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在26周治疗期内任意时间点,接受利拉鲁肽治疗的患者HbA1c达标的可能均高于西格列汀和艾塞那肽治疗者

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在26周治疗期内任意时间点,接受利拉鲁肽治疗的患者HbA1c达标的可...

中华医学会糖尿病学分会第十六次全国学术会议

作者：罗小夫 Eduard Montanya claus bo svendsen Monet Sifford-Wilson Robert Ratner IDIBELL-Hospital Universitari Bellvitge BarcelonaSpain Novo Nordisk A/S SФborgDenmark Novo Nordisk Inc PrincetonNJUSA MedStar Research Institute HyattsvilleMDUSA

目的在2型糖尿病(T2DM)强化治疗中,较早达到目标HbA1c水平可提高患者对治疗的依从性。方法在一项事后分析中,我们评估了在两项3b期试验中第12、20和26周时达到HbA1c<7.0%的患者比例,这两项试验分别是将利拉鲁肽(n=233)与艾塞那肽BID(n=2...

目的在2型糖尿病(T2DM)强化治疗中,较早达到目标HbA1c水平可提高患者对治疗的依从性。方法在一项事后分析中,我们评估了在两项3b期试验中第12、20和26周时达到HbA1c<7.0%的患者比例,这两项试验分别是将利拉鲁肽(n=233)与艾塞那肽BID(n=23 1)进行比较(LEAD-6)以及将利拉鲁肽OD(1.2 mg:n=221和1.8 mg:n=218)与西格列汀OD(n=219)进行比较(LIRA-DPP-4)。使用

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基线HbA1c＜8.0%的T2DM患者使用利拉鲁肽较西格列汀或艾塞那肽治疗的HbA1c达标率更高

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基线HbA1c＜8.0%的T2DM患者使用利拉鲁肽较西格列汀或艾塞那肽治...

中华医学会糖尿病学分会第十六次全国学术会议

作者：罗小夫 Allen King Eduard Montanya Richard E Pratley Lawrence Blonde claus bo svendsen Morten Donsmark Giorgio Sesti Diabetes Care Center SalinasCAUSA IDIBELL-Hospital Universitari Bellvitge BarcelonaSpain Florida Hospital OrlandoFLUSA Dept.Endocrinology Ochsner Medical CenterNew OrleansLAUSA Novo Nordisk A/S SФborgDenmark Department of Clinical and Experimental Medicine University Magna Graecia of CatanzaroItaly

目的获取关于肠促胰素治疗距离血糖控制目标(≤7.0%)在1%以内的2型糖尿病(T2DM)患者的疗效数据。方法在这项事后分析中,将利拉鲁肽1.8 mg每日1次(OD)与艾塞那肽10μg每日2次(BID)(LEAD-6研究)和西格列汀100 mg OD治疗26周(LIRA-DPP-4研...

目的获取关于肠促胰素治疗距离血糖控制目标(≤7.0%)在1%以内的2型糖尿病(T2DM)患者的疗效数据。方法在这项事后分析中,将利拉鲁肽1.8 mg每日1次(OD)与艾塞那肽10μg每日2次(BID)(LEAD-6研究)和西格列汀100 mg OD治疗26周(LIRA-DPP-4研究)的疗效进行了比较;这项分析仅纳人在二甲双胍基础上真实加用上述药物且基线HbA1c<8%的患者。除在艾塞那肽与利拉鲁肽进行比

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基线体质指数不影响利拉鲁肽在2型糖尿病患者中降低HbA1c的效应

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基线体质指数不影响利拉鲁肽在2型糖尿病患者中降低HbA1c的效应

中华医学会第十二次全国内分泌学学术会议

作者： E Montanya V Fonseca S Colagiuri L Blonde Morten Donsmark claus bo svendsen M Nauck Hospital Universitari Bellvitge-IDIBELL BarcelonaSpain Tulane University Medical School TulaneNew OrleansLAUSA boden Institute of Obesity NutritionExercise and Eating DisordersSydneyAustralia Ochsner Medical Center New OrleansLAUSA Novo Nordisk A/S SoborgDenmark Diabeteszentrum Bad LauterbergGermany

目的:利拉鲁肽3期研究项目(Liraglutide Effect andAction in Diabetes,LEAD)的试验结果表明1.2 mg或1.8mg利拉鲁肽治疗2型糖尿病患者可以有效改善血糖控制并减轻体重。然而,这些试验没有研究利拉鲁肽降低血糖的作用是否依赖于患者的基...

目的:利拉鲁肽3期研究项目(Liraglutide Effect andAction in Diabetes,LEAD)的试验结果表明1.2 mg或1.8mg利拉鲁肽治疗2型糖尿病患者可以有效改善血糖控制并减轻体重。然而,这些试验没有研究利拉鲁肽降低血糖的作用是否依赖于患者的基线体质指数(BMI)水平。

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Using motion capture to assess colonoscopy experience level

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World Journal of Gastrointestinal Endoscopy 2014年第5期6卷 53-59页

作者： Morten bo svendsen Louise Preisler Jens Georg Hillingsoe Lars bo svendsen Lars Konge Centre for Clinical Education University of Copenhagen and the Capital Region of Denmark Department of Surgical Gastroenterology Rigshospitalet and University of Copenhagen

AIM: To study technical skills of colonoscopists using a Microsoft Kinect? for motion analysis to develop a tool to guide colonoscopy ***: Ten experienced endoscopists(gastroenterologists, n = 2; colorectal surgeons, n = 8) and 11 novices participated in the study. A Microsoft Kinect? recorded the movements of the participants during the insertion of the colonoscope. We used a modified script from Microsoft to record skeletal data. Data were saved and later transferred to MatLab for analysis and the calculation of statistics. The test was performed on a physical model, specifically the "Kagaku Colonoscope Training Model"(Kyoto Kagaku Co. Ltd, Kyoto, Japan). After the introduction to the scope and colonoscopy model, the test was performed. Seven metrics were analyzed to find discriminative motion patterns between the novice and experienced endoscopists: hand distance from gurney, number of times the right hand wasused to control the small wheel of the colonoscope, angulation of elbows, position of hands in relation to body posture, angulation of body posture in relation to the anus, mean distance between the hands and percentage of time the hands were approximated to each ***: Four of the seven metrics showed discriminatory ability: mean distance between hands [45 cm for experienced endoscopists(SD 2) vs 37 cm for novice endoscopists(SD 6)], percentage of time in which the two hands were within 25 cm of each other [5% for experienced endoscopists(SD 4) vs 12% for novice endoscopists(SD 9)], the level of the right hand below the sighting line(z-axis)(25 cm for experienced endoscopists vs 36 cm for novice endoscopists, P < 0.05) and the level of the left hand below the z-axis(6 cm for experienced endoscopists vs 15 cm for novice endoscopists, P < 0.05). By plotting the distributions of the percentages for each group, we determined the best discriminatory value between the groups. A pass score was set at the intersection of the distributions, and

关键词： Colonoscopy Assessment Simulation Motion-capture Motion-analysis

Mesenteric traction syndrome in pigs:A single-blinded,randomized controlled trial

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Animal Models and Experimental Medicine 2021年第2期4卷 162-168页

作者： Rune B.Strandby Jens T.F.Osterkamp Rikard Ambrus Amelie Henriksen Jens P.Goetze Niels H.Secher Michael P.Achiam Lars-bo svendsen Department of Surgical Gastroenterology RigshospitaletUniversity of CopenhagenCopenhagenØDenmark Department of Clinical Biochemistry RigshospitaletUniversity of CopenhagenCopenhagenØDenmark Department of Anaesthesia RigshospitaletUniversity of CopenhagenCopenhagenØDenmark

Background:Mesenteric traction syndrome is commonly observed in patients undergoing upper abdominal surgery and is associated with severe postoperative complications.A triad of hypotension,tachycardia,and facial flushing seems provoked by prostacyclin(PGI 2)release from the gut in response to mesenteric *** administration of nonsteroidal anti-inflammatory drugs(NSAID)inhibits PGI 2 release,stabilizing the hemodynamic ***,we examined the effect of mesenteric traction on splanchnic blood flow in pigs randomized to NSAID or placebo *** and Methods:Twenty pigs were allocated to either ketorolac or pla-cebo *** minutes of manual mesenteric traction was *** 6-keto-PGF1,a stable metabolite of PGI 2,hemodynamic variables,and regional blood flow(laser speckle contrast imaging)to the liver,stomach,small intestine,upper lip,and snout(laser Doppler flowmetry)were recorded prior to traction and 5 and 30 minutes ***:both groups of pigs presented a decrease in systemic vascular resistance(P.01),mean arterial blood pressure(P.001),and blood flow in the gastric an-trum(P.002).Plasma 6-keto-PGF1 did not increase in either group(P.195),and cardiac output,heart rate,central venous pressure,and blood flow to the liver,small intestine,upper lip,and snout remained ***:Mesenteric traction resulted in cardiovascular depression,including re-duced blood flow in the gastric *** 6-keto-PGF1 did not increase,and ketorolac administration did not alter the response to mesenteric *** studies are needed to identify which substance is responsible for eliciting the cardio-vascular response to mesenteric traction in pigs.

关键词： 6-keto-PGF1 gastric blood flow hemodynamics laser speckle contrast imaging mesenteric traction syndrome prostacyclin

Fluorescence guided intraluminal endoscopy in the gastrointestinal tract: A systematic review

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World Journal of Gastrointestinal Endoscopy 2020年第10期12卷 388-400页

作者： Olivia Engholt Mortensen Nikolaj Nerup Morten Thorsteinsson Morten bo Søndergaard svendsen Hironari Shiwaku Michael Patrick Achiam Department of Surgical Gastroenterology Copenhagen University HospitalCopenhagen 2100Denmark Copenhagen Academy for Medical Education and Simulation Copenhagen University HospitalCopenhagen 2100Denmark Department of Surgical Gastroenterology Fukuoka University Faculty of MedicineFukuoka 814-0133Japan

BACKGROUND Conventional endoscopy is based on full spectrum white ***,different studies have investigated the use of fluorescence based endoscopy systems where the white light has been supplemented by infrared light and the use of relevant *** endoscopy utilizes the fluorescence emitted from a fluorophore,visualizing what is not visible to the naked *** To explore the feasibility of fluorescence endoscopy and evaluate its use in diagnosing and evaluating gastrointestinal *** We followed the PRISMA guidelines for this systematic *** research covered five databases;PubMed,Scopus,Web of Science,Embase,and the Cochrane Collection,including only studies in English and Scandinavian *** screened title and abstract for inclusion,subsequently full-text for inclusion according to eligibility criteria listed in the *** risk of bias was assessed for all studies according to the Newcastle-Ottawa *** authors extracted the data and reported the results in both text and *** We included seven studies in the systematic review after screening a total of 2769 *** most prominent fluorophore was indocyanine green(n=6),and whereas one study(n=1)used Bevacizumab *** studies investigated fluorescence endoscopy in detecting varices,adenomas in patients with familial adenomatous polyposis and neoplasms in the gastrointestinal *** studies evaluated the usefulness of fluorescence endoscopy in assessing tumor *** of the four studies reported an exceptional diagnostic accuracy(93%,89%and 88%)in assessing tumor invasion,thus representing better visualization and more correct diagnosis by fluorescence endoscopy compared with the conventional *** relationship between the endoscopic findings,tumor invasion,and tumor vascularity was evaluated in two studies showing a significant correlation(dP<0.05 and bP<0.01).CONCLUSION The use of fluorescence endoscopy is a prom

关键词： Fluorescence endoscopy Gastroscopy Gastrointestinal tract Gastrointestinal diseases Infrared light Fluorophore Indocyanine green

The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm

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Journal of Molecular Cell Biology 2023年第10期15卷 39-53页

作者： Matthias Hamdorf Thomas Imhof Ben Bailey-Elkin Janina Betz Sebastian JTheobald Alexander Simonis Veronica Di Cristanziano Lutz Gieselmann Felix Dewald Clara Lehmann Max Augustin Florian Klein Miguel AAlejandre Alcazar Robert Rongisch Mario Fabri Jan Rybniker Heike Goebel Jörg Stetefeld Bent Brachvogel claus Cursiefen Manuel Koch Felix bock Cornea Lab Experimental Ophthalmology Department of OphthalmologyFaculty of Medicine and University Hospital Cologne50937 CologneGermany Terasaki Institute for Biomedical Innovation Los AngelesCA 90024USA Center for Biochemistry Faculty of Medicine and University Hospital Cologne50931 CologneGermany Institute for Experimental Dentistry and Oral Musculoskeletal Biology Faculty of Medicine and University Hospital Cologne50931 CologneGermany Department of Microbiology University of ManitobaWinnipeg MB R3B 2E9 ManitobaCanada Department I of Internal Medicine Division of Infectious DiseasesFaculty of Medicine and University Hospital Cologne50937 CologneGermany Center for Molecular Medicine Cologne University of Cologne50931 CologneGermany Institute of Virology Faculty of Medicine and University Hospital Cologne50935 CologneGermany German Center for Infection Research(DZIF) Partner Site Bonn-Cologne50931 CologneGermany Department of Children and Adolescent Medicine Faculty of Medicine and University Hospital Cologne50931 CologneGermany Cologne Excellence Cluster Stress Responses in Aging-associated Diseases 50931 CologneGermany Institute for Lung Health(ILH) Universities of Gießen and Marburg Lung CentreMember of the German Center for Lung Research35392 GießenGermany Dermatology Faculty of Medicine and University Hospital Cologne50937 CologneGermany Institute of Pathology Faculty of Medicine and University Hospital Cologne50937 CologneGermany Department of Pediatrics and Adolescent Medicine Experimental NeonatologyFaculty of Medicine and University Hospital Cologne50931 CologneGermany

The novel coronavirus pandemic,first reported in December 2019,was caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).SARS-CoV-2 infection leads to a strong immune response and activation of antigen-presenting cells,which can elicit acute respiratory distress syndrome(ARDS)characterized by the rapid onset of widespread inflammation,the so-called cytokine *** response to viral infections,monocytes are recruited into the lung and subsequently differentiate into dendritic cells(DCs).DCs are critical players in the development of acute lung inflammation that causes ***,we focus on the interaction of a specific SARS-CoV-2 open reading frame protein,ORF8,with *** show that ORF8 binds to DCs,causes pre-maturation of differentiating DCs,and induces the secretion of multiple proinflammatory cytokines by these *** addition,we identified DC-SIGN as a possible interaction partner of ORF8 on *** of ORF8 leads to reduced production of IL-1β,IL-6,IL-12p70,TNF-α,MCP-1(also named CCL2),and IL-10 by ***,a neutralizing antibody blocking the ORF8-mediated cytokine and chemokine response could be an improved therapeutic strategy against SARS-CoV-2.

关键词： COVID-19 SARS-CoV-2 ORF8 cytokine storm dendritic cells