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World Journal of Gastroenterology 2014年第17期20卷 4839-4845页

作者： Gianluca Rizzo Daniela Pugliese Alessandro Armuzzi claudio Coco Department of Surgical Sciences Complesso Integrato ColumbusCatholic University of the Sacred Heart00168 RomeItaly Internal Medicine and Gastroenterology Unit Complesso Integrato ColumbusCatholic University of the Sacred Heart00168 RomeItaly

Ulcerative colitis (UC) is an inflammatory bowel disease affecting large bowel with variable clinical course. The history of disease has been modified by the introduction of biologic therapy, in particular Infliximab (IFX), that has demonstrated efficacy in inducing fast symptoms remission, promoting mucosal healing and maintaining long-term remission. However, surgery is still needed for UC patients: in case of failure of medical therapy and if acute complications or a malignancy occurred. Surgical treatment is associated with a short-term post-operative mortality and morbidity respectively of 0%-4% and 30%. In this study we systematically analyzed: the role of IFX in reducing the colectomy rate, the risk of post-operative morbidity in pre-operatively IFX-treated patients and the cost-effectiveness of IFX therapy. Four of 5 analyzed randomized controlled trials demonstrated that therapy with IFX significantly reduces the colectomy rate. Moreover, pre-operative treatment with IFX doesn’t seem to increase post-operative infectious complications. By an economic point of view, the cost-effectiveness of IFX-therapy was demonstrated for UC patients suffering from moderate to severe UC in a study based on a cost estimation of the National Health Service of England and Wales. However, the argument is debated.

关键词： Ulcerative colitis Infliximab Colectomy Post-operative complications Cost-effectiveness Inflammatory bowel disease

Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults:A case report and review of the literature

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World Journal of Gastroenterology 2008年第6期14卷 960-965页

作者： Cosimo Sperti Mattia Berselli claudio Pasquali Davide Pastorelli Sergio Pedrazzoli Department of Medical and Surgical Sciences Clinica Chirurgica Ⅳ University of Padua Padua 35128 Italy Department of Oncology Istituto Oncologico Veneto Padua Italy

Solid-pseudopapillary tumor (SPT) is a rare neoplasm of the pancreas that usually occurs in young females. It is generally considered a low-grade malignant tumor that can remain asymptomatic for several years. The occurrence of infiltrating varieties of SPT is around 10%-15%. Between 1986 and 2006, 282 cystic tumors of the pancreas were observed. Among them a SPT was diagnosed in 8 patients (2.8%) with only one infiltrating variety. This was diagnosed in a 49-year-old female 13 years after the sonographic evidence of a small pancreatic cystic lesion interpreted as a pseudocyst. The tumor invaded a long segment of the portal- mesenteric vein confluence, and was removed with a total pancreatectomy, resection of the portal vein and reconstruction with the internal jugular vein. Histological examination confirmed the R-0 resection of the primary SPT, although a vascular invasion was demonstrated. The postoperative course was uneventful, but 32 mo after surgery the patient experienced diffuse liver metastases. Chemotherapy with different drugs was started. The patient is alive and symptom-free, with stable disease, 75 mo after surgery. Twenty-five patients with invasion of the portal vein and/or of mesenteric vessels were retrieved from the literature, 16 recent patients with tumor relapse after potentially curative resection were also retrieved. The best treatment remains a radical resection whenever possible, even in locally advanced or metastatic disease. The role of chemotherapy, and/or radiotherapy, is still to be defined.

关键词： Solid-pseudopapillary tumor Pancreatectomy Vascular resection Liver metastases Follow-up

Feeding of yeast(Candida spp.) improves in vitro ruminal fermentation of fibrous substrates

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Journal of Integrative Agriculture 2015年第3期14卷 514-519页

作者： Yoandra Marrero Yamicela Castillo Oscar Ruiz Eduviges Burrola claudio Angulo Department of Physiology Animal Science Institute Multidisciplinary Division Autonomous University of Juárez Faculty of Animal Science and Ecology Autonomous University of Chihuahua

In vitro gas production technique（IVGPT） was used with the objective of determining the inclusion effect of live cells of two strains of Candida yeast on in vitro ruminal fermentation of two fibrous substrates. In order to achieve this, two experiments were performed： A） using oat straw（Avena sativa） as substrate; B） using alfalfa hay（Medicabo sativa） as substrate, comparing the effect of two different strains of Candida genre, both isolated from the rumen, on the mentioned substrates. Levica 25（Candida tropicalis） yeast belongs to the culture collection of the Institute of Animal Science, Cuba, and Levazoot 15（Candida norvegensis） yeast is part of the collection of the Faculty of Zootechnology and Ecology of the Autonomous University of Chihuahua, Mexico. Both strains demonstrated their potential in activating the ruminal fermentation. They stimulated（P〈0.0001） the ruminal fermentation of the substrates under study. However, the Levazoot strain stimulated the dry matter（DM） fermentation of alfalfa in 21.43%, more than Levica 25. It is concluded that there is an influence of yeast strain and diet on the rumen environment and, therefore, it is important to select the appropriate strain in every production condition.

关键词： rumen yeast gas production fermentation product microbial additive

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SOME PRELIMINARY INFORMATION ON SYNDIOTACTIC POLYSTYRENE CATALYSTS

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Chinese Journal of Polymer Science 1988年第4期6卷 365-369页

作者： Adolfo Zambelli,claudio Pellecchia,Leone Oliva,韩世敏 Dipartimento di Fisica Universita'di Salerno 84081 Baronissi (SA) Italy Dipartimento di Fisica Universita'di Salerno 84081 Baronissi (SA) Italy Dipartimento di Chimica Universita'di Napoli Via Mezzocannone 4 Ⅰ-80134 Napoli Italy Institute of Chemistry Academia Sinica Beijing China

Syndiotactic specific polymerization of styrene has been investigated by13C NMR analysis and isotopic laelling methods. The value of the activation energy involved in the steric control has been determined. Some infor... 详细信息

关键词： We wish to thank prof. A. Di Donato Universita’ di Napoli Italy for radioactivity measurements

Analysis of the factors controlling performances of Au-modified TiO2 nanotube array based photoanode in photo-electrocatalytic(PECa)cells

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Journal of Energy Chemistry 2017年第2期26卷 284-294页

作者： claudio Ampelli Francesco Tavella Chiara Genovese Siglinda Perathoner Marco Favaro Gabriele Centi Department of Chemical BiologicalPharmaceutical and Environmental SciencesUniversity of MessinaERIC aisbl and CASPE/INSTMV.le F.Stagno d’Alcontres 3198166 MessinaItaly Department of Chemical Sciences University of Paduavia Marzolo 135136 PaduaItaly Department of Mathematical ComputerPhysical and Earth SciencesUniversity of MessinaERIC aisbl and CASPE/INSTMV.le F.Stagno d’Alcontres 3198166 MessinaItaly Advanced Light Source Joint Center for Artificial PhotosynthesisLawrence Berkeley National Laboratory1 Cyclotron Rd.M/S 30R0205 BerkeleyCA 94720USA.

The efficiency of photo-electrocatalytic（PECa） devices for the production of solar fuels depends on several limiting factors such as light harvesting, charge recombination and mass transport diffusion. We analyse here how they influence the performances in PECa cells having a photo-anode based on Au-modified TiOnanotube（TNT） arrays, with the aim of developing design criteria to optimize the photo-anode and the PECa cell configuration for water photo-electrolysis（splitting） and ethanol photo-reforming *** TNT samples were prepared by controlled anodic oxidation of Ti foils and then decorated with gold nanoparticles using different techniques to enhance the visible light response through heterojunction and plasmonic effects. The activity tests were made in a gas-phase reactor, as well as in a PECa cell without applied bias. Results were analysed in terms of photo-generated current, Hproduction rate and photoconversion efficiency. Particularly, a solar-to-hydrogen efficiency of 0.83% and a Faradaic efficiency of 91%were obtained without adding sacrificial reagents.

关键词： H2 production Au nanoparticles Solar fuels TiO2 nanotubes Electrodeposition Photoelectrochemical cells(PEC) Solar-to-hydrogen efficiency Anodic oxidation

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Pediatric nonalcoholic fatty liver disease,metabolic syndrome and cardiovascular risk

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World Journal of Gastroenterology 2011年第26期17卷 3082-3091页

作者： Lucia Pacifico Valerio Nobili Caterina Anania Paola Verdecchia claudio Chiesa Department of Pediatrics Sapienza University of Rome Department of Hepato-gastroenterology and Nutrition Pediatric Hospital "Bambino Gesù" Institute of Translational Pharmacology National Research Council

Nonalcoholic fatty liver disease(NAFLD) encompasses a range of liver histology severity and outcomes in the absence of chronic alcohol *** mildest form is simple steatosis in which triglycerides accumulate within hepatocytes.A more advanced form of NAFLD,nonalcoholic steatohepatitis,includes inflammation and liver cell injury,progressive to cryptogenic *** has become the most common cause of chronic liver disease in children and *** recent rise in the prevalence rates of overweight and obesity likely explains the NAFLD epidemic *** is strongly associated with abdominal obesity,type 2 diabetes,and dyslipidemia,and most patients have evidence of insulin ***,NAFLD shares many features of the metabolic syndrome(MetS),a highly atherogenic condition,and this has stimulated interest in the possible role of NAFLD in the development of *** evidence suggests thatNAFLD is associated with a significantly greater overall mortality than in the general population,as well as with increased prevalence of cardiovascular disease(CVD),independently of classical atherosclerotic risk ***,several studies including the pediatric population have reported independent associations between NAFLD and impaired flow-mediated vasodilatation and increased carotid artery intimal medial thickness-two reliable markers of subclinical atherosclerosis-after adjusting for cardiovascular risk factors and ***,the rising prevalence of obesity-related MetS and NAFLD in childhood may lead to a parallel increase in adverse cardiovascular *** children,the cardiovascular system remains plastic and damage-reversible if early and appropriate interventions are established *** goals for NAFLD should address nutrition,physical activity,and avoidance of smoking to prevent not only end-stage liver disease but also CVD.

关键词： Nonalcoholic fatty liver disease Metabolicsyndrome Cardiovascular risk Children

Search for heavy sterile neutrinos in trileptons at the LHC

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Chinese Physics C 2017年第10期41卷 31-36页

作者： claudio O.Dib C.S.Kim Kechen Wang CCTVal and Department of Physics Universidad Técnica Federico Santa María Department of Physics and IPAP Yonsei University DESY Center for Future High Energy Physics Institute of High Energy PhysicsChinese Academy of Sciences

We present a search strategy for both Dirac and Majorana sterile neutrinos from the purely leptonic decays of W^±→e^±e^±μ ν and μ^±^±e ν at the 14 TeV LHC. The discovery and exclusion limits for sterile neutrinos are shown using both the Cut-and-Count（CC） and Multi-Variate Analysis（MVA） methods. We also discriminate between Dirac and Majorana sterile neutrinos by exploiting a set of kinematic observables which differ between the Dirac and Majorana cases. We find that the MVA method, compared to the more common CC method, can greatly enhance the discovery and discrimination limits. Two benchmark points with sterile neutrino mass m N =20 GeV and 50 GeV are tested. For an integrated luminosity of 3000 fb^-1, sterile neutrinos can be found with 5σ significance if heavy-to-light neutrino mixings ｜U_（Ne）｜^2~｜U_（Nμ）｜^2~10^-6, while Majorana vs. Dirac discrimination can be reached if at least one of the mixings is of order 10^-5.

关键词： sterile neutrinos LHC trileptons BSM physics

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Different behavioral profles between invasive and native nudibranchs:means for invasion success?

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Current Zoology 2024年第3期70卷 406-417页

作者： Armando Macali Sara Ferretti Serena Scozzafava Elia Gatto claudio Carere Ichthyogenic Experimental Marine Centre(CISMAR) Department of Ecological and Biological SciencesTuscia University01016 Borgo Le SalineTarquiniaItaly Department of Chemical Pharmaceutical and Agricultural SciencesFerrara Universityvia Luigi Borsari 4644121 FerraraItaly Department of Life Sciences and Biotechnology Ferrara Universityvia Luigi Borsari 4644121 FerraraItaly

Behavior is predicted to be a primary determinant of the success of the invasion process during the early phases of *** invaders with sympatric native species may provide a good approach to unravel behavioral traits involved in an invasion *** this study,we carried out an experimental simulation of the introduction and the acclimatization phase into a new environment and assessed the expression of activity,alertness,and habituation in an invasive Mediterranean population of the South African nudibranch Godiva quadricolor comparing its profles with those of the sympatric Mediterranean native nudibranchs Cratena peregrina and Caloria *** of these 3 species were subjected to 3 behavioral tests:spontaneous activity,carried out in the introduction phase(immediately after sampling)and after a week of acclimatization;alert test,in which a potential threat was simulated by means of a tactile stimulus,and habituation test,in which the same alert test stimulus was repeated 5 times at 30-min *** invasive *** showed higher levels of exploration activity,thigmotaxis,alertness,and sensitization than the native *** behavioral traits may represent pivotal drivers of the ongoing invasion process.

关键词： biological invasion invasive phenotype invertebrate cognition molluscs personality

Protein kinase CK2: a potential therapeutic target for diverse human diseases

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1698-1717页

作者： Christian Borgo claudio D'Amore Stefania Sarno Mauro Salvi Maria Ruzzene Department of Biomedical Sciences University of PaduaPaduaItaly CNR Institute of Neuroscience University of PaduaPaduaItaly

CK2 is a constitutively active Ser/Thr protein kinase,which phosphorylates hundreds of substrates,controls several signaling pathways,and is implicated in a plethora of human *** best documented role is in cancer,where it regulates practically all malignant *** well-known functions of CK2 are in human infections;in particular,several viruses exploit host cell CK2 for their life *** recently,also SARS-CoV-2,the virus responsible for the COVID-19 pandemic,has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates(either viral and host proteins).CK2 is also considered an emerging target for neurological diseases,inflammation and autoimmune disorders,diverse ophthalmic pathologies,diabetes,and *** addition,CK2 activity has been associated with cardiovascular diseases,as cardiac ischemia-reperfusion injury,atherosclerosis,and cardiac *** hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many ***,psychiatric disorders and syndromes due to CK2 mutations have been recently *** these bases,CK2 is emerging as an increasingly attractive target in various fields of human medicine,with the advantage that several very specific and effective inhibitors are already ***,we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings.

关键词： diseases inflammation potential

Pancreatic involvement in pediatric inflammatory bowel diseases

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World Journal of Pediatrics 2015年第3期11卷 207-211页

作者： Sabrina Cardile Antonino Randazzo Simona Valenti claudio Romano Department of Pediatrics IBD UnitUniversity of Messina Via Consolare ValeriaMessina 98125Italy

Background:Inflammatory bowel diseases(IBDs)are a group of chronic diseases affecting the gastrointestinal tract,with a disabling *** incidence of IBDs is increasing in different geographical areas,indicating its emergence as a global disease,especially in *** patients with IBDs develop extraintestinal manifestations(EIMs)during follow-up,as IBDs have a potential risk of systemic involvement..Data sources:A systematic review of the literature was made to analyze latest studies on pancreatic involvement in children with IBD including our experience in assessing possible implications and its future ***:The involvement of the hepatobiliary system is considered a rare EIM of children with IBD,with an incidence much higher than that in the general *** pancreatic hyperenzymemia,which occurs in the absence of typical symptoms and/or characteristic imaging findings,may be found in many patients with *** frequent causes of pancreatitis are drugs,bilio-pancreatic disorders,immunologic disturbances and pancreatic auto-antibodies,although in some cases idiopathic forms have been ***:It is important to establish a correct diagnostic approach based on etiology and to assess the most appropriate therapeutic strategy,thus avoiding complications and improving the quality of life of children with IBD.

关键词： Crohn's disease extraintestinal manifestations inflammatory bowel diseases pancreatitis ulcerative colitis