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Seasonal changes in sperm parameters, testicular histology and circulating levels of reproductive hormones in the male African straw-colored fruit bat (Eidolon helvum)

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Asian pacific Journal of Reproduction 2020年第4期9卷 197-203页

作者： clifford N Abiaezute Chike F Oguejiofor Innocent C Nwaogu Ikechukwu R Obidike Udensi M Igwebuike Department of Veterinary Anatomy Faculty of Veterinary MedicineUniversity of NigeriaNsukka 410001Nigeria Department of Veterinary Obstetrics and Reproductive Diseases Faculty of Veterinary MedicineUniversity of NigeriaNsukka 410001Nigeria Department of Veterinary Physiology and Pharmacology Faculty of Veterinary MedicineUniversity of NigeriaNsukka 410001Nigeria

Objective: To investigate seasonal changes in some reproductive characteristics of the male African straw-colored fruit bat [Eidolon (E.) helvum] in a tropical rain forest area of South-East ***: Spermatozoal characteristics in the testes and cauda epididymides, testicular histology, and the circulating levels of the reproductive hormones, testosterone, follicle stimulating hormone and luteinizing hormone were evaluated in male bats captured in late January (peak dry season), late May (early rainy season) and late September (late rainy season) of 2019. The bats were captured in Obiagu community in Enugu State, South-East Nigeria. Data were analyzed with analysis of variance. Results: There were high serum concentrations of testosterone in early and late rainy season and of luteinizing hormone in early rainy season, but the concentrations of both hormones were low during peak dry season. These hormonal changes corresponded with the testicular seminiferous and spermatogenic activities and testicular and epididymal sperm concentrations, which were also maximal during early and late rainy season but minimal during peak dry season. Epididymal sperm motility and vitality were also high in early and late rainy season but low in peak dry season, while sperm morphological abnormalities were low in early and late rainy season but elevated in peak dry season. There was histological evidence that spermatogenesis did not cease completely during testis regression, but continued at a reduced rate during the dry season. Conclusions: The findings do not support concurrent epididymal sperm storage with testis regression in E. helvum. Altogether, these indicate that seasonal changes significantly alter sperm characteristics, testicular histology and circulating levels of reproductive hormones in E. helvum within the study area.

关键词： Eidolon helvum Spermatozoa Reproductive characteristics Seasonal changes

On the Fourier Spectra of Distributions in clifford Analysis

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Chinese Annals of Mathematics,Series B 2006年第5期27卷 495-506页

作者： Fred BRACKX Bram De KNOCK Hennie De SCHEPPER clifford Research Group Department of Mathematical Analysis Faculty of EngineeringGhent UniversityGalglaan 29000 GentBelgium

在由 Brackx 的最近的报纸， Delanghe；Sommen，一些基本更高维的分布在克利福德分析的框架被重新考虑，最后在欧几里德几何学的空格导致新分布的四个宽广的类的介绍。在当前的纸，我们继续这些分布的深入的学习，更明确地他们在频率... 详细信息

在由 Brackx 的最近的报纸， Delanghe；Sommen，一些基本更高维的分布在克利福德分析的框架被重新考虑，最后在欧几里德几何学的空格导致新分布的四个宽广的类的介绍。在当前的纸，我们继续这些分布的深入的学习，更明确地他们在频率空间的行为的学习，泛音分析的因此延长的古典结果。

关键词：傅立叶光谱分布 clifford分析基础高阶分布框架

Zinc Complexes of New Chiral Aminophenolate Ligands: Synthesis, Characterization and Reactivity toward Lactide

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Open Journal of Inorganic Chemistry 2016年第3期6卷 205-218页

作者： Pascal Binda Kimberly Rivers clifford Padgett Department of Chemistry and Forensic Science Savannah State University Savannah GA USA Department of Chemistry and Physics Armstrong State University Savannah GA USA

The syntheses of a library of new chiral aminophenolate bidentate O,N-type ligands HOC6H4(2-R- 4-R′)CH2N(Me)CH(Me)C6H5 [R = R′ = But, 1;R = R′ = Pent, 2;R = But, R′ = Me, 3;R = Me, R′ = But, 4;R = R′ = Me, 5] and tridentate O,N,O-type ligands HOC6H4(2,4-But)CH = NCH(R′′)C6H5 [R′′ = Me, 6;R′′ = CH2OMe, 7] are reported. These ligands were characterized by elemental analysis, nuclear magnetic resonance spectroscopy (1H & 13C), and single crystal X-ray diffraction. These ligands serve as chiral auxiliaries for inorganic chemists to design chiral metal-based complexes for asymmetric catalysis and stereoselective polymerization reactions. Three new heteroleptic zinc complexes based on these ligands have been synthesized in moderate yields via a ligand-exchange transamination reaction between homoleptic [Zn(N(SiMe3)2)2] and one equivalent of corresponding ligands to afford [L3ZnN- (SiMe3)2] (3a), [L4ZnN(SiMe3)2] (4a), and [L7ZnN(SiMe3)2] (7a). Solvent-free polymerization of raclactide at 130°C using these zinc compounds yielded atactic polylactides with Mw 10,000 g/mol and narrow polydispersity of 1.3.

关键词： Chiral Ligands Aminophenolate Zinc Lactide Polymerization

Metabolic programming determines the lineage-differentiation fate of murine bone marrow stromal progenitor cells

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Bone Research 2019年第4期7卷 410-423页

作者： Michaela Tencerova Elizabeth Rendina-Ruedy Ditte Neess Nils Faergeman Florence Figeac Dalia Ali Morten Danielsen Anders Haakonsson clifford J.Rosen Moustapha Kassem Department of Molecular Endocrinology University of Southern Denmark and Odense University Hospital5000 OdenseDenmark Center for Molecular Medicine Maine Medical Center Research InstituteScarboroughME 04074USA Villum Center for Analytical Biosciences Department of Biochemistry and Molecular BiologyUniversity of Southern Denmark5230 OdenseDenmark MSOmics 2950 CopenhagenDenmark Department of Cellular and Molecular Medicine Novo Nordisk Foundation Center for Stem Cell Biology(DanStem)University of Copenhagen2200 CopenhagenDenmark

Enhanced bone marrow adipogenesis and impaired osteoblastogenesis have been observed in obesity,suggesting that the metabolic microenvironment regulates bone marrow adipocyte and osteoblast progenitor differentiation *** determine the molecular mechanisms,we studied two immortalized murine cell lines of adipocyte or osteoblast progenitors(BMSCs^adipo and BMSC^sosteo,respectively)under basal and adipogenic culture *** baseline,BMSCs^adipo,and BMSCs^osteo exhibit a distinct metabolic program evidenced by the presence of specific global gene expression,cellular bioenergetics,and metabolomic signatures that are dependent on insulin signaling and glycolysis in BMSCs^osteo versus oxidative phosphorylation in BMSCs^*** test the flexibility of the metabolic program,we treated BMSCsadipo with parathyroid hormone,S961(an inhibitor of insulin signaling)and oligomycin(an inhibitor of oxidative phosphorylation).The treatment induced significant changes in cellular bioenergetics that were associated with decreased adipocytic ***,12 weeks of a high-fat diet in mice led to the expansion of adipocyte progenitors,enhanced adipocyte differentiation and insulin signaling in cultured *** data demonstrate that BMSC progenitors possess a distinct metabolic program and are poised to respond to exogenous metabolic cues that regulate their differentiation fate.

关键词： progenitor impaired programming

Identifying and validating novel analgesic drug targets

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Identifying and validating novel analgesic drug targets

大跨度节段拼装混凝土桥梁的耐久性设计和施工

第十五届国际药理学大会

作者： clifford J Woolf Neural Plasticity Research Group Department of Anesthesia and Critical CareMassachusetts General Hospital and Harvard Medical SchoolBostonMAUSA

＜正＞ A feature of both inflammatory and neuropathic pain is the induction either in immune cells or in neurons, of very many genes. Expression profile analyses performed with high-density oligonucleotide microarrays have revealed many hundreds of genes whose transcripts are dynamically either up- or down regulated in the peripheral or central nervous system in multiple pain-related rodent models. The challenge is how to identify which of the induced genes are potential targets for the development of new analgesics. We find that only 10 % of all transcripts identified from a replicate array analysis as changing in three neuropathic pain models in the dorsal root ganglion or dorsal horn are common to all the models. We have analyzed this subset for novel potential analgesic target candidates using gain and loss of function strategies in vivo and in vitro to try establish how they contribute to increased pain sensitivity and if blcoking their activity produces analgesia. A single nucleotide polymorphism analysis of the candidates in patients with chronic pain was also performed to establish validity of the targets in humans. Several candidates that have emerged from this approach will be presented.

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公路 2009年第5期54卷 43-47页

作者： clifford Lloyd Freyermuth 美国节段拼装桥梁学会

全美现在共有597479座桥梁。绝大多数桥梁都是在两次桥梁建设大潮中建起来的，一次是在经济大萧条之后，另一次是在州际公路大规模建设时期。因此许多桥梁都已经有40～70年的使用期了，逐渐开始达到它们的使用寿命。从2006年12月联邦公... 详细信息

全美现在共有597479座桥梁。绝大多数桥梁都是在两次桥梁建设大潮中建起来的，一次是在经济大萧条之后，另一次是在州际公路大规模建设时期。因此许多桥梁都已经有40～70年的使用期了，逐渐开始达到它们的使用寿命。从2006年12月联邦公路管理署的NBI数据可知，其中有73798座桥梁（占桥梁总数的12．5％）被认定为具有结构缺陷。另外有80317座桥梁被列为功能老化桥梁。本文针对这些结构缺陷的桥梁进行讨论。

关键词：混凝土桥梁耐久性大跨度拼装

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世界灵巧炸弹的发展

飞航导弹 1993年第7期 5-10页

作者： clifford Beal 思棋

介绍了决定灵巧炸弹导引头选用的两个重要因素——成本和导引头灵敏度,以及一些国家灵巧炸弹的发展现状和研究计划。

关键词：炸弹自主制导组合制导导引头

Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第28期25卷 3704-3721页

作者： clifford Akateh Sylvester M Black Lanla Conteh Eric D Miller Anne Noonan Eric Elliott Timothy M Pawlik Allan Tsung Jordan M Cloyd Department of Surgery The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Transplant Surgery Department of Surgery The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Gastroenterology Hepatology and Nutrition Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus OH 43210 United States Department of Radiation Oncology The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Medical Oncology Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Diagnostic Radiology Department of Radiology The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Surgical Oncology Department of Surgery The Ohio State University Wexner Medical Center Columbus OH 43210 United States

Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research.

关键词： Hepatocellular carcinoma Neoadjuvant therapy Adjuvant therapy Neoplasm recurrence Hepatectomy Liver cirrhosis

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世界防区外发射武器的发展

飞航导弹 1993年第4期 18-23页

作者： clifford Beal 郭福清

目前军方和工业界正根据海湾战争的经验研究下一代防区外发射武器(SOW),评估此类武器的设计和作战策略。包括自主制导,人在回路,射程与有效载荷、动力和非动力运载器以及攻击各种潜在目标的战斗部和子弹药等方面。

关键词：防区外发射武器空对面导弹