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A CHINESE WOMAN WITH GLUCAGONOMA SYNDROME

中华医学杂志(英文版) 1992年第6期105卷 514-517页

作者： Lcung CB Yeung VTF,Chung SCC Chan JCN cockram cs Prince of Wales Hospital.Chinese University of Hong Kong ShatinN.T.Hong Kong

The glucagonoma syndrome was firstdescribed by McGavran et al in 1966.1It isalso known as the diabetes-dermatitissyndrome' due to the typical combination ofdiabetes2mellitus and necrolytic migratoryerythema with a pancreatic islet-cell *** rare syndrome is frequently unrecog-nized until the underlying pancreaticislet-cell tumor has reached considerable *** the majority of cases liver metastases arealready present at the time of *** the occurrence of this syndrome in a75-year-old Chinese woman,who is the firstpatient to be described in Hong Kong,andreview the current literature.

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Management of nephropathy in patients with type 2 diabetes

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Chinese Medical Journal 2002年第1期115卷 129-135页

作者： Critchley JA Zhao HL Tomlinson B Leung W Thomas GN Chan JC cockram cs Chinese Univ Hong Kong Prince Wales Hosp Dept Med & Therapeut Div Clin Pharmacol Shatin Hong Kong Peoples R China

Purpose To review evidence-based management of nephropathy in patients with type 2 *** sources A literature search (MEDLINE 1966 to 2000) was performed using the key word 'diabetic nephropathy'. Relevant book chapters were also *** selection Well-controlled, prospective landmark studies and expert review articles on diabetic nephropathy were *** extraction Data and conclusions from the selected articles that provide solid evidence to the optimal management of diabetic nephropathy were extracted and interpreted in light of our clinical research experience with many thousands of Hong Kong Chinese *** Hypertension, long diabetes duration, poor glycaemic control and central obesity are the most important risk factors. Microalbuminuria is a practical marker to predict overt nephropathy in type 2 diabetic patients. Risk factor modification, renal function monitoring and combined therapies are the current integrated approaches to manage patients with diabetic kidney disease. Optimal glycaemic control is the mainstay of treatment but effective antihypertensive therapy is also key to delaying the progression of diabetic nephropathy. Angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor antagonists have important renoprotective actions independent of their blood pressure lowering actions. Conclusions Diabetic nephropathy is the leading cause of end-stage renal disease worldwide. Monitoring renal function and screening for microalbuminuria will allow the identification of patients with nephropathy at a very early stage for intervention. Tight glycaemic control and aggressive antihypertensive treatment as well as the use of renin-angiotensin system inhibitors should substantially delay the progression of nephropathy.

关键词： type 2 diabetes · nephropathy · albuminuria · hypertension · renin-angiotensin system

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