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DEVELOPmENT OF A STANDARDIZED ACUPUNCTURE FOR FATIGUE IN WESTERN PATIENTS WITH mULTIPLE SCLEROSIS

Journal of Integrative medicine 2014年第3期 273-273页

作者： Ying-hui Chang Daniel Pach Judith Bellmann-Strobl Friedemann Paul Xue-min Shi claudia m witt Institute for Social medicine Epidemiology and Health EconomicsCharité – Universittsmedizin Berlin NeuroCure Clinical Research Center Charité – Universittsmedizin Berlin First Teaching Hospital of Tianjin University of Traditional Chinese medicine Center for Integrative medicine University of Maryland School of Medicine

Background: Fatigue is the most common clinical symptom of patients with multiple sclerosis(mS) and strongly influences their quality of *** Tianjin, China, Xingnao Kaiqiao(XNKQ)acupuncture is widely used to treat *** is a standard acupuncture therapy developed by Shi Xuemin with a strict set of points and standard quantitative *** retention time is about 15 min for each session, which is usually applied five times a week over at least four *** acupuncture aims to alert the spirit, refresh and regulate the *** "mind" here not only refers to mental, conscious and thinking activities, but also manifests the function of zang-fu organs and ***: Our aim was to improve that the intervention could be applied as a standardized acupuncture in a randomized controlled trial in the West(***: NCT01864707,trial performed in Germany).The trial compared usual care plus acupuncture with usual care only for fatigue in Western mS patients in an outpatient ***: A consensus was achieved involving Chinese acupuncture experts, Western mS experts, and research methodologists in an onsite group of discussions and email ***: A XNKQ-based prescription for fatigue is based on the following assumption: regulate and harmonize zang-fu organs, reinforce the function of liver and kidney, and improve the motor *** is applied twice a week over twelve weeks and consists of 19 points and 34 needles(0.25 mm × 40 mm stainless steel disposable).For each point a standardized manual manipulation which reflects the manipulation also used in China is *** retention time is 15 min per ***: A standardized acupuncture for fatigue in mS patients who are suitable for a clinical trial in the West can be developed.

关键词： mS DEVELOPmENT OF A STANDARDIZED ACUPUNCTURE FOR FATIGUE IN WESTERN PATIENTS WITH mULTIPLE SCLEROSIS

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利用经济学评价证据支持针灸医疗保险报销决策:现有证据及挑战

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英国医学杂志中文版 2022年第6期25卷 315-319页

作者：李洪超金雪晶 Patricia m Herman claudia m witt 陈英耀岗卫娟景向红宋坪杨龙会 Dan Ollendorf 张渊 Gordon Guyatt 黄璐琦张誉清(文/译) 王欣恬中国药科大学国际医药商学院中国药科大学药物经济学评价研究中心北京中医药大学循证医学中心 RAND Corporation USA Institute for Complementary and Integrative medicine University Hospital Zurich and University of ZurichZurichSwitzerland 复旦大学公共卫生学院复旦大学国家卫生委员会卫生技术评估重点实验室中国中医科学院针灸研究所中国中医药循证医学研究中心中国医学科学院 Center for the Evaluation of Value and Risk in Health Institute for Clinical Research and Health Policy StudiesTufts Medical CenterUSA 加拿大麦克马斯特大学健康研究方法、证据与影响学系 Department of medicine Faculty of Health SciencesMcMaster UniversityHamiltonONCanada 中国中医科学院广安门医院中加整合医学循证医学研究合作中心宁波诺丁汉大学宁波诺丁汉GRADE中心

李洪超和同事们探索了在针灸医疗保险报销决策过程中引入经济学评价证据的全球挑战。医疗保险报销决策的过程本质上是复杂的。除了安全性和有效性,社会、经济、政治、地理、制度等非医学因素通常也会对决策制订产生重要的影响。

关键词：经济学评价医疗保险非医学因素报销决策评价证据针灸全球挑战证据支持

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DIFFERENTIAL CEREBRAL RESPONSE TO SOmATOSENSORY STImULATION OF AN ACUPUNCTURE POINT VERSUS TWO NONACUPUNCTURE POINTS mEASURED WITH fmRI

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Journal of Integrative medicine 2014年第3期 219-219页

作者： Daniel Pach Till Nierhaus Wenjing Huang Xiangyu Long Vitaly Napadow Stephanie Roll Fanrong Liang Burkhard Pleger Arno Villringer claudia m.witt Institute for Social medicine Epidemiologyand Health EconomicsCharité-Universittsmedizin Berlin mind-Brain Institute and Berlin School of mind and Brain Charité-Universittsmedizin Berlin and Humboldt-University max Planck Institute for Human Cognitive and Brain Sciences Chengdu University of Traditional Chinese medicine Athinoula A.martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General Hospital 6. Department of RadiologyLogan College of Chiropractic 7. Center for Integrative MedicineUniversity of Maryland School of Medicine

Objective: To evaluate whether different point locations chosen for a somatosensory stimulation with acupuncture needles differently change the brain activity in healthy ***: We used event-related fmRI, and resting-state functional connectivity fmRI to assess neural responses to standardized manual needle stimulation of the acupuncture point ST36(lower leg) and two control point locations(CP1 same dermatome, and CP2 different dermatome) that are not *** responses were expected to differ for stimulation in two different dermatomes(CP2 different from ST36 & CP1), or stimulation at the acupuncture point versus the control *** scans all healthy subjects(n=22) received manual needle stimulation at all 3 points in a randomized *** needle stimulation consisted of 6-minute intermittent penetrating needle manipulation on one *** sensation was measured by the massachusetts General Hospital Acupuncture Sensation Scale(mASS) and correlated with fmRI ***: The fmRI analysis found that insula and S2 activation was more pronounced with ST36 stimulation, and there was increased S2 connectivity to thalamus and brainstem following ST36 *** in needle sensation between ST36 ***1 and ST36 ***2 were statistically significant(pairwise t-test, P=0.009 and P=0.005, respectively).No correlation was found when exploring the relationship between the mASS index and the β values of the fmRI BOLD ***: Our results suggest that stimulation at acupoints may modulate somatosensory and saliency processing regions more readily.

关键词： fmRI DIFFERENTIAL CEREBRAL RESPONSE TO SOmATOSENSORY STImULATION OF AN ACUPUNCTURE POINT VERSUS TWO NONACUPUNCTURE POINTS mEASURED WITH fmRI ST

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Exclusive breastfeeding greater than 50%, success of education in a university hospital in Bogotá: Case-control study

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World Journal of Clinical Pediatrics 2024年第1期13卷 23-30页

作者： marcela murillo Galvis Sofia Ortegon Ochoa Clara Eugenia Plata García maria Paula Valderrama Junca Dayanna Alejandra Inga Ceballos Daniel mauricio mora Gómez claudia m Granados martin Rondón Department of Pediatrics Hospital Universitario San IgnacioBogotá110111Colombia Department of Clinical Epidemiology and Biostatistics Pontifica Universidad JaverianaBogotá110111Colombia

BACKGROUND maintenance rates of exclusive breastfeeding(EBF)worldwide are low,thus,one of the objectives of the summary of policies on breastfeeding(BF)in world nutrition goals for 2025 are that at least 50%of infants under six months of age receive EBF that *** Objective of this study is to document the rates of EBF in children born in San Ignacio University Hospital(HUSI)and identify factors associated with *** To document the percentages of EBF in those that were born at HUSI and identify factors associated to their *** This is a study of cases and controls in an analytic,retrospective cohort that took children born alive between January 2016 and January 2019 at HUSI located in the city of Bogotá,*** Receiving information about BF at HUSI was able to maintain EBF up until 4 mo(OR=1.65;95%CI:1.02-2.66).The presence of gynecologic and obstetric comorbidities(OR=0.32;95%CI:0.12-0.83),having mastitis(OR=0.56;95%CI:0.33-0.94),and receiving information from mass media(OR=0.52;95%CI:0.31-0.84)are factors associated with not maintaining *** Receiving education at a Women-and Child-Friendly Institution was the only significant factor to achieve EBF until 4 mo,with a frequency greater than the one reported in the country,which matches multiple studies where counseling and individualized support on BF achieve this *** about BF and early detection of obstetric/gynecologic complications must be strengthened among the healthcare staff in charge of mothers during ***,strategies must be promoted to continue BF such as creating milk banks with the objective of increasing BF rates even when mothers return to work.

关键词： Breastfeeding Women-and Child-Friendly Institutional Strategy Strategies Adherence Education

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Does the use of double hormone replacement therapy for trauma patient organ donors improve organ recovery for transplant

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World Journal of Transplantation 2024年第2期14卷 119-125页

作者： Eden m Gallegos Tanner Reed Paige Deville Blake Platt claudia Leonardi Lillian Bellfi Jessica Dufrene Saad Chaudhary John Hunt Lance Stuke Patrick Greiffenstein Jonathan Schoen Alan marr Anil Paramesh Alison A Smith Department of Physiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Department of medicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Trauma Surgery Tacoma General HospitalTacoma 98405United States Department of Public Health Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Donation Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Department of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

BACKGROUND With an ongoing demand for transplantable organs,optimization of donor management protocols,specifically in trauma populations,is important for obta-ining a high yield of viable organs per *** management of brain-dead potential organ donors(BPODs)is controversial,leading to heterogeneous clinical management *** studies have shown that when levo-thyroxine was combined with other treatments,including steroids,vasopressin,and insulin,BPODs had better organ recovery and survival outcomes were increased for transplant *** To determine if levothyroxine use in combination with steroids in BPODs increased the number of organs donated in trauma *** A retrospective review of adult BPODs from a single level 1 trauma center over ten years was *** criteria included patients who were not solid organ donors,patients who were not declared brain dead(donation after circulatory death),and patients who did not receive steroids in their hospital *** and steroid administration,the number of organs donated,the types of organs donated,and demographic information were *** analyses were performed with Pmet inclusion criteria,69(78%)of whom received levothyroxine and steroids(ST/LT group)vs 19(22%)receiving steroids without levothyroxine(ST group).No differences were observed between the groups for gender,race,pertinent injury factors,age,or other hormone therapies used(P>0.05).In the ST/LT group,68.1%(n=47)donated a high yield(3-5)of organ types per donor compared to 42.1%(n=8)in the ST group(P=0.038).There was no difference in the total number of organ types donated between the groups(P=0.068).CONCLUSION This study suggests that combining levothyroxine and steroid administration increases high-yield organ donation per donor in BPODs in the trauma patient *** to this study include

关键词： Organ donation Trauma Brain death Levothyroxine Hormone replacement therapy Steroids Organ donor Retrospective

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Assessment of the effectiveness of weight-adjusted antibiotic administration,for reduced duration,in surgical prophylaxis of primary hip and knee arthroplasty

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World Journal of Orthopedics 2024年第2期15卷 170-179页

作者： Tosan Okoro michael Wan Takura Darlington mukabeta Ella malev marketa Gross claudia Williams muhammad manjra Jan Herman Kuiper John murnaghan Department of Arthroplasty Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation TrustOswestry SY107AGUnited Kingdom School of medicine Keele UniversityStaffordshire ST55BGUnited Kingdom St Joseph’s Health Centre Unity Health TorontoToronto M6R 1B5Canada Department of Arthroplasty The Royal London HospitalBarts Health NHS TrustLondon E11BBUnited Kingdom Department of Arthroplasty Sunnybrook Holland Orthopaedic and Arthritis CentreToronto M4Y 1H1Canada Institute for Science and Technology in medicine Keele UniversityStaffordshire ST51BGUnited Kingdom

BACKGROUND Prophylactic antibiotics have significantly led to a reduction in the risk of postoperative surgical site infections(SSI)in orthopaedic *** aim of using antibiotics for this purpose is to achieve serum and tissue drug levels that exceed,for the duration of the operation,the minimum inhibitory concentration of the likely organisms that are *** antibiotics reduce the rate of SSIs in lower limb arthroplasty from between 4%and 8%to between 1%and 3%.Controversy,however,still surrounds the optimal frequency and dosing of antibiotic *** To evaluate the impact of introduction of a weight-adjusted antibiotic prophylaxis regime,combined with a reduction in the duration of administration of post-operative antibiotics on SSI incidence during the 2 years following primary elective total hip and knee arthroplasty mETHODS Following ethical approval,patients undergoing primary total hip arthroplasty(THA)/total knee arthroplasty(TKA)with the old regime(OR)of a preoperative dose[cefazolin 2 g intravenously(IV)],and two subsequent doses(2 h and 8 h),were compared to those after a change to a new regime(NR)of a weight-adjusted preoperative dose(cefazolin 2 g IV for patients120 kg)and a post-operative dose at 2 *** primary outcome in both groups was SSI rates during the 2 years *** A total of n=1273 operations(THA n=534,TKA n=739)were performed in n=1264 *** was no statistically significant difference in the rate of deep(OR 0.74%(5/675)vs NR 0.50%(3/598);fishers exact test P=0.72),nor superficial SSIs(OR 2.07%(14/675)vs NR 1.50%(9/598);chi-squared test P=0.44)at 2 years *** propensity score weighting and an interrupted time series analysis,there was also no difference in SSI rates between both groups[RR 0.88(95%CI 0.61 to 1.30)P=0.46].CONCLUSION A weight-adjusted regime,with a reduction in number of post-operative doses had no adverse impact on S

关键词： Antibiotics Weight-adjusted Hip and knee arthroplasty Surgical site infection

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Assessing the impact of concurrent high-fructose and highsaturated fat diets on pediatric metabolic syndrome:A review

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World Journal of Clinical Pediatrics 2024年第2期13卷 62-79页

作者： manuel Alejandro Vargas-Vargas marcela González-montoya Olin Torres-Isidro claudia Isabel García-Berumen Omar Ortiz-Avila Elizabeth Calderón-Cortés Christian Cortés-Rojo Instituto de Investigaciones Químico–Biológicas Universidad Michoacana de San Nicolás de HidalgoMorelia 58030MichoacánMexico Facultad de Enfermería Universidad Michoacana de San Nicolás de HidalgoMorelia 58020MichoacánMexico

High-saturated fat(HF)or high-fructose(HFr)consumption in children predispose them to metabolic syndrome(metS).In rodent models of metS,diets containing individually HF or HFr lead to a variable degree of ***,simultaneous intake of HF plus HFr have synergistic effects,worsening metS *** children,the effects of HF or HFr intake usually have been addressed ***,we have reviewed the outcomes of HF or HFr diets in children,and we compare them with the effects reported in *** humans,HFr intake causes increased lipogenesis,hypertriglyceridemia,obesity and insulin *** the other hand,HF diets promote low grade-inflammation,obesity,insulin *** the deleterious effects of simultaneous HF plus HFr intake on metS development in rodents,there is little information about the combined effects of HF plus HFr intake in *** aim of this review is to warn about this issue,as individually addressing the effects produced by HF or HFr may underestimate the severity of the outcomes of Western diet intake in the pediatric *** consider that this is an alarming issue that needs to be assessed,as the simultaneous intake of HF plus HFr is common on fast food menus.

关键词： Fructose Saturated fat metabolic syndrome Insulin resistance Type 2 diabetes Ultra processed foods Children Obesity Dyslipidemia Non-alcoholic fatty liver disease

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如何设计高质量针刺临床研究:基于证据的专家共识

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英国医学杂志中文版 2022年第6期25卷 325-337页

作者：张誉清焦睿珉 claudia m witt 劳力行刘建平 Lehana Thabane Karen J Sherman mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim myeong Soo Lee michael E Wechsler Benno Brinkhaus Jun J mao Caroline A Smith 岗卫娟刘保延刘志顺刘岩郑晖吴佳霓 AloBSO Carrasco-Labra mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt 中国中医科学院针灸研究所中国中医科学院广安门医院中加整合医学循证医学研究合作中心 Department of Health Research methods Evidenceand ImpactMcMaster UniversityHamiltonONCanada 宁波诺丁汉大学宁波诺丁汉GRADE中心中国中医药循证医学中心 Institute for Complementary and Integrative medicine University Hospital Zurich and University of ZurichZurichSwitzerland Virginia University of Integrative medicine FairfaxVAUSA 北京中医药大学循证医学中心北京中医药大学国际循证中医药研究院 Department of medicine Faculty of Health SciencesMcMaster UniversityHamiltonONCanada Kaiser Permanente Washington Health Research Institute Seattle WAUSA Department of Epidemiology University of WashingtonSeattle WAUSA British medical Acupuncture Society LondonUK Patient and Public Engagement Clinical Trials OntarioTorontoONCanada Department of Western medicine Virginia University of Integrative MedicineFairfaxVAUSA Korean medicine Clinical Trial Center SeoulRepublic of Korea Korean medicine Hospital SeoulRepublic of Korea Kyung Hee University SeoulRepublic of Korea Clinical medicine Division Korea Institute of Oriental MedicineDaejeonRepublic of Korea Korean Convergence medicine University of Science and TechnologyDaejeonRepublic of Korea National Jewish Health DenverCOUSA Institute of Social medicine Epidemiology and Health EconomicsCharitéUniversit?ts medizin BerlinFreie Universit?t Berlin and Humboldt-Universittzu BerlinBerlinGermany Integrative medicine Service Memorial Sloan Kettering Cancer CenterBendheim Integrative Medicine CenterNew YorkNY USA Translational Health Research Institute Western Sydney UniversityPenrithNew South WalesAustralia 中国中医科学院中国中医科学院广安门医院北京中医药大学东直门医院中医内科学教育部重点实验室成都中医药大学针灸推拿学院/第三附属医院 Center for Integrative Global Oral Health School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究... 详细信息

本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。

关键词：临床流行病学针刺试验临床试验临床医生专家共识随机对照试验资助者期刊编辑

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Crystal structure evolution of complex metal aluminum hydrides upon hydrogen release

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Journal of Energy Chemistry 2020年第3期29卷 133-143页

作者： claudia Weidenthaler max-Planck-Institut für Kohlenforschung 45470 Mülheim an der RuhrGermany

Complex aluminum hydrides have been widely studied as potential hydrogen storage materials but also,for some time now, for electrochemical applications. This review summarizes the crystal structures of alkali and alkaline earth aluminum hydrides and correlates structure properties with physical and chemical properties of the hydride compounds. The crystal structures of the alkali metal aluminum hydrides change significantly during the stepwise dehydrogenation. The general pathway follows a transformation of structures built of isolated [AlH4]- tetrahedra to structures built of isolated [Al H6]3- *** crystal structure relations in the group of alkaline earth metal aluminum hydrides are much more complicated than those of the alkali metal aluminum hydrides. The structures of the alkaline earth metal aluminum hydrides consist of isolated tetrahedra but the intermediate structures exhibit chains of cornershared octahedra. The coordination numbers within the alkali metal group increase with cation sizes which goes along with an increase of the decomposition temperatures of the primary hydrides. Alkaline earth metal hydrides have higher coordination numbers but decompose at slightly lower temperatures than their alkali metal counterparts. The decomposition pathways of alkaline metal aluminum hydrides have not been studied in all cases and require future research.

关键词： Complex aluminum hydrides Hydrogen storage Crystal structure

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Oxidized organic molecules in the tropical free troposphere over Amazonia

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National Science Review 2024年第1期11卷 174-184页

作者： Qiaozhi Zha Diego Aliaga Radovan Krejci Victoria A.Sinclair Cheng Wu Giancarlo Ciarelli Wiebke Scholz Liine Heikkinen Eva Partoll Yvette Gramlich Wei Huang markus Leiminger Joonas Enroth Otso Per?kyl? Runlong Cai Xuemeng Chen Alkuin maximilian Koenig Fernando Velarde Isabel moreno Tuukka Pet?j? Paulo Artaxo Paolo Laj Armin Hansel Samara Carbone markku Kulmala marcos Andrade Douglas Worsnop claudia mohr Federico Bianchi Institute for Atmospheric and Earth System Research/Physics University of Helsinki Joint International Research Laboratory of Atmospheric and Earth System Sciences Nanjing University Department of Environmental Science & Bolin Centre for Climate Research Stockholm University Department of Chemistry and molecular Biology University of Gothenburg Institute for Ion and Applied Physics University of Innsbruck Ionicon Analytik GmbH Laboratory for Atmospheric Physics Institute for Physics Research Universidad Mayor de San Andrés Institute of Physics University of Sao Paulo Institute for Geosciences and Environmental Research (IGE) University of Grenoble Alpes Agrarian Sciences Institute Federal University of Uberl?ndia Beijing Advanced Innovation Center for Soft matter Science and Engineering Beijing University of Chemical Technology Department of Atmospheric and Oceanic Sciences University of Maryland Aerodyne Research Inc. Department of Environmental System Science ETH Zürich Switzerland and Laboratory of Atmospheric Chemistry Paul Scherrer Institute

New particle formation(NPF) in the tropical free troposphere(FT) is a globally important source of cloud condensation nuclei, affecting cloud properties and climate. Oxidized organic molecules(OOms)produced from biogenic volatile organic compounds are believed to contribute to aerosol formation in the tropical FT, but without direct chemical observations. We performed in situ molecular-level OOms measurements at the Bolivian station Chacaltaya at 5240 m above sea level, on the western edge of Amazonia. For the first time, we demonstrate the presence of OOms, mainly with 4–5 carbon atoms, in both gas-phase and particle-phase(in terms of mass contribution) measurements in tropical FT air from Amazonia. These observations, combined with air mass history analyses, indicate that the observed OOms are linked to isoprene emitted from the rainforests hundreds of kilometers away. Based on particle-phase measurements, we find that these compounds can contribute to NPF, at least the growth of newly formed nanoparticles, in the tropical FT on a continental scale. Thus, our study is a fundamental and significant step in understanding the aerosol formation process in the tropical FT.

关键词： oxidized organic molecules tropical aerosol formation Amazon free troposphere

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