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A new type numerical model for action balance equation in simulating nearshore waves

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Chinese Science Bulletin 2001年第11期46卷 963-968页

作者： Yan, YX Xu, fm Mao, LH Hohai Univ Res Inst Coastal & Ocean Engn Nanjing 210098 Peoples R China

Several current used wave numerical models are briefly described, the computing techniques of the source terms, numerical wave generation and boundary conditions in the action balance equation model are discussed. Not only the quadruplet wave-wave interactions, but also the triad wave-wave interactions are included in the model, so that nearshore waves could be simulated reasonably. The model is compared with the Boussinesq equation and the mild slope equation. The model is applied to calculating the distributions of wave height and wave period field in the Haian Bay area and to simulating the influences of the unsteady current and water level variation on the wave field. Finally, the developing tendency of the model is discussed.

关键词： action balance equation numerical generating waves quadruplet wave-wave interactions triad wave-wave interactions Boussinesq equation mild slope equation.

SYNTHESIS　OF　4－S－（1＂－ARYL－TETRAZOLE－5＂－YL）－4－DEOXY－4＇－DEMETHYL－EPIPODOPHYLLOTOXIN　ANALOGUES

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Chinese Chemical Letters 1995年第3期6卷 197-198页

作者： Lu, KK Liu, fm Chen, YZ Lanzhou Univ Dept Chem Lanzhou 730000 Peoples R China

As continuation of our study, 6 title compouds were synthesized by con- densing 1-aryl-5-mercapto-tetrazoles with 4'-demethyl-epipodophyllotoxin in the presence of CF3COOH(TFA).

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Ceramic Carbon/Polypyrrole Materials for the Construction of Bienzymatic Amperometric Biosensor for Glucose

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Chinese Chemical Letters 2001年第11期12卷 1011-1014页

作者： Tian, fm Zhu, LD Xu, B Zhu, GY Chinese Acad Sci Changchun Inst Appl Chem Electroanalyt Chem Lab Changchun 130022 Peoples R China

A novel amperometric glucose biosensor was constructed by electrochemical formation of a polypyrrole (PPy) membrane in the presence of glucose oxidase (GOD) on the surface of a horseradish peroxidase (HRP) modified ferrocenecarboxylic acid (FCA) mediated sol-gel derived ceramic carbon electrode. The amperometric detection of glucose was carried out at +0.16 V (vs. SCE) in 0.1 mol/L phosphate buffer solution (pH 6.9) with a linear response range between 8.0x10(-5) and 1.3x10(-3) mol/L of glucose. The biosensor showed a good suppression of interference and a negligible deviation in the amperometric detection.

关键词： biosensor for glucose polypyrrole ceramic carbon electrode sol-gel

Study on 3D Quantitative Structure-Activity Relationships of Taxoid

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Chinese Chemical Letters 1997年第10期8卷 893-896页

作者： Zhu, QQ Guo, ZR Huang, N Wang, MM Chu, fm CHINESE ACAD MED SCI INST MAT MEDDEPT SYNTH MED CHEMBEIJING 100050PEOPLES R CHINA

A series of 94 taxol analogues exhibiting antitumor activity were investigated using comparative molecular field analysis (CoMFA) method. The most optimal CoMFA from 80 compounds selected randomly yielded a two-components model, with significant cross-validation r(cv)(2) of 0.640 and conventional r(2) of 0.868. The robustness of the CoMFA model was further validated by prediction of 14 test set compounds. The CoMFA model explained present SAR and particularly the importance of the hydroxyl group at C-2' position and the stereochemistry at C-2' and C-3' positions.

关键词： Activity Study on 3D Quantitative Structure-Activity Relationships of Taxoid

Effects of DIMBOA on impulse discharges of maxillary lateral sensillum styloconicum of armyworm larvae

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Chinese Science Bulletin 1997年第1期42卷 72-76页

作者： Yang, DM Luo, L Yan, fm Cheng, HW Zhou, PA BEIJING UNIV COLL LIFE SCIBEIJING 100871PEOPLES R CHINA

THE DIMBOA (2, 4-dihydroxy-7-methoxy-1, 4-benzoxazin-3-one), a secondary product present in corn plants, plays an important role in protecting the plant against the pest attack. DIMBOA is rich in seedlings of cereal crops, especially in maize. Many investigators demonstrated a linear relationship between the DIMBOA content in plant and the resistance of the plant to pest. Feng et al. (1992) summarized that the toxicity of DIMBOA is associated

关键词： armyworm larvae gustatory chemoreceptor lateral sensillum styloconicum DIMBOA.

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无对应点匹配的三维重建

电子学报 1995年第9期23卷 6-11页

作者：丁明跃 Wahl.,fm 华中理工大学图象识别与工人智能研究所

本文首先纠正了基于二次曲线匹配视觉算法中所存在的推导错误，并对于重建曲线解的存在性进行了讨论，给出了一种能保证解存在的修改算法。其次，为了保证解的唯一性，我们给出了采用三眼视觉的唯一性匹配定理，最后采用机械零件进行了... 详细信息

本文首先纠正了基于二次曲线匹配视觉算法中所存在的推导错误，并对于重建曲线解的存在性进行了讨论，给出了一种能保证解存在的修改算法。其次，为了保证解的唯一性，我们给出了采用三眼视觉的唯一性匹配定理，最后采用机械零件进行了实验，证明所提出的方法可以快速、准确、完整地重建空间曲线。

关键词：立体视觉三维重建无对应点匹配视觉二次曲线

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

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World Journal of Gastrointestinal Oncology 2011年第6期3卷 79-98页

作者： Alexandra MJ Langers Hein W Verspaget Daniel W Hommes Cornelis fm Sier Department of Gastroenterology andHepatology Leiden University Medical CenterPO Box 96002300 RC LeidenThe Netherlands

Matrix metalloproteinases(MMPs) are implicated in cancer development and progression and are associated with ***-nucleotide polymorphisms(SNPs) of MMPs,most frequently located in the promoter region of the genes,have been shown to influence cancer susceptibility and/or *** of MMP-1,-2,-3,-7,-8,-9,-12,-13 and-21 and of the tissue inhibitor of metalloproteinases(TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract *** contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper.

关键词： Matrix metalloproteinase Tissue inhibitor of metalloproteinase Single nucleotide polymorphism Promoter region Digestive tract Cancer

倾斜试验中真假阳性的血流动力学和神经激素的研究

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中华心血管病杂志 2001年第8期29卷 473-477页

作者：王珂逄健 fm Leonelli 大连医科大学附属第一医院 116011 美国肯它基大学医学中心

目的　探讨血管迷走性晕厥患者和正常人倾斜试验阳性时不同的触发机制。方法　倾斜试验采用静息平卧 10min和 80°直立 30min。心脏监测仪连续监测心率和血压。试验阳性标准为晕厥先兆伴收缩压 <90mmHg (1mmHg =0 .133kPa)和 (或 )心率 ... 详细信息

目的　探讨血管迷走性晕厥患者和正常人倾斜试验阳性时不同的触发机制。方法　倾斜试验采用静息平卧 10min和 80°直立 30min。心脏监测仪连续监测心率和血压。试验阳性标准为晕厥先兆伴收缩压 <90mmHg (1mmHg =0 .133kPa)和 (或 )心率 <6 0次 /min。超声心动图于基础平卧 ,直立 2min和每隔 3min直至试验结束时连续记录左室内径及降低速率 ,左室短轴缩短分数 (SF)和每分心输出量 (CO)。同时测量平卧和直立时儿茶酚胺血浆浓度。试验分组为 :正常自愿者且倾斜试验阴性者 8例 (组 1) ,平均年龄 (34± 5 )岁 ;正常自愿者伴倾斜试验阳性者 8例 (组 2 ) ,平均年龄(31± 6 )岁 ;原因不明晕厥伴倾斜试验阳性者 16例 (组 3) ,平均年龄 (30± 9)岁。结果　三组间年龄、性别以及基础状态下心率 ,平均动脉压、左室内径、SF、CO和儿茶酚胺血浆浓度无明显差异。直立时各组发生改变为 :(1)组 3出现阳性反应时间明显短于组 2 [(10± 4)min比 (17± 8)min ,P <0 .0 5 ];(2 )组 3平均动脉压有即刻和持续性降低 ;(3)组 3左室舒张末期内径降低速率明显大于其他两组 ;(4)SF在组 3显著增强 ;(5 )肾上腺素浓度在组 3升高显著 ,试验终止时组 1为 (6 5± 35 )pg/ml,组 2为(78± 2 9)pg/ml,组 3为 (12 6± 80 )pg/ml (P均 <0 .0

关键词：血管迷走性晕厥倾斜台试验儿茶酚胺类超声心动描记术

Hemoglobin Subunit Beta Gene Polymorphism rs33949930 T>C and Risk of Sickle Cell Disease—A Case Control Study from Tabuk (Northwestern Part of Saudi Arabia)

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International Journal of Clinical Medicine 2016年第1期7卷 25-31页

作者： Rashid Mir Fawzia Sharaf Abu-Duhier fm Prince Fahd Bin Sultan Research Chair Division of Cancer Molecular Genetics Faculty of Applied Medical Sciences University of Tabuk Tabuk Kingdom of Saudi Arabia King Khaled Hospital Ministry of Health Tabuk Kingdom of Saudi Arabia

Background: Sickle cell disease and sickle cell trait are common erythrocyte disorders that are most often caused by a point mutation (rs334, designated HbS) in the hemoglobin beta gene (HBB);however of this fact, there is extreme variability in occurrence and clinical presentation of sickle cell disease which may be explained by some other genetic changes associated with the gene. In the present study we examined the association between HBB gene polymorphism rs33949930 T>C in the occurrence of sickle cell disease in Saudi Arabia population. Materials and Methods: A case control study of 100 sickle cell disease patients and 100 healthy controls from Tabuk, Saudi Arabia. HBB gene rs33949930 T>C polymorphism was analyzed using Allele specific polymerase chain reaction technique. Results: It was observed that the genotype percentages TT, TC and CC among the patients with sickle cell disease were 63.0%, 35.0% and 2.0% and healthy controls were 68.0%, 27.0% and 5.0% respectively. Allele frequency for T allele was observed to be fT = 0.20 and fT = 0.19, where as for C allele was fC = 0.80 and fC = 0.81 among cases and controls respectively (p = 0.29). Compared to the TT genotype, the odds ratio of 1.4 (95% CI 0.76 - 2.57), risk ratio of 1.2 (95% CI 0.86 - 1.65) and risk difference of 8.4 (-6.66 - 23.38) for heterozygous genotype of HBB rs33949930 T>C was observed in relation to sickle cell disease. In addition, some difference in the laboratory values was observed among sickle cell disease patients with the different variants of HBB gene rs33949930 T>C polymorphism, especially the carriers of heterozygous TC genotype;however, the difference doesn’t reach to statically significant number. Conclusion: Present study suggested that there was not any significant association between HBB gene rs33949930 T>C polymorphism and occurrence of sickle cell disease. However, the heterozygous TC genotype of the polymorphism showed some higher ratios among cases as compared to healthy con

关键词： Hemoglobin Subunit Beta (HBB) Sickle Cell Disease (SCD) Tabuk-Northwestern Part of Saudi Arabia