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Variation for Health-Enhancing Compounds and Traits in Onion (Allium cepa l.) Germplasm

Food and Nutrition Sciences 2016年第7期7卷 577-591页

作者： E. Marina Insani Pablo F. Cavagnaro Virginia M. Salomón leandro langman María Sance Adriana A. Pazos Fernando O. Carrari Olga Filippini laura Vignera claudio R. Galmarini INTA Food Technology Institute Hurlingham Argentina INTA Biotechnology Institute Hurlingham Argentina Cuyo National University Mendoza Argentina CONICET Buenos Aires Argentina luján National University Luján Argentina INTA EEA La Consulta La Consulta Argentina

Consumption of onion has been associated with reduced incidence of chronic diseases. Phenolic, organosulfur and carbohydrate compounds present are largely responsible for these effects. This study examined compositional variation for health-enhancing compounds in a genetically diverse collection of onion cultivars. Total antioxidant activity and aroma profiles were characterized. Significant variation in bulb concentration for total and individual phenolic compounds, thiosulfinates, carbohydrates, and total and soluble solids was found. The range of variation was particularly large (>50-fold difference between the cultivars with the highest and lowest content) for fructo-oligosaccharides (FOS) and the polyphenols quercetin, epigallocatechin gallate and epicatechin gallate. Amino acid profiles varied significantly as well with substantial variation (~10 fold) observed in both total and essential amino acids. Total antioxidant activity was positively correlated with polyphenols content, and quercetin in particular (r = 0.83), suggesting a major contribution from phenolic compounds to onion antioxidant properties. Significant positive correlation was also found between solids and thiosulfinates content (r = 0.74) and between solids and FOS (r = 0.81), suggesting a dilution/concentration effect for organosulfur compounds and FOS in onion bulbs. The present study revealed broad variation for health-enhancing compounds content in onion germplasm, which can be exploited in breeding programs aiming at increasing onion nutraceutical value.

关键词： Onion Polyphenols Carbohydrates Amino Acids Aroma Profiles

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New Amphiphilic Amino Acid Derivatives for Efficient DNA Transfection in Vitro

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Advances in Chemical Engineering and Science 2017年第2期7卷 191-205页

作者： lucía C.Pena María F.Argaraná María M.De Zan Antonella Giorello Sebastián Antuna claudio C.Prieto Carolina M.I.Veaute Diana M.Müller lAQUIMAP Dto.Química OrgánicaUniversidad Nacional del LitoralSanta FeArgentina Cát.Microbiología General Universidad Nacional del LitoralSanta FeArgentina laoratorio de Control de Medicamentos Universidad Nacional del LitoralSanta FeArgentina Instituto de Investigaciones en Catálisis y Petroquímica Universidad Nacional del LitoralSanta FeArgentina laboratorio de Cultivos Celulares Universidad Nacional del LitoralSanta FeArgentina laboratorio de Inmunología Básica Universidad Nacional del LitoralSanta FeArgentina

Nucleic acids-based therapies have recently developed as next-generation agents for treating and preventing viral infection, cancer, and genetic disorders, but their use is still limited due to its relatively poor delivery into targeted cells. We designed and synthesized new amphiphilic amino acid derivatives (cysteine-based) of low molecular weight, formed by the same pentapeptide (AG2: WWCOO) N-acylated, with different hydrophobic chains containing from 12 to 18 carbons, named AG2-Cn (N), which dimerize by oxidation in the presence of plenti-CMV-GFP Puro plasmid (P) in the respective gemini. We determined transfection efficiency, critical micelle concentration, particle size, ζ-potential and cytotoxicity for the derivatives obtained. We found that all the synthesized compounds were active for DNA delivery and had greater ability to transfect CHO-K1 cells. In particular, AG2-C18 is a promising carrier for gene delivery because it showed no cytotoxicity and its activity was greater than or equal to the commercial actives currently used.

关键词： Amphiphile N-Acylated Cysteine Gemini Ornithine Transfection

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需要以专业技能为基础的随机对照试验

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英国医学杂志中文版 2005年第3期8卷 182-185页

作者： PJ Devereaux Mohit Bhandari Mike Clarke Victor M Montori Deborah J Cook Salim Yusuf David l Sackett claudio S Cina SD Walter Brian Haynes Holger J Schunemann 许群 Department of Clinical Epidemiology and Biostatistics，McMaster University，1200 Main Street，West Hamilton ON，Canada l8N 3Z5 Department of Surgery，McMaster University UK Cochrane Centre Oxford Department of Medicine Mayo Clinic College of Medicine，Rochester，Minnesota United States Population Health Research Institute，McMaster University Trout Research and Education Centre of Irish lake，Markdale Ontario，Canada Departments of Medicine and Social and Preventive Medicine，University at Buffalo Buffalo，New York United States

外科手术不大可能像药物治疗那样严格的以证据为基础，因为其难以随机化分组。因此，以专业技能为基础的试验可能是今后发展的方向。

关键词：随机对照试验专业技能临床医生非药物干预外科手术随机分配试验设计

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Antimicrobial Activity, Structural, Crystallographic and Thermal Characteristics of Alpha-Titanium Phosphate Promoted by Silver Ions

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Materials Sciences and Applications 2024年第8期15卷 253-269页

作者： Enzo Erbisti Garcia Agnes Maria Cupertino Fernandes Araujo Gerson Alberto Valencia Albitres Daniela de França da Silva Freitas Danielle Mattos Mariano Carlos Magno Fialho Soares Sibele Piedade Cestari Marco Antônio lemos Miguel luis claudio Mendes Institute of Macromolecules Professora Eloisa Mano Federal University of Rio de Janeiro Avenida Horacio Macedo 2030 Centro de Tecnologia Bloco J Ilha do Fundo Rio de Janeiro Brazil Institute of Microbiology Paulo de Ges Federal University of Rio de Janeiro Centro de Ciencias da Saude Bloco I Ilha do Fundo Rio de Janeiro Brazil Innovation in Polymer Engineering (PIEP) University of Minho Guimares Portugal

The recent global spread of the pandemic underscores the necessity of seeking new materials effective against microorganisms. Nanotechnology offers avenues for developing multifunctional materials. In this study, alpha-titanium phosphate (α-TiP) nanoparticles were synthesized and treated with silver salt to enhance their antimicrobial properties. The physicochemical characteristics and antimicrobial activity were evaluated. It was revealed by X-ray diffraction analysis that the structural integrity of α-TiP was influenced by ethylenediamine and silver ions. Distinct degradation profiles for each chemical modification were shown by thermogravimetric analysis. Infrared spectroscopy detected shifts and new absorption peaks in the spectra depending on the type of modification. Energy dispersive spectroscopy confirmed the disaggregation of α-TiP galleries following the addition of silver salt, which increased their effectiveness against microorganisms. Notably, only the sample treated with silver ions exhibited antimicrobial action. Antimicrobial activity was tested against the bacteria of medical importance Escherichia coli, Salmonella Enteritidis, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, listeria momocytogenes and the yeast Candida albicans. All microorganisms were inhibited by sample containing silver. Minor inhibition was observed against the Gram-positive bacteria l. monocytogenes and Bacillus cereus, while the greatest inhibition occurred against the fungus (yeast) C. albicans. The results revealed a potential application of the nanoparticles for control of microorganisms in public health.

关键词： Titanium Phosphate Silver Nitrate Antimicrobial Action

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垂体腺瘤所致ACTH依赖性库欣综合征患者循环肾上腺髓质素增加

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国际内分泌代谢杂志 2001年第3期21卷 162-162页

作者： claudio l 程洁姜宏卫董砚虎

肾上腺髓质素(AM)在调节下丘脑-垂体-肾上腺轴中有一定的作用。本实验旨在研究人体内促肾上腺皮质激素(ACTH)和皮质醇水平是否影响AM的产生。对象与方法 14名库欣病患者，8名肾上腺性库欣综合征患者，21名年龄相匹配的健康对照者。诊... 详细信息

肾上腺髓质素(AM)在调节下丘脑-垂体-肾上腺轴中有一定的作用。本实验旨在研究人体内促肾上腺皮质激素(ACTH)和皮质醇水平是否影响AM的产生。对象与方法 14名库欣病患者，8名肾上腺性库欣综合征患者，21名年龄相匹配的健康对照者。诊断标准为典型临床表现、实验室检查、CT或核磁共振(NMR)确诊的垂体或肾上腺肿瘤。采血前2周停止药物治疗，饮食控制钠(120～140 mmol/d)、钾(40～60 mmol/d)摄入。患者空腹平卧至少60 min状态下，双侧颞骨岩静脉窦下方插导管及肘静脉采血。注射羊促肾上腺皮质激素释放激素(CRF)100 μg之前和之后15、30、60 min测血ACTH和AM水平，中央与外周血ACTH浓度之比大于2提示其是由垂体产生，左右岩静脉窦血ACTH浓度之比大于1.5可用于腺瘤的定位。实验组14名垂体腺瘤患者中8名作了外科切除术，这些患者在临床症状和激素消退后继续采血。放射免疫分析法测血皮质醇、ACTH、AM及尿皮质醇水平，应用单因素方差分析进行统计学处理。结果与讨论库欣病患者平均动脉压、心率、血皮质醇、尿皮质醇、ACTH比对照组显著升高(Pl］比对照组［(13.7±6.1)ng/l］或肾上腺腺瘤组［(17.8±2.2)ng/l］显著升高(Pl］比术前显著降低(P<0.01)；注射CRF后右侧岩静脉窦血AM在30 min后比基础值升高42.6%，周围血AM无显著升高，提示腺瘤位于右侧。本实验未显示AM和ACTH及皮质醇有直接的相关性，库欣病患者循环AM升高的机制尚不清楚，可能为内源性皮质醇分泌过多促进AM的合成和分泌，或作为ACTH、皮质醇分泌不足的代偿机制，但不能排除AM升高与库欣病临床并发症有关。

关键词：垂体腺瘤库欣病库欣综合征肾上腺疾病 ACTH 肾上腺髓质患者

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Effects of Imazethapyr-Based Herbicide Formulation in the Zebrafish (Danio rerio) Hepatocyte Cell line (ZF-l): Cytotoxicity and Oxidative Stress

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Journal of Environmental Protection 2024年第6期15卷 747-765页

作者： Edila Maria Kickhöfel Ferrer Milena Mattes Cerveira Pedro Henrique Flores Da Cruz Cleiton Jesus Andrade Pereira lucas Moraes Berneira claudio Martin Pereira de Pereira Nathalia Stark Pedra Roselia Maria Spanevello Jean Carlos Bauer Vieira Clarissa Piccinin Frizzo Mateus Tavares Kütter Janice luehring Giongo Rodrigo de Almeida Vaucher Center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil Department of Microbiology and Parasitology Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical formulations have increased in Brazil and Rio Grande do Sul is among the Brazilian states with the highest number of seizures of these products obtained illicitly. The use of illicit formulations can cause significant harm to agricultural production, the environment, and non-target species. This study evaluated the cytotoxicity and oxidative stress of a seized formulation containing the herbicide imazethapyr (IMZT). Characterization of the herbicide included gas chromatography-mass spectrometry (GC-MS) and thermal analyses (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)). Hemolytic and cytotoxicity assays in ZF-l hepatic cells showed IC50 values of 12.75 µg/ml, 3.01 µg/ml, 2.67 µg/ml, and 1.61 µg/ml for erythrocytes, [3(4,5-dimethyl)-2 bromide-5 diphenyl tetrazolium] (MTT), neutral red (NR), and lactate dehydrogenase (lDH) assays, respectively. The median IC50 of 2.84 µg/ml was used in oxidative stress assays, revealing increased reactive oxygen species (ROS) production, reduced total sulfhydryl content, and decreased superoxide dismutase (SOD) and catalase (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-l cell line, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemicals on human health and the environment.

关键词： Agrochemical Imidazolinone Zebrafish Cell Viability Oxidative Damage

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联合应用氯吡格雷和质子泵抑制剂对急性冠状动脉综合征患者经皮冠状动脉介入术后预后的影响

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中国医药 2017年第2期12卷 161-166页

作者：严研王晓范婧尧聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose Paulo Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose Ramon Gonzalez-Juanatey Stephen B. Wilton Wouter J. Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph liebetrau Testuma Kawaji claudio Moretti Zenon Huczek Toshiharu Fujii luis claudio Correia Masa-aki Kawashiri Sasko Kedev 首都医科大学附属北京安贞医院急诊危重症中心 000029 西班牙比戈市阿尔瓦罗康克雷诺医院心内科 36312 荷兰阿姆斯特丹大学学术医学中心心内科 1105 意大利都灵市圣乔瓦尼巴蒂斯塔医院心内科 10126 美国芝加哥市北岸大学医院心内科 60201 西班牙圣地亚哥·德·孔波斯特拉大学临床医院心内科 15706 加拿大卡尔加里市阿尔伯塔利宾心血管研究所心脏科学医学科 T2N4N1 西班牙马德里市圣卡洛斯医院心内科 28040 西班牙巴塞罗纳市贝尔维尔医院心内科 08907 希腊雅典市佩特雷大学医院心内科 26504 德国法兰克福市基尔霍夫胸腔心脏中心心内科 61231 日本京都大学医学研究生院心内科 606-8507 波兰华沙市临床医院心内科 02-091 日本东京市东海大学医学院心内科 259-1193 巴西萨尔瓦多市圣拉斐尔医院 41253-190 日本金泽大学医学研究生院心内科 920-0942 马其顿斯科普里市临床心脏病诊所心内科 1000

目的探讨联合应用氯吡格雷和质子泵抑制剂（PPI）对急性冠状动脉综合征（ACS）患者经皮冠状动脉介入（PCI）术后预后的影响。方法回顾性分析2003年至2014年来自10个国家（加拿大，巴西，德国，波兰，荷兰，西班牙，意大利，希腊，中国... 详细信息

目的探讨联合应用氯吡格雷和质子泵抑制剂（PPI）对急性冠状动脉综合征（ACS）患者经皮冠状动脉介入（PCI）术后预后的影响。方法回顾性分析2003年至2014年来自10个国家（加拿大，巴西，德国，波兰，荷兰，西班牙，意大利，希腊，中国，日本）15个临床中心的ACS合并PCI术后18077例患者的临床资料。研究氯吡格雷、PPI与ACS患者PCI术后预后的关系。比较患者的基本临床特征、既往病史、生化指标、药物应用，以及终点事件的发生率情况。通过Cox回归模型进行分析及倾向性评分调整其他可能影响患者的预后因素包括人口学信息（年龄、性别）和临床指标，计算PPI这一干预因素的风险比并评价其是否能够明显影响患者的预后。结果基于国际多中心Blee MACs注册登记研究分析，排除关键数据缺失过多患者2676例。根据纳入与排除标准及倾向性评分调整整理后，再排除患者6461例，最终列队患者8940例。根据患者用药不同，将患者分为氯吡格雷＋PPI组（4814例）和氯吡格雷组（4126例）。氯吡格雷＋PPI组患者女性、高血压病史、高脂血症病史、糖尿病史、外周血管疾病史、既往急性心肌梗死史、慢性肾功能不全病史、消化道溃疡病史、冠状动脉旁路移植术病史、既往出血病史、恶性肿瘤病史、不稳定型心绞痛、非sT段抬高型心肌梗死、心功能Killip分级≥2级、经皮腔内冠状动脉成形术、出院后血管紧张素转换酶抑制剂／血管紧张素Ⅱ受体拮抗剂应用比例、年龄和入院时血肌酐水平明显高于氯吡格雷组[25．4％（1225／4814）比21．0％（865／4126）、59．9％（2882／4814）比49．2％（2032／4126）、48．3％（2327／4814）比42．7％（1762／4126）、26．4％（1272／4814）比22．1％（910／4126）、8．0％（386／4814）比5．6％（231／4126）、12．3％（593／4814）比10．6％（436／4126）、2．0％（98／4814）比0．7％（30／4126）、2．3％（112／4814）比1．0％（42／4126）、3．6％（172／4814）比2．2％（92／4126）、4．5％（219／4814）比3．0％（123／4126）、8．0％（387／4814）比4．7％（193／4126）、13．4％（644／4814）比9．1％（374／4126）、29．1％（1400／4814）比15．9％（656／4126）、14．5％（699／4814）比11．2％（462／4126）、56．0％（2697／4814）比55．7％（2300／4126）、75．5％（3633／4814）比68．6％（2829／4126）、（66±12）岁比（61±13）岁、（10±6）mg／l比（9±4）mg／l]；且入院时血红蛋白水平和出院后β受体阻滞剂应用比例明显低于氯吡格雷组[（138±19）g／l比（141±16）g／l、80．6％（3880／4814）比83．1％（3428／4126）]，差异均有统计学意义（均P〈0．05）。调整前，氯吡格雷＋PPI组主要终点事件（全因死亡／再发心肌梗死／出血）发生率明显高于氯吡格雷组，差异有统计学意义（风险比为1．331，95％置信区间为1．161-1．524）。调整后，氯吡格雷＋PPI组主要终点事件（全因死亡／再发心肌梗死／出血）发生率与氯吡格雷组比较，差异无统计学意义（风险比为1．036，95％置信区间为0．903-1．189）。结论ACS患者PCI术后联合应用PPI与氯吡格雷是合理的，尤其在胃肠道出血高危患者中。

关键词：急性冠状动脉综合征氯吡格雷质子泵抑制剂预后

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Modified combustion synthesis of g-liAlO_2 using metal oxides

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Transactions of Nonferrous Metals Society of China 2018年第9期28卷 1793-1800页

作者： Daniel CRUZ H.B.ORTIZ-OlIVEROS l.M.PéREZ-DíAZ R.M.FlORES-ESPINOSA G.ROSANO-ORTEGA Facultad de Ingeniería Química Benemérita Universidad Autónoma de Puebla14 Sur y San ClaudioCiudad UniversitariaC.P.72570Cd.PueblaMéxico Instituto Nacional de Investigaciones Nucleares Dirección de Investigación TecnológicaApartado Postal 18-102711801 MéxicoDFMéxico Universidad Popular Autónoma del Estado de Puebla 21 Sur no.1103Colonia SantiagoC.P.72410PueblaMéxico

An alternative solution for the direct formation of?-liAlO2 was presented by a modified combustion method,to apply it to rather simple systems,utilizing non-oxidizer compounds such as Al2O3 and liOH,and urea as ***2 was prepared via non-stoichiometric 1:1,1.5:1 and 2:1 of li/Al molar ratios at 900 and 1000°C for 5 *** and structural characterization ofγ-liAlO2 was ***,the effect of different li/Al molar ratios on material morphology and its stability before high gamma radiation gradients was *** results showed that the crystal structures of the obtained powders wereγ-liAlO2 and?-liAlO2,depending on the li/Al molar *** results obtained demonstrate that?-liAlO2 microbricks,polyhedral and laminar shapes can be successfully synthesized with the proposed method and without any subsequent ***,gamma irradiation showed that the?-liAlO2 obtained does not decompose,forming only small amounts of *** can be established that the irradiation produces consolidation,which is not favourable for an efficient extraction of ***,it could be demonstrated that nitrate precursors are not necessary in the combustion method to produceγ-liAlO2 with high purity.

关键词： urea oxide combustion lithium aluminate ceramic

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微创髋关节成形术后关节囊外持续输注0．3％罗哌卡因与安慰剂对患者吗啡自控镇痛的前瞻随机双盲对照研究

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麻醉与镇痛 2013年第5期9卷 54-59页

作者： Jose Aguirre, MD, MSc Barbara Baulig, MD claudio Dora, MD Georgios Ekatodramis, MD Gina Votta-Velis, MD, PhD Philipp Ruland, MD Alain Borgeat, MD 赵燕君(译) 邓小明(校) Division of Anesthesiology Department of Orthopedic Surgery Balgrist University Hospital Zurich Zurich Switzerland. Gina Votta-Velis is currently affiliated with the Department of Anesthesiology University of Illinois at Chicago 不详

背景本研究中，我们探讨了微创髋关节成形术后创口持续输注0．3％罗哌卡因对疼痛和吗啡用量的影响。方法在这项双盲研究中，前瞻性纳入连续67例在蛛网膜下隙麻醉下择期行微创髋关节成形术的患者。外科医师将15cm长的有孔导管放入关节囊... 详细信息

背景本研究中，我们探讨了微创髋关节成形术后创口持续输注0．3％罗哌卡因对疼痛和吗啡用量的影响。方法在这项双盲研究中，前瞻性纳入连续67例在蛛网膜下隙麻醉下择期行微创髋关节成形术的患者。外科医师将15cm长的有孔导管放入关节囊外。患者随机分为两组：在关闭切口前，创口内单次注入20ml的0．3％罗哌卡因（R-组）或0．9％生理盐水（P-组）。随后用弹性泵以8ml／h的速度分别持续泵入0．3％的罗哌卡因或者安慰剂至术后48小时。所有患者均给予静脉吗啡自控镇痛。记录48小时内患者吗啡用量、静息和运动时疼痛以及血浆罗哌卡因总浓度和游离浓度。术后随访3个月。结果两组-般资料和手术数据相似。术后第一个48小时期间，R-组平均吗啡用量显著低于P组：45．4±9．5VS69．7±9．6（P〈0．001）。R-组吗啡用量在术后第一个24小时期间平均减少14．4mg[95％可信区间（confidenceinterval，CI）12．6～16．1]，在术后第二个24小时期间平均减少20．8mg（95％CI为19．1～22．4）。R组患者静息和运动时疼痛评分均较低（P〈0．0001）。R-组患者平均满意度较基线增加了22．7％（95％CI为15．9～16．1）。R-组血浆罗哌卡因总浓度和游离浓度均低于中毒浓度。R-组在第24小时和第48小时时血浆罗哌卡因游离浓度分别是0．141μmol／ml和0．11μmol／ml。在术后3个月时，两组臀部疼痛和镇痛药用量相似，但是R．组患者创口接触（31．2；95％CI27．7～34．7）不适感和压迫不适感（24；95％CI为20．1-27．9）明显减轻（P〈0．0001）。结论微创髋关节置换术后关节囊外创口持续输注0．3％罗哌卡因是-种减少吗啡用量，改善术后镇痛质量的有效方法，术后3个月时该方法依然具有-定优势。

关键词：随机双盲对照研究髋关节成形术罗哌卡因静脉吗啡持续输注自控镇痛后关节安慰剂

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The enhanced X-ray Timing and Polarimetry mission—eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 3-27页

作者： ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi Xuelei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino Joséluis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli claudio labanti luca latronico Gang li MaoShun li Xian li Wei li ZhengWei li Olivier limousin HongWei liu XiaoJing liu Bo lu Tao luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto claudio Piemonte Jinlu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen liZhi Sheng JiangBo Song liMing Song Carmelo Sgro liang Sun Ying Tan Phil Uttley Bo Wang Dianlong Wang GuoFeng Wang Juan Wang langPing Wang YuSa Wang Anna l.Watts XiangYang Wen Jörn Wilms Shaolin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang long Zhang Tong Zhang Yi Zhang Xiaoli Zhang Ziliang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Key laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences Institut für Astronomie und Astrophysik Eberhard Karls Universität INAF-Istituto di Astrofisica e Planetologia Spaziali INFN-Roma Tor Vergata Via della Ricerca Scientifica 1 Department of Engineering Physics and Center for Astrophysics Tsinghua University DTU Building 327DK-2800 Kongens Institute of Space Sciences 08193 Cerdanyola del Valles Institut d’Estudis Espacials de Catalunya Sezione di Pisa Istituto Nazionale di Fisica NucleareLargo Bruno Pontecorvo3 Department of Astronomy University of Genevachemin d’Ecogia 16 Osservatorio di Astrofisica e Scienza Dello Spazio di Bologna Istituto Nazionale di Astofisica Astronomical Institute Czech Academy of Sciences Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1 CEA Paris-Saclay/IRFU Beijing Institute of Spacecraft System Engineering CAST Osservatorio Astronomico di Brera Istituto Nazionale di Astofisica Space Research Center Polish Academy of Sciences Key laboratory of Advanced Material Microstructure of Education Ministry of China Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji University Department of Physics and Center for Astrophysics Tsinghua University Universita’degli Studi di Udine Via delle Scienze 206 Mullard Space Science laboratory University College London Department of Nuclear and Particle Physics University of Geneva SRON Netherlands Institute for Space Research Politecnico di Milano Sezione di Perugia Istituto Nazionale di Fisica Nucleare Dipartimento di Fisica e Chimica Fondazione Bruno Kessler Dr.Karl Remeis-Observatory and Erlangen Centre for Astroparticle Physics Universität Erlangen-Nürnberg University of Pavia Department of ElectronicsInformation and Biomedical Engineering and INFN Pavia Sezione di Torino Istituto Nazionale di Fisica NucleareVia Pietro Giuria1 Department of Physics and Astronomy University of Leicester Sezione di Trieste Istituto Nazionale di Fisica Nucleare

In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave *** paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment.

关键词： X-ray instrumentation X-ray polarimetry X-ray timing space mission:eXTP

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