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Migration of bone marrow progenitor cells in the adult brain of rats and rabbits

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World Journal of stem Cells 2016年第4期8卷 136-157页

作者： Donnahue Dennie Jean-Pierre Louboutin David s strayer section of Anatomy Department of Basic Medical SciencesUniversity of the West IndiesMona Campus Department of Cell Biology Anatomy and PathologyThomas Jefferson University

Neurogenesis takes place in the adult mammalian brain in three areas:subgranular zone of the dentate gyrus(DG);subventricular zone of the lateral ventricle;olfactory *** molecular markers can be used to characterizethe cells involved in adult *** has been recently suggested that a population of bone marrow(BM)progenitor cells may migrate to the brain and differentiate into neuronal *** explore this hypothesis,we injected recombinant sV40-derived vectors into the BM and followed the potential migration of the transduced ***-term BM-directed gene transfer using recombinant sV40-derived vectors leads to expression of the genes delivered to the BM firstly in circulating cells,then after several months in mature neurons and microglial cells,and thus without central nervous system(CNs)*** of transgene-expressing cells expressed NeuN,a marker of mature ***,BM-derived cells may function as progenitors of CNs cells in adult *** mechanism by which the cells from the BM come to be neurons remains to be *** the observed gradual increase in transgene-expressing neurons over 16mo suggests that the pathway involved differentiation of BM-resident cells into neurons,cell fusion as the principal route cannot be totally ruled *** studies using similar viral vectors showed that BM-derived progenitor cells migrating in the CNs express markers of neuronal precursors or immature ***-positive cells were found in the subgranular zone of the DG of the hippocampus 16 mo after intramarrow injection of the *** addition to cells expressing markers of mature neurons,transgene-positive cells were also positive for nestin and doublecortin,molecules expressed by developing neuronal *** cells were actively proliferating,as shown by short term BrdU incorporation *** seizures by using kainic acid increased the number of BM progenitor cells transduced by sV40vectors migrating

关键词： stem cells Bone marrow Hippocampus Cell therapy sV40 Brain Nestin Doublecortin Neurons Development Epilepsy seizures

Interaction of a root-knot nematode (Meloidogyne hapla) and plant intraspecific diversity in clover-grass communities

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Journal of Plant Ecology 2019年第1期12卷 1-9页

作者： Xiaohui Guo Jana s.Petermann susanne Wurst Dahlem Centre of Plant sciences Institute of BiologyFreie Universität BerlinKönigin-Luise-Str.1-3Berlin D-14195Germany Key Laboratory of Biological and Ecological Engineering Ministry of EducationInstitute of Biodiversity ScienceFudan UniversitySonghu Road 2005Shanghai 200438China Berlin-Brandenburg Institute of Advanced Biodiversity Research Altensteinstr.34Berlin D-14195Germany Department of Ecology and Evolution University of SalzburgHellbrunnerstr.34Salzburg 5020Austria

Aims soil organisms can influence the plant diversity-productivity rela-tionship at species level;however,little is known about their role in the relationship at an intraspecific *** study aimed to investigate the interaction between the effects of plant intraspe-cific diversity and a root-knot nematode on primary production and community *** A greenhouse experiment was conducted by using intraspecific diversity of a clover-grass community through sowing 2-,4-,8-and 16-cultivar mixtures of Trifolium pratense *** Lolium perenne *** by adding the nematode Meloidogyne *** investigated the effects of plant intraspecific diversity and *** on biomass of plant community,biomass of cultivar individuals and community *** Findings We found that *** dominated the communities,yet its bio-mass was not affected by the *** hapla influ-enced the effect of plant intraspecific diversity on aboveground biomass of *** at the four-cultivar mixture level of plant intraspecific *** evenness increased linearly with increasing plant intraspecific diversity,and *** affected community evenness at the four-cultivar mixture *** ***-ense and *** cultivars differed in aboveground *** on plant intraspecific diversity and cultivar identity,nematode addition positively affected the aboveground biomass of *** *** response of *** cultivars to *** and to various plant intraspecific diversity levels influenced the intraspecific diversity-productivity *** study high-lights the influence of *** on the effect of plant intraspecific diversity on aboveground biomass of ***,suggesting that future research on the impact of intraspecific plant diversity on eco-system functions should consider the effects of soil organisms.

关键词： nematode diversity-productivity relationship biomass legume-grass community

Mapping cloud computing in university e-governance system

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International Journal of Intelligent Computing and Cybernetics 2018年第1期11卷 141-162页

作者： Maroof Naieem Qadri s.M.K.Quadri Directorate of IT&ss University of KashmirSrinagarIndia and PG Department of Computer ScienceUniversity of KashmirSrinagarIndia Department of Computer science Jamia Millia IslamiaNew DelhiIndia

Purpose–The purpose of this paper is to propose a model to map the on-premise computing system of the university with cloud computing for achieving an effective and reliable university e-governance(e-gov)***/methodology/approach–The proposed model incorporates the university’s internal e-gov system with cloud computing in order to achieve better reliability,accessibility and availability of e-gov services while keeping the recurring expenditure *** model has been implemented(and tested on a university e-gov system)in the University of Kashmir(UOK);case study of this implementation has been chosen as the research methodology to discuss and demonstrate the proposed ***–According to the results based on practical implementation,the proposed model is ideal for e-governed systems as it provided adequate cost savings and high availability(HA)with operational ease,apart from continuing to have the necessary security in place to maintain confidential information such as student details,grades,*** implications–The implication of this study is to achieve HA and to reduce the cost from using external clouds,mapping internal IT servers of the university with the external cloud computing ***/value–Because no established mapping model for universities has been provided for effective,low-cost,highly available university e-gov system,the proposed mapping model through this paper closes this gap and provides guidelines to implement a hybrid-mapped e-gov model for universities while keeping the recurring expenditure on cloud computing *** paper provides the perceptions of its adoption at UOK for achieving high reliability,accessibility and uptime of its e-gov applications while keeping the recurring expenditure on cloud computing minimal.

关键词： Universities Cloud computing Cloud services Hybrid computing Mapped computing University e-governance

Clay-polymer Nanocomposites: Preparation, Properties, Future Applications and New synthesis Approach of EPDM/clay Nanocomposites

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Journal of Harbin Institute of Technology(New series) 2004年第2期11卷 138-145页

作者： s.J.AHMADI 黄玉东李伟 Dept. of Applied Chemistry Harbin Institute of Technology Harbin 150001 China

The synthetic routes, materials properties and future applications of clay-polymer nanocomposites are reviewed. Nannocomposites are composite *** contain particles in the size rang 1-100 nm. The particles generally have a high aspect ratio and a layered structure that maximizes bonding between the polymer and particle. Adding a small quantity of these additives (0.5%～5%) can increase many of the properties of polymer materials, such as tensile characteristics, heat distortion temperature, scratch resistance, gas permeability resistance, and flame retardancy. This new type of materials may be prepared via various synthetic routes comprising exfoliation adsorption, in-situ intercalative polymerization and melt intercalation. In this paper we report the new method for preparation EPDM-clay nanocomposites. The EPDM-clay nanocomposites were prepared by using two different approaches (direct and indirect). It is found that there is no difference between both methods but the direct method is easier, its cost is lower and industrially more practical. X-ray diffraction (XRD) and transmission electron microscopy (TEM) results showed a exfoliation structure. The mechanical properties of these nanocomposites significantly improved.

关键词： nanocomposites organoclay intercalation exfoliation EPDM

The kinematical and space structures of IC 2391 open cluster and moving group with Gaia-DR2

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Research in Astronomy and Astrophysics 2020年第2期20卷 21-30页

作者： E.s.Postnikova W.H.Elsanhoury Devesh P.sariya N.V.Chupina s.V.Vereshchagin Ing-Guey Jiang Institute of Astronomy of Russian Academy of sciences(INAsAN) 48 Pyatnitskaya st.MoscowRussia Astronomy Department National Research Institute of Astronomy and Geophysics(NRIAG)11421HelwanCairoEgypt(Affiliation ID:60030681) Physics Department Faculty of Science and ArtsNorthern Border UniversityTuraif BranchSaudi Arabia Department of Physics and Institute of Astronomy “National Tsing Hua University”Hsinchu 30013

The kinematical parameters,spatial shape and structure of the open cluster IC 2391 and the associated stellar stream are studied here using Gaia Data Release 2(GDR2) astrometry *** apex positions are determined for the open cluster IC 2391(data taken from Cantat-Gaudin et al.) and for the kinematical stream’s stars mentioned in Montes et *** both convergent point and AD-diagram *** values of apex coordinates are:(A,D)CP=(6.~h17 ± 0.~h004,-6.°88 ± 0.°381;for cluster) and(6.~h07 ± 0.~h007,-5.°00 ± 0.°447;stream),and(A0,D0) =(6.~h12 ± 0.~h004,-3.°4 ± 0.°3;cluster) and(6.~h21 ±0.~h007,-11.°895 ± 0.°290;stream).The results are in good agreement with the previously calculated *** positions of the stars in the disk and the spatial dispersion velocities are *** paths of cluster and associated stream are traced in the disk by orbit calculation back in time to their places of formation.A possible genetic relationship between the cluster and stream has been *** approximation of the spatial and kinematical shape of the stream and the cluster is *** to this study,even though currently the cluster and stream seem to have a spatial difference in their locations,they appear to have formed in the same region of the Galactic disk.

关键词： stars:kinematics and dynamics Galaxy:stellar content (Galaxy:)open clusters and associations:individual:IC 2391

Insulin resistance and adipose tissue interactions as the cornerstone of metabolic(dysfunction)-associated fatty liver disease pathogenesis

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World Journal of Gastroenterology 2023年第25期29卷 3999-4008页

作者： shreya C Pal Nahum Méndez-sánchez Faculty of Medicine National Autonomous University of MexicoMexico City 04510Mexico Liver Research Unit Medica Sur Clinic&FoundationMexico City 04510Mexico

The relationship between metabolic derangements and fatty liver development are undeniable,since more than 75% of patients with type 2 diabetes mellitus present with fatty *** is also significant epidemiological association between insulin resistance(IR)and metabolic(dysfunction)-associated fatty liver disease(MAFLD).For little more than 2 years,the nomenclature of fatty liver of non-alcoholic origin has been intended to change to MAFLD by multiple *** a myriad of reasons for which MAFLD is thought to be of metabolic origin could be exposed,the bottom line relies on the role of IR as an initiator and perpetuator of this *** is a reciprocal role in MAFLD development and IR as well as serum glucose concentrations,where increased circulating glucose and insulin result in increased de novo lipogenesis by sterol regulatory elementbinding protein-1c induced lipogenic enzyme stimulation;therefore,increased endogenous production of *** same effect is achieved through impaired suppression of adipose tissue(AT)lipolysis in insulin-resistant states,increasing fatty acid influx into the *** complementary reciprocal situation occurs when liver steatosis alters hepatokine secretion,modifying fatty acid metabolism as well as IR in a variety of tissues,including skeletal muscle,AT,and the *** aim of this review is to discuss the importance of IR and AT interactions in metabolic altered states as perhaps the most important factor in MAFLD pathogenesis.

关键词： Metabolic(dysfunction)-associated fatty liver disease Insulin resistance Adipose tissue Fatty liver Metabolic syndrome Adipokine

Peristaltic transport of Herschel-Bulkley fluid in a non-uniform elastic tube

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Propulsion and Power Research 2019年第3期8卷 253-262页

作者： C.K.selvi A.N.s.srinivas Department of Mathematics School of Advanced SciencesVIT UniversityVellore632014TamilnaduIndia

The influence of elasticity on peristaltic transport of Herschel-Bulkley fluid in a tube of non-uniform cross-section is *** exact solutions for flow quantities such as velocity,stream function,pressure gradient,and volume flow rate are *** relationship between flux and pressure difference is *** effects of different pertinent parameters on variation of flux along the radius of the tube are analyzed through *** results show that the yield stress and fluid behavior index has significant effect on flux variation of Herschel-Bulkley fluid in a non-uniform elastic *** effect of elastic parameters on flux variation is *** phenomenon is presented graphically to understand the physical behavior of various *** the absence of non-uniform parameter the present results are similar to the observations of Vajravelu et al.[19].

关键词： Peristaltic flow Non-uniform tube Non-newtonian fluid Yield stress Volume flow rate Elasticity

Physiological traits contributed to the recent increase in yield potential of winter wheat from Henan Province, China

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Journal of Integrative Plant Biology 2014年第5期56卷 492-504页

作者： Bangwei Zhou álvaro sanz-sáez Abdelhalim Elazab Tianmin shen Rut sánchez-Bragado Jordi Bort Maria Dolors serret José Luis Araus Unit of Plant Physiology Faculty of Biology University of Barcelona Henan Tianmin seed Company Lankao County Department of Plant Biology University of Illinois Urbana-Champaign

This experiment aims to test the traits responsible for the increase in yield potential of winter wheat released in Henan Province, China. seven established cultivars released in the last 20 years and three advanced lines were assayed. The results showed that grain yield was positively correlated with harvest index（HI）, kernel number per square meter, and aboveground biomass. In addition, the HI and aboveground biomass showed an increasing trend with the year of ***, we can conclude that bread wheat breeding advances during recent decades in Henan Province, China,have been achieved through an increase in HI, kernel number per square meter, and aboveground biomass. A higher d13C seems also to be involved in these advances, which suggests a progressive improvement in constitutive water use efficiency not associated with a trend towards lower stomatal conductance in the most recent genotypes. However, genetic advance Researchdoes not appear related to changes in photosynthesis rates on area basis when measured in the flag leaf or the spike,but only to a higher, whole‐spike photosynthesis. Results also indirectly support the concept that under potential yield conditions, the spike contributed more than the flag leaf to kernel formation.

关键词： Carbon isotopes grain yield net carbon exchange nitrogen content yield potential

The Method of Fundamental solutions for solving Exterior Axisymmetric Helmholtz Problems with High Wave-Number

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Advances in Applied Mathematics and Mechanics 2013年第4期5卷 477-493页

作者： Wen Chen Ji Lin C.s.Chen College of Engineering Mechanics Hohai UniversityNanjing 210098JiangsuChina Department of Mathematics University of Southern MississippiHattiesburgMS 39406USA

In this paper,we investigate the method of fundamental solutions(MFs)for solving exterior Helmholtz problems with high wave-number in axisymmetric *** the coefficientmatrix in the linear system resulting fromtheMFs approximation has a block circulant structure,it can be solved by the matrix decomposition algorithm and fast Fourier transform for the fast computation of large-scale problems and meanwhile saving computer memory *** numerical examples are provided to demonstrate its applicability and efficacy in two and three dimensional domains.

关键词： Method of fundamental solutions exterior Helmholtz problem circulant matrix fast Fourier transform axisymmetric domain