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Data-driven,client-centric applied behavior analysis treatment-dose optimization improves functional outcomes

世界儿科杂志:英文版 2023年第8期19卷 753-760页

作者： Andrey Ostrovsky Melissa Willa Ted Cho Maxwell Strandberg Sage Howard colin Davitian Social Innovation Ventures LewesDEUSA Kyo San FranciscoCAUSA UCSF Beniof Children’s Hospital San FranciscoCAUSA SKF group GöteborgSweden

Background With increasing numbers of individuals diagnosed with autism spectrum disorder(ASD)and with affirmation of applied behavior analysis(ABA)as an evidence-based standard of care for ASD,there has been a proliferation of agencies offering ABA services over the last several *** exists among ABA providers and health plans that reimburse those providers on the optimal number of hours of ABA services that should be *** study aims to understand whether children who receive more hours of ABA therapy achieve better outcomes and to evaluate the impact of the COVID-19-induced shift to telehealth clinical supervision on *** A retrospective cohort analysis was performed using data from the Vineland 3 Comprehensive Interview Form to assess function throughout ABA *** sample t tests,independent sample t tests,Cohen’s D,and Pearson correlations were used to determine relationships between Vineland scores and input variables including hours of service and modality of supervision(in-person ***).Results While statistically and clinically significant improvements in function were observed,children appear to have improved outcomes independent of the number of hours of service *** were also no significant associations between modality of supervision and Vineland standard *** These findings challenge prior research that demonstrated a linear dose–response *** tailoring treatment dosage to the individual client’s needs,providers may be able to better maximize functional progress of the client,to preserve family time,and to utilize health plan dollars more efficiently.

关键词： Autism spectrum disorder(ASD) Autistic disorder Autistic rehabilitation Autistic therapy Telemedicine

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Human Error and Customer Service Quality-Framework and Application

Human Error and Customer Service Quality-Framework and Appli...

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The 6th Pan-Pacific Conference on Occupational Ergonomics

作者： colin g.Drury State University of New York at Buffalo NY USA

Due to the growing service-based economy and global competition, service quality is receiving more and more attention from today’ s management. Customer services, which are the service operations involving interactions with customers, play a crucial role in the quality of service. Because of the interactive nature, customer services are best investigated through the human errors involved. In the present study, a framework is proposed for the human error analysis in customer services towards service quality improvement and ergonomics intervention in particular. This proposed framework in fact consists of two schemes for error classification: Service Stage

关键词： Human error Customer service Service quality

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Efficient and Stereoselective Synthesis of C-(β-2'-Deoxynucleosides)

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有机化学 2004年第Z1期24卷 27-28页

作者： WU,Qin-Pei REES,B.colin School of Life Science Beijing Institute of Technology Beijing 100081 King''s College London WC2R 2LS UK

　　The formation of triplex DNA is, in principle, an effective way of regulating the expression of selected genes.[1]Many cytosine mimics were investigated to form triplex DNA, e.g., 2-amino-(2'-deoxy-β-D-ribofuranosyl)pyridine (9)was proved to have some effectiveness in stabilizing triplex DNA under neutral conditions.[2] Stereoselective synthesis of 9 was achieved starting from 2-deoxyribose.……

关键词： triplex DNA

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Using Doubly-Labeled Water to Measure Energy Expenditure in an Important Small Ectotherm Drosophila melanogaster

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Journal of genetics and genomics 2014年第9期41卷 505-512页

作者： Matthew D.W.Piper colin Selman John R.Speakman Linda Partridge Institute of Healthy Ageing Department of GeneticsEvolution and EnvironmentUniversity College LondonGower StreetLondonWCIE 6BTUK Institute of Biodiversity Animal Health and Comparative Medicine University of Glasgow Institute of Biological and Environmental Sciences University of Aberdeen State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences

Energy expenditure is a key variable in the study of ageing, and the fruit fly Drosophila melanogaster is a model organism that has been used to make step changes in our understanding of the ageing process. Standard methods for measurement of energy expenditure involve placing individuals in metabolic chambers where their oxygen consumption and CO2 production can be quantified. These measurements require separating individuals from any social context, and may only poorly reflect the environment in which the animals normally live. The doubly-labeled water （DLW） method is an isotope-based technique for measuring energy expenditure which overcomes these problems. However, technical challenges mean that the smallest animals this method has been previously applied to weighed 50-200 mg. We overcame these technical challenges to measure energy demands in Drosophila weighing 0.78 mg. Mass-specific energy expenditure varied between 43 and 65 mW·g^-1. These estimates are considerably higher than estimates using indirect calorimetry of Drosophila in small metabolic chambers （around 18 mW·g^-1）. The methodology we have established extends downwards by three orders of magnitude the size of animals that can be measured using DLW. This approach may be of considerable value in future ageing research attempting to understand the genetic and genomic basis of ageing.

关键词： Doubly-labeled water Respiration rate Effect of mating status and sex Drosophila

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Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

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World Journal of gastroenterology 2016年第27期22卷 6192-6200页

作者： Natalia A Osna Wayne g Carter Murali ganesan Irina A Kirpich Craig J Mc Clain Dennis R Petersen colin T Shearn Maria L Tomasi Kusum K Kharbanda Research Service Veterans Affairs Nebraska-Western Iowa Health Care System Omaha NE 68105 United States Department of Internal Medicine 982000 Nebraska Medical Center Omaha NE 68198 United States School of Medicine University of Nottingham Royal Derby Hospital Centre Derby DE22 3DT United Kingdom Division of gastroenterology Hepatology and Nutrition Department of Medicine Department of Medicine and Pharmacology and Toxicology University of Louisville Louisville KY 40202 United States University of Colorado Denver School of Pharmacy Department of Pharmaceutical Sciences Aurora CO 80045 United States Division of gastroenterology Department of Medicine Davis research building suite 2096/2035 Cedars-Sinai Medical Center Los Angeles CA 90048 United States Department of Biochemistry and Molecular Biology 985870 Nebraska Medical Center Omaha NE 68198 United States

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European Society for the Biomedical Research on Alcoholism Meeting held September 12-15, 2015, in Valencia, Spain.

关键词： Alcohol Acetylation Liver Carbonylation methylation Dysfunction Methylation glycosylation Phosphorylation Ubiquitination Sumoylation Betaine Post-translational protein modification

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Smart Sediment Particle: A novel approach to investigating fluvial bed entrainment using instrumented sensors

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International Journal of Sediment Research 2023年第1期38卷 66-82页

作者： Yushu Xie Bruce W.Melville Asaad Y.Shamseldin colin N.Whittaker Yifan Yang Department of Civil and Environmental Engineering The University of Auckland School of Engineering The University of Waikato

The Smart Sediment Particle(SSP) instrumented with multiple sensors to obtain tri-axial linear accelerations is used for studying the mechanism of coarse grain entrainment. Three bed arrangements are tested to examine their influences on entrainment processes and the threshold force and impulse conditions. The SSP shows satisfactory precision to capture the imperceptible movement tendencies immediately(e.g., 0.15 s) after the dislodgement. The experimental results show that bed packing can significantly affect the particle’s entrainment threshold and the path of movement. Lateral movement is predominant for some cases because the entrainment path is based on the least work done by the flow,even if the direction is not aligned with the flow. The concept of effective protrusion height is proposed to quantify the effect of local bed arrangement on entrainment. The mean velocity field around the SSP is also measured together with the acceleration data. The mean threshold velocity and resultant impulse show consistent dependence on the bed arrangement. In general, the SSP shows a good prospect of being used to study small-scale entrainment mechanism.

关键词： Smart Sediment Particle Instrumented sensors Entrainment behaviours Tri-axial acceleration Hydrodynamic force impulse

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退耕还林还草政策的农户影响——以甘肃省华池县为例

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干旱区资源与环境 2011年第9期25卷 60-66页

作者：江丽杨丽雅张越安萍莉 colin g Brown 中国农业大学资源与环境学院北京100193 昆士兰大学

退耕还林还草工程是我国为改善西部地区恶化的生态环境、改善农民生活而采取的一项空前的重大举措。文中以华池县为例,采用实地调查和数据分析的方法,分析华池县主要的退耕还林还草政策及其实施情况。研究表明:退耕实施后农民的种地积... 详细信息

退耕还林还草工程是我国为改善西部地区恶化的生态环境、改善农民生活而采取的一项空前的重大举措。文中以华池县为例,采用实地调查和数据分析的方法,分析华池县主要的退耕还林还草政策及其实施情况。研究表明:退耕实施后农民的种地积极性提高了,收入有了显著的增加,同时带动了林业、草业的发展,促进了农村剩余劳动力向二、三产业转移,但同时退耕过程中仍存在一些问题,如退耕政策只注重补偿,忽视了提高农民的自我发展能力;剩余劳动力转移相对滞后,农业科技投入不足,并根据上述存在问题,提出了延长补助期限,促进后续产业发展、提高农民自我发展能力的建议,进一步完善退耕还林还草政策,促进农民增收,提高农民生活水平。

关键词：退耕还林还草政策农户华池县

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The effects of four transplantation methods on five coral species at the Sanya Bay

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Acta Oceanologica Sinica 2016年第10期35卷 88-95页

作者： ZHANg Yuyang HUANg Hui HUANg Jieying YOU Feng LIAN Jiansheng YANg Jianhui WEN colin K.C. Key Laboratory of Tropical Marine Bio-resources and Ecology guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China graduate University of Chinese Academy of Sciences Beijing 100049China Tropical Marine Biological Research Station in Hainan Chinese Academy of SciencesSanya 572000China Hainan Academy of Ocean and Fisheries Sciences Haikou 570100China

Coral transplantation is considered as one of the major tools to increase coral abundance for degraded coral *** investigate the effects of various methods and coral species in transplantation, coral fragments（n=902） of five coral species were transplanted by four methods at Luhuitou, the Sanya Bay, Hainan Province, China, where the reef has been over-exploited and is still threatened by human activities and natural disasters. Ten months after the transplant, the average survivorship of the transplanted corals was 45.5%. Methodologies had different effects on the transplanted corals, but none of them was efficacious for all coral species. Methodology could not change the decreasing trend for Montipora foliosa and Acropora hyacinthus, although it did slow down their decline. All transplants of A. hyacinthus and M. foliosa had high mortalities and significant decrease on survival area, while Porites andrewsi and galaxea fascicularis had lower mortalities and partial mortalities. Only one method had significant effect on increasing survival area of g. fascicularis, same as P. andrewsi. Out of the five transplanted coral species, Pocillopora damicornis was the only species that had living tissue area increase in all applied methods, while the others had decreased live tissue area in one or more methods. The results of this study suggested that performing coral transplantation in a highly threatened area was not efficient unless the threats were diminished or erased. Moreover, proper species selection for coral transplantation is crucial, especially in a disturbed environment. Methodology, although having limited effects on improving results of coral transplantation, cannot compensate the maladjustment of vulnerable species to the stresses on the Luhuitou Reef. Coral transplantation on Luhuitou Reef should not be performed unless the stresses are under controlled,and corals with good tolerance to the environment should be considered first.

关键词： coral reef rehabilitation methodology coral transplantation Luhuitou

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基于重、磁异常的西太平洋中段构造特征研究

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地球物理学报 2022年第5期65卷 1712-1731页

作者：朱莹洁王万银 J.Kim Welford colin g.Farquharson 杨永罗新刚王丁丁马涛马杰长安大学重磁方法技术研究所长安大学地质工程与测绘学院长安大学西部矿产资源与地质工程教育部重点实验室西安710054 海洋油气勘探国家工程研究中心北京100028 纽芬兰纪念大学地球科学系加拿大圣约翰斯A1B3X5 南方海洋科学与工程广东省实验室(广州) 广州511458 自然资源部海底矿产资源重点实验室广州海洋地质调查局广州510075

西太平洋中段包含发育众多独立海山、海山链及海岭的西太平洋海山省(WPSP)、马里亚纳海沟和马里亚纳岛弧,其形成与演化与构造运动密切相关.研究区金属矿产、尤其是WPSP区域的富钴结壳资源较丰富,具有重要的研究意义.本文采用重、磁异常... 详细信息

西太平洋中段包含发育众多独立海山、海山链及海岭的西太平洋海山省(WPSP)、马里亚纳海沟和马里亚纳岛弧,其形成与演化与构造运动密切相关.研究区金属矿产、尤其是WPSP区域的富钴结壳资源较丰富,具有重要的研究意义.本文采用重、磁异常数据研究了西太平洋中段的构造特征.其中,采用归一化总水平导数垂向导数(NVDR-THDR)方法技术划分区域内的断裂,并采用欧拉反褶积深度反演方法得到断裂的视深度;采用深度约束下的双界面模型快速反演方法得到研究区莫霍面的起伏形态;同样采用NVDR-THDR方法技术识别NE向和NW向磁条带;采用重磁对应分析方法圈定研究区的火成岩,包括独立海山、海山链、海岭、马里亚纳岛弧型火成岩及大洋盆地溢流型玄武岩省.通过对研究区断裂分布、莫霍面深度、磁条带分布及火成岩分布的研究,得到了西太平洋中段的构造单元分布特征.马里亚纳海沟东侧,即WPSP区域内识别的断裂走向主要为NW(WNW)向和NE(ENE)向,而西侧,即马里亚纳岛弧区域识别的断裂与马里亚纳岛弧近N-S向的走向特征一致.研究区的大洋盆地溢流型玄武岩省呈NW向条带状展布、NE向块状分布的特征,并与独立海山、海山链和海岭相间分布.综合对西太平洋中段构造特征的研究,认为断裂对研究区的构造演化起到了重要作用.莫霍面深度在一级深大断裂两侧普遍存在突变;一些磁条带被断裂错断;火成岩的形成与分布也受控于断裂:独立海山、海山链、海岭及马里亚纳岛弧型火成岩位于莫霍面凹陷区,大洋盆地溢流型玄武岩省位于莫霍面隆起区.综合以上研究,划分了西太平洋中段的构造单元.在WPSP的构造单元呈NW向条带状展布、NE向块状分布的特征,而马里亚纳弧沟体系的构造单元呈近N-S向带状展布的特征.

关键词：西太平洋海山省马里亚纳重、磁异常断裂莫霍面深度磁条带火成岩

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傅里叶变换红外光谱(FTIR)方法在南海定量矿物学研究中的应用:以MD01-2393孔为例

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地球科学（中国地质大学学报） 2005年第1期30卷 25-29页

作者：刘志飞 Christophe colin Alain Trentesaux 同济大学海洋地质教育部重点实验室 Laboratoire Orsayterre FRE 2566 BAT. 504 Université de Paris XI 91405 Orsay France PBDS Laboratoire UMR 8110 CNRS Université de Lille Ⅰ 59655 Villeneuve d'Ascq France

傅里叶变换红外光谱 (FTIR)方法以其测量多种矿物绝对含量的能力在古环境研究中有很大的优势 .运用FTIR方法分析了南海南部湄公河口MD0 1 - 2 393孔的矿物成分含量 ,对比运用X射线衍射 (XRD)的半定量分析方法 ,研究了青藏高原东部和湄... 详细信息

傅里叶变换红外光谱 (FTIR)方法以其测量多种矿物绝对含量的能力在古环境研究中有很大的优势 .运用FTIR方法分析了南海南部湄公河口MD0 1 - 2 393孔的矿物成分含量 ,对比运用X射线衍射 (XRD)的半定量分析方法 ,研究了青藏高原东部和湄公河盆地晚第四纪 1 90ka以来风化剥蚀演化历史 .结果显示 ,全岩高岭石 /石英和粘土粒级 ( <2 μm)高岭石 /蒙脱石比率可用作陆源区风化侵蚀的矿物学标志 .晚第四纪 190ka以来 ,青藏高原东部和湄公河盆地机械侵蚀作用在冰期比间冰期强 ,化学风化作用在间冰期比冰期强 ,揭示出亚洲季风气候驱动的风化剥蚀演化历史 .全新世期间 ,虽然全岩高岭石 /石英与粘土粒级 ( <2 μm)蒙脱石 /高岭石比率指示相同趋势的风化剥蚀作用 ,但全岩高岭石 /石英比率显示更强的机械侵蚀能力。

关键词：粘土矿物傅里叶变换红外光谱(FTIR) 晚第四纪湄公河南海

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