检索结果-南通市图书馆

COMPOSITION OPERATORS ON BERGMAN SPACES

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2003年第4期24卷 433-448页

作者： j.H.clifford ZHENGDECHAO DepaxtmentofMathematicsandStatistics UniversityofMichiganatDearbornDearbornMichigan48128USA DepartmentofMathematics VanderbiltUniversityNashvilleTN37240USA.

The authors obtain function theoretic characterizations of the compactness on the standardweighted Bergman spaces of the two operators formed by multiplying a composition operatorwith the adjoint of another compositio... 详细信息

关键词： Bergman spaces Composition operator

Bone Remodeling and Energy Metabolism:New Perspectives

在线全文

学校读者我要写书评

暂无评论

Bone Research 2013年第1期1卷 72-84页

作者： Francisco j.A.de Paula clifford j.Rosen Department of Internal Medicine School of Medicine of Ribeiro PretoUniversity of So PauloBrazil Center for Clinical and Translational Research Maine Medical Center Research InstituteUSA

Bone mineral, adipose tissue and energy metabolism are interconnected by a complex and multilevel series of networks. Calcium and phosphorus are utilized for insulin secretion and synthesis of high energy compounds. Adipose tissue store lipids and cholecalciferol, which, in turn, can influence calcium balance and energy expenditure. Hormones long-thought to solely modulate energy and mineral homeostasis may influence adipocytic function. Osteoblasts are a target of insulin action in bone. Moreover, endocrine mediators, such as osteocalcin, are synthesized in the skeleton but regulate carbohydrate disposal and insulin secretion. Finally, osteoblasts and adipocytes originate from the same mesenchymal progenitor. The mutual crosstalk between osteoblasts and adipocytes within the bone marrow microenvironment plays a crucial role in bone remodeling. In the present review we provide an overview of the reciprocal control between bone and energy metabolism and its clinical implications.

关键词： bone adipose tissue mineral metabolism energy metabolism leptin osteocalcin

A peptide containing the receptor binding site of insulin-like growth factor binding protein-2 enhances bone mass in ovariectomized rats

在线全文

学校读者我要写书评

暂无评论

Bone Research 2018年第3期6卷 280-288页

作者： Gang Xi Christine Wai clifford j.Rosen David R.Clemmons Department of Medicine University of North Carolina at Chapel HillChapel HillUSA Maine Medical Center Research Institute ScarboroughUSA

Male Igfbp2-/-mice have a significant reduction in bone mass and administration of a peptide that contains the insulin-like growth factor binding protein-2(IGFBP-2) receptor-binding domain stimulates bone formation in these animals. Female Igfbp2-/-mice do not have this phenotype but following ovariectomy(OVX) lose more bone than OVX wild-type mice. This suggests that in the absence of estrogen, IGFBP-2 is required to maintain bone mass. Therefore these studies were undertaken to determine if this peptide could stimulate bone acquisition in OVX rats. OVX rats were divided into seven treatment groups: sham animals, OVX animals, OVX animals receiving a control scrambled peptide, or one of three doses of the active peptide termed PEG-HBD-1(0.7, 2,and 6 mg·kg^(-1)) and an OVX group receiving parathyroid hormone(PTH)(50 μg·kg-1 per day). The peptides were administered for8 weeks. DXA revealed a significant reduction in femoral and tibial areal bone mineral density(aBMD) after OVX, whereas treatment with the high-dose peptide increased aBMD by 6.2% ± 2.4%(P < 0.01) compared to control peptide; similar to the increase noted with PTH(5.6% ± 3.0%, P < 0.01). Similar increases were noted with two lower doses of the peptide(3.8% ± 1.5%, P < 0.05 for low dose; 3.1% ± 1.6%, P = 0.07 for middle dose). Micro CT showed that the OVX control peptide animals had reductions of 41% and64% in femoral trabecular BV/TV and trabecular number, respectively. All three doses of the peptide increased bone volume/total volume(BV/TV) significantly, while the low and middle doses increased trabecular number. Cortical BV/TV and thickness at the midshaft increased significantly with each dose of peptide(18.9% ± 9.8%, P < 0.01 and 14.2% ± 7.9%, P < 0.01 for low dose; 23.7% ±10.7%, P < 0.001 and 15.8% ± 6.1%, P < 0.001 for middle dose; 19.0% ± 6.9%, P < 0.01 and 16.2% ± 9.7%, P < 0.001 for high dose)and with PTH(25.8% ± 9.2%, P < 0.001 and 19.4% ± 8.8%, P < 0.001). Histomorphometry showed that the low

关键词： insulin-like growth factor binding protein-2 OVX wild-type mice

Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells

在线全文

学校读者我要写书评

暂无评论

Bone Research 2019年第4期7卷 410-423页

作者： Michaela Tencerova Elizabeth Rendina-Ruedy Ditte Neess Nils Faergeman Florence Figeac Dalia Ali Morten Danielsen Anders Haakonsson clifford j.Rosen Moustapha Kassem Department of Molecular Endocrinology University of Southern Denmark and Odense University Hospital5000 OdenseDenmark Center for Molecular Medicine Maine Medical Center Research InstituteScarboroughME 04074USA Villum Center for Analytical Biosciences Department of Biochemistry and Molecular BiologyUniversity of Southern Denmark5230 OdenseDenmark MSOmics 2950 CopenhagenDenmark Department of Cellular and Molecular Medicine Novo Nordisk Foundation Center for Stem Cell Biology(DanStem)University of Copenhagen2200 CopenhagenDenmark

Enhanced bone marrow adipogenesis and impaired osteoblastogenesis have been observed in obesity,suggesting that the metabolic microenvironment regulates bone marrow adipocyte and osteoblast progenitor differentiation *** determine the molecular mechanisms,we studied two immortalized murine cell lines of adipocyte or osteoblast progenitors(BMSCs^adipo and BMSC^sosteo,respectively)under basal and adipogenic culture *** baseline,BMSCs^adipo,and BMSCs^osteo exhibit a distinct metabolic program evidenced by the presence of specific global gene expression,cellular bioenergetics,and metabolomic signatures that are dependent on insulin signaling and glycolysis in BMSCs^osteo versus oxidative phosphorylation in BMSCs^*** test the flexibility of the metabolic program,we treated BMSCsadipo with parathyroid hormone,S961(an inhibitor of insulin signaling)and oligomycin(an inhibitor of oxidative phosphorylation).The treatment induced significant changes in cellular bioenergetics that were associated with decreased adipocytic ***,12 weeks of a high-fat diet in mice led to the expansion of adipocyte progenitors,enhanced adipocyte differentiation and insulin signaling in cultured *** data demonstrate that BMSC progenitors possess a distinct metabolic program and are poised to respond to exogenous metabolic cues that regulate their differentiation fate.

关键词： progenitor impaired programming

Identifying and validating novel analgesic drug targets

在线全文

学校读者我要写书评

暂无评论

Identifying and validating novel analgesic drug targets

Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status

第十五届国际药理学大会

作者： clifford j Woolf Neural Plasticity Research Group Department of Anesthesia and Critical CareMassachusetts General Hospital and Harvard Medical SchoolBostonMAUSA

＜正＞ A feature of both inflammatory and neuropathic pain is the induction either in immune cells or in neurons, of very many genes. Expression profile analyses performed with high-density oligonucleotide microarrays have revealed many hundreds of genes whose transcripts are dynamically either up- or down regulated in the peripheral or central nervous system in multiple pain-related rodent models. The challenge is how to identify which of the induced genes are potential targets for the development of new analgesics. We find that only 10 % of all transcripts identified from a replicate array analysis as changing in three neuropathic pain models in the dorsal root ganglion or dorsal horn are common to all the models. We have analyzed this subset for novel potential analgesic target candidates using gain and loss of function strategies in vivo and in vitro to try establish how they contribute to increased pain sensitivity and if blcoking their activity produces analgesia. A single nucleotide polymorphism analysis of the candidates in patients with chronic pain was also performed to establish validity of the targets in humans. Several candidates that have emerged from this approach will be presented.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Bone Research 2023年第4期11卷 876-894页

作者： Ananya Nandy Ron C.M.Helderman Santosh Thapa Shobana jayapalan Alison Richards Nikita Narayani Michael P.Czech clifford j.Rosen Elizabeth Rendina-Ruedy Department of Medicine Division of Clinical PharmacologyVanderbilt University Medical CenterNashvilleTN 37232USA Program in Molecular Medicine University of Massachusetts Chan Medical SchoolWorcesterMA 01605USA Maine Medical Center Research Institute ScarboroughMEUSA Molecular Physiology and Biophysics Vanderbilt UniversityNashvilleTN 37232USA

Bone formation is a highly energy-demanding process that can be impacted by metabolic *** has been considered the principal substrate for osteoblasts,although fatty acids are also important for osteoblast ***,we report that osteoblasts can derive energy from endogenous fatty acids stored in lipid droplets via lipolysis and that this process is critical for bone *** such,we demonstrate that osteoblasts accumulate lipid droplets that are highly dynamic and provide the molecular mechanism by which they serve as a fuel source for energy generation during osteoblast *** cytoplasmic lipolysis leads to both an increase in lipid droplet size in osteoblasts and an impairment in osteoblast *** fatty acids released by lipolysis from these lipid droplets become critical for cellular energy production as cellular energetics shifts towards oxidative phosphorylation during nutrient-depleted *** vivo,conditional deletion of the ATGL-encoding gene Pnpla2 in osteoblast progenitor cells reduces cortical and trabecular bone parameters and alters skeletal lipid ***,our data demonstrate that osteoblasts store fatty acids in the form of lipid droplets,which are released via lipolysis to support cellular bioenergetic status when nutrients are *** in this process result in impairment of bone formation,specifically reducing ATP production and overall osteoblast function.

关键词： endogenous maintain osteoblast

Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing

在线全文

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2015年第7期21卷 2011-2029页

作者： Rajagopal N Aravalli Neil C Talbot clifford j Steer Department of Radiology University of Minnesota Medical School Minneapolis Beltsville Agricultural Research Center US Department of Agriculture Departments of Medicine and Genetics Cell Biology and Development University of Minnesota

AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem ***:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in ***-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human *** identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RNA sequencing,and genes identified by this method were validated using real-time *** vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient ***:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and *** ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and ***,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,ENPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for ***:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver.

关键词： Hepatocellular carcinoma MYC Stem cells Gene expre

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Flash好莱坞20动画革命

丛书名：游戏开发经典丛书

2006年

作者：（美）Sandro Corsaro （美）clifford j. Parrott 涂颖芳熊炜张骥译

本书通过大量精美实例介绍如何用Flash解决在影视动画中经常遇到的角色设计、镜头移动、动画特效和音频处理等问题。

ISBN: (纸本)7302124906

本书通过大量精美实例介绍如何用Flash解决在影视动画中经常遇到的角色设计、镜头移动、动画特效和音频处理等问题。

关键词：图形软件动画

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Linux IP协议栈源代码分析第一版