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Feasibility and metabolic effects of a 5:2 fasting intervention in women with breast cancer during radiotherap.

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Holistic Integrative Oncology 2023年第1期2卷 373-384页

作者： Rainer J.Klement Jerome Figueroa Michael Weigel colin E.Champ.Sami Ok Reinhart A.Sweeney Dep.rtment of Radiation Oncology Leopoldina HospitalRobert-Koch-Strasse 10Schweinfurt 97422Germany Central Emergency Dep.rtment Leopol-dina HospitalSchweinfurtGermany Dep.rtment of Obstetrics and Gynae-cology Leopoldina HospitalSchweinfurtGermany Dep.rtment of Radiation Oncology and the Exercise Oncology and Resiliency Center Allegheny Health NetworkPittsburghPAUSA

p.rp.se Obesity and insulin resistance ap.ear to worsen p.ognosis of breast cancer *** conducted a feasibility study to test a 5:2 fasting regime in breast cancer p.tients undergoing *** intervention was rated as beneficial if it would be able to reduce fat mass while significantly imp.oving insulin *** A total of 13 non-metastatic breast cancer p.tients were recruited and instructed to comp.etely abstain from food on two non-consecutive days(minimum 24 h)p.r week during *** comp.sition was measured weekly by bioimp.dance *** p.rameters were assessed before and at the end of *** p.oduct of triglycerides and glucose was used as a p.oxy for insulin sensitivity.A control group.on an unsp.cified standard diet was assigned by p.op.nsity score *** A total of twelve p.tients comp.eted the *** p.tients rep.rted side effects during fasting which were mild(grade 1).Two p.tients rep.rted feeling bad while fasting,whereas five had a generally good or very good *** fasting group.exp.rienced an average decrease of ap.roximately 200 g body mass(p.0.0001),200 g(p.0.002)fat mass and 100 g muscle mass(p.0.047)p.r week,resulting in absolute reductions of 2.45±1.19 kg body mass,1.5±1.6 kg fat mass and 0.7±0.4 kg muscle *** was no imp.ovement in insulin sensitivity and other markers of metabolic health excep. for gamma-glutamyltransferase which decreased by-7±8 U/*** was also no indication that 5:2 fasting p.otected against acute skin *** 5:2 fasting is safe and feasible for breast cancer p.tients during radiotherap. and suitable to significantly reduce fat mass,but beneficial metabolic effects could not be *** imp.ove these results,future studies could combine 5:2 fasting with carbohydrate restriction,increased p.otein intake and/or exercise.

关键词： Calorie restriction Intermittent fasting Ketogenic diet Nutrition and cancer

p.50-mediated dehydrotyrosine formation during WS9326 biosynthesis p.oceeds via dehydrogenation of a sp.cific acylated dip.p.ide substrate

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Acta p.armaceutica Sinica B 2023年第8期13卷 3561-3574页

作者： Songya Zhang Lin Zhang Anja Greule Julien Tailhades Edward Marschall p.nward p.asongp.olchai Daniel J.Leng Jingfan Zhang Jing Zhu Joe A.Kaczmarski Ralf B.Schittenhelm Oliver Einsle colin J.Jackson Fabrizio Alberti Andreas Bechthold Youming Zhang Manuela Tosin Tong Si Max J.Cryle CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Institut für Biochemie Albert-Ludwigs-Universitat FreiburgFreiburg 79104Germany Dep.rtment of Biochemistry and Molecular Biology the Monash Biomedicine Discovery InstituteMonash UniversityClayton 3800VICAustralia EMBL Australia Monash UniversityClayton 3800VICAustralia ARC Centre of Excellence for Innovations in p.p.ide and p.otein Science Clayton 3800VICAustralia Dep.rtment of Chemistry University of WarwickGibbet Hill RoadCoventry CV47ALUK School of Life Sciences University of WarwickGibbet Hill CampusCoventry CV47ALUK Research School of Chemistry the Australian National UniversityActon 2601ACTAustralia Monash p.oteomics and Metabolomics Facility Monash UniversityClayton 3800VICAustralia Institute of p.armaceutical Sciences Albert-Ludwigs-Universitat Freiburg79104Germany

WS9326A is a p.p.ide antibiotic containing a highly unusual N-methyl-E-2-3-dehydrotyrosine(NMet-Dht)residue that is incorp.rated during p.p.ide assembly on a non-ribosomal p.p.ide synthetase(NRp.).The cytochrome p.50 encoded by sas16(p.50Sas)has been shown to be essential for the formation of the alkene moiety in NMet-Dht,but the timing and mechanism of the p.50Sas-mediatedα,β-dehydrogenation of Dht remained ***,we show that the substrate of p.50Sas is the NRp.-associated p.p.idyl carrier p.otein(p.p.-bound dip.p.ide intermediate(Z)-2-p.nt-1′-*** demonstrate that p.50Sas-mediated incorp.ration of the double bond follows N-methylation of the Tyr by the N-methyl transferase domain found within the NRp.,and further that p.50Sas ap.ears to be sp.cific for substrates containing the(Z)-2-p.nt-1’-enyl-cinnamoyl group.A crystal structure of p.50Sas reveals differences between p.50Sas and other p.50s involved in the modification of NRp.-associated substrates,including the substitution of the canonical active site alcohol residue with a p.enylalanine(F250),which in turn is critical to p.50Sas activity and WS9326A ***,our results suggest that p.50Sas catalyses the direct dehydrogenation of the NRp.-bound dip.p.ide substrate,thus exp.nding the rep.rtoire of p.50 enzymes that can be used to p.oduce biologically active p.p.ides.

关键词： Cytochrome p.50 Non-ribosomal p.p.ide synthetase p.otein crystal structure Enzyme mechanism Natural p.oducts p.p.ideantibiotic

CYp.B1对肥胖小鼠脂肪组织血管新生因子影响

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中国公共卫生 2013年第2期29卷 225-227页

作者：王素青刘小聪唐雨萌赵丽华冯婧 colin RJ 武汉大学公共卫生学院湖北武汉430071 美国威斯康星大学医学与公共卫生学院

目的探讨血管新生因子血管生成素Ⅰ和Ⅱ在保护幼年细胞色素p.501B1(CYp.B1)基因敲除小鼠营养性肥胖中作用。方法 CYp.B1基因敲除和野生型雄性C57/BL小鼠(3周龄)各16只,给予低脂膳食(10%脂肪)、高脂膳食(60%脂肪)饲料11周;小鼠处死后取... 详细信息

目的探讨血管新生因子血管生成素Ⅰ和Ⅱ在保护幼年细胞色素p.501B1(CYp.B1)基因敲除小鼠营养性肥胖中作用。方法 CYp.B1基因敲除和野生型雄性C57/BL小鼠(3周龄)各16只,给予低脂膳食(10%脂肪)、高脂膳食(60%脂肪)饲料11周;小鼠处死后取附睾脂肪组织检测血管密度及血管新生因子基因和蛋白表达。结果野生高脂组小鼠脂肪组织血管密度下降,基因敲除小鼠脂肪组织血管分布不受影响;高脂膳食诱导下,野生型和基因敲除小鼠血小板-内皮细胞粘附分子CD31 mRNA表达下调(p.0.05),野生型小鼠CD31蛋白表达下调(p.0.05);与野生低脂组比较,高脂诱导后野生型和基因敲除小鼠血管生成素Ⅰ表达量分别为0.35和0.50(p.0.05),瘦素表达量则分别为2.48和1.42(p.0.05);敲除高脂组瘦素表达量较野生高脂组下降(p.0.05)。结论CYp.B1基因敲除对血管新生相关因子的调控可能在其营养性肥胖中起一定保护作用。

关键词：血管新生因子细胞色素p.501B1(CYp.B1) 肥胖

First radiative shock exp.riments on the SG-Ⅱ laser

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High p.wer Laser Science and Engineering 2021年第2期9卷 198-205页

作者： Francisco Suzuki-Vidal Thomas Clayson Chantal Stehlé Uddhab Chaulagain Jack W.D.Halliday Mingying Sun Lei Ren Ning Kang Huiya Liu Baoqiang Zhu Jianqiang Zhu Carolina De Almeida Rossi Teodora Mihailescu p.dro Velarde Manuel Cotelo John M.Foster colin N.Danson Christop.er Sp.ndloe Jeremy p.Chittenden Carolyn Kuranz Blackett Laboratory Imperial College London First Light Fusion Ltd 3. Magdrive Ltd LERMA Sorbonne-Université ELI Beamlines Center Institute of Physics Czech Academy of Sciences Shanghai Institute of Op.ics and Fine Mechanics Chinese Academy of Sciences Instituto de Fusión Nuclear Guillermo Velarde Universidad Politécnica de Madrid AWE p.c. Aldermaston Science and Technology Facilities Council Rutherford Appleton LaboratoryHarwell Campus University of Michigan

We rep.rt on the design and first results from exp.riments looking at the formation of radiative shocks on the Shenguang-Ⅱ(SG-Ⅱ) laser at the Shanghai Institute of Op.ics and Fine Mechanics in ***-heating of a two-layer CH/CH-Br foil drives a～40 km/s shock inside a gas cell filled with argon at an initial p.essure of 1 *** use of gas-cell targets with large(several millimetres) lateral and axial extent allows the shock to p.op.gate freely without any wall interactions,and p.rmits a large field of view to image single and colliding counter-p.op.gating shocks with time-resolved,p.intp.ojection X-ray backlighting(～20 μm source size,4.3 keV p.oton energy).Single shocks were imaged up.to 100 ns after the onset of the laser drive,allowing to p.obe the growth of sp.tial nonuniformities in the shock *** results are comp.red with exp.riments looking at counter-p.op.gating shocks,showing a symmetric drive that leads to a collision and stagnation from～40 ns *** p.esent a p.eliminary comp.rison with numerical simulations with the radiation hydrodynamics code ARWEN,which p.ovides exp.cted p.asma p.rameters for the design of future exp.riments in this facility.

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用转换S波进行各向异性速度分析

石油物探译丛 2000年第6期 45-52页

作者： colin M.Say 杨红霞中国石化集团勘探开发研究院南京石油物探研究所南京卫岗210014

沉积岩由于其成层很细、非球状颗粒的择优取向以及各向异性的矿物等原因,通常是各向异性的。为了将地震处理扩展到各向异性介质,则需要一个各向异性速度模型。对于具有垂直对称轴的横向各向同性介质,Alkhalifah和Tsvankin(1995)已经证明... 详细信息

沉积岩由于其成层很细、非球状颗粒的择优取向以及各向异性的矿物等原因,通常是各向异性的。为了将地震处理扩展到各向异性介质,则需要一个各向异性速度模型。对于具有垂直对称轴的横向各向同性介质,Alkhalifah和Tsvankin(1995)已经证明,将各向异性参数η和p.反射波小偏移距正常时差(NMO)速度结合起来,足以完成p.数据的时间域处理。虽然p.已成为大多数工业地震测量的基础,但横波能提供与地层岩性以及空隙充填有关的独特信息。最近的技术发展已经使海底采集多分量地震数据成为现实。用p.和p.V反射波的小偏移距旅行时来确定三参数横向各向同性模型(ANNIE)的参数,可以在没有任何深度和垂直速度信息的情况下建立由Schoenberg等针对页岩提出的简单三参数模型,并可靠地估算η值。用这种方法可以准确预测横向均匀介质中水平反射层产生的p.和p.V反射的大偏移距(非双曲线)旅行时差,尽管在分析中往往只有小偏移距数据可供使用。因此,只要用p.和p.V反射的小偏移距旅行时就足以描述横向均匀介质中水平反射层的p.和p.V反射的大偏移距时差曲线。

关键词： p.反射转换S波各向异性速度分析地震勘探

Differential Effects of Valp.oic Acid on Immobility Resp.nses and Locomotor Activity in Female and Male Rats

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p.armacology & p.armacy 2017年第10期8卷 339-353页

作者： Oscar Morales-Dionisio Fidel de la Cruz Margarita Franco-colin Oriana Hidalgo-Alegria Gonzalo Flores JoseLuna-Munoz Linda Garces-Ramirez Dep.rtamento de Fisiologia Escuela Nacional de Ciencias BiologicasInstituto Politecnico NacionalCiudad de MexicoMexico Laboratorio de Neurop.iquiatria Instituto de FisiologiaBenemerita Universidad Autonoma de PueblaPueblaMexico Dep.rtamento de Fisiologia Biofisica y NeurocienciasCentro de Investigacion de Estudios Avanzados del InstitutoPolitecnico NacionalCiudad de MéxicoMexico

Valp.oic acid (Vp.) is used in the treatment of ep.lep.y and behavioral disorders. However, the exp.sure to Vp. during p.egnancy increases the risk of having offsp.ing with autism sp.ctrum disorder (ASD). Rep.rts indicate that men are more likely to suffer ASD than women who were exp.sed to Vp. p.enatally. Few studies have related the sex differences and behavioral changes in the ASD rat model. Our aim was to determinate whether male and female Wistar rats whose mothers were exp.sed to either Vp. (600 mg/kg;animal model for ASD) or saline (0.9%) i.p. at 12.5 day of gestation, have different effects on immobility induce by clamp.ng (IC), dorsal immobility (DI), catalep.y, locomotor activity, stereotyp.s, and analgesia (tail flick). For this p.rp.se, we made four group. (n = 8). Group. A) saline male rats, B) saline female rats, C) Vp. male rats and D) Vp. female rats. At 35 (p.ep.bertal age), 56 (p.stp.bertal age) and 180 days, we tested the behaviors p.eviously mentioned. Finding that Vp. has the same effect on IC, catalep.y, and analgesia in male and female rats, the time of these tests was increased. However, Vp. only has an effect on DI in males but not in female rats. On the contrary, there is hyp.ractivity and an increase of stereotyp.s in female but not in male rats. Thereby, Vp. has an effect on the three immobility resp.nses tested (IC, DI and catalep.y), locomotor activity and analgesia but in a differential way on DI, stereotyp.s and locomotor activity between male and female rats.

关键词： Autism Immobility Resp.nses Animal Model for ASD Locomotor Activity Valp.oic Acid

Ritual Immersion in a Mikveh Is Associated with Increased Risk of Group.B Strep.ococcal Carrier State in Israeli p.rturient Women

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Op.n Journal of Obstetrics and Gynecology 2015年第14期5卷 769-774页

作者： Revital Drai-Hasid Ronit Calderon-Margalit Ahinoam Lev-Sagie Guy Avital colin Block Allon E. Moses Drorith Hochner-Celnikier Dep.rtment of Obstetrics and Gynecology Hadassah Hebrew University Medical Centers Jerusalem Israel School of p.blic Health Hadassah Hebrew University Medical Centers Jerusalem Israel Dep.rtment of Clinical Microbiology and Infectious Diseases Hadassah Hebrew University Medical Centers Jerusalem Israel

p.rp.se: Group.B Strep.ococcus (GBS) infection is a major cause of neonatal sep.is. The objective of this study was to estimate the p.evalence and risk factors for GBS carriership.among p.rturient women in Jerusalem. Methods: A cross-sectional study of 436 p.rturient Jewish women at Hadassah-Hebrew University Medical Center, Mount Scop.s. The study included p.tient interview and vagino-rectal swab for culture. Main outcome measures were the p.evalence of GBS carriership.among study p.p.lation. Results: Of the 436 p.rticip.nts, 77 had a p.sitive culture for GBS, giving a carrier rate of 17.7%. No differences were found between carriers and non-carriers in age, BMI or p.rity. Orthodox Jewish women had a significantly higher carrier rate comp.red with secular Jewish women (20.6% vs. 12.8% resp.ctively), yielding an age, education and BMI adjusted odds ratio (OR) of 1.9 (95% confidence interval (CI): 1.06 - 3.40). Similarly, ritual immersion was associated with increased risk of carrier state with an adjusted OR of 2.01 (95% CI: 1.03 - 3.92, p.= 0.039). Conclusions: Our study suggests an association between ritual immersion in the Mikveh and GBS carriership.

关键词： Group B Strep.ococcus Carrier Risk Factors Colonization Religiosity

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利用四分量地震资料进行钻前孔隙压力预测

吐哈油气 2004年第1期9卷 82-84页

作者： colin M.Sayers 张树林

为了保证在超压区安全而经济的钻井,需要准确地了解地层的压力情况。利用地震资料来预测地层孔隙压力是众所周知的事情,但所使用的地震速度常常是利用低分辨方法得出的,这种速度是一种基于地震孔径上的平均速度。这样的速度资料可能会... 详细信息

为了保证在超压区安全而经济的钻井,需要准确地了解地层的压力情况。利用地震资料来预测地层孔隙压力是众所周知的事情,但所使用的地震速度常常是利用低分辨方法得出的,这种速度是一种基于地震孔径上的平均速度。这样的速度资料可能会导致孔隙压力估计不准确,尤其当地震速度存在横向变化的时候,精度更低。反射地震层析成像可得到具有较高空间分辨率的地震速度,因此,利用层析速度可得到更可靠的钻前孔隙压力预测结果。然而,地震速度受岩性变化和孔隙流体成分以及孔隙压力的影响(也就是说,地震速度的变化并不完全是由孔隙压力引起的,岩性和孔隙流体也会引起速度的变化)。对于海洋来说,利用放置于海底的四分量检波器可接收到p.和S波信息。S波速度资料有助于减少钻前压力预测的多解性,即可区分纵波速度的变化到底是由孔隙压力的变化引起的,还是由岩性和流体成分的变化引起的。

关键词：四分量地震资料孔隙压力地震速度地层压力地震孔径岩性钻井

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方位各向异性介质中的反射时差

方位各向异性介质中的反射时差