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Validation of an objective scar pig.entation measurement by.using.a spectrocolorimeter

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Validation of an objective scar pigmentation measurement by ...

Characterization of amy.oid-β precursor protein intracellular domain-associated transcriptional complexes in SH-Sy.y.neurocy.es

第八届全国烧伤外科学年会

作者： Cecilia W．P．Li-Tsang.Joy.C．M．lau Sally.K．y.Liu Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHung HomKowloonHong KongPR China Occupational Therapy.Department Pamela Youde Nethersole Eastern HospitalHospital AuthorityChai WanHong KongPR China

＜正＞Scar pig.entation chang.s throug.out its maturation process and it is often used as one of the indicators for scar maturation,y.t it is often rated *** purpose of this study.was to investig.te the application of a commercial spectrocolorimeter to produce a reliable measurement on scar *** Internationale de l’Eclairag. （CIE） model of color has been adopted in this study.for measurement of scar pig.entation 24 patients with hy.ertrophic scars at different stag.s of maturation were selected for the study.were inspected by.two therapists using.the Vancouver scar scale （VSS） and then using.spectrocolorimeter for inter-rater *** measurements were taken after 30 min by.the same g.oup of therapists （test-retest reliability..Results indicated that the inter-rater reliability.among.the three therapists was satisfactory.with intra-class correlation coefficient （ICC）（2,2） from 0.50 to 0.99 in all the three color *** test-retest reliability.of the spectrocolorimeterwas satisfactory.with ICC （3,6） rang.d from 0.95 to *** difference was also noted between the measurements of normal skin and hy.ertrophic scar （P＜0.00,t-values:from 2.78 to 0.05,d.f.:from 29.7 to 46.00） in all color parameters,except the chroma C*.We also found a positive relationship between VSS scores and the spectrocolorimeter *** spectrocolorimeter is found to be a reliable instrument to quantify.scar pig.entation and to differentiate normal skin and scar *** further studies,the constructs of scar properties could further be explored using.this spectrocolorimeter. 2003 Elsevier Ltd and *** rig.ts reserved.

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Neuroscience Bulletin 2012年第3期28卷 259-270页

作者： Wulin y.ng.Amy.y.ng.Chen lau Shuizhong.Luo Qian Zhu Li Lu School of Biotechnolog. and Food Eng.neering Hefei University of TechnologyHefei 230009China Laboratory.of Metabolic Medicine Singapore Bioimaging Consortium(SBIC)Agency for ScienceTechnology and Research(A*STAR)Singapore Department of Anatomy Shanxi Medical UniversityTaiyuan 030001China

Objective Alzheimer＇s disease （AD） is one of the major disorders worldwide. Recent research sug.ests that the amy.oid-β precursor protein intracellular domain （AICD） is a potential contributor to AD development and prog.ession. The small AICD is rapidly.deg.aded after processing.from the full-leng.h protein. The present study.aimed to apply.a hig.ly.efficient biotiny.ation approach in vitro to study.AICD-associated complexes in neurocy.es. Methods By.coexpressing.Escherichia coli biotin lig.se with biotiny.-tag.ed AICD in the SH-Sy.y.neuronal cell line, the effects of AICD overexpression on cell proliferation and apoptosis were analy.ed. Besides, AICD-associated nuclear transcriptional complexes were purified and then examined by.mass spectrometry. Results Our data showed that AICD overexpression not only.affected cell proliferation but also led to apoptosis in differentiated SH-Sy.y.cells. Moreover, biotiny.ation allowed sing.e-step purification of biotiny.ated AICD-associated complexes from total nuclear extract via hig.-affinity.biotin-streptavidin binding. Following.this by.mass spectrometry. we identified phy.ically.associated proteins, some reported previously.and other novel binding.partners, CUX1 and SPT5. Conclusion Based on these results, a map of the AICD-associated nuclear interactome was depicted. Specifically. AICD can activate CUX1 transcriptional activity. which may.be associated with AICD-dependent neuronal cell death. This work helps to understand the AICD-associated biolog.cal events in AD prog.ession and provides novel insig.ts into the development of AD.

关键词： Alzheimer's disease amy.oid-β precursor protein AICD biotiny.ation apoptosis

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伺服系统模糊算法探讨

华东地质学院学报 1991年第2期14卷 162-175页

作者： y.F Li C C lau 刘卫红

文章探讨了模糊算法应用于伺服电机控制器的可能性.文中就PID控制、MRA控制和模糊控制的稳态误差、建立时间和响应时间等方面的性能作了比较。文章也陈述了模糊控制算法的局限性。

关键词：伺服电机调节器模糊算法

聚氯乙烯/聚己二酸新戊基乙酯/聚乙烯叉氟共混体的拉伸、应力—应变及蠕变破坏性能

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橡胶参考资料 1989年第9期19卷 48-51页

作者： Way.e W.y.lau. 黄祖长

1 前言PVC 是一种用途广泛的廉价聚合物,它能与许多其它聚合物,尤其是聚酯很好地混合而成多种有用的共混体。PVC 最常用的增塑剂是邻苯二甲酸二(2-乙基己)酯(DOP)。但是,现已发现分子量为390的 DOP。

关键词： PVC 性能共混体 PDPA PVDF

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聚合型抗氧剂

塑料助剂 2001年第3期 8-10页

作者： Way.e W.y.lau 潘江庆杨明国立新加坡大学化工系中国科学院化学所北京100080

本文介绍了抗氧剂的分子量对其性能的影响 ,最佳分子量及聚合型抗氧剂的合成方法。引用文献 2

关键词：聚合型抗氧剂单官能团分子最佳分子量合成

Thoracic surg.ry.in 2030

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中华胸部外科电子杂志 2021年第3期8卷 145-152页

作者： Joy.e W.y.Chan Rainbow W.H.lau Aliss T.C.Chang.Ivan C.H.Siu Teddy.H.y.Wong.Zheng.Li Calvin S.H.Ng Department of Surg.ry Prince of Wales Hospitalthe Chinese University of Hong KongHong Kong SARChina

Introduction Thoracic surg.ry.has evolved at an exponential pace since the first clinical lung.resection in *** first pneumonectomy.was performed in 1895,the first lobectomy.in 1901,while double lumen endotracheal intubation for pulmonary.resection did not occur until *** 1990s saw the development of g.me-chang.r video-assisted thoracoscopic surg.ries(VATS),while the 2000s g.ve witness to the explosive boom of robotic *** Abraham Lincoln once said,“The best way.to predict the future is to create it”,in this article we discuss the current cutting.edg. technolog.es and attempt to predict the future of thoracic surg.ry.in 10 y.ars’time.

关键词： surg.ry lung clinical

慢性丙型肝炎中ISg.析确定蛇毒素为一种潜在的抗病毒效应物质

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 41-42页

作者： Helbig.K.J. lau D.T.-y. Semendric L. M.R. Beard 郑世成 School of Molecular and Biomedical Science University of Adelaide North Terrace Adeleide SA 5005 Australia Dr.

Interferon (IFN) α inhibits hepatitis C virus (HCV) replication both clinically.and in vitro; however, the complete spectrum of interferon-stimulated g.nes (ISg.) expressed in the HCV infected liver or the g.nes responsible for control of HCV replication have not been defined. To better define ISg.expression in the chronically.infected HCV liver, DNA microarray.analy.is was performed on 9 individuals with chronic hepatitis C (CHC). A total of 232 messeng.r RNAs were differentially.reg.lated in CHC compared with nondiseased liver controls. A sig.ificant proportion of these were potential ISg. that were transcriptionally.elevated, sug.esting.an ong.ing.response to endog.nous IFN and/or double-stranded RNA. One ISg.sig.ificantly.elevated in all patients was viperin, an evolutionary.conserved ISg.that has antiviral activity.ag.inst human cy.omeg.lovirus. Stimulation of Huh-7 and Hepg. cells with IFN-α or -γ revealed viperin is predominantly.a ty.e I ISg. Furthermore, viperin expression could also be induced following.transfection of Huh-7 cells with either poly.I:C) or HCV RNA. Transient expression of viperin in cells harboring.the HCV g.nomic replicon resulted in a sig.ificant decrease in HCV replication, sug.esting.that viperin has anti-HCV activity. In conclusion, even in the face of a persistent HCV infection, there is an active ISg.antiviral cellular response, hig.lig.ting.the complexity.of the host viral relationship. Furthermore, ISg.viperin has anti-HCV activity.in vitro; we postulate that viperin, along.with other ISg., acts to limit HCV replication.

关键词：慢性丙型肝炎 ISg 抗病毒效应体外试验细胞反应持续性感染人巨细胞病毒短暂表达转染保守

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微创技术治疗肝细胞癌的进展

中华消化外科杂志 2009年第2期8卷 81-84页

作者：刘允怡赖俊雄刘晓欣香港中文大学医学院、沙田威尔斯亲王医院

肝细胞癌（hepatocellular carcinoma，HCC）是全球第5位常见恶性肿瘤，50％以上发生在我国。HCC的高危人群以35～65岁为主，尤其以男性患者较多，是女性患者的2～4倍。HCC早期症状不明显，导致大多数患者就诊较晚，整体预后很差。80％... 详细信息

肝细胞癌（hepatocellular carcinoma，HCC）是全球第5位常见恶性肿瘤，50％以上发生在我国。HCC的高危人群以35～65岁为主，尤其以男性患者较多，是女性患者的2～4倍。HCC早期症状不明显，导致大多数患者就诊较晚，整体预后很差。80％～90％的患者在确诊时，由于受肿瘤的大小、部位以及肝脏的基本病变、肝功能和全身状况的影响，不能耐受手术切除。此时，微创技术就成为治疗HCC的重要手段。

关键词：肝肿瘤腹腔镜检查肝切除术导管消融术经肝动脉治疗

Metabolic Control and g.owth Reg.lation in the Reg.nerating.Human Liver Measured in Vivo by.31—phosophorus Mag.etic Resonance Spectroscopy

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The Chinese-g.rman Journal of Clinical Oncolog. 2002年第3期1卷 152-155页

作者：文达伦刘允怡香港中文大学威尔斯亲王医院外科学系

Objectives Partial hepatectomy.induces a rapid transformation within the remnant liver, prompting.a wave of hepatocy.e mitosis which abates when the lost cell mass has been recovered. The mechanism of co-ordinated control of metabolism and maintenance of function during.this period of dy.amic chang. is incompletely.understood. Furthermore, the biochemical basis of g.owth reg.lation in the reg.nerating.liver has not been well defined. We have studied human liver reg.neration using.in vivo 31-phosphorus mag.etic resonance spectroscopy.(31 P MRS). This non-invasive technique allows assay.of hig.-energ. phosphate compounds and also of phospholipid metabolites thoug.t to be involved in cellular renewal *** Five patients underg.ing.liver resection were studied. Hepatic metabolism was evaluated using.31P MRS before surg.ry.and on postoperative day. 2,4,6 and 14. Estimation of liver volume by.mag.etic resonance imag.ng.and blood sampling.for biochemistry.were performed at the same time *** We found that the reg.nerative response following.loss of liver parenchy.a produced a reversible decline in energ. state which necessitated compensatory.adjustments in liver sy.thetic and excretory.(unctions. Volume reg.in was associated with alterations in phospholipid metabolism, which normalized when the hepatic g.owth spurt was *** These observations indicate that modulation of hepatocy.e energ. economy.is necessary.for the integ.ated recovery.of liver cell mass and function. We propose that deficient hepatic energ. production may.explain the mechanism of liver failure after hepatectomy. and sug.est that in vivo measurement of liver metabolism may.provide a rational basis for the development and evaluation of hepatic support strateg.es.

关键词： hepatocy.e mitosis metabolism energ. phosphollpid