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Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3163-3164页

作者： Marina Kolesnichenko claus Scheidereit Department of Hepatology and Gastroenterology Charite-Universitatsmedizin BerlinBerlinGermany Laboratory for Signal Transduction in Tumor Cells Max Delbruck Center for Molecular Medicine in the Helmholtz Association(MDC)BerlinGermany

In a landmark study recently published in Nature,Petropoulous et *** that synthetic lethality of poly(ADP-ribose)polymerase(PARP)inhibitors in cells with defective homologous recombination repair(HR)results predominantly from transcription replication conflicts(TRC)and not,as previously proposed,from PARP trapping on DNA(Fig.1).The article unveils a new mechanism behind synthetic lethality of PARP inhibitors with relevance for cancer therapy.

关键词： al. PARP mechanism

BFP1:One of 700 Arabidopsis F-box proteins mediates degradation of JA oxidases to promote plant immunity

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Molecular Plant 2024年第3期17卷 375-376页

作者： claus Wasternack Bettina Hause Department of Molecular Signal Processing Leibniz Institute of Plant Biochemistry7 Weinberg 306120 Halle(Saale)Germany Department of Cell and Metabolic Biology Leibniz Institute of Plant Biochemistry06120 Halle(Saale)Germany

A switch off in jasmonate(JA)signaling by hydroxylation upon wounding was described in 2008(Miersch et al.,2008).This initiated the cloning of CYP450 enzymes involved in hydroxylation and carboxylation of JA and its amino acid conjugate JA-le,the most active form of JA compounds(reviewed by Wasternack and Feussner[2018]and Heitz et al.[2019]).Due to the central role of JA and JA-lle in plant stress responses and development(Wasternack and Hause,2013),catabolism of JA and its derivatives is an essential component in the sustainment of homeostasis of active JA compounds(Howe et al.,2018;Heitz et al.,2019).Catabolism of JA and JAIle takes place by JA-induced oxygenases(JOXs),also named JA-oxidases(JAOs),and by hydroxylation(CYP94B3/B1)followed by carboxylation(CYP94C1),respectively(Heitz et al.,2019).Another reaction performed by IAR3/ILL6 results in the deconjugation of JA-lle and 12-OH-JA-le to JA and 12-OH-JA,respectively(Heitz et al.,2019;Wasternack and Feussner,2018).

关键词： conjugate initiated media

Learning from the COVID-19 pandemic:A systematic review of mathematical vaccine prioritization models

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Infectious Disease Modelling 2024年第4期9卷 1057-1080页

作者： Gilberto Gonzalez-Parra Md Shahriar Mahmud claus Kadelka Instituto de Matematica Multidisciplinar Universitat Politecnica de ValenciaValenciaSpain Department of Mathematics New Mexico Tech801 Leroy PlaceSocorro87801NMUSA Department of Mathematics Iowa State University411 Morrill RdAmes50011IAUSA

As the world becomes ever more connected,the chance of pandemics increases as *** recent COVID-19 pandemic and the concurrent global mass vaccine roll-out provides an ideal setting to learn from and refine our understanding of infectious disease models for better future *** this review,we systematically analyze and categorize mathematical models that have been developed to design optimal vaccine prioritization strategies of an initially limited *** older individuals are disproportionately affected by COVID-19,the focus is on models that take age explicitly into *** lower mobility and activity level of older individuals gives rise to non-trivial *** research questions concern the optimal time interval between vaccine doses and spatial vaccine *** review showcases the effect of various modeling assumptions on model outcomes.A solid understanding of these relationships yields better infectious disease models and thus public health decisions during the next pandemic.

关键词： Review Mathematical model Age COVID-19 Vaccine allocation Vaccine roll-out

Stress Relief Measurements in Young Adults and Adolescents—A Comparative Pilot Study with Different Relaxation Programs

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Open Journal of Preventive Medicine 2024年第6期14卷 131-142页

作者： Andrea Bevelaqua claus Muss St. Elisabeth University Bratislava Bratislava Slovakia Department of Public Health St. Elisabeth University Bratislava Bratislava Slovakia

Background: Chronic stress is a emotional challenge. Constant pressure presents a serious risk of damage to mental and physical health and hence is associated with increased incidence of various diseases. The ability to cope with chronic stress may be a function of psychological resilience including intellectual capacities, but more so of external factors such as life experience and education. Adolescents are more vulnerable to chronic stress than adults. The measures introduced during the COVID-19 pandemic brought up major societal problems. As both children and adolescents lost their life anchors, the prevalence of stress in adolescents increased from 20% to 45%. Chronic psychological stress can impede the normal development of schoolchildren. It may cause anxiety, social withdrawal, interpersonal conflicts and aggression. This applies particularly to those in puberty, with the adolescent already facing unstable social bonds and elevated fear about the future. It is likely that the puberty cohort accounts for the dramatic increase in the prevalence of stress. Since it impacts public health, chronic stress among school-age children is increasingly taking on a socio-political dimension. Non-clinical stress intervention studies can investigate how to achieve stress reduction in school children. Methods: In a small pilot study, we analysed the effects of a training program with four different standard interventions, i.e. mindfulness training, progressive muscle reflection, autogenic training, and sound meditation. We obtained baseline scores of 10 stress-indicators, and re-tested after the interventions were performed. Results: The four applied interventions resulted in a reduction of 8 (out of 10) stress-indicators, such as “feeling stressed” or stress related symptoms (headaches, dizziness, sweating). This positive impact of the interventions significantly reduced “Fears about the future” (p Discussion: School children recognise the positive potential of stress redu

关键词： Stress in Children and Young Adults Comparison of Different Stress Relief Interventions in a Cohort of Pupils

Optimal choice of Reed-Solomon codes to protect against queuing losses in wireless networks

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The Journal of China Universities of Posts and Telecommunications 2009年第3期16卷 71-83页

作者： claus Bauer Dolby Laboratories 100 Potrero Avenue San Francisco

This article proposes algorithms to determine an optimal choice of the Reed-Solomon forward error correction （FEC） code parameters （n,k） to mitigate the effects of packet loss on multimedia traffic caused by buffer overflow at a wireless base station. A network model is developed that takes into account traffic arrival rates, channel loss characteristics, the capacity of the buffer at the base station, and FEC parameters. For Poisson distributed traffic, the theory of recurrent linear equations is applied to develop a new closed form solution of low complexity of the Markov model for the buffer occupancy. For constant bit rate （CBR） traffic, an iterative procedure is developed to compute the packet loss probabilities after FEC recovery.

关键词： FEC packet loss buffer occupancy Markov model

Sums of Five Almost Equal Prime Squares

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Acta Mathematica Sinica,English Series 2005年第4期21卷 833-840页

作者： claus BAUER Dolby Laboratories 100 Potrero AvenueSan FranciscoCA94103USA

Let Pi, 1≤i≤5, be prime numbers. It is proved that every integer N that satisfies N=5 （mod 24） can be written as N=p1^2＋p2^2＋P3^2＋p4^2 ＋p5^2, where │√N5-Pi│≤N^1/2-19/850＋∈.

关键词： Prime numbers Exponential sums L-functions

Large sieve inequality with sparse sets of moduli applied to Goldbach conjecture

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Frontiers of Mathematics in China 2017年第2期12卷 261-280页

作者： claus BAUER Dolby Laboratories Beijing 100020 China

We use the large sieve inequality with sparse sets of moduli to prove a new estimate for exponential sums over primes. Subsequently, we apply this estimate to establish new results on the binary Goldbach problem where... 详细信息

关键词： Three primes theorem exponential sums over primes sparse set ofmodules

The Short Local Algebras of Dimension 6 with Non-projective Reflexive Modules

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Communications in Mathematics and Statistics 2023年第2期11卷 195-227页

作者： claus Michael Ringel Fakultät für Mathematik Universität BielefeldPO Box 10013133501 BielefeldGermany

Let A be a finite-dimensional local algebra over an algebraically closed field,let J be the radical of *** modules we are interested in are the finitely generated left *** are always reflexive,and an algebra is self-injective iff allmodules are *** discuss the existence of non-projective reflexive modules in case A is not *** assume that A is short(this means that J^(3)=0).In a joint paper with Zhang Pu,it has been shown that 6 is the smallest possible dimension of A that can occur and that in this case the following conditions have to be satisfied:J^(2)is both the left socle and the right socle of A and there is no uniform ideal of length *** present paper is devoted to showing the converse.

关键词： Short local algebra Reflexive module Gorenstein-projective module Bristle Atom Bar Bristle-bar layout

Determination of sex by jasmonate^FA

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Journal of Integrative Plant Biology 2020年第2期62卷 162-164页

作者： claus Wasternack Department of Molecular Signal Processing Leibniz Institute of Plant BiochemistryHalle(Saale)D‐06120Germany Laboratory of Growth Regulators Institute of Experimental Botany AS CR&Palacky UniversityOlomoucCZ‐78371Czech Republic

Jasmonic acid (JA) and some of its derivatives are important signals in plant stress responses such as biotic or abiotic stresses during alteration of the environment and are signals in several developmental processes such as trichome development, growth/defense balance, root growth, senescence, or light signaling (Wasternack and Hause 2013).

关键词： Determination sex jasmonate