

作者： Arthur b. Rates Daniela b.anares Daniele S. g. Pianetti Felipe Della-Torre Joni E. Lima Marcel g. C. França Department of b.tany and Plant Physiolog. Lab.ratory Federal University of Minas Gerais Belo Horizonte Brazil

The spatial pattern distrib.tion of plant hormones in response to aluminum (Al) toxicity in roots remains to b. show.. This study w.s performed to assess the root hormonal accumulation and g.ne expression in response to Al toxicity in five transg.nic miniature dw.rf tomatoes cv. Micro-Tom (MT). MT and MT transg.nics to acid indole acetic, cytokinin, g.b.erellin, ab.cisic acid and ethylene w.re cultivated in nutrient solutions containing.different Al concentrations. Root g.ow.h elong.tion w.s measured and cellular damag. w.s visualized b. staining.Evans’s b.ue. The g.S reporter g.ne staining.technique w.s used to visualize hormonal chang.s in MT apex root tissues. Data indicated that the MT is sensitive to Al that induced sig.ificant g.ow.h inhib.tion and cellular damag.. Al concentration of 27 μM w.s sig.ificantly toxic, inducing.root apex darkening.and inhib.tion of root development. The qualitative evaluation of g.S reporter g.ne expression show.d intense crosstalk among.all hormones studied, underscoring.the complexity of sig.aling.induced b. Al in apex roots. Results point out to a major understanding.of the hormonal sig.aling.in response to Al toxicity, w.ich may induce a chang. of root g.ow.h and architecture w.th g.ow.h inhib.tion and cell constraints modulated b. all different hormones evaluated.

关键词： g.ne Reporter Metal Plant Hormones Root Staining

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覆盖UVA1的新型防晒剂MCE对色素和老化体征的影响:一项在两个不同遗传背景的人群进行的为期8周、随机、自身对照、前瞻性户外研究

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中华皮肤科杂志 2024年第6期57卷 579-580页

作者： F. Flament D. g. Mercurio b. Muller J. Li C. Tricaud F. b.rnerd A. Roudot D. Candau T. Passeron L'Oréal Research and Innovation Clichy France L'Oréal Research and Innovation Rio de Janeiro Brazil L'Oréal Research and Innovation Shanghai China L'Oréal Research and Innovation Aulnay-sous-Bois France L'Oréal Research and Innovation Chevilly-Larue France CHU Nice Department of Dermatology Université Côte d'Azur Nice France Université Côte d'Azur INSERM U1065 C3M Nice France

一、引言在不同的紫外线(UV)波段中,长波UVA(UVA1,340~400nm)具有更高的皮肤穿透力,并且受气象条件和臭氧层厚度等环境参数的影响较小,因此更容易到达皮肤深部的真皮层,对细胞成分(如DNA、脂质和蛋白质)造成氧化损伤。UVA1已经越来越多... 详细信息

一、引言在不同的紫外线(UV)波段中,长波UVA(UVA1,340~400nm)具有更高的皮肤穿透力,并且受气象条件和臭氧层厚度等环境参数的影响较小,因此更容易到达皮肤深部的真皮层,对细胞成分(如DNA、脂质和蛋白质)造成氧化损伤。UVA1已经越来越多地被发现与衰老、致癌作用、多种皮肤疾病和色素问题相关。

关键词： UVA1 真皮层自身对照致癌作用皮肤疾病防晒剂遗传背景氧化损伤

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Semi-analytical investig.tion of heat transfer in a porous convective radiative moving.long.tudinal fin exposed to mag.etic field in the presence of a shape-dependent trihyb.id nanofluid

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Applied Mathematics and Mechanics(Eng.ish Edition) 2024年第1期45卷 197-216页

作者： C.g.PAVITHRA b.J.g.REESHA M.L.KEERTHI Department of Pg.Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of Mathematics and Statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integ.r-ordered mob.le fin w.th a mag.etism in the presence of a trihyb.id nanofluid(Fe_3O_4-Au-Zn-b.ood) is carried out. Three types of nanoparticles, each having.a different shape, are considered. These shapes include spherical(Fe_3O_4), cylindrical(Au), and platelet(Zn) config.rations. The comb.nation approach is utilized to evaluate the physical and thermal characteristics of the trihyb.id and hyb.id nanofluids, excluding.the thermal conductivity and dynamic viscosity. These tw. properties are inferred b. means of the interpolation method b.sed on the volume fraction of nanoparticles. The g.verning.equation is transformed into a dimensionless form, and the Adomian decomposition Sumudu transform method(ADSTM) is adopted to solve the conundrum of a moving.fin immersed in a trihyb.id nanofluid. The ob.ained results ag.ee w.ll w.th those numerical simulation results, indicating.that this research is reliab.e. The influence of diverse factors on the thermal overview.for varying.noninteg.r values of γ is analyzed and presented in g.aphical representations. Furthermore, the fluctuations in the heat transfer concerning.the pertinent parameters are studied. The results show.that the heat flux in the presence of the comb.nation of spherical, cylindrical, and platelet nanoparticles is hig.er than that in the presence of the comb.nation of only spherical and cylindrical nanoparticles. The temperature at the fin tip increases b. 0.705 759% w.en the value of the Peclet numb.r increases b. 400%, w.ile decreases b. 11.825 13% w.en the value of the Hartman numb.r increases b. 400%.

关键词： convection radiation moving.long.tudinal fin Adomian decomposition Sumudu transform method(ADSTM) trihyb.id nanofluid mag.etic field

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Nonlinear corrections for the nuclear g.uon distrib.tion in eA processes

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Chinese Physics C 2024年第3期48卷 52-64页

作者： g.R.b.roun b.Rezaei F.Ab.i Department of Physics Razi UniversityKermanshah 67149Iran.

An analytical study w.th respect to the nonlinear corrections for the nuclear g.uon distrib.tion function in the next-to-leading.order approximation at small x is presented.w. consider the nonlinear corrections to the nuclear g.uon distrib.tion functions at low.values of x and Q^(2) using.the parametrization F_(2)(x,Q^(2))and the nuclear modification factors ob.ained from the Khanpour-Soleymaninia-Atashb.r-Spiesb.rg.r-g.zey model.The CT18 g.uon distrib.tion is used for the b.seline proton g.uon density at Q^(2)_(0)=1.69g.V2.w. discuss the b.havior of the g.uon densities in the next-to-leading.order and the next-to-next-to-leading.order approximations at the initial scale Q^(2)_(0),as w.ll as the modifications due to the nonlinear corrections.w. find that the QCD nonlinear corrections are more sig.ificant for the next-to-leading.order accuracy than the next-to-next-to-leading.order for lig.t and heavy nuclei.The results of the nonlinear g.R-MQ evolution equation are similar to those ob.ained w.th the Rausch-g.zey-Klasen g.uon upw.rd and dow.w.rd evolutions w.thin the uncertainties.The mag.itude of the g.uon distrib.tion w.th the nonlinear corrections increases w.th a decrease in x and an increase in atomic numb.r A.

关键词： g.uon distrib.tion nonlinear corrections lig.t and heavy nuclei low.x physics

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