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Bacterobilia in pancreatic surgery-conclusions for perioperative antibiotic prophylaxis

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World Journal of Gastroenterology 2019年第41期25卷 6238-6247页

作者： colin Markus Kruger Ulrich Adam Thomas Adam Axel Kramer Claus d Heidecke Frank Makowiec Hartwig Riediger department of Surgery Immanuel Hospital RüdersdorfBerlin 15562Germany department of General Surgery Vivantes-Humboldt hospitalBerlin 13503Germany department of Microbiology Labor Berlin GmbHBerlin 13353Germany Institute of Hygiene and Environmental Medicine University Medicine GreifswaldGreifswald 17495Mecklenburg VorpommernGermany department of Surgery Clinic of GeneralVisceralVascular and Thoracic SurgeryUniversity Medicine GreifswaldGreifswald 17475Mecklenburg VorpommernGermany Section of clinical risk assessment University hospital of FreiburgFreiburg 79106Baden-WürttembergGermany

BACKGROUNd Jaundice or preoperative cholestasis(PC)are typical symptoms of pancreatic *** 50%of patients undergo preoperative biliary drainage(PBd)*** is a common cause of bacterobilia(BB)and is a known surgical site infection risk *** adjustment of preoperative antibiotic prophylaxis(PAP)may be reasonable according to the profile of *** this,we examined the microbiological findings in routine series of *** To investigate the incidence and profile of biliary bacterial colonization in patients undergoing pancreatic head *** In the period from January 2009 to december 2015,285 consecutive pancreatic head resections were *** for surgery were malignancy(71%),chronic pancreatitis(18%),and others(11%).A PBd was in 51%and PC was in 42%.The standard PAP was ampicillin/***,a smear was taken from the hepatic *** analysis of the isolated species and resistograms was *** were categorized according to the presence or absence of PC(PC+/PC-)and PBd(PBd+/PBd-)into four *** efficiency was analyzed for standard PAP and possible *** BB was present in 150 patients(53%).BB was significantly more frequent in PBd+(n=120)than in PBd-(n=30),Pd without PC:(PBd-/PC-:18%,PBd-/PC+:30%,PBd+/PC-:88%,PBd+/PC+:80%).BB was more frequent in malignancy(56%)than in chronic pancreatitis(45%).PBd,however,was the only independent risk factor in multivariate *** total,357 pathogens(342 bacteria and 15 fungi)were *** five most common groups(n=256,74.8%)were Enterococcus spp.(28.4%),Streptococcus spp.(16.9%),Klebsiella spp.(12.6%),Escherichia coli(10.5%),and Enterobacter spp.(6.4%).A polymicrobial BB(PBd+:77% vs PBd-:40%,Pd a more frequent detection of Enterococcus(Pd with PBd+.In PBd+,the efficiency of imipenem and piperacillin/tazobactam was significantl

关键词： Pancreatic surgery Bacteriobilia Antibiotic prophylaxis Cholestasis Cholangiopancreatography Endoscopic retrograde

Improved bridge pier collar for reducing scour

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International Journal of Sediment Research 2022年第1期37卷 37-46页

作者： Christopher Valela colin david Rennie Ioan Nistor department of Civil Engineering University of Ottawa

This study performed a bridge pier collar comparison for the purpose of reducing scour,while introducing a new collar *** new collar,referred to as Collar Prototype Number 3,was designed based on an equilibrium scour hole and provides a method of controlling the horseshoe *** modelling was utilized to show the flow field and bed shear stress as a result of using Collar Prototype Number 3.A prototype model of Collar Prototype Number 3 and a flat plate collar were constructed for the purpose of comparing both experimentally under different flow *** Prototype Number 3 proved to be an effective device as it reduced scour in terms of the maximum depth downstream of the pier and overall volume,in some instances,by up to 69.7%and 75.7%,***,Collar Prototype Number 3 outperformed the flat plate collar,especially because,unlike the flat plate collar,Collar Prototype Number 3 did not experience undermining.

关键词： Bridge pier Scour Horseshoe vortex Pier collar Scour countermeasure

The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic dopamine d2 (-dRd2/ANKK (Taq1A)), OPRM1 (A/G), dRd3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANdAS/CANS: Positive Clinical Outcome with Precision-Guided dNA Testing and Pro-dopamine Regulation (KB220) and Antibacterial Therapies

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Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman david Han colin Hanna david Baron Ashim Gupta Shan Kazmi Jag Khalsa debasis Bagchi Thomas McLaughlin Rajendra d. Badgaiyan Edward J. Modestino drew Edwards Catherine A. dennen Eric R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole Jafari Foojan Zeine Paul R. Carney Mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA division of Personalized Interventions Peak Logic Del Mar CA USA division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA department of Psychiatry Harvard School of Medicine Cambridge MA USA department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA department of Family Medicine Jefferson Health Northeast Philadelphia PA USA departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANdAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward deficiency Syndrome (RdS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANdAS, especially those with known dNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine d2 (-dRd2/ANKK (Taq1A), OPRM1 (A/G), dRd3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research Id-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided dNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANdAS CANS Genetic Addiction Risk Testing (GARS) Pro-dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections

Porous solid inspired hyper-crosslinked polymer liquids with highly efficient regeneration for gas purification

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Science China Materials 2022年第7期65卷 1937-1942页

作者： Stefan J.d.Smith colin d.Wood Paul H.M.Feron Hamidreza Mahdavi Roger J.Mulder Cara M.doherty Matthew R.Hill Xavier Mulet CSIRO Manufacturing Private Bag 10Clayton SouthVIC 3169Australia department of Chemical Engineering Monash UniversityClaytonVIC 3800Australia Australian Resources Research Centre KensingtonWA 6155Australia CSIRO Energy P.O.Box 330NewcastleNSW 2300Australia

Separation media that combine the desired material properties within a single material for a given process remain an ongoing challenge for the gas separations in *** integration of porous solid adsorbents is difficult due to their limited volumetric capacity,whereas issues of volatility and high regeneration temperatures exist for liquid amines and physical ***,we report a family of polymer liquids inspired by hyper-crosslinked polymers(HCPs),a class of highly swellable network *** with a chemically similar porous solid,the HCP-liquids demonstrate good volumetric capacity and improved selectivity of carbon dioxide over *** appears to be enhanced by intramolecular swelling of the HCP-liquids at elevated pressures,while guests are strongly rejected from the HCP-liquids at slightly elevated temperatures,leading to highly efficient *** of adsorption and specific heat capacity of the HCP-liquids are also low,further suggesting favourable process *** being easily prepared at scale,the presented HCP-liquids represent a promising step towards a material with the requisite properties to replace conventional scrubbing solvents to drastically reduce the footprint and energy needs of gas separations.

关键词： hyper-crosslinked polymers swellable network efficient regeneration porous liquids gas sorption

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Smaller bar spacings in a Nordmøre grid reduces the bycatch of redfish(Sebastes spp.)in the offshore Northern shrimp(Pandalus borealis)fishery of eastern Canada

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Aquaculture and Fisheries 2023年第6期8卷 661-671页

作者： Tomas Araya-Schmidt Shannon M.Bayse Paul d.Winger colin H.Frank Centre for Sustainable Aquatic Resources Fisheries and Marine InstituteMemorial University of NewfoundlandSt.John’sNLA1C 5R3Canada

The offshore Northern shrimp(Pandalus borealis)bottom trawl fishery in eastern Canada currently uses 22 and 28 mm bar spacing Nordmøre grids to limit bycatch from using small mesh ***,a recent rebound of juvenile redfish(Sebastes spp.),that can pass through the grids,has greatly increased *** address this concern,this study investigated the effectiveness of 17 and 15 mm bar spacing Nordmøre grids in a twin-trawl(paired)configuration against the traditional 22 mm bar spacing *** selectivity analyses showed that the 17 and 15 mm grids resulted in no significant reduction in shrimp catch across all length *** 17 mm grid significantly reduced redfish bycatch for all length classes and the 15 mm grid significantly reduced redfish bycatch for individuals larger than 95 mm total *** redfish entered the codend with the experimental grids,however,the overlap in width between redfish and Northern shrimp limits the overall sorting efficiency of the grids,leaving some redfish still vulnerable to capture.

关键词： Size selectivity Twin trawling Catch comparison Bycatch reduction device

Low Cost 1d dCT Core for Multiple Video Codec

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Chinese Journal of Electronics 2016年第6期25卷 1052-1057页

作者： JIA Rui CHEN Rui LIN colin Yu GUO Zhenhong YANG Haigang Institute of Electronics Chinese Academy of Sciences The University of Chinese Academy of Sciences

The expandability of high demands for multimedia applications brings out more and more video standards for improving the coding and compression efficiency. As the most commonly used transform, discrete cosine transform(dCT) achieves excellent energy compaction property and good compression efficiency. Hardware sharing is the mostly used efficient strategy to reduce the cost for video codec. Based on traditional matrix factorization, this paper makes three observations to direct the design of proposed hardware sharing architecture. The proposed architecture can be generally used to compute 8×8 dCT of AVS, H.264, VC-1 and HEVC in a low cost way, and can be used to decode Full-Hd and WQXGA formate video sequences in real time. The design has been synthesized in 0.13μm technology. The synthesis results show that the proposed architecture achieves76.9% reduction in gate count, 85.6% decrease in power consumption and 35% improvement in operational speed in comparison with other existing designs.

关键词： discrete cosine transform(dCT) 8×8 integer transform AVS H.264 VC-1 HEVC Hardware sharing

Phylogenetic placement of lichenicolous Phoma species in the Phaeosphaeriaceae(Pleosporales,dothideomycetes)

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Fungal diversity 2012年第4期55卷 195-213页

作者： James d.Lawrey Paul diederich Matthew P.Nelsen colin Freebury dries Van den Broeck Masoumeh Sikaroodi damien Ertz department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA Musée national d’histoire naturelle 25 rue MunsterL-2160 LuxembourgLuxembourg Committee on Evolutionary Biology University of Chicago1025 E.57th StreetChicagoIL 60637USA department of Botany The Field Museum1400 S.Lake Shore DriveChicagoIL 60605USA Canadian Museum of Nature P.O.Box 3443Station DOttawaON K1P 6P4Canada Jardin Botanique National de Belgique Domaine de BouchoutB–1860 MeiseBelgium

More than twenty species of lichenicolous fungi have been described in Phoma,a large anamorphic genus of primarily plant-associated pathogens with broad geographic *** obtained nuclear and mitochondrial rdNA sequences from 19 fungal cultures isolated from specimens representing four described and two undescribed lichenicolous species in the *** multilocus phylogeny indicates that lichenicolous Phoma species represent at least two phylogenetically distinct clades in the Phaeosphaeriaceae,one including a new species,Phoma puncteliae,isolated from a specimen of Punctelia rudecta collected inMaryland,USA,and another group of primarily lichenicolous *** latter group includes four described lichenicolous Phoma species,an unidentified melanized rock fungus,and a new lichenicolous Phoma species isolated from Xanthomendoza species collected in Canada that we are naming *** specimens in this clade collected from different lichen genera and species were found to be very similar genetically,which calls into question the recent practice of recognizing lichenicolous Phoma species mainly by differences in host preference.

关键词： Anamorphic fungi Coelomycetes Conidial fungi Parasitic fungi

Phylogenetic insights resolve dacampiaceae(Pleosporales)as polyphyletic:didymocyrtis(Pleosporales,Phaeosphaeriaceae)with Phoma-like anamorphs resurrected and segregated from Polycoccum(Trypetheliales,Polycoccaceae ***.)

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Fungal diversity 2015年第5期74卷 53-89页

作者： damien Ertz Paul diederich James d.Lawrey Franz Berger colin E.Freebury Brian Coppins Alain Gardiennet Josef Hafellner department Bryophytes-Thallophytes(BT) Botanic Garden MeiseNieuwelaan 38B-1860 MeiseBelgium Musée national d’histoire naturelle 25 rue MunsterL-2160 LuxembourgLuxembourg department of Biology George Mason University4400 University DriveFairfaxVA 22030USA Raiffeisenweg 130 A-4794 KopfingAustria Canadian Museum of Nature PO Box 3443Stn.BDOttawaOntarion K1P 6P4Canada Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburgh EH35LRUK 14 rue Roulette F-21260 VéronnesFrance Institute for Plant Sciences NAWI GrazKarl-Franzens-University GrazHolteigasse 6A-8010 GrazAustria

A phylogenetic analysis of nuLSU and ITS sequences representing genera previously included in dacampiaceae indicates that the family is strongly polyphyletic and that the type species of dacampia is placed in *** genus Munkovalsaria *** placed in didymosphaeriaceae(Pleosporales).Polycoccum *** two species of Clypeococcum are shown to form a new lineage sister to the Trypetheliaceae in Trypetheliales and described here as *** members of Polycoccum *** included in the Pleosporales and are closely related to lichenicolous Phoma-like species of the family *** genus didymocyrtis is resurrected for these species and for lichenicolous species previously assigned to diederichia,diederichomyces,Leptosphaeria and *** genera diederichia and diederichomyces are synonymized with *** new combinations didymocyrtis bryonthae,***,***,***,***,***,***,***,*** and *** are made,and the new name *** is introduced for Phoma *** anamorph-teleomorph relationships are resolved,such as didymocyrtis ramalinae–Phoma ficuzzae and didymocyrtis consimilis–Phoma caloplacae,the phylogenetic results being supported by single ascospore cultures that lead to the asexual stage producing pycnidia and conidia in *** by host switching is assumed to be important in the genus *** identification key to didymocyrtis species is provided.

关键词： dothideomycetes Leptosphaeria diederichia diederichomyces Lichenicolous fungi Phylogeny

root uv-b sensitive Mutants Are Suppressed by Specific Mutations in ASPARTATE AMINOTRANSFERASE2 and by Exogenous Vitamin B6

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Molecular Plant 2011年第4期4卷 759-770页

作者： colin d. Leasure Hong-Yun Tong Xue-Wen Hou Amy Shelton Mike Minton Raymond Esquerra Sanja Roje Hanjo Hellmann Zheng-Hui He department of Biology 1600 Holloway Avenue San Francisco State University San Francisco CA 94132 USA department of Chemistry and Biochemistry 1600 Holloway Avenue San Francisco State University San Francisco CA 94132 USA The Institute of Biological Chemistry Washington State University Pullman WA 99164 USA School of Biological Sciences Washington State University Pullman WA 99164 USA

Vitamin B6 （vitB6） serves as an essential cofactor for more than 140 enzymes. Pyridoxal 5＇-phosphate （PLP）, active cofactor form of vitB6, can be photolytically destroyed by trace amounts of ultraviolet-B （UV-B）. How sun-exposed organisms cope with PLP photosensitivity and modulate vitB6 homeostasis is currently unknown. We previously reported on two Arabidopsis mutants, rusl and rus2, that are hypersensitive to trace amounts of UV-B light. We performed mutagenesis screens for second-site suppressors of the rus mutant phenotype and identified mutations in the ASPARTATE AMINOTRANSFERASE2 （ASP2） gene. ASP2 encodes for cytosolic aspartate aminotransferase （AAT）, a PLP-dependent enzyme that plays a key role in carbon and nitrogen metabolism. Genetic analyses have shown that specific amino acid substitutions in ASP2 override the phenotypes of rusl and rus2 single mutants as well as rusl rus2 double mutant. These substitutions, all shown to reside at specific positions in the PLP-binding pocket, resulted in no PLP binding. Additional asp2 mutants that abolish AAT enzymatic activity, but which alter amino acids outside of the PLP-binding pocket, fail to suppress the rus phenotype. Furthermore, exogenously adding vitB6 in growth media can rescue both rusl and rus2. Our data suggest that AAT plays a role in vitB6 homeostasis in Arabidopsis.

关键词： Vitamin B6 pyridoxal-phosphate aspartate aminotransferase ultraviolet light photo protection.