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基于重、磁异常的西太平洋中段构造特征研究

地球物理学报 2022年第5期65卷 1712-1731页

作者：朱莹洁王万银 J.Kim Welford colin g.farquharson 杨永罗新刚王丁丁马涛马杰长安大学重磁方法技术研究所长安大学地质工程与测绘学院长安大学西部矿产资源与地质工程教育部重点实验室西安710054 海洋油气勘探国家工程研究中心北京100028 纽芬兰纪念大学地球科学系加拿大圣约翰斯A1B3X5 南方海洋科学与工程广东省实验室(广州) 广州511458 自然资源部海底矿产资源重点实验室广州海洋地质调查局广州510075

西太平洋中段包含发育众多独立海山、海山链及海岭的西太平洋海山省(WPSP)、马里亚纳海沟和马里亚纳岛弧,其形成与演化与构造运动密切相关.研究区金属矿产、尤其是WPSP区域的富钴结壳资源较丰富,具有重要的研究意义.本文采用重、磁异常... 详细信息

西太平洋中段包含发育众多独立海山、海山链及海岭的西太平洋海山省(WPSP)、马里亚纳海沟和马里亚纳岛弧,其形成与演化与构造运动密切相关.研究区金属矿产、尤其是WPSP区域的富钴结壳资源较丰富,具有重要的研究意义.本文采用重、磁异常数据研究了西太平洋中段的构造特征.其中,采用归一化总水平导数垂向导数(NVDR-THDR)方法技术划分区域内的断裂,并采用欧拉反褶积深度反演方法得到断裂的视深度;采用深度约束下的双界面模型快速反演方法得到研究区莫霍面的起伏形态;同样采用NVDR-THDR方法技术识别NE向和NW向磁条带;采用重磁对应分析方法圈定研究区的火成岩,包括独立海山、海山链、海岭、马里亚纳岛弧型火成岩及大洋盆地溢流型玄武岩省.通过对研究区断裂分布、莫霍面深度、磁条带分布及火成岩分布的研究,得到了西太平洋中段的构造单元分布特征.马里亚纳海沟东侧,即WPSP区域内识别的断裂走向主要为NW(WNW)向和NE(ENE)向,而西侧,即马里亚纳岛弧区域识别的断裂与马里亚纳岛弧近N-S向的走向特征一致.研究区的大洋盆地溢流型玄武岩省呈NW向条带状展布、NE向块状分布的特征,并与独立海山、海山链和海岭相间分布.综合对西太平洋中段构造特征的研究,认为断裂对研究区的构造演化起到了重要作用.莫霍面深度在一级深大断裂两侧普遍存在突变;一些磁条带被断裂错断;火成岩的形成与分布也受控于断裂:独立海山、海山链、海岭及马里亚纳岛弧型火成岩位于莫霍面凹陷区,大洋盆地溢流型玄武岩省位于莫霍面隆起区.综合以上研究,划分了西太平洋中段的构造单元.在WPSP的构造单元呈NW向条带状展布、NE向块状分布的特征,而马里亚纳弧沟体系的构造单元呈近N-S向带状展布的特征.

关键词：西太平洋海山省马里亚纳重、磁异常断裂莫霍面深度磁条带火成岩

Crustal Electrical Structure and Deep Metallogenic Potential in Northern Wuyi Area(South China),based on Magnetotelluric Data

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Acta geologica Sinica(English Edition) 2022年第3期96卷 791-805页

作者： LUO Fan Lü Qingtian ZHANg Kun YAN Jiayong colin gfarquharson ZHANg Chong FU guangming School of geophysics and Measurement-control Technology' East China University of TechnologyNanchang 330013China Chinese Academy of geological Sciences Beijing 100037China China Deep Exploration Center China Geological Survey&Chinese Academy of Geological SciencesBeijing 100037China Department of Earth Sciences Memorial University of NewfoundlandSt.John'sNL A1B 3X5Canada

The northern Wuyi area,which is located in the northern Wuyi metallogenic belt,has superior mineralization *** Pingxiang-guangfeng-Jiangshan-Shaoxing fault(PSF)extends across the whole region regardless of whether or how the PSF relates to the near-surface *** carried out an MT survey in the region and obtained a reliable 2D model of the crustal electrical structure to a depth of 30 *** the resistivity model,we inferred that a continuous high conductivity belt that ranges from the shallow to deep crust is a part of the ***,we estimated the fluid content and pressure gradient to identify the deep sources of fluid as well as its pattern of motion ***,we proposed a model for the deep metallogenic migration processes that combines geological data,fluid content data,pressure gradient data,and the subsurface resistivity *** model analysis showed that the Jiangnan orogenic belt and the Cathaysia block formed the PSF during the process of *** deep fluid migrated upward through the PSF to the shallow ***,we believe that the PSF is an ore-forming fluid migration channel and that it laid the material basis for large-scale mineralization in the shallow crust.

关键词： magnetotellurics crustal electrical structure PSF deep metallogenic background model northern Wuyi area

2.5维起伏地表条件下频率域地空电磁正演模拟

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地球物理学报 2021年第1期64卷 327-342页

作者：张铭 colin g.farquharson 刘长胜吉林大学仪器科学与电气工程学院长春130061 吉林大学地球信息探测仪器教育部重点实验室长春130061 Department of Earth Sciences Memorial University of NewfoundlandSt.John′sCanada A1B3S7

频率域地空电磁探测方法是指在地面布设人工场源,在空中测量电磁场的一种高效的地球物理勘探技术.该方法具有大范围、高通过性、快速测量的优势,尤其适合崎岖山地、沙漠、沼泽、海陆交互带等复杂地貌区域的资源勘查.但是这些地区的地形... 详细信息

频率域地空电磁探测方法是指在地面布设人工场源,在空中测量电磁场的一种高效的地球物理勘探技术.该方法具有大范围、高通过性、快速测量的优势,尤其适合崎岖山地、沙漠、沼泽、海陆交互带等复杂地貌区域的资源勘查.但是这些地区的地形起伏通常较大,因此分析地形对地空电磁响应的影响具有重要意义.本文利用有限元法对频率域地空电磁响应进行了正演计算,分析了起伏地表条件下的频率域地空电磁响应特征.首先利用傅里叶变换将2.5维问题转化成二维问题,利用伽辽金加权余量法推导了相应的离散有限元方程组.采用任意四边形单元对区域进行不均匀网格剖分,源和异常体附近网格加密处理,保证计算精度,远离目标区域网格逐渐稀疏,模拟无穷远边界,降低对计算资源的要求.在单元内进行插值,将有限元方程组变换为线性方程组,采用总场算法,利用具有一定面积的伪δ函数表达源电流分布,源项近似为分布在以电偶极源为中心的25个节点上.通过求解线性方程组得到波数域电磁响应,再对波数域电磁场响应进行反傅里叶变换从而获得空间域2.5维频率域电磁场值.通过对比2.5维正演结果与均匀半空间解析解,验证了本文算法的精度,同时本文还对地空电磁场与地面电磁场的响应特性进行了对比.

关键词：地空电磁法 2.5维正演起伏地表总场算法

基于电场总场矢量有限元法的接地长导线源三维正演

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地球物理学报 2016年第4期59卷 1521-1534页

作者：李建慧 colin g.farquharson 胡祥云曾思红中国地质大学地球物理与空间信息学院地球内部多尺度成像湖北省重点实验室武汉430074 纽芬兰纪念大学地球科学系加拿大圣约翰斯中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221116

电磁场数值模拟的背景场/异常场算法是三维正演的有效策略之一,优点为采用解析法计算电磁场背景场代替场源项、克服了场源奇异性,缺点为不适用于发射源布置于起伏地表或背景模型复杂的情形.总场算法是直接对电磁场总场开展数值模拟,其... 详细信息

电磁场数值模拟的背景场/异常场算法是三维正演的有效策略之一,优点为采用解析法计算电磁场背景场代替场源项、克服了场源奇异性,缺点为不适用于发射源布置于起伏地表或背景模型复杂的情形.总场算法是直接对电磁场总场开展数值模拟,其难点是有效加载场源、保证近区与过渡区数值解精度.本文以水平电偶源形式分段加载接地长导线源,并以电场总场Helmholtz方程为矢量有限元法控制方程,实现了基于非结构化四面体网格剖分的接地长导线源频率域电磁法三维正演.通过与均匀全空间中水平电偶源产生的电场解析解对比,验证了本文算法的正确性,并分析了四面体外接圆半径与其最短棱边的最大比值和四面体二面角最小值对数值解精度的影响规律.通过与块状高导体地电模型的积分方程法、有限体积法和基于磁矢量势Helmholtz方程的有限元法数值解对比,进一步验证了本文算法正确性,同时说明了非结构化四面体网格能够更加精细地剖分电性异常体,利于获得精确数值解.

关键词：接地长导线源三维正演矢量有限元法电场总场非结构化网格

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基于重磁异常的西太平洋海山省构造特征研究

基于重磁异常的西太平洋海山省构造特征研究

Assessment of molecular markers and marker-assisted selection for drought tolerance in barley(Hordeum vulgare L.)

2022年中国地球科学联合学术年会

作者：朱莹洁王万银 J.Kim Welford colin g.farquharson 杨永罗新刚王丁丁

0引言西太平洋海山省(West Pacific Seamount Province, WPSP)位于西太平洋中段(图1),广泛发育独立海山、海山链和海岭,中间分布有东马里亚纳盆地和皮加费他盆地。WPSP的独立海山、海山链或海岭主要形成于白垩纪,由板内火山喷发而成,并... 详细信息

0引言西太平洋海山省(West Pacific Seamount Province, WPSP)位于西太平洋中段(图1),广泛发育独立海山、海山链和海岭,中间分布有东马里亚纳盆地和皮加费他盆地。WPSP的独立海山、海山链或海岭主要形成于白垩纪,由板内火山喷发而成,并随着太平洋板块向菲律宾板块俯冲,

关键词：重磁异常三维空间分布大洋盆地平顶海山太平洋海山构造特征三维物性反演磁性体磁力异常布格重力异常

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Journal of Integrative Agriculture 2024年第1期23卷 20-38页

作者： Akmaral Baidyussen gulmira Khassanova Maral Utebayev Satyvaldy Jatayev Rystay Kushanova Sholpan Khalbayeva Aigul Amangeldiyeva Raushan Yerzhebayeva KulpashBulatova Carly Schramm Peter Anderson colin L.D.Jenkins Kathleen LSoole Yuri Shavrukov Faculty of Agronomy S.Seifullin Kazakh AgroTechnical Research UniversityAstana 010000Kazakhstan A.I.Barayev Research and Production Centre of grain Farming Shortandy 021601Kazakhstan Kazakh Research Institute of Agriculture and Plant growing AlmalybakAlmaty District 040909Kazakhstan College of Science and Engineering Biological SciencesFlinders UniversityAdelaideSA 5042Australia

This review updates the present status of the field of molecular markers and marker-assisted selection(MAS),using the example of drought tolerance in *** accuracy of selected quantitative trait loci(QTLs),candidate genes and suggested markers was assessed in the barley genome *** common strategies are described for molecular marker development,candidate gene identification and verification,and their possible applications in MAS to improve the grain yield and yield components in barley under drought *** strategies are based on the following five principles:(1)Molecular markers are designated as genomic‘tags’,and their‘prediction’is strongly dependent on their distance from a candidate gene on genetic or physical maps;(2)plants react differently under favourable and stressful conditions or depending on their stage of development;(3)each candidate gene must be verified by confirming its expression in the relevant conditions,e.g.,drought;(4)the molecular marker identified must be validated for MAS for tolerance to drought stress and improved grain yield;and(5)the small number of molecular markers realized for MAS in breeding,from among the many studies targeting candidate genes,can be explained by the complex nature of drought stress,and multiple stress-responsive genes in each barley genotype that are expressed differentially depending on many other factors.

关键词： barley candidate genes drought tolerance gene verification via expression grain yield marker-assisted selection(MAS) molecular markers quantitative trait loci(QTLs) strategy for MAS

Comparative Study of Neurosurgical Complications of Thalassemia and Sickle Cell Disease

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Open Journal of Modern Neurosurgery 2024年第3期14卷 190-202页

作者： Léon Boukassa Didace Massamba Miabaou Hugues Brieux Ekouélé Mbaki Sinclair Brice Kinata Bambino Olivier Brice Ngackosso Rel Boukaka Kala gédéon colin Thouassa Ruth Ibara Wamé Department of Neurosurgery Brazzaville University Hospital Center Brazzaville Republic of the Congo Department of general Surgery Brazzaville University Hospital Center Brazzaville Republic of the Congo

Introduction: Sickle cell disease and thalassemia are the most frequent hemoglobinopathies. During their evolution, they present certain complications, among which are two neurosurgical emergencies, namely spontaneous cranial epidural hematoma and non traumatic radiculo-medullary compression, with some particularities for each. Method: In order to highlight these particularities, we compared the characteristics of these two complications, from a number of publications reported between 2000 and 2021. Results: Sickle cell disease was complicated by spontaneous cranial epidural hematoma. Forty-two cases were reported, the mean age was 14.7 years (2 - 21 years) and the sex ratio was 6.4. The clinical presentation combined, in a non-traumatic context, signs of intracranial hypertension with those of neurological focalization. Neuroimaging showed epidural-type collection, often frontal and parietal in location. The incriminating mechanisms were ischemia, hemorrhage and extra medullary hematopoiesis. The treatment was surgical. Non traumatic radiculo-medullary was the complication of thalassemia. Of the 77 cases reported, the mean age was 27.5 years (9 - 66 years) and the sex ratio was 4.1. The lesions were epidural with a clear thoracic predominance and resulted from extra marrow hematopoiesis. Treatment included: hypertransfusion, radiotherapy, hydroxyurea and surgery. Vital and functional prognosis were globally satisfactory when the management was rapid. Conclusion: Cranial and spinal epidural lesions, respective complications of sickle cell disease and thalassemia, result from similar mechanisms. Their prognosis depends on the rapidity of management. .

关键词： Hemoglobinopathy Sickle Cell Disease Thalassemia Spontaneous Epidural Hematoma Extra Marrow Hematopoiesis Slow Marrow Compression

CD8+T cell metabolic flexibility elicited by CD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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Cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： g.Aaron Holling colin A.Chavel Anand P.Sharda Mackenzie M.Lieberman Caitlin M.James Shivana M.Lightman Jason H.Tong guanxi Qiao Tiffany R.Emmons Thejaswini giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal Elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of Cancer genetics and genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of Colorado Boulder BoulderCO 80309USA Present address:Dana Farber Cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of Technology BostonMA 02139USA Present address:Melvin and Bren Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of CD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(CBC)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated CD8+T cells with flexibility of glucose ***2 upregulation driven by CD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the CD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of CD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of CD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in CD8+T cells.

关键词： Immunometabolism mRNA splicing CD8 T cells ARS2 PKM2

Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas goudin Ivan Nemazanyy gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent guibaud Paul Isenring guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous