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NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease

World Journal of Gastroenterology 2011年第23期17卷 2829-2837页

作者： Dylan M Glubb Richard B Gearry Murray L barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley Department of Medicine University of ChicagoIL 60637-1470United States Department of Medicine University of OtagoChristchurch8140New Zealand Department of Gastroenterology Christchurch HospitalChristchurch8140New Zealand Department of Biochemistry University of OtagoDunedin9054New Zealand Department of Pathology University of OtagoChristchurch8140New Zealand Department of Surgery University of OtagoChristchurch8140New Zealand Department of Haematology University of OtagoChristchurch8140New Zealand Department of Paediatrics University of OtagoChristchurch8140New Zealand

AIM： TO assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis （MAP） survival in monocytes from Crohn＇s disease （CD） patients METHODS： Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1, Monocytes were challenged with MAP and bacterial per- sistence assessed at subsequent time-points. Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines. RESULTS： Monooltes heterozygous for a NOD2 polymorphism （R702W, P268S, or 1007fs） were more permissive for growth of MAP （P = 0.045） than those without. There was no effect of NOD2 genotype on subsequent cytokine expression. The T300A polymorphism of ATG16L1 did not affect growth of MAP in our model （P = 0.175）, but did increase expression of cytokines interleukin （IL）-10 （P = 0.047） and IL-6 （P = 0.019）. CONCLUSION： CD-associated polymorphisms affected the eliminaUon of MAP from ex v/vo monooltes （NOD2）, or expression of certain oltokines （ATG16LI）, implying independent but contributory roles in the pathogenesis of CD.

关键词： Inflammatory bowel disease Mycobacteriumavium subspecies paratuberculosis Cytokine CARD15 Autophagy

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使用脉冲电磁波(Diapulsc)治疗各种手外伤

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神经损伤与功能重建 1984年第2期 89-91页

作者： barclay V 余超虹

Wilson Hall(1979)与Conolly Kid-grove(1979)提示手是人体最易受到外伤的部位。手外伤占医院急诊总病例的10%。这类损伤有些需要数月才能愈合,而且妨碍患者正常体力活动的及早恢复。近几年,脉冲电磁波(Diapulse)已有效地用于加速伤口... 详细信息

Wilson Hall(1979)与Conolly Kid-grove(1979)提示手是人体最易受到外伤的部位。手外伤占医院急诊总病例的10%。这类损伤有些需要数月才能愈合,而且妨碍患者正常体力活动的及早恢复。近几年,脉冲电磁波(Diapulse)已有效地用于加速伤口愈合、减轻肿胀.促进血肿吸收,增加血流,防止组织粘连及加固

关键词：脉冲电磁波 Diapulsc 手外伤

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原镁生产中的能耗

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轻金属 1978年第3期 45-47页

作者： J.barclay 郑宏

尽管镁是地壳中第三种最丰富的元素,而且海水中的镁取之不尽,此外,还有菱镁矿、白云石这些矿物和含MgCl的盐水以及大盐湖水等镁资沅,但至今镁仍未达到作为结构材料

关键词：海水制取非金属矿物氯化镁溶液能量消耗电解法电化学分析原产品白云石镁肥金属金属材料

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花香满径

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作者： (爱尔兰)巴克莱(William barclay)

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AHA更新血压处理指南

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心血管病学进展 2007年第2期28卷 324-325页

作者： barclay L 罗雪琚（编译） Vega C. Hypertension 四川大学华西医院

2006年1月美国心脏协会(AHA)更新了为防治高血压有关生活方式改变的指南,该指南载于2006年2月的Hypertension。当血压水平升高,心血管疾病的危险随血压水平增高而进行性增加,但它可以通过改善饮食来预防,人们可通过改善饮食降低他们的... 详细信息

2006年1月美国心脏协会(AHA)更新了为防治高血压有关生活方式改变的指南,该指南载于2006年2月的Hypertension。当血压水平升高,心血管疾病的危险随血压水平增高而进行性增加,但它可以通过改善饮食来预防,人们可通过改善饮食降低他们的血压并大大减少患包括脑卒中、冠心病和心力衰竭的心血管病危险。最近的“国家健康与营养检查调查”(NHANES)表明27%的美国成人有高血压[定义为:收缩压≥140mmHg(1mmHg=0.1333kPa),舒张压≥90himHg,或在应用降压药],另外31%为高血压前期(定义为未用降压药,收缩压120－139mmHg或舒张压80－89mmHg),对于50岁以上的成人约90%其一生中有发生高血压的危险,然而高血压的控制率仍低。不断增长的证据强烈支持多种饮食因素与血压之间的关系。[第一段]

关键词：血压处理指南 AHA 高血压前期美国心脏协会心血管疾病饮食因素血压水平

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Does Anesthesiologist-Directed Sedation Afford Superior Deep Cannulation Rates and Procedural Outcomes for ERCP in the Community Setting?

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Open Journal of Gastroenterology 2016年第2期6卷 46-52页

作者： Brad Bowyer Kathy Geissler Robert barclay Sumeet Tewani James Frakes Nicholas Brown Matthew Houlihan Kunal Patel Andrew Spiel Rockford Gastroenterology Associates Rockford IL USA University of Illinois College of Medicine Rockford Rockford IL USA

Aim: To compare outcomes by sedation class in community patients undergoing index endoscopic retrograde cholangiopancreatography (ERCP). Methods: Nineteen hundred sixteen consecutive patients underwent ERCP from May 2005 to May 2011. Eight hundred thirty seven patients were excluded due to prior papillary intervention or attempted ERCP. A total of 1079 patients were included. The 981 patients who underwent gastroenterologist directed sedation (GDS) served as the control population, while the 98 patients who received anesthesiologist directed sedation (ADS) served as the case population. Medical records were analyzed for patient demographics, procedure indication, adverse events, case complexity, procedural failure and sedation failure. Case complexity was defined by the grading system proposed by the working party of the ASGE Quality Committee. Sedation failure was defined by agitation or airway compromise prompting termination of the ERCP. Reasons for procedural failure included surgically altered anatomy, luminal obstruction, and technical failure. Study endpoint was defined as successful deep cannulation of the intended target duct. Results: Demographic distribution did not differ between the GDS and the ADS groups. Cannulation success rates were similar between the two groups, with 89.85% in the GDS group, and 89.58% in the ADS group (P = 0.864). There were no statistical differences between sedation groups in procedural or respiratory adverse events. Technical failure was the predominant basis for deep cannulation failure in both groups. Agitation and airway compromise accounted for deep cannulation failure similarly in both groups. The need for reversal agents was low but similar in both groups. There was no statistical advantage in deep cannulation success rate by complexity grade in either sedation class. Conclusion: Excellent procedural outcomes and low adverse event rates were achieved using GDS, a more accessible and cost-effective method in a community-b

关键词： ERCP Community-Based Medicine Conscious Sedation Anesthesiologist-Directed Sedation Gastroenterologist-Directed Sedation

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将动物脂肪转化成为可再生柴油

将动物脂肪转化成为可再生柴油

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第五届（2012）中国油脂化工行业年会

作者： Eliza barclay 杨琳

＜正＞从藻类、木屑到杂草和固体废弃物,科学家正在广阔的范围内寻找能够生产新一代可再生燃料的原料——一种不用将粮食转变成能源,又蕴藏丰富、足以对石油市场造成重大影响的资源。世界最大的肉品公司认为,答案就在其拥有技术中:动物脂

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结肠镜检前洁肠时给予患者磷酸钠口服液三剂服法的安全性、有效性及患者的耐受性

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世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 19-20页

作者： barclay R.L. 翟惠虹

Background: Sodium phosphate, administered orally, is an effective, well-tolerated colonic cleansing agent. However, colonoscopic visualization is suboptimal in many patients after a conventional 2-dose regimen. This study assessed the safety, the efficacy, and patient tolerance of a 3-dose regimen of sodium phosphate. Methods: Patients without cardiac, renal, or hepatic insufficiency were randomized to precolonoscopy purgation with 3 (45 mL) doses vs. two doses of aqueous sodium phosphate administered orally. Hemodynamic measurements and serum and urine biochemical tests were obtained at baseline and after purgation. Tolerance of the bowel preparation and colonoscopic visualization were assessed via questionnaires. Results: Quality of colonic cleansing was significantly better with the 3-dose regimen compared with the 2-dose regimen (p < 0.0001). No clinically significant adverse event was detected in either group. Subclinical orthostasis was observed in 5%of patients given the 2-dose regimen vs. 3%of those who took the 3-dose regimen. Post-purgation hyperphosphatemia was greater in the 3-dose group vs. the 2-dose group (p = 0.0003). No other significant differences in biochemistry were noted between the groups. Patient tolerance of the 2-dose regimen was better than the 3-dose regimen (p = 0.0379). Conclusions: A 3dose regimen of orally administered sodium phosphate provides superior colonic cleansing without compromising volume status or serum biochemistry but is associated with poorer overall patient tolerance compared with a conventional 2-dose regimen.

关键词：磷酸钠口服液结肠镜检肠内镜肝功能不全体位性低血压血流动力学显影效果亚临床便时生化指标

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