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城市生态网络功能性连接辨识方法

生态学报 2015年第19期35卷 6414-6424页

作者：陈春娣 Meurk d. colin Ignatieva E. Maria Stewart H. Glenn 吴胜军中国科学院水库水环境重点实验室、中国科学院重庆绿色智能技术研究院重庆400714 新西兰皇家科学院土地保护研究所新西兰基督城7608 林肯大学新西兰基督城7674

城市生态网络是景观生态学应用领域研究的热点和重点之一,识别、评估生境之间的连接是构建生态网络的关键环节。在总结已有连接辨识方法的基础上,提出采用最小费用模型和图论分析相结合的方法,探讨功能性连接的辨识和优先恢复途径。以... 详细信息

城市生态网络是景观生态学应用领域研究的热点和重点之一,识别、评估生境之间的连接是构建生态网络的关键环节。在总结已有连接辨识方法的基础上,提出采用最小费用模型和图论分析相结合的方法,探讨功能性连接的辨识和优先恢复途径。以新西兰基督城为案例,分别利用景观发展强度指数建立阻力面,新西兰鸡毛松(dacrycarpus dacrydioides)种子最大传播距离作为连接阈值来模拟、评价网络连接。结果表明:在1200 m距离阈值下,共有408条连接,其重要性分为10类。其中Richmond—Petrie公园,Hansons—Auburn保护地,Centaurus公园—King George保护地是整个生态网络的关键连接;若去除,景观整体连接度将下降31.73%。此外,研究发现连接重要值与两端的源面积之和没有显著相关性,即面积大的源斑块之间的连接不一定对网络构建起关键作用,这一结论还有待进一步证明。针对缺少动物迁移资料的城市环境,改进最小费用模型和网络连接分析的部分参数;可操作性与实用性强,对中国城市区域生态恢复建设、栖息地选择具有借鉴意义。

关键词：城市生态网络功能性连接乡土栖息地最小费用模型图论乡土树种子传播

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3β,20α-羟基甾体脱氢酶的动力学性质

生物化学杂志 1991年第2期7卷 177-182页

作者：陈清轩 colin d.Nancarrow Frederick Sweet 中国科学院发育生物学研究所 CSIRO division of Animal Production Prospect NSW 2148 Australia depart.of OB/CYN Washington University School of Medicine St. LouisMO 63110 U.S.A.

3β,20α-羟基甾体脱氢酶(3β,20α-Hydroxysteroid dehydrogenase,3β,20α-HSd)是从胎羊血中分离得到的。分子量为35kd。该酶以NAdPH为辅酶,有两种底物。以孕酮为底物时,Km=30.8μmol/L,Vmax=0.7nmol min^(-1)(nmol enzyme)^(-1);以5α-二氢睾酮(5α-dihydrotestosterone,5α-dHT)为底物时,Km=74μmol/L,Vmax=1.3nmol min^(-1)(nmol enzyme)^(-1)。5α-dHT竞争性抑制20α-还原活性,Ki=102μmol/L。16α-溴代乙酰氧基(16α-Bromo acetoxyprogesterone,16α-BAP)是3β,20α-HSd不可逆竞争性抑制剂,t_(1/2)=75min。对3β和20α还原活性的抑制常数Ki分别为23μmol/L和58μmol/L。

关键词：羟甾体脱氢酶动力学

Protein-based profiling of the human IgA1 clonal repertoire revealed shared clones of serum polymeric IgA1 and milk secretory IgA1

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Cellular & Molecular Immunology 2023年第3期20卷 305-307页

作者： Jan Novak Matthew B.Renfrow R.Glenn King colin Reily Todd J.Green department of Microbiology University of Alabama at BirminghamBirminghamALUSA department of Biochemistry and Molecular Genetics University of Alabama at BirminghamBirminghamALUSA

Human adaptive immunity involves the production and secretion of antibodies by differentiated B cells(ie.,antibody-secreting cells,also called plasma cells)in response to *** secreted antigen-specific antibodies are immunoglobulins that are present at substantial concentrations in blood,mucosal secretions,and breast ***,human immunoglobulins consist of two identical heavy(H)chains and two identical light(L)chains that are connected by disulfide bridges to form a homodimer of heterodimers(ie.,H+Ll2).Each heterodimer consists of one H chain linked with one L chain,whereas the homodimer is formed by linking two H chains *** genes for both the L and H chains are encoded by ligated gene segments that are genetically rearranged during V(d)J recombination,a process that endows each B cell with a unique receptor,giving rise to the enormous diversity of the B-cell antigen receptor repertoire.

关键词： IgA1 immunity chains

Isolated left ventricular apical hypoplasia:Systematic review and analysis of the 37 cases reported so far

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世界临床病例杂志 2023年第23期11卷 5494-5503页

作者： Pier Paolo Bassareo Sophie duignan Adam James Esme dunne colin J McMahon Kevin P Walsh University College of dublin School of Medicine and Department of Cardiology at Mater Misericordiae University HospitalDublin D07 R2WYIreland department of Cardiology Children's Health CrumlinDublin D12 N512Ireland University College of dublin School of Medicine and Department of CardiologyChildren's Health IrelandDublin D12 N512Ireland

BACKGROUNd Isolated left ventricular apical hypoplasia(ILVAH),also known as truncated left ventricle(LV),is a very unusual *** is characterised by a truncated,spherical,and non-apex forming *** true apex is occupied by the right *** to the rarity of the disease,just a few case reports and limited case series have been published in the *** To analysing the so far 37 reported ILVAH cases *** The electronic databases PubMed and Scopus were investigated from their establishment up to december 13,*** The majority of cases reported occurred in males(52.7%).Mean age at diagnosis was 26.1±19.6 *** than a third of the patients were asymptomatic(35.1%).The most usual clinical presentation was breathlessness(40.5%).The most commonly detected electrocardiogram changes were T wave abnormalities(29.7%)and right axis deviation with poor R wave progression(24.3%).Atrial fibrillation/flutter was detected in 24.3%.Echocardiography was performed in 97.3%of cases and cardiac MRI in 91.9%of *** fraction was reduced in more than a half of patients(56.7%).An associated congenital heart disease was found in 16.2%.Heart failure therapy was administered in 35.1%of *** outcome was favorable in the vast majority of patients,with just one *** ILVAH is a multifaceted entity with a so far unpredictable course,ranging from benign until the elderly to sudden death during adolescence.

关键词： Isolated left ventricular apical hypoplasia Truncated left ventricle Electrocardiography Echocardiography Cardiac magnetic resonance imaging Heart failure

Congenital Absence of Pericardium:The Largest Systematic Review in the Field on 247 Worldwide Cases(1977-Now)

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Congenital Heart disease 2023年第6期18卷 595-610页

作者： Pier Paolo Bassareo Aurelio Secinaro Paolo Ciliberti Massimo Chessa Marco Alfonso Perrone Kevin Patrick Walsh colin Joseph Mcmahon Mater Misericordiae University Hospital National Adult Congenital Heart Disease ServiceDublinD07 R2WYIreland Children’s Health Ireland Crumlin DublinIreland School of Medicine University College of DublinDublinIreland Advanced Cardiovascular Imaging Unit Bambino GesùChildren’s HospitalIRCCSRomeItaly department of Cardiac Surgery CardiologyHeart and Lung Transplantation Bambino Gesu’Children’s HospitalIRCCSRomeItaly Adult Congenital Heart disease UNIT Paediatric and Adult Congenital Heart CentreIRCCS-Policlinico San DonatoSan Donato MilaneseMilanItaly School of Medicine Vita Salute San Raffaele UniversityMilanItaly division of Cardiology and CardioLab Department of Clinical Sciences and Translational MedicineUniversity of Rome Tor VergataRomeItaly

Background:Congenital absence of pericardium(CAP),also known as pericardial agenesis,represents an uncommon cardiac abnormality and mostly incidental *** can be subdivided into complete and partial(left or right-sided)*** of its infrequency,just case reports and a few case series have been released so *** paper represents the largest systematic review in the *** features(age at diagnosis,type,gender,clinical presentation,electrocardiography,imaging(ultrasounds,CT/MRI),concomitant cardiac defects,and outcome)were ***:The electronic database PubMed was investigated from its establishment up to July 15th,*** case reports and case series were *** studies,papers that were not in English,Spanish,and Italian,and those manuscripts not reporting at least seven of the nine analysed *** ruled *** analysed data were reported mostly in terms of ***:One hundred eighty studies were included encompassing 247 *** than half of reviewed CAP cases were in males(63.2%).The mean age at diagnosis was 31.8±19.3 years;a range of 32 weeks of gestation-81 years).23.5%of the patients did not report any *** most common clinical presentations were chest pain(35.2%)and dyspnoea(29.2%).The most commonly seen ECG changes were right axis deviation(28.7%)and right bundle branch block(23.9%).CAP was suspected or diagnosed by echocardiography in 20.1%of *** diagnosis was made by CT and/or MRI in 61.9%of *** was left-sided in 71.2%,complete in 23.1%,and right-sided in 5.7%.A concomitant congenital heart defect was found in 22.7%,especially in the form of atrial septal defect(6.5%)and patency of ductus arteriosus(2.8%).The pericardial repair was required in 12.9% of the incomplete forms of the *** did the complete form require surgical *** outcome appeared favourable in the vast majority of cases,with just 18 deaths(7.3%).discussion:The main limitation of this syste

关键词： Congenital absence pericardium pericardial agenesis electrocardiography echocardiography computed tomography cardiac magnetic resonance imaging

Rudolph's pediatrics / 22th ed

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Intrinsic subtypes and bladder cancer metastasis

2011年

作者： Rudolph, colin david,

ISBN: (纸本)9780071497237

Summary: Publisher Summary 1 The landmark pediatrics reference -- now extensively updated in full color and more clinically relevant than everA doody's Core Title ESSENTIAL PURCHASE for 2011!Rudolph's Pediatricshas virtually defined the pediatric field for over a century, becoming one of the most important and well-respected pediatrics texts ever published. Renowned for its balance of clinical features and treatment of disease with underlying biological principles, this classic sourcebook has helped generations of pediatricians optimize their care of infants, children, and adolescents. The 22nd edition of Rudolph's Pediatricscontinues a long tradition of adapting its content to changes in our understanding of children's health and disease, providing an up-to-date, in-depth survey of pediatric medicine unmatched by any other text. With its algorithmic approach to pediatric systems, the book facilitates the diagnosis and treatment of both common and uncommon pediatric illnesses; and it reflects new technologies and advances in molecular medicine that continue to evolve with current thinking about normal childhood development and pediatric disease *** TO THIS EdITION: New four-color design adds depth and clarity to the book's content Over 900 full-color, high-quality images and illustrations A reorganized, reader-friendly format broken down into sections and chapters for easier navigation and referenceNew emphasis on the clinical management of the patient makes this the most practical edition to dateNew sections provide a timely overview of pediatric care fundamentals and an entirely revised discussion of health promotion and disease preventionSubstantially revised sections cover key areas of pediatric study and practice, including infectious diseases, immunology, allergy, neoplastic disorders, the cardiovascular system, urinary complications, and more Greater use of tables and lists conveniently summarize need-to-know diagnostic and therapeutic informationNe

关键词： Pediatrics.

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Asian Journal of Urology 2016年第4期3卷 260-267页

作者： david J.McConkey Woonyoung Choi Andrea Ochoa colin P.N.dinney Johns Hopkins Greenberg Bladder Cancer Institute BaltimoreMDUSA department of Urology Brady Urological InstituteJohns Hopkins UniversityBaltimoreMDUSA department of Urology U.T.M.D.Anderson Cancer CenterHoustonTXUSA

Recent studies demonstrated that bladder cancers can be grouped into basal and luminal molecular subtypes that possess distinct biological and clinical *** bladder cancers express biomarkers characteristic of cancer stem cells and epithelial-tomesenchymal transition(EMT).Patients with basal cancers tend have more advanced stage and metastatic disease at *** preclinical models basal human orthotopic xenografts are also more metastatic than luminal xenografts are,and they metastasize via an EMT-dependent ***,preclinical and clinical data suggest that basal cancers are also more sensitive to neoadjuvant chemotherapy(NAC),such that most patients with basal cancers who are aggressively managed with NAC have excellent ***,luminal bladder cancers can also progress to become invasive and metastatic,but they appear to do so via mechanisms that are much less dependent on EMT and may involve help from stromal cells,particularly cancer-associated fibroblasts(CAFs).Although patients with luminal cancers do not appear to derive much clinical benefit from NAC,the luminal tumors that are infiltrated with stromal cells appear to be sensitive to anti-PdL1 antibodies and possibly other immune checkpoint ***,neoadjuvant and/or adjuvant immunotherapy may be the most effective approach in treating patients with advanced or metastatic infiltrated luminal bladder cancers.

关键词： Bladder cancer Metastasis Basal subtypes Luminal subtypes Epithelial-tomesenchymal transition

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英国的金属回收产业

资源再生 2003年第12期 34-35页

作者： colin d ILES 欧洲金属回收公司

本文是欧洲金属回收公司常务董事colindILES先生在2003年中国国际金属回收市场及技术论坛上的发言。发言简单介绍了英国废金属工业的概况,同时希望能促进欧洲和中国市场间的更紧密合作和相互间的贸易。本刊略有删改。

关键词：金属回收欧洲废物回收地区金属废料废钢废金属有色金属产量大不列颠及北爱尔兰联合王国英国产业

The significance of strong force chains on shear modulus, shear strength and strain localisation

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The significance of strong force chains on shear modulus, sh...