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World Journal of Hepatology 2020年第12期12卷 1341-1348页

作者： Cory Higley Christine C Hsu coleman smith Sandeep Nadella Alexander T.Lalos Department of Medicine MedStar Georgetown University HospitalWashingtonDC 20007United States Transplant Institute MedStar Georgetown University HospitalWashingtonDC 20007United States Department of Gastroenterology Medstar Georgetown University HospitalWashingtonDC 20007United States

BACKGROUND Direct-acting antiviral(DAA)therapy regimens are highly effective at eliminating hepatitis C virus(HCV)infection but rates of sustained virologic response(SVR)are lower in patients with decompensated cirrhosis or hepatocellular *** many of these patients will be referred for liver transplant,they will require retreatment after ***/velpatasvir/voxilaprevir(SOF/VEL/VOX)is recommended by guidelines as the preferred regimen to treat HCV in DAA-experienced patients following liver transplant however there is limited *** SUMMARY We present the cases of six liver transplant recipients who had previous treatment failure with sofosbuvir-based DAA therapy prior to transplantation and who then received SOF/VEL/VOX after *** This case series demonstrate the real-world efficacy and safety of SOF/VEL/VOX in the post liver transplant *** was successful with all patients achieving SVR,it was well tolerated,and there were minimal drug-drug interactions with their immunosuppressants.

关键词： Sofosbuvir/velpatasvir/voxilaprevir Hepatitis C Liver transplant Directacting antiviral Drug-drug interactions Case report

Screening Helicobacter pylori genes induced during infection of mouse stomachs

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世界胃肠病学杂志：英文版 2012年第32期18卷 4323-4334页

作者： Aparna Singh Nathaniel Hodgson Ming Yan Jungsoo Joo Lei Gu Hong Sang Emmalena Gregory-Bryson William G Wood Yisheng Ni Kimberly smith Sharon H Jackson William G coleman Laboratory of Biochemistry and Genetics National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD 20892 United States Laboratory of Host Defenses National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD 20892 United States

AIM:To investigate the effect of in vivo environment on gene expression in Helicobacter pylori(***) as it relates to its survival in the ***:In vivo expression technology(IVET) systems are used to identify microbial virulence *** modified the IVET-transcriptional fusion vector,pIVET8,which uses antibiotic resistance as the basis for selection of candidate genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 and *** novel IVET systems were developed by the fusion of random Sau3A DNA fragments of *** and a tandem-reporter system of chloramphenicol acetyltransferase and ***,each vector contains a kanamycin resistance *** used a mouse macrophage cell line,RAW 264.7 and mice,as selective media to identify specific genes that *** expresses in *** expression studies were conducted by infecting RAW 264.7 cells with *** was followed by real time polymerase chain reaction(PCR) analysis to determine the relative expression levels of in vivo induced ***:In this study,we have identified 31 in vivo induced(ivi) genes in the initial *** 31 genes belong to several functional gene families,including several well-known virulence factors that are expressed by the bacterium in infected mouse *** factors,vacA and cagA,were found in this screen and are known to play important roles in *** infection,colonization and *** detection validates the efficacy of these screening *** of the identified ivi genes have already been implicated to play an important role in the pathogenesis of *** and other bacterial pathogens such as Escherichia coli and Vibrio *** profiles of allivi genes were confirmed by real time PCR analysis of *** RNA isolated from *** infected RAW 264.7 *** compared the expression profile of *** and RAW 264.7 coculture with that of *** *** ge

关键词：幽门螺旋杆菌基因表达感染过程诱导基因胃炎小鼠筛选卡那霉素抗性基因

Predicting outcome after early brain insult

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中华物理医学与康复杂志 2014年第5期36卷 385-385页

作者： Anderson VA Spencer-smith MM coleman L

BACKGROUND AND OBJECTIVE Recent advances in neuroscience demonstrate that brain plasticity can facilitate changes in the brain in response to environment and *** study was designed to further understand the impact of age at the time of brain insult,as well as the influence of insult and environmental factors on cognitive and behavioral outcomes.

关键词：脑损伤预测预后早期环境因素神经科学可塑性大脑

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关于军用计算机系列体系结构的选择

系统工程与电子技术 1979年第1期 34-41页

作者： W.E.Burr ,A.H.coleman ,W.R.smith ,王公昊

本文综述了为美国陆军和海军系统采用新的军用计算机系列(MCF)挑选一个计算机系列体系结构的选择过程。陆、海两军联合评选委员会研究了许多体系结构的适用性,在对三种“最后决赛对象”的体系结构作了透彻的评价之后,选出了其中一种,PDP... 详细信息

本文综述了为美国陆军和海军系统采用新的军用计算机系列(MCF)挑选一个计算机系列体系结构的选择过程。陆、海两军联合评选委员会研究了许多体系结构的适用性,在对三种“最后决赛对象”的体系结构作了透彻的评价之后,选出了其中一种,PDP-11,作为MCF。

关键词： MCF CFA 对象评选委员会检验程序计算机系列军用计算机军事领域用计算机 PDP

比较计算机系列体系结构用的寿命周期成本模型

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系统工程与电子技术 1979年第3期 28-43页

作者： John J. Cornyn ,William R. smith ,Aaron H. coleman ,William R. Svirsky ,蔡文廷

本文描述军用计算机系统寿命周期成本的计算方法,计算机系统作为三种竞争军用计算机系列体系结构(IBM S/370,DEC PDP-11,Interdata 8/32)的函数;介绍此方法用于两种不同的军用计算机资源要求的模型(名曰“自顶向下”和“自底向上”)所... 详细信息

本文描述军用计算机系统寿命周期成本的计算方法,计算机系统作为三种竞争军用计算机系列体系结构(IBM S/370,DEC PDP-11,Interdata 8/32)的函数;介绍此方法用于两种不同的军用计算机资源要求的模型(名曰“自顶向下”和“自底向上”)所得的结果。体系结构的比较这样进行:设计,计算,并使硬件与软件成本的估算跟依赖于体系结构的因素相结合以求得寿命周期(研制周期加维护周期)成本与成本比。结果表明,对于这两种模型,三种体系结构的寿命周期成本大致可相比较。然而,如果忽略假设及输入数据的不定性,那末对于自底向上模型来说,DEC PDP-11多数情况下优于IBM S/370和Interdata 8/32。另一方面,对于自顶向下模型,当软件与硬件之成本比大于1时,S/370为优;此比值小于1/4时,Interdata 8/32稍佳;比值大于1/4而小于1时,PDP-11最好。

关键词：自顶向下软件成本估算估计计算机系列寿命周期成本

RACIAL DIFFERENCES OF OPTIC DISC TOPOGRAPHY IN OCULAR HYPERTEN- SIVE EYES: RESULTS FROM THE CON- FOCAL SCANNING LASER OPHTHAL- MOSCOPY ANCILLARY STUDY TO THE OCULAR HYPERTENSION TREATMENT STUDY

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国际眼科杂志 2003年第1期3卷 92-92页

作者： L.M.Zangwill R.N.Weinreb C.C.Berry A.R.smith K.A.Dirkes A.L.coleman J.R.Piltz-Sevmour J.L.Liebmann G.A.Cioffi G.Trick J.D.Brandt M.O.Gordon M.A.Kass University of California at San Diego CAUniversity of California at San Diego CAUniversity of California at San Diego CAUniversity of California at San Diego CAUniversity of California at San Diego CAUniversity of California at Los Angeles CAUniversity of Pennsyl-vania PANew York Eye and Ear Infirmary NY.Devers Eye Institute ORHenry Ford Medical Center MIUniversity of California St Davis CAWashington University School of Medicine MI USAWashington University School of Medicine MI USA

Purpose: To examine racial differences in optic disc topography among ocular hypertensive participants in the Ocular Hypertension Treatment Study (OHTS). Methods: 436 participants

关键词：高眼压视神经盘地形图人种差异共聚焦扫描激光眼科显微镜治疗

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视盘地形图的种族差异：由共焦激光扫描检眼镜对高眼压治疗研究的补充研究得到的基线结果

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美国医学会眼科杂志（中文版） 2004年第4期16卷 242-242页

作者： LindaM.Zangwill RobertN.Weinreb CharlesC.Berry AmandaR.smith KeriA.Dirkes AnneL.coleman JodyR.Piltz-Seymour JeffreyM.Liebmann GeorgeA.Cioffi GaryTrick JamesD.Brandt MaeO.Gordon MichaelA.Kass 肖真

目的：在高眼压治疗研究中检测高眼压受检者视盘地形图的种族差异。方法：7个高眼压治疗研究中心的439名受检者纳入了这项研究，通过三维定量共焦激光扫描检眼镜获取这些人的基线图，所使用的仪器是Heidelberg视网膜断层摄影(Heidelberg... 详细信息

目的：在高眼压治疗研究中检测高眼压受检者视盘地形图的种族差异。方法：7个高眼压治疗研究中心的439名受检者纳入了这项研究，通过三维定量共焦激光扫描检眼镜获取这些人的基线图，所使用的仪器是Heidelberg视网膜断层摄影(Heidelberg Retina Tomograph，Heidelberg Engineering，Dossenheim，Germany)。首先在所有的分析中得到10°或者15°视野的平均局部地形图。海德堡视网膜断层扫描视盘参数的种族差异通过一个混合效应线性模型来评估，这个线性模型用来控制混淆因素并且在双眼分析中使用。

关键词：治疗高眼压视盘参数种族差异眼镜受检者视网膜共焦断层扫描双眼