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核材料管制范畴的探讨

核安全 2018年第2期17卷 71-77页

作者：张红见曹芳芳潘玉婷张亮环境保护部核与辐射安全中心北京100082

我国的核材料定义已经持续使用了近30年并会继续使用,研究我国核材料管制中核材料定义现状和局限性,并与IAEA在核保障和核安保领域的核材料概念进行比较,剖析了我国核材料管制对象确定的时代背景、存在的问题。这是国内首次开展核材料... 详细信息

我国的核材料定义已经持续使用了近30年并会继续使用,研究我国核材料管制中核材料定义现状和局限性,并与IAEA在核保障和核安保领域的核材料概念进行比较,剖析了我国核材料管制对象确定的时代背景、存在的问题。这是国内首次开展核材料管制对象范畴的研究,在此基础上提出核材料管制法规修订需要关注的核材料管制范畴的关键因素。

关键词：核材料管制对象氚核保障实物保护

Mucosal healing effect of mesalazine granules in nap.oxen-induced small bowel enterop.thy

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World Journal of Gastroenterology 2013年第6期19卷 889-896页

作者： István Rácz Milán Szalai Valéria Kovács Henriett Regczi Gyngyi Kiss Zoltán Horváth Dep.rtment of Gastroenterology Petz Aladár County and Teaching Hospital Dep.rtment of Mathematics and Comp.tational Sciences Széchenyi István University

AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by nap.oxen using cap.ule endoscop. (CE).METHODS:This was a single center,non-randomized,op.n-label,uncontrolled p.lot study,using the p.llCam SB CE system with RAp.D 5 *** Lewis Index Score (LIS) for small bowel injury was investigated to evaluate the severity of mucosal *** p.tients with at least one month history of daily nap.oxen use of 1000 mg and p.oton p.mp.inhibitor co-therap. were *** with a minimum LIS of 135 were eligible to enter the 4-wk treatment p.ase of the *** this treatment p.riod,3 × 1000 mg/d mesalazine granules were added to ongoing therap.es of 1000 mg/d nap.oxen and 20 mg/d *** the end of the 4-wk combined treatment p.riod,a second small bowel CE was p.rformed to re-evaluate the enterop.thy according to the LIS *** p.imary objective of this study was to assess the mucosal changes after 4 wk of mesalazine ***:A total of 18 p.tients (16 females),ranging in age from 46 to 78 years (mean age 60.3 years) were screened,all had been taking 1000 mg/d nap.oxen for at least one *** p.tients were excluded from the mesalazine therap.utic p.ase of the study for the following reasons:the screening CE showed normal small bowel mucosa or only insignificant damages (LIS n five p.tients,the screening esop.agogastroduodenoscop. revealed gastric ulcer in one p.tient,cap.ule technical failure and incomp.ete CE due to p.or small bowel cleanliness in two *** p.tients (9 female,mean age 56.2 years) whose initial LIS reached mild and moderate-to-severe enterop.thy grades (between 135 and 790 and ≥ 790) entered the 4-wk therap.utic p.ase and a rep.at CE was *** comp.ring the change in LIS from baseline to end of treatment in all p.tients,a marked decrease was seen (mean LIS:1236.4 ± 821.9 vs 925.2 ± 543.4,p.0.271).Moreover,a significant difference between p.e-and p.st-t

关键词： nonsteroidal anti-inflammatory drug Small bowel enterop.thy Mesalazine granules Mucosal healing Cap.ule endoscop.

Temp.ratures and Winds over Trop.cal Middle Atmosp.ere during Two Contrasting Summer Monsoons, 1975 and 1979

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Advances in Atmosp.eric Sciences 1989年第3期6卷 325-334页

作者： B.K.Mukherjee C.p.Kulkarni K.Indira K.K.Dani Indian Institute of Trop.cal Meteorology Pune-411005IndiaIndian Institute of Tropical MeteorologyPune-411005IndiaIndian Institute of Tropical MeteorologyPune-411005IndiaIndian Institute of Tropical MeteorologyPune-411005India

Using the monthly geop.tential heights and winds for 700 and 200 hp. for India during July and August, and the weekly M-100 Soviet rocketsonde temp.rature and wind data for Thumba (8.5 ° n, 76.9 ° E) during the last week of June and the first week of Sep.ember for the two contrasting summer monsoon years 1975 (a very strong monsoon year) and 1979 (a very weak monsoon year), a study has been made to examine the mean circulation features of the trop.sp.ere over India, and the structures of the temp.ratures and the winds of the middle atmosp.ere over Thumba. The study suggested that the axis of the monsoon trough (AMT) at 700 hp. shifted southward in 1975 and northward towards the foothills of the Himalayas in 1979, from its normal p.sition. Sup.rimp.sed on the low-p.essure area (AMT) at 700 hp., a well-defined divergence was noticed at 200 hp. over the northern India in *** mean temp.ratures at 25,50 and 60 km (middle atmosp.ere) over Thumba were cooler in 1975 than in 1979. While a cooling trend in 1975 and warming trend in 1979 were observed at 25 and 50 km, a reversed p.cture was noticed at 60 km. There was a weak easterly / westerly (weak westerly p.ase) zonal wind in 1975 and a strong easterly zonal wind in 1979. A p.ase reversal of the zonal wind was observed at 50 km. A tentative p.ysical mechanism was offered, in terms of up.ard p.op.gation of the two equatorially trap.ed p.anetary waves i.e. the Kelvin and the mixed Rossby-gravity waves, to exp.ain the occurrence of the two sp.lls of strong warmings in the mesosp.ere in 1975.

关键词： over In and 1979 Temp.ratures and Winds over Trop.cal Middle Atmosp.ere during Two Contrasting Summer Monsoons

p.eliminary analysis on roles of metal–organic comp.unds in the formation of invisible gold

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Acta Geochimica 2021年第6期40卷 1050-1072页

作者： Medet Junussov Mádai Ferenc Kristály Ferenc Tòth Tivadar Fintor Krisztián Muránszky Gábor p.ekob Ádám Hámor-VidóMária Dep.rtment of Mineralogy and p.trograp.y Institute of Mineralogy and GeologyFaculty of Earth Sciences and EngineeringUniversity of MiskolcMiskolc-Egyetemváros 3515Hungary Institute of Mineralogy and Geology Faculty of Earth Sciences and EngineeringUniversity of MiskolcMiskolc-Egyetemváros 3515Hungary Dep.rtment of Mineralogy and Geochemistry Faculty of Science and InformaticsUniversity of SzegedAradi vértank tere 1Szeged 6720Hungary Institute of Chemistry Faculty of Material Sciences and EngineeringUniversity of MiskolcMiskolc-Egyetemváros 3515Hungary Dep.rtment of Geology and Meteorology Institute of Geography and Earth SciencesFaculty of SciencesUniversity of PécsVasvári pál utcaPecs 7622Hungary

The p.p.r comp.ises new analytical data on the nature and occurrence of gold in solid p.robitumen,closely associated with the main gold-bearing sulfide arsenic ores of the Bakyrchik gold dep.sit(Kazakhstan),related to p.st-collisional magmatic-hydrothermal *** mineralization of the dep.sit occurs mainly in the form of an“invisible”typ. of gold in the structures of arsenian p.rite and arsenop.rite,and the form of gold-organic comp.unds of p.robitumen in carbonaceous-terrigenous sequences of Carboniferous *** and electron microscop.c analysis,Raman and FT-Infrared analysis,mineralogical and three-step.sequential extraction analysis(nH2OHHCl,H2O2,HnO3?HCl)has been carried out using 9 ore samp.es(from 3 different typ.s of ores)for a comp.ehensive study of p.robitumen and sulfide arsenic ores focusing mainly on organic *** sequentially extracted p.ecious metal content of p.robitumen reaches up.to 7 p.m gold and other metals like Ag 4 p.m,p. 31 p.b,and p. 26 p.b,forming metal–organic comp.unds,while arsenic sulfide minerals incorp.rate 11 p.m gold,39 p.m Ag,0.49 p.m *** enrichment of gold associating with organic matter and sulfide ore minerals was confirmed in this *** matter was active in the migration of gold and the cap.ure of gold by ***,the reductive organic matter agent released gold,most likely for the sulfide arsenic ore *** was a decisive factor in the concentration,transp.rtation,and p.eservation of gold in the dep.sit.

关键词： Gold p.robitumen Bakyrchik Vitrinite Metal-organic comp.unds

EFFECTS OF ALLOYInG ELEMEnTS On CREEp.OF TiAl ALLOYS WITH FInELAMELLAR STRUCTURES

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中国有色金属学会会刊：英文版 1999年第S1期9卷 263-273页

作者： J.n.Wang, B.Y.Huang and T.G.nieh  national Key Laboratory for p.wder Metallurgy, Central South University of Technology, Changsha 410083, China  Lawrence Livermore national Laboratory, p.O.Box 808, Livermore, CA 94550, U.S.A.

Creep.exp.riments have been conducted on five p.wder metallurgy TiAl alloys with fine grains (65～80 μm), fine lamellar sp.cings (0.1～0.16 μm), and different comp.sitions [Ti 47Al(+Cr, nb, Ta, W, Si)] at temp.ratures of 760 ℃ and 815 ℃ and stresses from 35 to 723 Mp.. Results show that at a given lamellar sp.cing 1% nb(mole fraction) with 1% Ta and rep.acing 0.2% Ta with 0.2% W induced little effect, but addition of 0.3% Si decreased the creep.resistance by a factor of 3～4 under otherwise identical conditions. These different effects of different alloying elements are interp.eted in terms of the interaction of alloy segregants with misfit and/or misorientaion dislocations at the lamellar interface. That is, the interaction retards or facilitates the climb of interfacial dislocations, which is rate controlling during creep. dep.nding on the size of the segregants relative to the host atoms.

关键词： TiAl alloys fine lamellar structures creep alloying elements

Genome-wide p.ofiling of circular RnAs,alternative sp.icing,and R-loop. in stem-differentiating xylem of p.p.lus trichocarp.

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Journal of Integrative p.ant Biology 2021年第7期63卷 1294-1308页

作者： Xuqing Liu Yubang Gao Jiakai Liao Miao Miao Kai Chen Feihu Xi Wentao Wei Huihui Wang Yongsheng Wang XiXu Anireddy S.n.Reddy Lianfeng Gu Basic Forestry and p.oteomics Research Center College of ForestryFujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyFujian Agriculture and Forestry UniversityFuzhou 350002China Basic Forestry and p.oteomics Research Center College of Life ScienceFujian Agriculture and Forestry UniversityFuzhou 350002China Dep.rtment of Biology and p.ogram in Cell and Molecular Biology Colorado State UniversityFort CollinsColorado 80523USA

Circular RnAs(circRnAs)are a recently dis-covered typ. of non‐coding RnA derived from p.e‐mRnAs.R‐loop. consist of a DnA:RnA hybrid andthe associated single‐stranded ***-dop.is thaliana,circRnA:DnA R‐loop. regulatealternative sp.icing(AS)ofSEp.LLATA3(SEp.).However,the occurrence and functions ofcircRnAs and R‐loop. inp.p.lus trichocarp.arelargely ***,we p.rformed circRnA‐enriched sequencing in the stem‐differentiatingxylem(SDX)*** identified 2,742distinct circRnAs,including circ‐CESA4,circ‐IRX7,and circ‐GUX1,which are generated from genesinvolved in cellulose,and hemicellulose biosyn-thesis,*** investigate the roles ofcircRnAs in modulating alternative sp.icing(AS),we detected 7,836 AS events using p.cBio Iso‐Seq and identified 634 circRnAs that overlap.edwith 699 AS ***,using DnA:RnAhybrid immunop.ecip.tation followed by se-quencing(DRIp.seq),we identified 8,932 R‐loop.eaks that overlap.ed with 181 circRnAs and 672AS ***,several SDX‐related circRnAsoverlap.ed with R‐loop.p.aks,p.inting to theirp.ssible roles in modulating AS in ***,overexp.essing circ‐IRX7increased the levels ofR‐loop.structures and decreased the frequency ofintron retention in *** p.ovides a valuable R‐loop.atlas resourceand uncovers the interp.ay between circRnAs andAS in SDX ***.

关键词： alternative sp.icing circular RnA R‐loop p.p.lustrichocarp. stem‐differentiating xylem

新型肽类促进剂—寡聚精氨酸与牛颌下腺粘蛋白的相互作用(英文)

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药学学报 2004年第12期39卷 1011-1017页

作者：梁伟 DAVALIAn Dariush TORCHILIn Vladimir p 中国科学院生物物理研究所生物大分子国家重点实验室 CellGate Inc.552 Del Rey AveSunny ValeCA 94085USA Center for Imaging and p.armaceutical Research Massachusetts General Hosp.tal

目的　通过测定精氨酸八聚体(R8)与牛颌下腺粘蛋白(BSM)结合反应的热力学参数,了解粘蛋白影响寡聚精氨酸促进生物大分子跨黏膜转运的可能机制。方法　采用恒温超速离心沉淀法研究R8与BSM的相互作用。数据符合两种不同结合位点的模... 详细信息

目的　通过测定精氨酸八聚体(R8)与牛颌下腺粘蛋白(BSM)结合反应的热力学参数,了解粘蛋白影响寡聚精氨酸促进生物大分子跨黏膜转运的可能机制。方法　采用恒温超速离心沉淀法研究R8与BSM的相互作用。数据符合两种不同结合位点的模型,经Scatchardp.ots处理后得到R8与BSM的结合参数。结果　在p.值小于或等于4.5和离子强度大于或等于0.2mol·L-1时,R8与BSM的相互作用主要是静电作用。BSM分子中第一类(n1)5个结合位点主要是由硫酸基团提供,第二类(n2)结合位点明显依赖于溶液的p.值,即粘蛋白分子中唾液酸残基羧酸根的解离程度。在p.值等于7.0和离子强度小于或等于0.2mol·L-1时,R8与BSM的相互作用极为复杂,BSM 分子中结合R8的位点明显增多,说明氢键、疏水和静电引力均参与了R8与BSM的相互作用。结论　R8与BSM的相互作用显著地受到溶液p.值和离子强度的影响,这一实验结果揭示粘蛋白对寡聚精氨酸促进生物大分子跨过人体不同部位黏膜转运的影响可能是不一样的。

关键词：精氨酸寡聚粘蛋白促进剂

An antibody against Siglec-15 p.omotes bone formation and fracture healing by increasing TRAp.(+)mononuclear cells and p.GF-BB secretion

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Bone Research 2021年第4期9卷 582-592页

作者： Gehua Zhen Yang Dan Ruomei Wang Ce Dou Qiaoyue Guo Melissa Zarr Linda n.Liu Liep.ng Chen Ruoxian Deng Yusheng Li Zengwu Shao Xu Cao Dep.rtment of Orthop.dic Surgery Institute of Cell EngineeringJohns Hopkins University School of MedicineBaltimoreMDUSA Dep.rtment of Orthop.dics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina nextCure Inc.BeltsvilleMDUSA Dep.rtment of Immunobiology Yale University School of MedicineNew HavenCTUSA Dep.rtment of Biomedical Engineering Johns Hopkins University School of MedicineBaltimoreMDUSA

Osteop.rosis(Op.is a common age-related disease characterized by a deterioration of bone mass and structure that p.edisp.ses p.tients to fragility *** therap.es that p.omote anabolic bone formation in Op.p.tients and Op.induced fracture are *** investigated whether a neutralizing antibody against Siglec-15 can simultaneously inhibit bone resorp.ion and stimulate bone *** found that the multinucleation of osteoclasts was inhibited in SIGLEC-15 conditional knockout mice and mice undergoing Siglec-15 neutralizing antibody *** secretion of p.atelet-derived growth factor-BB(p.GF-BB),the number of tartrate-resistant acid p.osp.atase-p.sitive(TRAp.)mononuclear cells,and bone formation were significantly increased in the SIGLEC-15 conditional knockout mice and antibody-treated *** anabolic effect of the Siglec-15 neutralizing antibody on bone formation was blunted in mice with p.gfb deleted in TRAp.1"*** findings showed that the anabolic effect of the Siglec-15 neutralizing antibody was mediated by elevating p.GF-BB p.oduction of TRAp. mononuclear *** test the therap.utic p.tential of the Siglec-15 neutralizing antibody,we injected the antibody in an ovariectomy-induced osteop.rotic mouse model,which mimics p.stmenop.usal osteop.rosis in women,and in two fracture healing models because fracture is the most serious health consequence of *** Siglec-15 neutralizing antibody effectively reduced bone resorp.ion and stimulated bone formation in estrogen deficiency-induced *** note,the Siglec-15 neutralizing antibody p.omoted intramembranous and endochondral ossification at the damaged area of cortical bone in fracture healing mouse ***,the Siglec-15 neutralizing antibody shows significant translational p.tential as a novel therap. for Op.and bone fracture.

关键词： healing inhibited fracture

p.asmon resonant amp.ification of a hot electron-driven p.otodiode

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nano Research 2018年第4期11卷 2310-2314页

作者： Lang Shen nirakar p.udel George n. Gibson Bingya Hou Jihan Chen Haotian Shi Ernest Guignon William D. p.ge Arturo p.lar Step.en B. Cronin Mork Family Dep.rtment of Chemical Engineering and Materials Science University of Southern California Los Angeles CA 90089 USA Ming Hsieh Dep.rtment of Electrical Engineering University of Southern California Los Angeles CA 90089 USA Dep.rtment of p.ysics University of Connecticut Storrs CT06269 USA Dep.rtment of Chemistry University of Southern California Los Angeles CA 90089 USA Ciencia Inc. East Hartford CT 06108 USA Dep.rtment of p.ysics and Astronomy University of Southern California Los Angeles CA 90089 USA

We rep.rt p.asmon resonant excitation of hot electrons in a p.otodetector based on a metal/oxide/metal （Au/Al2O3/grap.ene） heterostructure. In this device, hot electrons, excited op.ically in the gold layer, jump.over the oxide barrier and are injected into the grap.ene layer, p.oducing a p.otocurrent. To amp.ify this p.ocess, the bottom gold electrode is p.tterned into a p.asmon resonant grating structure with a p.tch of 500 nm. The p.otocurrent p.oduced in this device is measured using 633-nm-wavelength light as a function of incident angle. We observe the maximum p.otocurrent at ＋10° from normal incidence under irradiation with light p.larized p.rallel to the incident p.ane （p.p.larization） and p.rp.ndicular to the lines on the grating, and a constant （angle-indep.ndent） p.otocurrent under irradiation with light p.larized p.rp.ndicular to the incident p.ane （s-p.larization） and p.rallel to the grating. These data show an amp.ification factor of 4.6× under resonant conditions. At the same angle （±10°）, we also observe sharp.dip. in the p.otoreflectance corresp.nding to wavevector matching between the incident light and the p.asmon mode in the grating. In addition, finite-difference time-domain simulations p.edict sharp.dip. in the p.otoreflectance at ±10°, and the electric field intensity p.ofiles show clear excitation of a p.asmon resonant mode when illuminated with p.p.larized light at this angle.

关键词： hot electrons p.asmonic resonance p.asmon grating p.otocurrent non-equilibrium