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Ampulla of Vater carcinoma: Molecular landscape and clinical implications

World Journal of Gastrointestinal Oncology 2018年第11期10卷 370-380页

作者： Antonio Pea Giulio Riva Riccardo Bernasconi Elisabetta Sereni Rita Teresa Lawlor Aldo Scarpa claudio luchini Department of Surgery University and Hospital Trust of Verona Department of Diagnostics and Public Health Section of Pathology University and Hospital Trust of Verona ARC-Net Research Center University and Hospital Trust of Verona

Ampulla of Vater is a peculiar anatomical structure, characterized by the crossroad of three distinct epithelia: Intestinal, ductal pancreatic and biliary. Adenocarcinomas arising in this area represent an opportunity to understand the comparative biology of all periampullary malignancies. These neoplasms can exhibit intestinal, pancreaticobiliary or mixed features, whereas the subclassification based on morphology and immunohistochemical features failed in demonstrating a robust prognostic reliability. In the last few years, the molecular landscape of this tumor entity has been uncovered, identifying alterations that may serve as prognostic and predictive biomarkers. In this review, the histological and genetic characteristics of ampullary carcinomas are discussed, taking into account the main clinical and therapeutic implications related to this tumor type as well.

关键词： Pancreatobiliary Intestinal Mixed ELF3 TP53 KRAS Ampullary Vater Histotype

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Histo-molecular oncogenesis of pancreatic cancer:From precancerous lesions to invasive ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2018年第10期10卷 317-327页

作者： Giulio Riva Antonio Pea Camilla Pilati Giulia Fiadone Rita Teresa Lawlor Aldo Scarpa claudio luchini Department of Diagnostics and Public Health Section of PathologyUniversity and Hospital Trust of Verona Department of Surgery University and Hospital trust of Verona Personalized Medicine PharmacogenomicsTherapeutic Optimization Paris-Descartes University ARC-Net Research Center University and Hospital Trust of Verona

Pancreatic cancer is a lethal malignancy,whose precursor lesions are pancreatic intraepithelial neoplasm,intraductal papillary mucinous neoplasm,intraductal tubulopapillary neoplasm,and mucinous cystic *** better understand the biology of pancreatic cancer,it is fundamental to know its precursors and to study the mechanisms of *** of these precursors displays peculiar histological features,as well as specific molecular *** from such pre-invasive lesions,this review aims at summarizing the most important aspects of carcinogenesis of pancreatic cancer,with a specific focus on the recent advances and the future perspectives of the research on this lethal tumor type.

关键词： Oncogenesis Intraductal papillary mucinous neoplasm Mucinous cystic neoplasm Pancreatic ductal adenocarcinoma Pancreatic intraepithelial neoplasm KRAS Carcinogenesis Pancreatic cancer Intraductal tubulopapillary neoplasm

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Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale

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World Journal of Meta-Analysis 2017年第4期5卷 80-84页

作者： claudio luchini Brendon Stubbs Marco Solmi Nicola Veronese Department of Diagnostics and Public Health University and Hospital Trust of Verona Surgical Pathology Unit Santa Chiara Hospital Physiotherapy Department South London and Maudsley NHS Foundation Trust Health Service and Population Research Department Institute of Psychiatry Psychology and Neuroscience King's College London Faculty of Health Social Care and Education Anglia Ruskin University Department of Neurosciences University of Padova Nicola Veronese Institute for Clinical Research and Education in Medicine IREM National Research Council Neuroscience Institute Aging Branch

One of the most important points in the meta-analyses is certainly represented by the assessment of the quality of the studies included in such research. The meta-analyses are considered the highest level of evidence in science. Also for this reason, the quality of the studies included should be accurately evaluated by standardized tools. The overall results of the metaanalysis depend indeed also on a rigorous evaluation of the studies quality. Among all the possible tools for this complex evaluation, the Newcastle Ottawa Scale(NOS) is one of the most used worldwide, above all for observational studies. In this review, we will discuss the strengths and limitation of the NOS, also on the basis of the branch of science in which it has been applied.

关键词：英文文摘荟萃杂志

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