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Role of the phase angle in the prognosis of the cirrhotic patient:15 years of follow-up

World Journal of Methodology 2023年第4期13卷 238-247页

作者： Letícia Pereira Pinto claudio Augusto Marroni Juliana Czermainski Maria Luiza Fernandes Dahlem Randhall b Carteri Sabrina Alves Fernandes Department of Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Department of Veterinary Medicine Universidade Federal do Rio Grande do SulPorto Alegre 91540-000Brazil Department of Nutrition Centro Universitário Metodista IPAPorto Alegre 90420-060Brazil Department of Nutrition Centro Universitário CesucaCachoerinha 94935-630Brazil

bACKGROUND In 2019,cirrhosis accounted for 2.4%of global *** projection for 2030 is an increase in this *** recent years,hospitalization costs have escalated by 36%for compensated cirrhosis and 24%for decompensated ***,it is necessary to identify a tool capable of predicting the mortality of these patients according to their clinical condition and consequently extending their survival *** studies have shown that the phase angle(PA)can be a feasible method in clinical practice,with the potential to guide assertive patient management in the therapeutic of chronic liver *** To evaluate the prognostic role of PA in cirrhotic patients over a 15-year followup *** Retrospective cohort study with 129 cirrhotic patients of both sexes over 18 years *** of cirrhosis by liver *** first year of data collection was 2007,and data regarding outcomes was collected in *** were gathered from medical records,such as esophageal varices(EV),EV bleeding,ascites,spontaneous bacterial peritonitis(SbP),encephalopathy,laboratory findings and *** cut-off value for the PA was 5.4°,a value described in 2012 by Fernandes et al for 129 patients evaluated in this study and the cut-off points for the brazilian population presented in percentiles(P),as described by Mattiello et *** mortality was assessed using the PA percentile through Kaplan-Meier curves and multivariate binary logistic regression *** Patients were divided into two groups according to the PA 5.4th(PA>5.4°,n=40;PA≤5.4°,n=89)PA percentile(ber of relevant complications such as ascites,SbP,liver encephalopathy and *** is strongly correlated with serum albumin(Pbilirubin(P=0.02)and direct bilirubin(P=0.003).PA is correlated with survival

关键词： Liver cirrhosis Phase angle Prognosis Liver transplantation Electrical bioimpedance

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Clinical Significance of Apurinic/Apyrimidinic Endodeoxyribonuclease 1 and MicroRNA Axis in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1291-1307页

作者： Giovanna Mangiapane Devis Pascut Emiliano Dalla Giulia Antoniali Monica Degrassi Lory Saveria Crocè Veronica De Sanctis Silvano Piazza Giulia Canarutto claudio Tiribelli Gianluca Tell Laboratory of Molecular biology and DNA Repair Department of MedicineUniversity of UdineUdineItaly Fondazione Italiana Fegato-ONLUS Liver Cancer UnitTriesteItaly Department of Medical Sciences University of TriesteTriesteItaly Clinica Patologie Fegato Azienda Sanitaria Universitaria Giuliano Isontina(ASUGI)TriesteItaly NGS Core Facility Department CIBIOUniversity of TrentoTrentoItaly Computational biology International Centre for Genetic Engineering and BiotechnologyICGEBTriesteItaly

background and Aims:Identification of prognostic factors for hepatocellular carcinoma(HCC)opens new perspectives for *** and cellular onco-miRNAs are noncoding RNAs which can control the expression of genes involved in oncogenesis through post-transcriptional *** microRNAs(miRNAs)are considered novel prognostic and predictive factors in *** apurinic/apyrimidinic endodeoxyribonuclease 1(APE1)contributes to the quality control and processing of specific onco-miRNAs and is a negative prognostic factor in several *** present work aims to:a)define APE1 prognostic value in HCC;b)identify miRNAs regulated by APE1 and their relative target genes and c)study their prognostic ***:We used The Cancer Genome Atlas(commonly known as TCGA)data analysis to evaluate the expression of APE1 in *** identify differentially-expressed miRNAs(DEmiRNAs)upon APE1 depletion through specific small interfering RNA,we used NGS and nanostring approaches in the JHH-6 HCC tumor cell *** analyses were performed to identify signaling pathways involving APE1-regulated *** analysis was performed to identify miRNAs correlating with serum APE1 ***:APE1 is considerably overexpressed in HCC tissues compared to normal liver,according to the TCGA-liver HCC(known as LIHC)*** analyses showed that APE1-regulated miRNAs are implicated in signaling and metabolic pathways linked to cell proliferation,transformation,and angiogenesis,identifying Cyclin Dependent Kinase 6 and Lysosomal Associated Membrane Protein 2 as ***-33a-5p,miR-769,and miR-877 are related to lower overall survival in HCC *** array profiling,we identified eight circulating DE-miRNAs associated with APE1 overexpression.A training phase identified positive association between sAPE1 and miR-3180-3p and ***:APE1 regulates specific miRNAs having prognostic value in HCC.

关键词： APE1 miRNAs Prognostic factors Hepatocellular carcinoma

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Peripancreatic paraganglioma:Lesson from a round table

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World Journal of Gastroenterology 2022年第21期28卷 2396-2402页

作者： Federica Petrelli Geri Fratini Andrea Sbrozzi-Vanni Andrea Giusti Raffele Manta claudio Vignali Gabriella Nesi Andrea Amorosi Andrea Cavazzana Marco Arganini Maria Raffaella Ambrosio Pathology Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Surgery Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Endoscopic Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Endoscopic Unit Santa Maria Misericordia HospitalPerugia 06122Italy Interventional Radiology Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Department of Health Sciences University of FlorenceFlorence 50139Italy Pathology Unit UniversitàMagna GraeciaCatanzaro 88100Italy

We described the case of a peripancreatic paraganglioma(PGL)misdiagnosed as pancreatic *** exploration revealed an unremarkable pancreas and a large well-defined cystic mass originating at the mesocolon *** enucleation of the mass was performed,preserving the pancreatic ***,a diagnosis of PGL was ***,two previously unreported mutations,one affecting the KDR gene in exon 7 and another on the JAK3 gene in exon 4 were *** mutations are known to be *** and cytologic findings were blindly reviewed by an expert panel of clinicians,radiologists,and pathologists to identify possible causes of the *** major issue was lack of evidence of a cleavage plane from the pancreas at imaging,which prompted radiologists to establish an intraparenchymal *** blinded revision shifted the diagnosis towards an extrapancreatic lesion,as the pancreatic parenchyma showed no structural alterations and no dislocation of the Wirsung *** post,the identified biases were the emergency setting of the radiologic examination and the very thin mesocolon sheet,which hindered clear definition of the lesion *** endoscopic ultrasonography diagnosis was confirmed,emphasizing the intrinsic limit of this technique in detecting large ***,pathologic review favored a diagnosis of PGL due to the morphological features and immonohistochemical *** months after tumor excision,the patient is asymptomatic with no disease relapse evident by either radiology or laboratory *** report strongly highlights the difficulties in rendering an accurate preoperative diagnosis of PGL.

关键词： Peripancreatic paraganglioma Pancreatic neuroendocrine tumor Solid pseudopapillary neoplasm S100 Succinate dehydrogenase subunit b gene and expression Fine needle biopsy

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Evaluation of in vitro cell and blood compatibility and in vivo analgesic activity of plant-derived dietary supplements

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Journal of Integrative Medicine 2019年第3期17卷 213-220页

作者： Stefania Lamponi Anna Maria Aloisi Claudia bonechi Marco Consumi AlessANDro Donati Gemma Leone claudio Rossi Gabriella Tamasi Luana GhiANDai Ersilia Ferrini Paolo Fiorenzani Ilaria Ceccarelli Agnese Magnani Department of biotechnology Chemistry and PharmacyUniversity of Siena Union b.I.O.S.r.l. Labor Chimica S.r.l. Department of Medicine Surgery and NeurosciencesUniversity of Siena

Objective: In vitro cell and blood compatibility of three dietary supplements, comprised of multiple plant extracts, Pneumo Go(PG), Green active(GA) and Equistasi(Eq), and their main component, the phytocomplex Matrix U.b.ò(Union bio S.r.l.)(M), were evaluated. Moreover, preliminary in vivo tests were performed on GA in order to assess its ability to reduce pain in an animal ***: Cell compatibility was determined using fibroblasts(NIH3T3) and primary adult human microvascular endothelial cells(HMVECad) and the neutral red uptake test. blood compatibility was evaluated by analyzing blood parameters after incubation of the products with sodium citrate anticoagulated whole blood. Thrombin time was determined by adding thrombin to aliquots of human plasma containing the samples. Clotting time was revealed by an automatic coagulometer. The in vivo analgesic effect of GA was evaluated in Wistar rats using the formalin ***: M and PG reduced the percentage of viable NIH3T3 cells, indicating their interference in the cell cycle. GA and Eq stimulated fibroblast proliferation and neutralized the toxic effect of M. M and PG reduced HMVECad cell viability. GA and Eq did not affect cell viability as well as negative control. The hemocompatibility tests indicated that all the samples did not interfere with fibrinogen. The in vivo test carried out in male rats showed a significant analgesic effect of GA in all formalin-induced pain ***: No hemotoxicity and good cell compatibility were found for all the tested samples. GA and Eq were the best candidates for further biocompatibility testing. Moreover, GA reduced pain in the animal model.

关键词： Plant extracts Fibroblasts Endothelial cells Cytotoxicity Cytocompatibility Haemocompatibility Pain reduction In vivo animal model

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Two-Dimensional Continuous Model in bimolecular Reactive Transport

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Open Journal of Fluid Dynamics 2023年第1期13卷 47-60页

作者： Daniel A. Cuch Diana Rubio claudio D. El Hasi Instituto de Ciencias Universidad Nacional de General Sarmiento Buenos Aires Argentina ITECA (CONICET-UNSAM)-Centro de Matemática Aplicada ECyT-Universidad Nacional de San Martín Buenos Aires Argentina Departamento de Ciencias básicas Facultad de Ingeniería Universidad Argentina de la Empresa Buenos Aires Argentina

In this work, a continuum 2D model is proposed to study the interaction at the interface of reactive transport processes in porous media. The analysis of the segregation produced by poor reactant homogenization at the poral scale is addressed by a parametric heuristic model that considers the relative gradient of the reacting species involved in the process. The micro inhomogeneities are incorporated by means of longitudinal and transversal mechanical dispersion coefficients. A two-dimensional continuous model for the bimolecular reactive transport is considered where modelling parameters are estimated numerically from experimental data. A competitive effect between segregation and dispersion is observed that is analyzed by means of numerical experiments. The two-dimensional model reproduces properly both the total mass of the product as well as its increase with the velocity of flow and the inhomogeneity of the advanced front. The methodology used is simple and fast, and the numerical results presented here indicate its effectiveness.

关键词： bidimensional Model Transverse Dispersion Segregation Parameter Estimation

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Pyrolysis of Agroindustrial Residues of Coffee, Sugarcane Straw and Coconut-Fibers in a Semi-pilot Plant for Production of bio-oils： Gas Chromatographic Characterization

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Journal of Earth Science and Engineering 2016年第5期6卷 235-244页

作者： Mozart D. bispo Jamilly Andressa Santos barros Debora Tomasini Carmem Primaz Elina b. Caramao claudio Dariva Laiza C. Krause Nucleo de Estudos em Sistemas Coloidais Instituto de Tecnologia e Pesquisa PBI/PEP/UNIT Aracaju-SE 49032-490 Brasil Instituto de Quimica INCT Energia e Ambiente UFRGS-Porto Alegre RS--Brasil

Microbial, vegetal or animal organic matter, which has potential to be transformed into energy, is considered biomass. Among the various alternative energy sources, biomass is the only one with the possibility of generating a class of substances of interest for fine chemistry （ketones, aldehydes, alcohols, phenols, etc.）. From biomass, it is possible to produce bio-oil using pyrolysis, a thermodegradation process. The quality of the bio-oil depends on the process conditions （pyrolysis temperature, heating temperature, etc.） and biomass used. In this paper, the pyrolysis （using a fixed bed reactor） of three biomasses （coconut fiber, coffee grounds and sugar cane straw） is studied. The results indicated that the bio-oil yields for all biomass were similar, approximately 37%. The chemical profile obtained by gas chromatography coupled with mass spectrometry （GC/qMS） showed high amounts of fatty acids in the coffee grounds bio-oil and aliphatic and aromatic hydrocarbons in coconut fiber bio-oil, whereas guaiacols were the predominant components of the sugar cane straw bio-oil.

关键词： Pyrolysis GC/qMS biomass coconut fiber coffee grounds sugarcane straw.

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A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles

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Nano Research 2016年第2期9卷 537-548页

作者： Sara Capolla Nelly Mezzaroba Sonia Zorzet claudio Tripodo Ramiro Mendoza-Maldonado Marilena Granzotto Francesca Vita Ruben Spretz Gustavo Larsen Sandra Noriega Eduardo Mansilla Michele Dal bo Valter Gattei Gabriele Pozzato Luis Nunez Paolo Macor Department of Life Sciences University of Trieste 34127 Trieste Italy Department of Human Pathology University of Palermo 90133 Sicilia Italy Molecular Oncology Unit National Laboratory Consorzio Interuniversitatio per le Biotecnologie (CIB) 34012 Trieste Italy Dipartimento Universitario Clinico di Scienze mediche Chirurgiche e della Salute University of Trieste 34149 Trieste Italy LNK Chemsolutions LLC Lincoln NE 68521 USA bio-Target Inc. Chicago IL 60637 USA Centro Unico Coordinador de Ablacion e Implante Provincia de buenos Aires (C.U.CA.I.b.A.) Ministry of Health La Plata Buenos AiresArgentina Clinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico Istituto di Ricerca e Cura a Carattere Scientifico(I.R.C.C.S.) 33081 Aviano Italy Callerio Foundation Onlus Institutes of Biological Researches 34127 Trieste Italy

Current approaches for the treatment of chronic lymphocytic leukemia （CLL） have greatly improved the prognosis for survival, but some patients remain refractive to these therapeutic regimens. Hence, in addition to reducing the long-term side- effects of therapeutics for all leukemia patients, there is an urgent need for novel therapeutic strategies for difficult-to-treat leukemia cases. Due to the cytotoxicity of drugs, the major challenge currently is to deliver the therapeutic agents to neoplastic cells while preserving the viability of non-malignant ceils. In this study, we propose a therapeutic approach in which high doses of hydroxychloroquine and chlorambucil were loaded into biodegradable polymeric nanopartides coated with an anti-CD20 *** first demonstrated the ability of the nanoparticles to target and internalize in tumor b-cells. Moreover, these nanoparticles could kill not only p53-mutated]deleted leukemia cells expressing a low amount of CD20, but also circulating primary ceils isolated from chronic lymphocytic leukemia patients. The safety of these nanoparticles was also demonstrated in healthy mice, and their therapeutic effects were shown in a new model of aggressive leukemia. These results showed that anti-CD20 nanoparticles containing hydroxychloroquine and chlorambucil can be effective in controlling aggressive leukemia and provided a rationale for adopting this approach for the treatment of other b-cell disorders.

关键词： chronic lymphocytic leukemia immune targeted nanoparticles treatment xenograft model

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COVID-19:It's still time for health professionals,physical activity enthusiasts and sportive leagues not to let guard down

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Sports Medicine and Health Science 2021年第1期3卷 49-53页

作者： Rodrigo L.Vancini Marília S.Andrade Pantelis T.Nikolaidis beat Knechtle Thomas Rosemann Ricardo b.Viana claudio A.b.de Lira Centro de Educaçao Física e Desportos(CEFD) Universidade Federal do Espírito Santo(UFES)Espírito Santo(ES)Brazil Departamento de Fisiologia Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo(SP)Brazil Exercise Physiology Laboratory NikaiaGreece Medbase St.Gallen Am Vadianplatz St.Gallen and Institute of Primary CareUniversity of ZurichZurichSwitzerland Institute of Primary Care University of ZurichSwitzerland Setor de Fisiologia Humana e do Exercício Faculdade de Educaçao Física e DançaUniversidade Federal de Goias(UFG)GoianiaGois(GO)Brazil Setor de Fisiologia Humana e do Exercício Faculdade de Educaçao Física e DançaUniversidade Federal de Goias(UFG)Goi^aniaGoias(GO)Brazil

Emerging viral diseases represent a serious issue to public and global healthcare systems and have a high potential for disease dissemination in sport/physical activity and exercise *** Coronavirus disease 2019(COVID-19)pandemic has frightened the sports and physical activity community and enthusiasts for potential trans-mission,dissemination,and lethality in vulnerable populations;those with chronic diseases,co-morbidities,the elderly people,and in young and healthy *** pandemic has caused a chain reaction with cancellations of sports competitions and gymnasiums closing around the ***,some sporting events are gradually resuming in certain regions of the world and also the return of competitions and *** general,without fans and public,the sports media can only report the infection of athletes and coaching staff ***,this situation is dynamic-the world is currently experiencing the second wave of the disease;with the safety and containment measures for the disease is changing *** purpose of this article is to present information concerning the COVID-19 pandemic,to clarify health issues for professionals and people connected to sport and physical activity venues,presenting information to assist in educations and the health promotion and *** time is now for making changes,reviewing the actions and conducts necessary for prevention,and most importantly not letting our guard down,even as vaccines become available for all people in the *** that even after getting vaccinated,it is necessary to continue with safety measures,for example,the use of facial masks and social distance and hygiene,that is,washing your hands frequently and/or sanitizing with 70%*** can't let our guard down for COVID-19.

关键词： Viral disease Covid-19 Coronavirus Sport Physical activity

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An Educational GUI-based Software for Dynamic Analysis of Framed Structural Models

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Journal of Software Engineering and Applications 2023年第7期16卷 265-286页

作者： claudio H. b. Resende Pedro C. Lopes Rafael L. Rangel Luis F. Paullo Muñoz Luiz F. Martha Department of Civil and Environmental Engineering Pontifical Catholic University of Rio de Janeiro Rio de Janeiro Brazil Institute of Computing Fluminense Federal University Niter&#243i Brazil International Centre for Numerical Methods in Engineering (CIMNE) Universitat Politècnica de Catalunya Barcelona Spain

This paper introduces a new version of the open-source educational software, LESM (Linear Elements Structure Model), developed in MATLAb for structural analysis of one-dimensional models such as frames, trusses, and grillages. The updated program includes dynamic analysis, which incorporates inertial and damping effects, time-dependent load conditions, and a transient solver with multiple time integration schemes. The software assumes small displacements and linear-elastic material behavior. The paper briefly explains the theoretical basis for these developments and the reorganization of the source code using Object-Oriented Programming (OOP). The updated Graphical User Interface (GUI) allows interactive use of dynamic analysis features and displays new results such as animations, envelope diagrams of internal forces, phase portraits, and the response of degrees-of-freedom in time and frequency domain. The new version was used in a structural dynamics course, and new assignments were elaborated to improve students’ understanding of the subject.

关键词： Structural Analysis Structural Dynamics Educational Software MATLAb Graphical User Interface

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Shared Memory Semi-Implicit Solver for Hydrodynamical Instability Processes

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Open Journal of Fluid Dynamics 2023年第1期13卷 32-46页

作者： Augusto Kielbowicz Diego Fernández Adriana Saal claudio El Hasi Carlos Vigh Instituto de Ciencias Universidad Nacional de General Sarmiento Los Polvorines Argentina Departamento de Ciencias básicas Facultad de Ingeniería Universidad Argentina de la Empresa Buenos Aires Argentina Departamento de Física Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Buenos Aires Argentina Instituto de Física Interdisciplinaria Aplicada (CONICET-UbA) Buenos Aires Argentina

The Advection-Diffusion Reaction (ADR) equation appears in many problems in nature. This constitutes a general model that is useful in various scenarios, from porous media to atmospheric processes. Particularly, it is used at the interface between two fluids where different types of instabilities due to surface mobility may appear. Together with the ADR equation, the Darcy-brinkman model describes the phenomena known as fingering that appear in different contexts. The study of this type of system gains in complexity when the number of chemical species dissolved in both fluids increases. With more solutes, the increasing complexity of this phenomenon generally requires much computational power. To face the need for more computational resources, we build a solver tool based on an Alternating Direction Implicit (ADI) scheme that can be run in Central Processing Unit (CPU) and Graphic Processing Unit (GPU) architectures on any notebook. The implementation is done using the MATLAb platform to compare both versions. It is shown that using the GPU version strongly saves both resources and calculation times.

关键词： Fingering Fluids Simulations Numerical Solver Hele-Shaw Cell

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