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Role of endothelium on the abnormal Angiotensin-mediated vascular functions in epileptic rats

Journal of Biophysical Chemistry 2012年第2期3卷 174-182页

作者： Carolina Restini Rosana Reis claudio costa-neto Norberto Garcia-Cairasco José Cortes-de-Oliveira Lusiane Bendhack Universidade de Ribeiraão Preto—UNAERP. Curso de Medicina Ribeirāo Preto Brasil Faculdade de Ciências Farmacêuticas de Ribeiro Preto-USP Ribeiro Preto Brasil Faculdade de Medicina de Ribeirão Preto-USP Ribeir&atildeo Preto Brasil Faculdade de Medicina de Ribeiro Preto-USP Ribeiro Preto Brasil

Epidemiological studies have found that the risk for cardiovascular disease is increased in patients with epilepsy. The Renin Angiontensin System (RAS), an important player in vascular tone control, is also involved in many neurological disorders, including seizures and epilepsy. Although it has been reported that Angiotensin II (Ang II) release and Angiotensin receptors expression are altered in many cerebral areas in patients/animal models with neurological disorders, there are no data on the vascular function. We evaluated Ang I and Ang II-mediated vascular responses and to correlate their contractile responses to the pres- ence of endothelium and the protein levels of components of the RAS (AT1, AT2, Mas and ACE) in aorta isolated from genetically epileptic rats (WAR strain). The major finding was that the vascular contractile response induced by Ang I and Ang II is endothelium-dependent. Ang II induced contractions in aortas from Wistar rats either with intact endothelium (E+) (1.16 ± 0.04 g, n = 6) and endothelium-denuded (E-) (1.24 ± 0.04 g, n = 6). Maximum contractile response (ME) induced by Ang I was lower in Wistar E+ (0.45 ± 0.03 g, n = 6) compared with Wistar E- (1.13 ± 0.08 g, n = 6). Ang I and Ang II failed to induce contraction in WAR E+, whereas the ME induced by Ang I in WAR E- was lower (0.52 ± 0.04 g, n = 11) than in the Wistar. ME induced by Ang II in aortas from WAR was also lower (0.40 ± 0.03 g, n = 11) compared with Wistar. AT1 receptor expression in both E+ WAR and Wistar was lower than in both E- WAR and Wistar. AT2 and Mas receptor expression was higher in Wistar E- and E+ as compared to WAR E- and E+. ACE expression was higher in both E+ WAR and Wistar, but it was lower in both E- WAR and Wistar. Endothelium impairs the contractile response induced by Angiotensin in WAR, suggesting that endothelial relaxing factors play important role on the aorta contraction.

关键词： Endothelium Aorta Myogenic Tone Angiotensin Angiotensin II Receptor Epilepsy

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Colorectal cancer screening:A review of current knowledge and progress in research

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1119-1133页

作者： Sara Ramos Lopes claudio Martins Inês costa Santos Madalena Teixeira Élia Gamito Ana Luisa Alves Department of Gastroenterology Centro Hospitalar de SetúbalSetúbal 2910-446Portugal

Colorectal cancer(CRC)is one of the most prevalent malignancies worldwide,being the third most commonly diagnosed malignancy and the second leading cause of cancer-related deaths *** the progress in screening,early diagnosis,and treatment,approximately 20%-25%of CRC patients still present with metastatic disease at the time of their initial ***,the burden of disease is still expected to increase,especially in individuals younger than 50 years old,among whom early-onset CRC incidence has been *** and early detection are pivotal to improve CRC-related *** is well established that CRC screening not only reduces incidence,but also decreases deaths from *** screening strategies have proven effective in decreasing both CRC incidence and mortality,though variations in efficacy have been reported across the ***,uncertainties persist regarding the optimal screening method,age intervals and ***,adherence to CRC screening remains globally *** recent years,emerging technologies,notably artificial intelligence,and non-invasive biomarkers,have been developed to overcome these ***,controversy exists over the actual impact of some of the new discoveries on CRC-related outcomes and how to effectively integrate them into daily *** this review,we aim to cover the current evidence surrounding CRC *** will further critically assess novel approaches under investigation,in an effort to differentiate promising inno-vations from mere novelties.

关键词： Colorectal cancer Screening Review Oncology Artificial intelligence

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CO_(2) conversion to solar fuels and chemicals:Opening the new paths

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Journal of Energy Chemistry 2024年第4期91卷 680-683页

作者： Gabriele Centi claudio Ampelli Department of Chemical BiologicalPharmaceutical and Environmental Sciences(ChiBioFarAm)University of MessinaERIC aisbl and CASPE/INSTMV.le F.Stagno d'Alcontres 3198166 MessinaItaly

This future article discusses the new prospects and directions of CO_(2)conversion via the photo-electrocatalytic(PEC)*** second(2nd)generation solar fuels and chemicals(SFs)are generated directly in PEC systems via electrons/protons reactions without forming molecular H_(2)as an intermediate,overcoming the thermodynamics limitations and practical issues encountered for electro-fuels produced by multistep thermocatalytic processes(***_(2)conversion with H_(2)coming from water electrolysis).A distributed and decentralized production of SFs requires very compact,highly integrated,and intensified *** the existing reactors of advanced design(based on artificial leaves or photosynthesis),the integrated photovoltaic plus electrocatalytic(PV-EC)device is the only system(demonstrated at large scale)to produce SFs with high solar-to-fuel(STF)***,while the literature indicates STF efficiency as the main(and only)measure of process performance,we remark here the need to refer to productivity(in terms of current density)and make tests with reliable flow PEC systems(with electrodes of at least 5–10 cm^(2))to accelerate the scaling-up *** approaches that minimize downstream separation costs is also *** limitations exist in PEC systems,but most can be overcome by proper electrode and cell engineering,thus going beyond the properties of the *** examples of current developments,we present the progress of(i)artificial leaf/tree devices for green H_(2)distributed production and(ii)a PEC device producing the same chemicals at both cathode and anode parts without downstream operations for green solvent distributed *** on these developments,future directions,such as producing fertilizers and food components from the air,are *** aim is to provide new ideas and research directions from a personal perspective.

关键词： Solar fuels Artificial leaf PEC devices PV-EC devices Cell engineering green H_(2) Chemicals from theair

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Preventing brain aging by the artificial enforcement of the unfolded protein response:future directions

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Neural Regeneration Research 2024年第2期19卷 393-394页

作者： Felipe Cabral-Miranda claudio Hetz Instituto de Ciências Biomédicas Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Center for Geroscience Brain Health and MetabolismSantiagoChile、Biomedical Neuroscience InstituteFaculty of MedicineUniversity of ChileSantiagoChile、Program of Cellular and Molecular BiologyInstitute of Biomedical SciencesFaculty of MedicineUniversity of ChileSantiagoChile、Buck Institute for Research on AgingNovatoCAUSA

As the life expectancy of the world’s population increases,age-related diseases are emerging as one of the greatest problems facing modern *** onset of dementia and neurodegenerative diseases is strictly dependent on aging as a major risk factor and has a profound impact on various aspects of the lives of individuals and their families.

关键词： diseases aging directions

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Endo-hepatology: Why should we do endoscopic ultrasound-guided interventions to the liver that we could do through the skin?

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World Journal of Gastroenterology 2024年第40期30卷 4333-4338页

作者： claudio Calvanese Pietro Fusaroli Gastroenterology Unit Hospital of ImolaUniversity of BolognaImola 40026BolognaItaly

Endoscopic ultrasound(EUS)-guided interventions on the liver such as diffuse biopsy and portal pressure gradient measurement are emerging as potential alternatives to percutaneous *** purpose of this editorial was to address all the indications that could potentially make an EUS-guided approach a possible alternative to the percutaneous procedures with respect to the proce-dures that could join the EUS examination such as upper endoscopy for gastro-esophageal varices,pancreaticobiliary investigation with EUS,and other potential advantages in terms of patient *** issue of a holistic gastroenterologist approach was also discussed along with the potential for developing clinical research.

关键词： Endo-hepatology Endoscopic ultrasound Endosonography Liver disease Liver biopsy Portal hypertension

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Digital twin-and extended reality-based telepresence for collaborative robot programming in the 6G perspective

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Digital Communications and Networks 2024年第2期10卷 315-327页

作者： Davide Calandra F.Gabriele Pratticò Alberto Cannavò claudio Casetti Fabrizio Lamberti Politecnico di Torino Department of Control and Computer EngineeringCorso Duca Degli Abruzzi2410129TurinItaly

In the context of Industry 4.0,a paradigm shift from traditional industrial manipulators to Collaborative Robots(CRs)is ongoing,with the latter serving ever more closely humans as auxiliary tools in many production *** this scenario,continuous technological advancements offer new opportunities for further innovating robotics and other areas of next-generation *** example,6G could play a prominent role due to its human-centric view of the industrial *** particular,its expected dependability features will pave the way for new applications exploiting highly effective Digital Twin(DT)-and eXtended Reality(XR)-based *** this work,a novel application for the above technologies allowing two distant users to collaborate in the programming of a CR is *** approach encompasses demanding data flows(e.g.,point cloud-based streaming of collaborating users and robotic environment),with network latency and bandwidth *** obtained by analyzing this approach from the viewpoint of network requirements in a setup designed to emulate 6G connectivity indicate that the expected performance of forthcoming mobile networks will make it fully feasible in principle.

关键词： 6G Digital twin Telepresence Collaborative robots Industry 4.0 Augmented reality Virtual reality Point cloud streaming

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Interleukin 1βreceptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1

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Neural Regeneration Research 2025年第2期20卷 416-423页

作者： Roberto Piacentini claudio Grassi Department of Neuroscience UniversitàCattolica del Sacro CuoreRomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly

Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s ***,the molecular mechanisms underlying this association are not completely *** the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central ***,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1βas a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.

关键词： herpes simplex virus type 1 interleukin 1β microglia neuroinflammation synaptic dysfunction

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香椿的树木年轮宽度与超年生殖行为的相互关系:对树轮学研究的警示

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Journal of Plant Ecology 2024年第1期17卷 165-171页

作者： Monique Silva costa Thaís Jorge de Vasconcellos claudio Sergio Lisi Arno Fritz Neves Brandes Mario Tomazello-Filho Cátia Henriques Callado Instituto de Aplicação Fernando Rodrigues da Silveira Universidade do Estado do Rio de JaneiroRua Barão de Itapagipe96.Rio Comprido 20261-005Rio de JaneiroBrazil Laboratório de Anatomia Vegetal Universidade do Estado do Rio de JaneiroRua São Francisco Xavier524Maracanã20550-013Rio de JaneiroBrazil Departamento de Biologia Universidade Federal de SergipeAv.Marechal Rondon s/n-Rosa Elze.São Cristóvão 49100-000SergipeBrazil Departamento de Biologia Geral Universidade Federal FluminenseRua Prof.Marcos Waldemar de Freitas ReisS/N.Gragoatá24210-201Rio de JaneiroBrazil Escola Superior de Agricultura Luiz de Queiroz Universidade de São PauloAv.Pádua Dias11.Piracicaba 13418-900São PauloBrazil

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的... 详细信息

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的树木年轮宽度与超年生殖行为相关联。总体而言,生殖结构的发育发生在湿润的年份,在生长季初期没有出现水分亏缺。然而,在这些年份,树木年轮宽度较小。这些结果可能与树木年轮宽度与当地气候之间缺乏相关性有关。因此,我们强调在径向生长研究中纳入生殖数据的重要性,以扩大对热带森林生长变异性的理解。

关键词：植物生长策略树木年轮学树木生态学生殖权衡

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Different behavioral profles between invasive and native nudibranchs:means for invasion success?

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Current Zoology 2024年第3期70卷 406-417页

作者： Armando Macali Sara Ferretti Serena Scozzafava Elia Gatto claudio Carere Ichthyogenic Experimental Marine Centre(CISMAR) Department of Ecological and Biological SciencesTuscia University01016 Borgo Le SalineTarquiniaItaly Department of Chemical Pharmaceutical and Agricultural SciencesFerrara Universityvia Luigi Borsari 4644121 FerraraItaly Department of Life Sciences and Biotechnology Ferrara Universityvia Luigi Borsari 4644121 FerraraItaly

Behavior is predicted to be a primary determinant of the success of the invasion process during the early phases of *** invaders with sympatric native species may provide a good approach to unravel behavioral traits involved in an invasion *** this study,we carried out an experimental simulation of the introduction and the acclimatization phase into a new environment and assessed the expression of activity,alertness,and habituation in an invasive Mediterranean population of the South African nudibranch Godiva quadricolor comparing its profles with those of the sympatric Mediterranean native nudibranchs Cratena peregrina and Caloria *** of these 3 species were subjected to 3 behavioral tests:spontaneous activity,carried out in the introduction phase(immediately after sampling)and after a week of acclimatization;alert test,in which a potential threat was simulated by means of a tactile stimulus,and habituation test,in which the same alert test stimulus was repeated 5 times at 30-min *** invasive *** showed higher levels of exploration activity,thigmotaxis,alertness,and sensitization than the native *** behavioral traits may represent pivotal drivers of the ongoing invasion process.

关键词： biological invasion invasive phenotype invertebrate cognition molluscs personality

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Real-world clinical efficacy of tofacitinib in moderate-to-severe ulcerative colitis

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World Journal of Gastroenterology 2024年第34期30卷 3929-3931页

作者： Sara R Lopes claudio Martins Madalena Teixeira David Tomás Department of Gastroenterology Unidade Local de Saúde da Arrábida-Hospital de São BernardoSetúbal 2910-446Portugal

Tofacitinib is an oral small-molecule Janus kinase(JAK)inhibitor that preferentially inhibits JAK1 and *** efficacy in inducing and maintaining remission in ulcerative colitis(UC)as well as its safety profile has been demonstrated in multicenter,randomized,double-blind,placebo-controlled ***,real-world studies evaluating the effectiveness and adverse effects of tofacitinib have been conducted,affirming its clinical efficacy in moderate-to-severe UC.

关键词： Ulcerative colitis Tofacitinib Real-world studies Inflammatory bowel disease Janus kinase inhibitor

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