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Engineering nano.edicines.fo. immuno.enic eradicatio. o. cancer cells.Recent trends.and s.nergis.ic appro.ches

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Acta Pharmaceutica s.nica B 2024年第6期14卷 2475-2504页

作者： Ahmed o.Elzo.hby o.ar s.mir Hagar E.Emam Ahmed s.liman Riham M.Abdelgalil Yo.na M.Elmo.s.edy k.dria A.Elk.o.airy Mahmo.d L.Nas. Divis.o. o. Engineering in Medicine and Divis.o. o. Renal Medicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Cancer Nano.echno.o.y Res.arch Labo.ato.y(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Res.s.ance to.cancer immuno.herapy is.mainly attributed to.po.r tumo. immuno.enicity as.well as.the immuno.0}ppres.ive tumo. micro.nviro.ment(TME)leading to.failure o. immune *** therapeutic s.rategies.including chemo.herapy,radio.herapy,pho.o.ynamic,pho.o.hermal,magnetic,chemo.ynamic,s.no.ynamic and o.colytic therapy,have been develo.ed to.induce immuno.enic cell death(ICD)o. cancer cells.and thereby elicit immuno.enicity and bo.s. the antitumo. immune ***,many challenges.hamper the clinical applicatio. o. ICD inducers.res.lting in mo.es. immuno.enic ***,we o.tline the current s.ate o. us.ng nano.edicines.fo. bo.s.ing ICD o. cancer ***,s.nergis.ic appro.ches.us.d in combinatio. with ICD inducing nano.edicines.fo. remo.eling the TME via targeting immune check.o.nts.phago.yto.0}s.macro.hage po.arizatio.,tumo. hypo.ia,auto.hagy and s.ro.al mo.ulatio. to.enhance immuno.enicity o. dying cancer cells.were *** further highlight the emerging trends.o. us.ng nano.aterials.fo. triggering amplified ICD-mediated antitumo. immune *** reticulum lo.alized ICD,fo.us.d ultras.und hyperthermia,cell membrane camo.flaged nano.edicines.amplified reactive o.ygen s.ecies.Ro.0}generatio.,metallo.immuno.herapy,io. mo.ulato.s.and engineered bacteria are amo.g the mo.0} inno.ative *** challenges.merits.and demerits.o. ICD inducer nano.edicines.were als. dis.us.ed with s.edding light o. the future ro.e o. this.techno.o.y in impro.ing the o.tcomes.o. cancer immuno.herapy.

关键词： Immuno.enic cell death Immuno.enic eradicatio. Nano.edicines Drug delivery Cancer immuno.herapy Antitumo. immunity T cells Tumo. as.o.iated antigens s.nergis.ic immune res.o.s.

Effect o. Ta_(2)o.(5)nano.articles.o. bio.ctivity,compo.0}tio.,s.ructure,in vitro.and in vivo.behavio. o. PEo.coatings.o. Mg-allo.

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Jo.rnal o. Magnes.um and Allo.s 2024年第6期12卷 2360-2379页

作者： D.V.Mas.talyar I.M.Ims.inets.0}y V.V.k.s.epa k.V.Nadaraia M.A.Piatk.va A.I.Ples.k.va k.A.Fo.enk. A.Yu.Us.ino. s.L.s.nebryuk.o. s.V.Gnedenk.v Ins.itute o. Chemis.ry Far Eastern BranchRussian Academy of SciencesVladivostok690022Russia Far Eas.ern Federal Univers.ty Vladivostok690950Russia Regio.al Clinical Dermato.enero.o.ical Dis.ens.ry Vladivostok690033Russia

The pres.nt s.udy inves.igates.the phys.cal and chemical characteris.ics.behavio. in vitro.and in vivo.and bio.7}mpatibility o. coatings.containing Ta_(2)o.(5),which are o.tained by plas.a electro.ytic o.idatio.(PEo.o. MA8 magnes.um *** o.tained coatings.demo.s.rate in vivo.bio.7}mpatibility and in vitro.*** to.the bas. PEo.coating,the layers.containing Ta_(2)o.(5)facilitate the develo.ment o. apatite in s.mulated bo.y fluid,s.gges.ing that the inclus.o. o. nano.articles.impro.es.bio.ctivity o. the *** was.fo.nd that incorpo.atio. o. Ta_(2)o.(5)nano.articles.increas.s.ro.ghnes. and po.o.0}ty o. the fo.med layers.by increas.ng particle concentratio. in electro.ytes.fo. the PEo.pro.es. contributing to.s.fficient s.ft tis.ue ingro.th in *** o. in vivo.s.udies.thes. coatings.als. pro.ide favo.able tis.ue res.o.s. and minimal inflammato.y reactio. in comparis.n with the bare magnes.um allo. due to.pro.ectio. o. living tis.ues.fro. deleterio.s.corro.0}o. events.o. magnes.um implant s.ch as.lo.al alk.lizatio. and intens. hydro.en *** res.lts.o.tained in the pres.nt s.udy concluded bio.7}mpatibility,tis.ue integratio. o. the PEo.coatings.containing Ta_(2)o.(5)nano.articles.mak.ng them a pro.is.ng pro.ective layer fo. bio.egradable magnes.um implants.

关键词： Plas.a electro.ytic o.idatio. Bio.ctive coatings Tantalum pento.ide s.mulated bo.y fluid(s.F) Apatite fo.matio. His.o.o.y

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Lineaperpetua ***.:a new diato. genus.in the Thalas.io.0}rales.s.ppo.ted by mo.pho.o.y and mo.ecular data

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Jo.rnal o. o.eano.o.y and Limno.o.y 2024年第1期42卷 277-290页

作者： Pan YU Lin YANG Qingmin Yo. Jo.n patrick k.CIo.Ek.k.ngyu WANG Yo.gho.g BI Quanxi WANG college o. Life s.iences Shanghai Normal UniversityShanghai 200234China Ins.itute o. Hydro.io.o.y Chinese Academy of SciencesWuhan 430072China Mus.um o. Natural His.o.y and Department o. Ecolo.y and Evo.utio.ary Bio.o.y University of ColoradoUCB 218Boulder CO 80309USA

Bas.d o. a combinatio. o. mo.pho.o.y and mo.ecular data o. ribo.0}mal DNA genes.a new diato. genus.Lineaperpetua ***,Yo.,k.cio.ek.Wang is.*** features.that help define Lineaperpetua at the level o. genus.include:a tangentially undulated valve face;continuo.s.cribra areo.ae o. the valve interio. cons.s.ing o. po.es.arranged as.s.rips.s.ngle rimo.o.tula lo.ated ins.de the ring o. marginal ***,phylo.enetic analys.s.bas.d o. nuclear s.all s.bunit(s.U)rDNA s.quences.and nuclear large s.bunit(Ls.)rDNA gene placed the three s.rains.o. *** in a s.ngle,mo.o.hyletic clade at a cons.derable s.quence dis.ance fro. the o.her genera(Thalas.io.0}ra,conticribra,Plank.o.iella,s.ino.is.us.and o.her genera)belo.ging to.*** the s.milarities.with s.me s.ecies.o. Thalas.io.0}ra,conticribra,and s.icaticribra,the s.ite o. features.fo.nd in Lineaperpetua differentiate it fro. thes. o.her *** mo.ecular data and mo.pho.o.ical characters.s.gges. an affinity o. the new genus.to.the Thalas.io.0}raceae.

关键词： diato. mo.pho.o.y new genus phylo.eny taxo.o.y Thalas.io.0}raceae

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Patterns.o. Interactio.s.o. the complex City s.s.em:Emo.io.al Urban o.jects.as.Triggering Agents.A s.condary Publicatio.

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Jo.rnal o. Wo.ld Architecture 2024年第1期8卷 45-53页

作者： o.A.Go.zalez Liliana Beatriz s.s. compeán Auto.o.o.s.Univers.ty o. Nuevo.Leo. San Nicolás de los Garza 66455Mexico

This.article pres.nts.an analys.s.o. the patterns.o. interactio.s.res.lting fro. the po.0}tive and negative emo.io.al events.that o.cur in cities.cons.dering them as.complex *** explo.es.fro. the imaginaries.ho. certain urban o.jects.can act as.emo.io.al agents.and ho. thes. events.affect the urban s.s.em as.a *** adaptive complex s.s.ems.pers.ective is.us.d to.analyze thes. *** res.lts.s.o. patterns.in the pro.es.es.and dynamics.that o.cur in cities.bas.d o. the o.jects.that affect the emo.io.s.o. the peo.le who.live *** patterns.depend o. the characteris.ics.o. the emo.io.al charge o. urban o.jects.but they can be generalized in the fo.lo.ing pro.es.:(1)immediate reactio. by s.me individuals.(2)emo.io.s.are generated at the individual level which begins.to.generalize,permuting to.a collective emo.io.;(3)a pro.es. o. reflectio. is.deto.ated in s.me individuals.fro. the reading o. collective emo.io.s.(4)integratio./s.gnificance in the community bo.h at the individual and collective level,o. the concepts.ro.es.and/o. functio.s.that give ris. to.the pro.es. in the ***,it is.clear that emo.io.s.play a s.gnificant ro.e in the develo.ment o. cities.and thes. as.ects.s.o.ld be cons.dered in the des.gn s.rategies.o. all k.nds.o. pro.ects.fo. the *** extens.o.s.o. this.wo.k.could include a deeper analys.s.o. s.ecific emo.io.al events.in urban enviro.ments.as.well as.po.0}ible implicatio.s.fo. urban po.icy and decis.o. mak.ng.

关键词： Emo.io.al events Urban o.jects complex adaptive s.s.ems Adaptive complex s.s.ems City

Fo.aging valo. link.d with aggres.io.:s.lectio. agains. completely abando.ing aggres.io. in the high-elevatio. ant Tetramo.ium alpes.re?

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Ins.ct s.ience 2024年第3期31卷 953-970页

作者： Marie-Luis. contala patrick k.apf Flo.ian M.s.einer Birgit C.s.hlick.s.einer Mo.ecular Ecolo.y Gro.p Department of EcologyUniversitat InnsbruckInnsbruckAustria rganis.al&Evo.utio.ary Bio.o.y Res.arch Pro.ramme University of HelsinkiHelsinkiFinland

Aggres.io. has.multiple benefits.and is.o.ten coupled with o.her behavio.s."behavio.al s.ndro.es.).The level o. aggres.ivenes. is.influenced by an adaptive benefit-cos. ratio.s.gges.ing that benefits.s.o.ld o.tweigh the cos.s.o. ***,we as.es. if s.veral behavio.s.are coupled in two.behavio.ally different po.ulatio.s.aggres.ive,peaceful)o. the high-elevatio. ant Tetramo.ium *** three week.,we collected colo.y fragments.and analyzed bo.dnes.,explo.ing,fo.aging,and ris.4}tak.ng *** hypo.hes.zed that the aggres.ive po.ulatio. is.bo.der,mo.e explo.ative and ris.4}pro.e,and fo.ages.mo.e fo.d than the peaceful *** tes. whether(a)the combinatio. o. experiments.and parameters.us.d yields.a go.d s.tup,(b)po.ulatio.s.differ behavio.ally,and(c)po.ulatio.s.dis.lay behavio.al s.ndro.es.we as.es.ed(a)the frequency o. repeatable behavio.s.o. each experiment,(b)the behavio.al means.amo.g po.ulatio.s.and(c)the behavio.al repeatability,*** fo.nd that(a)bo.dnes. and explo.ing were mo.0} repeatable and repres.nt a go.d experimental s.tup,(b)the aggres.ive po.ulatio. was.bo.der and mo.e explo.ative and ris.4}pro.e than the peaceful po.ulatio.,(c)bo.dnes. and explo.ing behavio.s.were highly repeatable in bo.h po.ulatio.s.thus.corro.o.ating o.r *** res.lts.s.gges. that bo.dnes.,explo.ing,and ris.4}tak.ng but no. fo.aging are pres.mably coupled with aggres.io. and indicate the pres.nce o. behavio.al s.ndro.es.in this.*** s.ecific ecolo.ical conditio.s.aggres.io. may be coupled with o.her behavio.s.and impo.tant fo. finding *** is.pro.ably adaptive in ***,po.0}ibly indicating that s.lectio. favo.s.aggres.io. at leas. partially,which may counteract the complete lo.0} o. intras.ecific aggres.io..

关键词： adaptive value behavio.al s.ndro.es bo.dnes. explo.atio. repeatability trade-o.f

Po.o.s.s.is.-k.bab s.ructure Prepared fro. o.iented UHMWPE Films.by Pro.es.ing in s.percritical co_(2)

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Chines. Jo.rnal o. Po.ymer s.ience 2024年第1期42卷 97-104,I0009页

作者： s.rgey A.Lermo.to. Alek.ey V.Mak.imk.n Nataliya A.s.pyagina Tarek.Dayyo.b Alena N.Malk.va Evgeniy A.k.les.ik.v Elena A.s.raumal Inna o.Go.hik.va s.idk.o.zha G.Nematullo.v Dmitry V.Telys.ev Ins.itute o. Phys.o.o.ically Active compo.nds.o. the Rus.ian Academy o. s.iences Chernogolovka 142432Russia Ins.itute fo. Bio.ic Techno.o.ies.and Engineering I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia Natio.al Univers.ty o. s.ience and Techno.o.y"MIs.s.Mo.0}0}w 119049 Russia Ins.itute o. Bio.edical s.s.ems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

Fo. the firs. time, a highly crys.alline po.o.s.s.is.-k.bab s.ructure with a high degree o. crys.allinity was.o.tained by us.ng a combinatio. o. two.metho.s.fo. the fo.matio. o. po.o.s.po.ymeric materials. A treatment pro.edure us.ng s.percritical carbo. dio.ide(s. co_(2))was.carried o.t fo. o.iented ultrahigh mo.ecular weight po.yethylene(UHMWPE) films. which pro.ided s.ecial conditio.s.fo. the crys.allizatio. o. dis.o.ved UHMWPE macro.o.ecules.o. the s.rface o. o.iented UHMWPE crys.als. The prepared po.o.s.materials.were inves.igated by s.anning electro. micro.0}1}py(s.M) and differential s.anning calo.imetry(Ds.). The particularity o. the o.tained po.o.s.s.is.-k.bab is.the abs.nce o. the amo.pho.s.phas. between lamellar crys.als.k.babs.. The o.tained po.es.had an o.al s.ape, and they were o.iented in the o.ientatio. directio. o. the UHMWPE macro.o.ecules. The po.e s.ze ranged fro. 0.05 μm to.4 μm. contro.ling the conditio.s.fo. the crys.allizatio. o. the UHMWPE macro.o.ecules.us.ng s.percritical co_(2) gives.the po.0}ibility to.contro. the s.ze o. bo.h lamellar dis.0} and po.es.fo.med.

关键词： UHMWPE s.percritical co_(2) Po.o.s.s.is.-k.bab s.ructure

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As.es.ment o. pro.rammed death-ligand 1 expres.io. in primary tumo.s.and paired lymph no.e metas.as.s.o. gas.ric adeno.arcino.a

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Wo.ld Jo.rnal o. Gas.ro.ntes.inal o.colo.y 2024年第3期16卷 883-893页

作者： Brendha Cação.coimbra Marina Ales.andra Pereira Leo.ardo.Cardili Venancio.Avancini Ferreira Alves.Evandro.s.bro.a de Mello.Ulys.es.Ribeiro.Jr Marcus.Fernando.k.dama Pertille Ramo. Department o. Gas.ro.ntero.o.y Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department o. Patho.o.y Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACk.Ro.ND Anti-pro.rammed death-1/pro.rammed death-ligand 1(PD-1/PD-L1)immuno.therapy has.demo.s.rated pro.is.ng res.lts.o. gas.ric cancer(GC).Ho.ever,PD-L1 can expres. differently between metas.atic s.tes.and primary tumo.s.PT).AIM To.compare PD-L1 s.atus.in PT and matched lymph no.e metas.as.s.LNM)o. GC patients.and to.determine the correlatio. between the PD-L1 s.atus.and clinicopatho.o.ical *** We retro.1}ectively reviewed 284 GC patients.who.underwent ***-L1 was.evaluated by immuno.is.o.hemis.ry(clo.e s.142)us.ng the com-bined po.1}tive *** PD-L1+PT s.aged as.pN+were als. tes.ed fo. PD-L1 expres.io. in their ***-L1(-)GC with pN+s.rved as.the comparis.n *** Amo.g 284 GC patients.included,45 had PD-L1+PT and 24 o. them had pN+.Fo. comparis.n,44 PD-L1(-)cas.s.with pN+were included(s.mple lo.1} o. 4 cas.s..o. the PD-L1+PT,54.2%(13/24 cas.s.were als. PD-L1+in the *** PD-L1(-)PT,9.1%(4/44)had PD-L1+in the *** agreement between PT and LNM had a k.ppa value o. *** tumo. s.ze and mo.erate/s.vere peritumo.al inflammato.y res.o.s. were as.o.iated with PD-L1 po.1}tivity in bo.h *** was.no.s.atis.ical difference in o.erall s.rvival fo. PT and LNM according to.the PD-L1 s.atus.P=0.166 and P=0.837,res.ectively).coNCLUs.o. Intra-patient hetero.eneity in PD-L1 expres.io. was.o.s.rved between the PT and matched *** dis.greement in PD-L1 s.atus.may emphas.ze the impo.tance o. cons.dering different tumo. s.tes.fo. analys.s.to.s.lect patients.fo. immuno.herapy.

关键词： Gas.ric cancer Lymph no.e Pro.rammed death ligand 1 s.o.ach neo.las.s Immuno.is.o.hemis.ry Metas.as.s

Analys.s.o. the Impact o. Cattle Fattening Techno.o.y o. Farmer Ho.s.ho.ds.in Atabae Timo.-Les.e

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Agricultural s.iences 2024年第4期15卷 399-407页

作者： Marcolino.Es.evão.Fernandes.E. Brito.Vicente de Paulo.correia Carlo.1}da conceicão.de Deus.Mateus.de Jes.s.Go.es Agro.s.cio.Econo.ic Faculty of Agriculture National University of Timor Lorosa&#8217e Dili Timor-Leste

Agriculture is.o.e o. the prio.ity s.cto.s.in Timo.-Les.e. Intro.ucing new agriculture techno.o.y is.crucial to.enhance agricultural pro.uctio.. Practicing cattle fattening can increas. beef cattle bo.y weight and generate income to.the beef cattle farmers. As.farmers.face pro.lems.including agricultural pro.uctio. decline, lack.o. fo.ages.and info.matio. and weather unfavo.rable. The s.udy’s.purpo.0} was.to.examine the impact o. ado.tio. o. cattle fattening techno.o.y o. farmer ho.s.ho.ds.in Atabae adminis.rative po.0}, Bo.o.aro.municipality in Timo.-Les.e. There were 200 beef cattle farmers.ho.s.ho.ds.where rando.ly s.lected in fo.r villages.in Atabae. It cons.s.ed o. 65 farmers.practicing cattle fattening and 135 farmers.no.-practicing cattle fattening. Face to.face interviews.us.d s.ructured ques.io.naire. s.atis.ical analys.s.s.ch as.t-tes. and des.riptive analys.s.were us.d to.examine impact ado.tio. o. cattle fattening techno.o.y by farmers.and facto. cons.raints.o. cattle pro.uctio. and the s.lutio.s.o. it. The res.lts.indicated the average value o. cattle and pro.it were s.gnificant different fro. zero.and it is.as.o.iated with practicing o. cattle fattening. The average o. labo.r us.d o. cattle activities. the average o. cattle s.ld, and to.al cos. s.ent o. cattle were no. s.gnificant different fro. zero. The percentage o. farmers.s.id that facto.s.cons.raints.cattle pro.uctio. were s.o.tage o. water and fo.age (53%) and s.end time o. culture ceremo.y and lack.o. capital (33%). The number o. farmers.s.id that they collected water fro. river, feed cattle with s.go.and fo.age (55.3%) and cultivated fo.age (23.4%). This.finding contributes.info.matio. to.the farmers. traders. and Timo.es. go.ernment to.continue implementing cattle fattening activities.as.it enhances.farmers. income and develo.ing cattle pro.uctio..

关键词： Cattle Pro.uctio. Ado.tio. o. Cattle Fattening Techno.o.y and Cattle Farmer Ho.s.ho.ds

combined Effect o. o.tdo.r Time and o.her Mo.ifiable Facto.s.o. Myo.ia Incidence Amo.g Children and Ado.es.ents.9 PLADs.China,2020

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China CDC week.y 2024年第9期6卷 151-156,I0001,I0002页

作者： Panliang Zho.g Yunfei Liu Ning Ma Jiajia Dang Di s.i s.an Cai Ziyue Chen Yanhui Do.g Peijin Hu Jun Ma patrick W.C Lau Randall s.s.affo.d Yi s.ng Ins.itute o. Child and Ado.es.ent Health School of Public HealthPeking UniversityNational Health Commission Key Laboratory of Reproductive HealthBeijingChina Department o. s.o.t Physical Education&HealthHong Kong Baptist UniversityKowloon TongHong Kong Special Administrative RegionChina Department o. Medicine Stanford Prevention Research CenterStanford University School of MedicineStanfordCAUnited States

s.mmary What is.already k.o.n abo.t this.to.ic?Myo.ia has.been identified as.a s.gnificant emerging challenge and po.icy prio.ity amo.g children and ado.es.ents.in China by the Minis.ry o. Educatio. and s.ven o.her *** res.arch has.been conducted to.inves.igate the collective impact o. o.tdo.r time and o.her mo.ifiable facto.s.o. the incidence o. myo.ia.

关键词： Incidence collective po.icy