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Nearest Neighbor Sampling of Point Sets Using Rays

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1131-1174页

作者： Liangchen Liu Louis Ly colin B.Macdonald Richard tsai Department of Mathematics The University of Texas at Austin2515 SpeedwayAustinTX 78712USA Oden Institute for Computational Engineering and Sciences The University of Texas at Austin201 E24th StAustinTX 78712USA Department of Mathematics University of British Columbia1984 Mathematics RdVancouverBCV6T1Z2Canada

We propose a new framework for the sampling,compression,and analysis of distributions of point sets and other geometric objects embedded in Euclidean *** approach involves constructing a tensor called the RaySense sketch,which captures nearest neighbors from the underlying geometry of points along a set of *** explore various operations that can be performed on the RaySense sketch,leading to different properties and potential *** information about the data set can be extracted from the sketch,independent of the ray *** integrals on point sets can be efficiently computed using the *** also present several examples illustrating applications of the proposed strategy in practical scenarios.

关键词： Point clouds Sampling Classification Registration Deep learning Voronoi cell analysis

Mortality of a Wild King Cobra, Ophiophagus hannah Cantor, 1836(Serpentes: Elapidae) from Northeast thailand after Ingesting a Plastic Bag

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Asian Herpetological Research 2014年第4期5卷 284-286页

作者： colin thomas strine Inês SILVA Matthew CRANE Bartosz NADOLSKI taksin ARtCHAWAKOM Matt GOODE Pongthep SUWANWAREE Suranaree University of technology Sakaerat Environmental Research Station School of Natural Resources and Environment University of Arizona

Wild King Cobras, Ophiophagus hannah, are known to prey almost exclusively on snakes. We observed opportunistic ingestion of a plastic bag by a radio-tracked adult male O. hannah, which was detrimental to the health of the individual and likely lead to its death. Our observation demonstrates that improper disposal of food and plastic waste can be a threat to snakes, highlighting the need to maintain a waste-free environment, especially in areas inhabited by vulnerable species.

关键词： Garbage Sakaerat Snake Waste King Cobra Ophiophagus hannah

Progress and challenges in CRISPR-mediated therapeutic genome editing for monogenic diseases

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the Journal of Biomedical Research 2021年第2期35卷 148-162页

作者： colin t.Konishi Chengzu Long Leon H.Charney Division of Cardiology New York University Grossman School of MedicineNew YorkNY 10016USA Helen and Martin Kimmel Center for Stem Cell Biology New York University Grossman School of MedicineNew YorkNY 10016USA Department of Neurology New York University Grossman School of MedicineNew YorkNY 10016USA Department of Neuroscience and Physiology New York University Grossman School of MedicineNew YorkNY 10016USA

there are an estimated 10000 monogenic diseases affecting tens of millions of individuals *** application of CRISPR/Cas genome editing tools to treat monogenic diseases is an emerging strategy with the potential to generate personalized treatment approaches for these ***/Cas-based systems are programmable and sequence-specific genome editing tools with the capacity to generate base pair resolution manipulations to DNA or *** complexity of genomic insults resulting in heritable disease requires patientspecific genome editing strategies with consideration of DNA repair pathways,and CRISPR/Cas systems of different types,species,and those with additional enzymatic capacity and/or delivery *** this review we aim to discuss broad and multifaceted therapeutic applications of CRISPR/Cas gene editing systems including in harnessing of homology directed repair,non-homologous end joining,microhomology-mediated end joining,and base editing to permanently correct diverse monogenic diseases.

关键词： gene editing CRISPR-associated protein 9 CRISPR-Cas system genetic disease medical genetics genetic therapy

Uncoupling protein 2 in the glial response to stress:implications for neuroprotection

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Neural Regeneration Research 2016年第8期11卷 1197-1200页

作者： Daniel t.Hass colin J.Barnstable Department of Neural and Behavioral Sciences The Pennsylvania State University College of Medicine

Reactive oxygen species（ROS） are free radicals thought to mediate the neurotoxic effects of several neurodegenerative *** the central nervous system,ROS can also trigger a phenotypic switch in both astrocytes and microglia that further aggravates neurodegeneration,termed reactive *** regulators of ROS,such as mitochondrial uncoupling protein 2（UCP2） are neuroprotective factors that decrease neuron loss in models of stroke,epilepsy,and ***,it is unclear whether UCP2 acts purely to prevent ROS production,or also to prevent *** this review article,we discuss published evidence supporting the hypothesis that UCP2 is a neuroprotective factor both through its direct effects in decreasing mitochondrial ROS and through its effects in astrocytes and microglia.A major effect of UCP2 activation in glia is a change in the spectrum of secreted cytokines towards a more anti-inflammatory *** are multiple mechanisms that can control the level or activity of UCP2,including a variety of metabolites and micro *** these mechanisms will be key to exploitingthe protective effects of UCP2 in therapies for multiple neurodegenerative conditions.

关键词： neuroprotection astrocytes microglia reactive oxygen species oxidative stress mitochondrial uncoupling proteins cytokines neurodegeneration

Probiotic bacteria change Escherichia coli-induced gene expression in cultured colonocytes:Implications in intestinal pathophysiology

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World Journal of Gastroenterology 2007年第47期13卷 6370-6378页

作者： Pinaki Panigrahi Gheorghe t Braileanu Hegang Chen O colin Stine Departments of Pediatrics University of Maryland School of Medicine 22 South Greene Street Baltimore MD 21201 United States Department of Epidemiology & Preventive Medicine University of Maryland School of Medicine 22 South Greene Street Baltimore MD 21201 United States Genomics Core University of Maryland School of Medicine 22 South Greene Street Baltimore MD 21201 United States

AIM: to investigate the change in eukaryotic gene expression profile in Caco-2 cells after infection with strains of Escherichia coli and commensal probiotic bacteria. MEtHODS: A 19 200 gene/expressed sequence tag gene chip was used to examine expression of genes after infection of Caco-2 cells with strains of normal flora E. coli,Lactobacillus plantarum,and a combination of the two. RESULtS: the cDNA microarray revealed up-regulation of 155 and down-regulation of 177 genes by E. coli . L. plantarum up-regulated 45 and down-regulated 36 genes. During mixed infection,27 genes were up-regulated and 59 were down-regulated,with nullification of stimulatory/inhibitory effects on most of the genes. Expression of several new genes was noted in this group. CONCLUSION: the commensal bacterial strains used in this study induced the expression of a large number of genes in colonocyte-like cultured cells and changed the expression of several genes involved in important cellular processes such as regulation of transcription,protein biosynthesis,metabolism,cell adhesion,ubiquitination,and apoptosis. Such changes induced by the presence of probiotic bacteria may shape the physiologic and pathologic responses they trigger in the host.

关键词： Lactobacillus Escherichia coli Gene expression Probiotic cDNA microarray

A road for a promising future for China＇s primates： the potential for restoration

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Zoological Research 2018年第4期39卷 244-248页

作者： colin A. Chapman Department of Anthropology McGill University Montreal Quebec H3A 2T7 Canada Wildlife Conservation Society Bronx New York 10460 USA Section of Social Systems Evolution Primate Research Institute Kyoto University Inuyama 484-8506 Japan

China is one of the most dynamic countries of the world and it shelters some amazing levels of biodiversity, including some very special primate species. However, primarily as a result of forest loss, most of which occurred in historical times, approximately 70% of China＇s primate species have less than 3 000 individuals. Here I evaluate one road for future conservation/development that could produce very positive gains for China＇s primates; namely forest restoration. I argue that for a large scale restoration project to be possible two conditions must be met; the right societal conditions must exist and the right knowledge must be in hand. this evaluation suggests that the restoration of native forest to support many of China＇s primates holds great potential to advance conservation goals and to promote primate population recovery.

关键词： Conservation Forest restoration Regeneration Primate population dynamics

CD8+t cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason H.tong Guanxi Qiao tiffany R.Emmons thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of technology BostonMA 02139USA Present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+t-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of t cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature t *** doing so,we discovered a novel signaling axis that endows activated CD8+t cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of t-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+t-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+t cells.

关键词： Immunometabolism mRNA splicing CD8 t cells ARS2 PKM2

Localization and the possible role of plasminogen activators and inhibitors in early stages of placentation

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Chinese Science Bulletin 2000年第22期45卷 2056-2062页

作者： Ockleford colin D Department of Pre-Clinical Sciences University of LeicesterLeicester LEI 9HNUK

the distribution of mRNAs of tissue type (t) and urokinase type (u) plasminogen activator (PA) plus their corresponding inhibitors, type-1 (PAI-1) and type-2 (PAI-2) have been studied in the tissues of human first and second trimester placentae by in situ hybridization. the results show that: (i) All the molecules, tPA, uPA, PAI-1 and PAI-2, were identified in the blood vessels, the majority of extravillous trophoblastic cells of the decidual layer between Rohr’s and Nitabuch’s stria and in the trophoblast cells lining the chorionic plate, basal plate, intercotyledonary septae and cytotrophoblast cells of the chorionic villous tree. (ii) No expression of such probes was observed in the basal and chorionic plate, glandular cells of the decidua, the septal tissues or the villous core mesenchyme. the co-distribution of the molecules observed suggests that the co-ordinated expression of the activators and inhibitors in various cells of the placental tissue may play a role in angiogenesis related to

关键词： plasminogen activator plasminogen activator inhibitor placentation angiogenesis in situ hybridization.

A NOtE ON tHE ONSEt OF MELtING IN A CLASS OF SIMPLE MEtALS CONDItION ON tHE APPLIED BOUNDARY FLUX

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Acta Mathematica Scientia 1988年第4期8卷 425-430页

作者： colin Rogers,郭本瑜 School of Mathematics Georgia Institute of technology Atlanta Georgia 30332 USA Shanghai Univ. of Sci. & tech. Shanghai China

the onset of melting in a class of simple metals is considered for an applied heat flux q0=h0/t1/2at the boundary. Reduction of the nonlinear problem to a linear canonical form is obtained by a reciprocal transformati... 详细信息

关键词： A NOtE ON tHE ONSEt OF MELtING IN A CLASS OF SIMPLE MEtALS CONDItION ON tHE APPLIED BOUNDARY FLUX