检索结果-南通市图书馆

Molecular mechanisms of liver carcinogenesis related to metabolic syndrome

Hepatoma Research 2022年第1期8卷 22-34页

作者： claudia Campani Jean-Charles Nault Team of Functional Genomics of Solid Tumors Centre de Recherche des CordeliersSorbonne UniversitéInsermUniversitéde ParisParis F-75006France Equipe labellisée Ligue Nationale Contre le Cancer Labex OncoImmunologyParis F-75006France Department of Experimental and Clinical Medicine University of FlorenceFlorence 50139Italy Service d’hépatologie Hôpital AvicenneHôpitaux Universitaires Paris-Seine-Saint-DenisAssistance-Publique Hôpitaux de ParisBobigny 93000France Unitéde Formation et de Recherche SantéMédecine et Biologie Humaine UniversitéParis 13Communautéd’Universités et Etablissements Sorbonne Paris CitéBobigny 93000France

Global prevalence of non-alcoholic fatty liver disease(NAFLD)and of NAFLD-hepatocellular carcinoma(HCC)is estimated to grow in the next *** burden of NAFLD and the evidence that NAFLD-HCC arises also in noncirrhotic patients,explain the urgent need of a better characterization of the molecular mechanisms involved in NAFLD *** and diabetes cause a chronic inflammatory state which favors changes in serum cytokines and adipokines,an increase in oxidative stress,DNA damage,and the activation of multiple signaling pathways involved in cell ***,a role in promoting NAFLD-HCC has been highlighted in the innate and adaptive immune system,dysbiosis,and alterations in bile acids *** dietary,genetic,or combined mouse models have been used to study nonalcoholic steatohepatitis(NASH)development and its progression to HCC,but models that fully recapitulate the biological and prognostic features of human NASH are still *** humans,four single nucleotide polymorphisms(PNPLA3,TM6SF2,GCKR,and MBOAT7)have been linked to the development of both NASH and HCC in cirrhotic and non-cirrhotic patients,whereas HSD17B13 polymorphism has a protective *** addition,higher rates of somatic ACVR2A mutations and a novel mutational signature have been recently discovered in NASH-HCC *** knowledge of the molecular pathogenesis of NAFLD-HCC will be helpful to personalized screening programs and allow for primary and secondary chemopreventive treatments for NAFLD patients who are more likely to progress to HCC.

关键词： Hepatocellular carcinoma mouse model genetic predisposition cirrhosis non-alcoholic fatty liver disease immune system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of light on seed germination and seedling shape of succulent species from mexico

引用

Journal of Plant Ecology 2016年第2期9卷 174-179页

作者： Joel Flores claudia González-Salvatierra Enrique Jurado División de Ciencias Ambientales Instituto Potosino de Investigación Científica y TecnológicaA.C.Camino a la Presa de San José2055Col.Lomas4SecciónSan Luis PotosíSan Luis Potosí78216México Facultad de Ciencias Forestales Universidad Autónoma de Nuevo LeónCarretera Nacionalkm 145LinaresN.L.67700México

Aims Light requirements for cactus seed germination have been considered to be associated with their adult plant height and seed mass,but this has not been thoroughly studied for other succulent *** order to understand seed photosensitivity from desert species belonging to Asparagaceae(subfamily Agavoideae)and Cactaceae,we performed a germination experiment with and without light for 12 species and 2 varieties from 1 species from the Southern Chihuahuan *** also determined if adult growth is totally determined by seedling‘growth form’in *** We performed a germination experiment using light and darkness for 13 species from Southern Chihuahuan Desert:10 rosette species(Asparagaceae),as well as 1 globose,1 columnar and 2 varieties from 1 depressed-globose species(Cactaceae).The response variables were seed germination percentage and relative light germination(RLG).In addition,in order to determine if adult-globose cacti could have cylindrical seedlings,we calculated the shape index(height/width ratio)for Coryphanta clavata and Mammillaria *** Findings All species were considered neutral *** species had similar seed germination in both light and dark conditions,and three taxa(*** and the two varieties of Ferocactus latispinus)showed higher germination with light than without *** salmiana,*** and the two varieties of *** had higher RLG than the other *** mass was an important factor because with higher seed mass there was lower dependence to *** findings support the hypothesis that small seed mass and light requirements have coevolved as an adaptation to ensure *** adult-globose cactus species,***,and one adult-columnar species,***,had small seeds and neutral *** from these two species exposed to light were cylindrical and those under darkness conditions were *** seeds from this species are able to germinate in

关键词： Asparagaceae Cactaceae Chihuahuan Desert photoblasticism seed germination succulent plants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Helicobacter pylori and cytokine gene variants as predictors of premalignant gastric lesions

引用

World Journal of Gastroenterology 2019年第30期25卷 4105-4124页

作者： Anca Negovan Mihaela Iancu Emoke Fulop claudia Banescu Department of Clinical Science-Internal Medicine University of MedicinePharmacySciences and Technology of Targu Mure.Mure.540139Romania Department of Medical Informatics and Biostatistics “Iuliu Ha.ieganu”University of Medicine and PharmacyCluj-NapocaCluj 400349Romania Department of Morphological Sciences HistologyUniversity of MedicinePharmacySciences and Technology of Targu Mure.Mure.540139Romania Genetics Laboratory Center for Advanced Medical and Pharmaceutical ResearchUniversity of MedicinePharmacySciences and Technology of Targu Mure.Mure.540139Romania

Gastric cancer remains the third leading cause of mortality from cancer worldwide and carries a poor prognosis,due largely to late *** importance of the interaction between Helicobacter pylori(***)infection,the main risk factor,and host-related genetic factors has been studied intensively in recent *** genetic predisposition for non-hereditary gastric cancer is difficult to assess,as neither the real prevalence of premalignant gastric lesions in various populations nor the environmental risk factors for cancer progression are clearly *** non-cardiac intestinal-type cancer,identifying the factors that modulate the progression from inflammation toward cancer is crucial in order to develop preventive *** role of cytokines and their gene variants has been questioned in regard to non-self-limiting *** gastritis and its evolution to gastric atrophy and intestinal metaplasia;the literature now includes various and non-conclusive results on this *** influence of the majority of cytokine single nucleotide polymorphisms has been investigated for gastric cancer but not for preneoplastic gastric *** the investigated gene variants onlyIL10T-819C,IL-8-251,IL-18RAP917997,IL-22 rs1179251,IL1-B-511,IL1-B-3954,IL4R-398 and IL1RN were identified as predictors for premalignant gastric lesions *** of the most important limiting factors is the inhomogeneity of the studies(e.g.,the lack of data on concomitant *** infection,methods used to assess preneoplastic lesions,and source population).Testing the modifying effect of *** infection upon the relationship between cytokine gene variants and premalignant gastric lesions,or even testing the interaction between *** and cytokine gene variants in multivariable models adjusted for potential covariates,could increase generalizability of results.

关键词： Helicobacter pylori Gastritis Premalignant Glandular atrophy Intestinal metaplasia Single-nuclear polymorphism Gene variants Interleukins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dyslipidemia： evidence of efficacy of the pharmacological and non-pharmacological treatment in the elderly

引用

Journal of Geriatric Cardiology 2012年第2期9卷 83-90页

作者： claudia F Gravina Marcelo Bertolami Giselle HP Rodrigues Geriatric Cardiology Section Dante Pazzanese Institute of Cardiology Avenida Dr Dante Pazzanese 500 Ibirapuera Sao Paulo 04012-180 Brazil Dante Pazzanese Institute of Cardiology Scientific Division Av. Dr. Dante Pazzanese 500 Ibirapuera Sao Paulo 04012-180 Brazil Heart Institute--INCOR University of Sao Paulo Medical School Rua Ministro GodoL 1186 Apartment 12 Perdizes Sao Paulo 05015-001 Brazil

The clinical decision to control risk factors for cardiovascular disease （CVD） in the elderly takes the followings into consideration：（1） the elderly life expectancy; （2） the elderly biological age and functional capacity; （3） the role of cardiovascular disease in the elderly group; （4） the prevalence of risk factors in the elderly; and （5） The effectiveness of treatment of risk factors in the elderly. A large number of studies showed the efficacy of secondary and primary prevention of dyslipidemia in the elderly. However, the only trial that included patients over 80 years was the Heart Protection Study （HPS）. Statins are considered the first line therapy for lowering low-density lipoprotein cholesterol （LDL-C）. Because lifestyle changes are very difficult to achieve, doctors in general tend to prescribe many drugs to control cardiovascular risk factors. However, healthy food consumption remains a cornerstone in primary and secondary cardiovascular prevention and should be implemented by everyone.

关键词： Elderly patient Risk factors Dyslipidemia Cardiovascular disease Diet

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improvement of carbon fiber surface properties using electron beam irradiation

引用

Nuclear Science and Techniques 2007年第1期18卷 39-41页

作者： Eddy Segura PINO Luci Diva Brocardo MACHADO claudia GIOVEDI Instituto de Pesquisas Energéticas e Nucleares-IPEN/CNEN-SP Av.Prof.Lineu Prestes2242Cidade Universitária05508-000Sāo PauloSP-Brazil Centro Tecnológico da Marinha em Sāo Paulo Av.Prof.Lineu Prestes2468Cidade Universitária05508-000Sāo PauloSP-Brazil

Carbon fiber-reinforced advance composites have been used for structural applications,mainly on account of their mechanical *** main factor for a good mechanical performance of carbon fiber-reinforced com- posite is the interfacial interaction between its components,which are carbon fiber and polymeric *** aim of this study is to improve the surface properties of the carbon fiber using ionizing radiation from an electron beam to obtain better adhesion properties in the resultant *** radiation was applied on the carbon fiber itself before preparing test specimens for the mechanical *** results showed that EB irradiation improved the ten- sile strength of carbon fiber *** maximum value in tensile strength was reached using doses of about 250 *** breakage,the morphology aspect of the tensile specimens prepared with irradiated and non-irradiated car- bon fibers were *** micrographs showed modifications on the carbon fiber surface.

关键词：碳纤维表面性质电子束辐射改性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolution of radical hysterectomy for cervical cancer along the last two decades: single institution experience

引用

Chinese Journal of Cancer Research 2016年第2期28卷 215-220页

作者： claudia Arispe Ana Isabel Pomares Javier De Santiago Ignacio Zapardiel Gynecologic Oncology Department La Paz University Hospital

Background： The radical hysterectomy （RH） surgical technique has improved along the years. It is used for the treatment of cervical cancer, endometrial cancer when affecting the cervix, and upper vaginal carcinomas. Our aim was to describe the historical evolution of the technique after the introduction of laparoseopy at our institution. Methods： We performed a retrospective review of medical records of patients who underwent RH, grouped in three periods according to the year of surgery： 1990-1999, 2000-2009 and 2010-2013. Patients＇ characteristics, pathologic details, intraoperative and postoperative complications were analyzed and comoared throughout the time periods. Results： A total of 102 cases of RH were performed at our center during the study period. Among all data collected, the presence of necrosis, age, number of lymph nodes, surgery route, operating time, hospital stay, blood loss and transfusion requirement were statistically significant different among groups. Conversion to laparotomy rate was 19% for the second period compared to the absence of cases in the last one. No significant differences （P=0.124） were observed in the adjuvant treatment received among the three different groups. At the time of the last contact the patients free of disease were 12 （85.7%）, 53 （91.3%） and 26 （86.6%） respectively （P=0.406）. Regarding the disease-free interval, we found significant better outcomes in the group of laparotomy compared to laparoscopy （P=0.015）.Conclusions： Laparoscopic RH is an acceptable surgery with advantages like magnified vision of the operation＇s field, lower surgical complications, shorter hospital stay and earlier resumption to daily activities.

关键词： Gynaecological cancer radical hysterectomy (RH) laparoscopy cervical cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Season of birth influences on breastfeeding incidence and duration

引用

World Journal of Pediatrics 2020年第6期16卷 635-636页

作者： claudia W.Strow Brian K.Strow Western Kentucky University 1906 College Heights Blvd.Bowling GreenKY 42101USA

Recent research suggests that an individual’s season of birth can influence his or her health,educational,professional,and behavioral outcomes[1-10].The consumption of breastmilk in infancy is also believed to be correlated with these *** existing studies identify breastfeeding seasonality patterns in developing nations[11-14].However,existing studies do not examine if seasonal differences in breastfeeding exist in the United *** whether or not the season of birth affects one’s breastfeeding likelihood is the first step in recognizing whether breastfeeding seasonality may contribute to the correlation between one’s season of birth and his or her outcomes.

关键词： season seasonal breast

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Obligatory parthenogenesis and TE load： Bacillus stick insects and the R2 non-LTR retrotransposon

引用

Insect Science 2017年第3期24卷 409-417页

作者： Livia Bonandin claudia Scavariello Valentina Mingazzini Andrea Luchetti Barbara Mantovani Dipartimento di Scienze Biologiche Geologiche e Ambientali Universit~ di Bologna Bologna Italy

Transposable elements （TEs） are selfish genetic elements whose self-replication is contrasted by the host genome. In this context, host reproductive strategies are predicted to impact on both TEs load and activity. The presence and insertion distribution of the non- LTR retrotransposon R2 was here studied in populations of the strictly bisexual Bacillus grandii maretimi and of the obligatory parthenogenetic Bacillus atticus atticus. Further- more, data were also obtained from the offspring of selected B. a. atticus females. At the population level, the gonochoric B. g. maretimi showed a significantly higher R2 load than the obligatory parthenogenetic B. a. atticus. The comparison with bisexual and unisexual Bacillus rossius populations showed that their values were higher than those recorded for B. a. atticus and similar, or even higher, than those of B. g. maretimi. Consistently, an R2 load reduction is scored in B. a. atticus offspring even if with a great variance. On the whole, data here produced indicate that in the obligatory unisexual B. a. atticus R2 is active and that mechanisms of molecular turnover are effective. Furthermore, progeny analyses show that, at variance of the facultative parthenogenetic B. rossius, the R2 activ- ity is held at a lower rate. Modeling parental-offspring inheritance, suggests that in B. a. atticus recombination plays a major role in eliminating insertions rather than selection, as previously suggested for unisexual B. rossius progeny, even if in both cases a high variance is observed. In addition to this, mechanisms of R2 silencing or chances of clonal selection cannot be ruled out.

关键词： insertion activity Muller's ratchet Phasmida recombination retrotranspo-son unisexuality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bacteriolytic therapy of experimental pancreatic carcinoma

引用

World Journal of Gastroenterology 2010年第28期16卷 3546-3552页

作者： claudia Maletzki Michael Gock Ulrike Klier Ernst Klar Michael Linnebacher Department of General VascularThoracic and Transplantation SurgerySection of Molecular Oncology and ImmunotherapyUniversity of Rostock18057 RostockGermany

AIM:To investigate the effectiveness of Clostridium novyi(***)-NT spores for the treatment of established subcutaneous pancreatic tumor in the syngeneic,immunocompetent Panc02/C57Bl/6 model. METHODS:***-NT spores were applied intravenously to animals carrying established pancreatic tumors of three different *** immune responses in peripheral blood and spleen were examined by flow ***,cytotoxic activity of lymphocytes against syngeneic tumor targets was analyzed. RESULTS:Application of spores identified,that(1) small tumors(450 mm3)responded with substantial necrosis followed by shrinkage and significant lethality most likely due to tumor lysis syndrome (n=6);and(3)an optimal treatment window exists for tumors of approximately 250 mm 3 (n=21).In this latter group,all tumor-bearing animals had complete tu-mor regression and remained free of tumor recurrence. In subsequent tumor rechallenge experiments a significant delay in tumor growth compared to the initial tumor cell inoculation was observed(tumor volume at day 28:197.8±87.3 mm 3 vs 500.1±50.9 mm3,P<0.05). These effects were accompanied by systemic activation of immune response mechanisms predominantly mediated by the innate arm of the immune system. CONCLUSION:The observed complete tumor regression is encouraging and shows that immunotherapy with ***-NT is an interesting strategy for the treatment of pancreatic carcinomas of defined sizes.

关键词： Bacteriolytic immunotherapy Clostridium novyi-NT Immune response Pancreatic carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Supply Chain Management and the "Bull-Whip Effect": An Empirical Analysis

The Supply Chain Management and the "Bull-Whip Effect": An E...

引用

作者： claudia CIONI 复旦大学

学位级别：硕士

在当今的国际化环境中,公司发展需要应对不断的战略变革以适应市场的灵活性与波动性。公司需要重新思考及定义他们与供应链上其他各方的关系,以此创造更加稳固的客户网络。同时,公司也致力于促进运营机制的整合,使其从个体的行为转变为... 详细信息

在当今的国际化环境中,公司发展需要应对不断的战略变革以适应市场的灵活性与波动性。公司需要重新思考及定义他们与供应链上其他各方的关系,以此创造更加稳固的客户网络。同时,公司也致力于促进运营机制的整合,使其从个体的行为转变为供应链上各方的互相作用和互相影响。供应链整合的战略变革影响可以从两个方面概括。第一,供应链整合强化了公司应对和阻止危机的能力;但是另一方面,个体行为所引起的错误做法若在供应链整合之前未能得到解决,常会以“长鞭效应”的形式放大在整个供应链上。这种效应的表现形式可能是短期的,例如利润表上的损失,但同样会长期影响公司与终端客户的关系。销售预测和规划活动是表现长鞭效应的很好的例子。但是,由于其同公司最终表现的相关性以及其对重要信息流的需求等特点,销售预测活动常被认为是一种“绑架”了过多注意的活动。在另一方面,每个基本的公司活动都影响着销售预测活动并同时被销售预测活动所影响,这个过程常常伴随着不当的做法以及被放大的错误。但是,在高准确性被认为是供应链整合过程中最重要的支持要素之一的情况下,正确的结果预测将会强化价值链上各个环节,特别是销售及物流部门。现有少数文献记载了预测错误带来的负面影响,在此基础上,本文将会从技术角度探索“长鞭效应”(例如不准确的销售预测行为)是否确实会将错误在供应链上放大。本文的研究尝试从实证角度证实供应链上的负面结果与预测的“长鞭效应”误差之间的短期及长期的线性相关关系。本文首先展示了从一个经历了较低预测准确性的北美制造业企业内部的研究项目中取得的结果。接下来,本文尝试估计了需要关注的导致低下表现的因素,并根据它们得到主要成功因子。这些成功因子同在研究项目中的“大平台”解决方案里的建议要点相同,其中“大平台”方案将建立在最关键的供应商的软件,来促进供应链上的主要的运营流程的整合过程并捉高最终的整合结果。实证结果显示,“长鞭效应”将会影响企业财务表现以及企业资产情况,在本案例中其影响还体现在公司与其终端客户的长期关系上。供应链上的低质量的信息交换过程将会加强“长鞭效应”的影响。基于以上结果,本文通过文中的研究项目展示了供应链整合过程被视为“双刃剑”的原因,即整合过程将会提升个体公司的表现,但是如果在供应链流程之初变产生了错误且未被及时修正,“长鞭效应”将会放大错误行为的影响并损害到公司与终端客户的关系。

关键词：供虑缒管理销售预测流程 “牛鞭效应”

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：