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Plant Communications 2024年第4期5卷 129-132页

作者： Enzo Lezin Ines Carqueijeiro clement cuello Mickael Durand Hans JJansen Valentin Verges Caroline Birer Williams Audrey Oudin Thomas Duge de Bernonville Julien Petrignet Noemie Celton Benoit St-Pierre Nicolas Papon Chao Sun Ron P.Dirks Sarah Ellen O’Connor Michael Krogh Jensen Sebastien Besseau Vincent Courdavault Biomole´cules et Biotechnologies Vegetales EA2106Universite´de Tours37200 ToursFrance Future Genomics Technologies 2333 BE Leidenthe Netherlands Laboratoire Synthe se et Isolement de Molecules BioActives(SIMBA EA 7502)Universitede Tours37200 ToursFrance Laboratoire de Cytoge´netique Constitutionnelle CHRU de Tours-Hopital Bretonneau37044 ToursFrance University Angers University BrestIRFSFR ICAT49000 AngersFrance Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 2800China Department of Natural Product Biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Novo Nordisk Foundation Center for Biosustainability Technical University of Denmark100193 Kgs LyngbyDenmark Present address:Limagrain Center de RechercheRoute d’EnnezatChappesFrance These authors contributed equally to this article

Dear Editor,Rauvolfia tetraphylla(aka the Devil pepper)(Supplemental Figure 1)is a well-known medicinal plant that produces monoterpenoid indole alkaloids(MIAs).This MIA biosynthesis occurs in several organs,including leaves,stems,fruit,and roots,which accumulate the famous antiarrhythmic ajmaline(Kumar et al.2016a,2016b;Kumara et al.,2019).MIAs are natural products notably involved in plant adaptation to the environment and defense against *** mainly results from their high biological activities,which also explain their pharmacological properties.

关键词： properties Figure roots

In‑depth proteome characterization of endometrium and extraembryonic membranes during implantation in pig

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1027-1055页

作者： Maria A.Gil Josep M.Cambra Heriberto Rodriguez‑Martinez Cristina cuello Inmaculada Parrilla Emilio A.Martinez Department of Medicine and Animal Surgery International Excellence Campus for Higher Education and Research“Campus Mare Nostrum”University of MurciaMurciaSpain Institute for Biomedical Research of Murcia(IMIB-Pascual Parrilla) MurciaSpain Technical University of Munich MunichGermany Department of Biomedical&Clinical Sciences(BKV) BKH/Obstetrics&GynaecologyLinkoping UniversityLinkopingSweden

Background Proteome characterization of the porcine endometrium and extraembryonic membranes is important to understand mother-embryo *** this study,the proteome of the endometrium and cho-rioallantoic membrane was characterized in pregnant sows(PS)during early gestation(d 18 and 24 of gestation)and in the endometrium of non-pregnant sows(NPS)during the same days using LC-MS/MS *** UniProtKB database and ClueGO were used to obtain functional Gene Ontology annotations and biological and functional networks,*** Our analysis yielded 3,254 and 3,457 proteins identified in the endometrium of PS and NPS,respectively;of these,1,753 being common while 1,501 and 1,704 were exclusive to PS and NPS,*** addition,we iden-tified 3,968 proteins in the extraembryonic membranes of *** analyses of function revealed some proteins had relevance for the immune system process and biological adhesion in endometrium while the embryonic chorion displayed abundance of proteins related to cell adhesion and cytoskeletal organization,suggesting they dominated the moment of endometrial remodeling,implantation and adhesion of the lining *** are available via Pro-teomeXchange with identifier *** This is the first in-depth proteomic characterization of the endometrium and extraembryonic mem-branes during weeks 3 to 4 of gestation;data that contribute to the molecular understanding of the dynamic environ-ment during this critical period,associated with the majority of pregnancy losses.

关键词： Endometrium Extraembryonic membranes Implantation Pig Proteome

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Study of the Textural Properties of Bovine Bones Char under Different Conditions

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Journal of Water Resource and Protection 2011年第3期3卷 176-181页

作者： Juan C. Moreno-Piraján Liliana Giraldo Vanessa S. García-cuello 不详

Environmental pollution is today a very important issue and the development of low cost materials and different sources need to be investigated. Our research group for several years she has been the development of adsorbent materials for industrial wastewater treatment and rivers. In this research compares the porosity developed by two different treatments using bovine bones to adsorb metal ions. Using bovine bones as raw material, two carbonized samples were obtained under different conditions. One of the carbonized samples was obtained in an oxidizing atmosphere at up to 600℃ for 2 hours. The other was obtained in an inert atmosphere at up to 800℃, during 2 hours. Different textural characteristics were obtained in each of the carbonized samples according to the conditions of synthesis. The carbonized sample obtained in the oxidizing atmosphere, CHUOX, produces a great pore distribution, with a significant mesopore volume, reflected in the hysteresis loop, while in carbonized bone obtained in an inert atmosphere, CHUN, a formation of micropores and mesopores smaller than that obtained in the other carbonized sample is observed. The surface area obtained is 130 m2 g-1 for CHUOX and 170 m2 g-1 for CHUN. Furthermore, the adsorption capacity of Ni2+ and Cu2+ ions from solution was measured for these two carbonized samples, and a higher retention of both ions in the carbonized sample obtained in the inert atmosphere was found, with values between 28.57 and 67.56 mg g-1. The immersion enthalpies of carbonized samples in ion solutions are determined with an exothermic effect for the solution-solid interaction.

关键词： Adsorption Heavy Metals Water Immersion Calorimetry Bovine Bone

CrN-Encapsulated Hollow Cr-N-C Capsules Boosting Oxygen Reduction Catalysis in PEMFC

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CCS Chemistry 2021年第5期3卷 208-218页

作者： Hui Yang Xu Wang Tao Zheng Nelly Cantillo cuello Gabriel Goenaga Thomas A.Zawodzinski He Tian Joshua T.Wright Robert W.Meulenberg Xiangke Wang Zhenhai Xia Shengqian Ma College of Environmental Science and Engineering North China Electric Power UniversityBeijing 102206 State Key Laboratory of Silicon Materials Center of Electron MicroscopySchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027 Department of Materials Science and Engineering University of North TexasDentonTX 76203 Chemical and Biomolecular Engineering Department University of TennesseeKnoxvilleTN 37996 Department of Physics Illinois Institute of TechnologyChicagoIL 60616 Department of Physics and Astronomy Frontier Institute for Research in Sensor TechnologiesUniversity of MaineOronoME 04469 Department of Chemistry University of North TexasDentonTX 76201

Understanding the origin of the catalytic activity for the development of efficient catalysts is critical yet ***,we report a simple strategy for the synthesis of chromium nitride nanoparticles(CrNNPs)encapsulated into hollow chromium-nitrogen-carbon capsules(CrN@H-Cr-N_(x)-C).The CrN@H-Cr-N_(x)-C demonstrated excellent electrocatalytic activity for the oxygen reduction reaction(ORR)in acidic *** applied as a cathode material in a proton-exchange membrane fuel cell(PEMFC),the CrN@H-Cr-N_(x)-C achieved outstanding initial performance,which is better than that of the PEMFC with H-Cr-N_(x)-C cathode *** CrN@H-Cr-N_(x)-C cathode also showed good stability over 110 h of *** results demonstrated that the coexistence of atomically dispersed CrN_(x) sites and sufficient CrNNPs is essential for excellent PEMFC *** functional theory(DFT)studies further corroborated that CrNNPs can boost the ORR activity of H-Cr-N_(x)-*** finding opens a new avenue for the fabrication of low-cost,highly active,and durable ORR catalysts for PEMFC and other applications.

关键词： chromium-nitrogen-carbon fuel cell chromiumnitride metal-organicframework durability

中世纪向近代过渡期间格拉那达王国之盐与饮食

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盐业史研究 2001年第4期 26-32页

作者： Antonio MALPICA cuello 郝名玮世界历史研究所

引言盐是中世纪经济生活中的一种非常重要的产品.其重要性体现在生产活动的许多方面:主要供食用,同时也用于贮存食物和食品加工.也就是说,盐通常用作调味品,并用于保存食物(特别是肉类和鱼类),从而就有了便于交易的剩余产品.此外,牛饲... 详细信息

引言盐是中世纪经济生活中的一种非常重要的产品.其重要性体现在生产活动的许多方面:主要供食用,同时也用于贮存食物和食品加工.也就是说,盐通常用作调味品,并用于保存食物(特别是肉类和鱼类),从而就有了便于交易的剩余产品.此外,牛饲料中也必须拌之以盐.

关键词：格拉那达王国盐业经济研究市政法令中世纪盐业史

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Adjuvants Derived from Neisseria meningitidisSerogroup B Induce a Cross Reactive Response against Neisseria gonorrhoeaein Mice

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Open Journal of Immunology 2020年第3期10卷 47-58页

作者： Laura M. Reyes Miriam Lastre Maribel cuello Osmir Cabrera Yusnaby Borrego Raúl Ramos Pupo Steve Black Oliver Pérez Department of Immunology Instituto de Ciencias Básicas y Preclínicas “Victoria de Girón” Universidad de Ciencias Médicas de la Habana Havana Cuba Facultad de Ingenierías Universidad Técnica “Luis Vargas Torres” de Esmeraldas Esmeralda Ecuador Biomedical Research Institute (BIOMED). Faculty of Medicine and Life Sciences Hasselt University Hasselt Belgium Cincinnati Children’s Hospital Cincinnati USA

Introduction: Neisseria is a large genus of bacteria that colonize mucosal surfaces. Of the 11 species that colonize humans, only two are pathogens, N. meningitidis and N. gonorrhoeae. Both are obligate human pathogens;the last is causal agent of gonorrhea disease. Although curable with timely antibiotic treatment, an annual incidence of more than 62 million cases is estimated by the World Health Organization and there are no successful vaccines available. In contrast, several prophylactic vaccine options for Neisseria meningitidis meningitis do exist. Of note, there is trace of cross parenteral response induced between N. meningitidis and N. gonorrhoeae, and Proteoliposome (PL, also named outer membrane vesicles, OMV) vaccine has shown high impact on this response. Objective: To determine effect of VAMENGOC-BC? and its derivates (AFPL1 and AFCo1) at mucosal and systemic level and possible cross response against Neisseria gonhorroeae in Balb/c and C57Bl/6 mice. Methods: We evaluated cross response against N. gonorrhoeae in mouse serum IgG and saliva IgA after mucosal immunization with VA-MENGOC-BC or its derivatives (AF, Adjuvant Finlay PL1 or AFCo (cochleate) 1). Results: Immunizations with AFPL1 or AFCo1 induce anti N. gonorrhoeae at saliva IgA and serum IgG responses similar to VA-MENGOC-BC? vaccine. Conclusions: Such data confirms a new possible window of prime-boost vaccination strategy against gonorrhea and extends our knowledge regarding the effect of PL vaccines on cross responses.

关键词： N. meningitidis N. gonorrhoeae Vaccine Cross Reactivity

First Characterization of Escherichia coliStrains Isolated from Wildlife Griffon Vulture (Gyps fulvus) in the Southeast of Spain

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Open Journal of Veterinary Medicine 2014年第12期4卷 329-333页

作者： Azucena Mora Nieves Ortega Elena Garcia Susana Viso Mónica G. Candela Ghizlane Dahbi Francisco cuello María Rosa Caro Laboratorio de Referencia de E. coli (LREC) Departamento de Microbiología y Parasitología Facultad de Veterinaria Universidad de Santiago de Compostela Lugo Spain Departamento de Sanidad Animal Facultad de Veterinaria Campus de Espinardo Universidad de Murcia Murcia Spain

The aim of the present study was to characterize a collection of Escherichia coli strains isolated from asymptomatic griffon vulture (Gyps fulvus) during a reintroduction program in the southeast of Spain, in order to establish if griffon vulture could play a role in the spread of resistant or potentially pathogenic E. coli strains. For this purpose, 14 E. coli strains obtained from 10 griffon vulture were studied to establish their serotypes, phylogroups, virulencegene profiles and antimicrobial resistances. High heterogeneity was observed within the 14 strains isolated which belonged to three phylogroups (A, B1 and D), 8 serogroups (O2, O21, O29, O60, 073, O78, O103 and O141) and 13 different serotypes. Out of 34 genes screened, we have detected eight virulence genes that are typical of extraintestinal pathogenic E. coli (ExPEC) (fimH, fimAvMT78, iroN, iucD, cvaC, iss, traT and tsh);however, none of the studied strains showed the ExPEC status. The 14 strains were also analyzed for the production of extended-spectrum beta-lactamases (ESBLs) and for antimicrobial resistances. None of the 14 strains were ESBL-producing E. coli, but high resistance-prevalences to ampicillin and cotrimoxazole were detected. To our knowledge, this is the first characterization of E. coli strains isolated from griffon vulture and although they did not show high virulencegene scores, they showed cotrimoxazole resistance.

关键词： Antibiotic Resistance APEC Escherichia coli ExPEC Griffon Vulture

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双杂交瘤和双特异性单克隆抗体的制备

细胞与分子免疫学杂志 1986年第Z1期 115-120页

作者： C.Milstein A.C.cuello 黄其全

目前已可应用细胞融合技术来产生具有两种不同特异性的抗体。本文中***和***讨论了他们设计的这一方法的理论基础,及其在组织化学和免疫试验中的初步应用。

关键词：抗体特异性双杂交瘤脑激素多肽激素重链轻链

Neonatal Necrotizing Fasciitis after Circumcision: A Case Report and Review of Literature

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Open Journal of Pediatrics 2016年第1期6卷 29-33页

作者： Ada L. Rivera Cruz Zasha F. Vázquez Colón Hector Quintero Cesar Carballo cuello Victor N. Ortiz Justiniano Puerto Rico Children’s Hospital Bayamón Puerto Rico Universidad Central del Caribe School of Medicine Bayamón Puerto Rico Pediatric Surgery Department Puerto Rico Children’s Hospital Bayamón Puerto Rico UPR School of Medicine San Juan Puerto Rico

Background: Necrotizing fasciitis is a soft tissue infection that occurs predominantly in adults. Although rare, only 70 cases have been reported in neonates. This entity, most commonly caused by multiple organisms is often fatal, with 50% mortality. The combination of a low incidence and high mortality in this subgroup strengthens the need for early diagnosis, prompt recognition and immediate surgical treatment in order to improve survival. Aim: The aim of this case report is to bring awareness of a clinical condition that relies mostly on physical examination and where early diagnosis and immediate surgical treatment are needed in order to improve survival. Case presentation: We report the case of an 8-day-old boy presenting neonatal necrotizing fasciitis after circumcision. Patient presented with lower back erythema and areas of fluctuation. He was started on antibiotic therapy and 24 hours after admission, he was taken to the operating room for multiple fasciotomies, debridement and cleansing of affected areas. Findings were consistent with necrotizing fasciitis. After surgical intervention, local care was given until complete healing was achieved, approximately one month after admission. Conclusion: The surgeon must be attentive for the possible occurrence of this lethal infection that may develop post operatively after clean or clean-contaminated procedures. Preparation for treating these patients immediately with adequate fluid resuscitation, appropriate antibiotics and aggressive surgical debridement of non-viable tissue will provide the maximal potential for recovery. These prompt measures will offer the best chance for survival and eventually decrease the 50% mortality rate associated to the neonatal population.

关键词： Cellulitis Abscess Subcutaneous Erythema Penrose Debridement Granulation

C群脑膜炎球菌多糖-蛋白结合疫苗在小鼠中的黏膜免疫应答

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国际生物制品学杂志 2007年第3期30卷 138-139页

作者： cuello M Cabrera O CampoJM 王石磊（摘）朱为（校）

目前大部分疫苗接种仍采作注射方式，然而，黏膜免疫接种的优点多于注射途径免疫。古巴Finlay研究所的cuello评估了其制备的C群脑膜炎球菌多糖-破伤风类毒素结合疫苗（MGCP-TT）在小鼠中的黏膜免疫应答。

关键词： C群脑膜炎球菌多糖黏膜免疫应答多糖-蛋白结合疫苗小鼠破伤风类毒素结合疫苗注射方式疫苗接种注射途径

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