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Olfactory receptors in neural regeneration in the central nervous system

Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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光彩熠熠

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现代装饰（家居） 2014年第10期 86-91页

作者： Abi Alice Andreu Carulla Studio Alvaro Uribe Design claudia raimondo Constance Guisset Design By Them Erik Magnussen FRG&BLANCHE Harry Allen Jake Phipps James Burgess Monica Frster Mukul Goyal Sander Mulder 伏平范嘉苑

在产品设计中,可使用的材料丰富多彩,其中金属材料以其高强度、良好的传导性、丰富的质感及特有的光泽和色彩占有相当大的比重。工业革命后,金属材质成为主流材质被广泛应用于各种生活用具与工艺品的设计中,不仅提升了产品的品质,也体... 详细信息

在产品设计中,可使用的材料丰富多彩,其中金属材料以其高强度、良好的传导性、丰富的质感及特有的光泽和色彩占有相当大的比重。工业革命后,金属材质成为主流材质被广泛应用于各种生活用具与工艺品的设计中,不仅提升了产品的品质,也体现了不同产品在金属材质的表现下独有的视觉美感。在现代设计理念影响下,金属的应用已由传统的机械工具方面扩展到人们的生活领域，并被不断赋予新的象征意义。

关键词：金属材质金属材料产品设计视觉美感现代设计理念生活用具机械工具材质美传导性光泽感

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ALD growth of ultra-thin Co layers on the topological insulator Sb2Te3

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Nano Research 2020年第2期13卷 570-575页

作者： Emanuele Longo Roberto Mantovan raimondo Cecchini Michael D.Overbeek Massimo Longo Giovanna Trevisi Laura Lazzarini Graziella Tallarida Marco Fanciulli Charles H.Winter claudia Wiemer CNR-IMM Unit of Agrate BrianzaVia C.Olivetti 2Agrate Brianza(MB)20864Italy Universitàdegli Studi di Milano-Bicocca Dipartimento di Scienza dei MaterialiVia R.Cozzi 55Milano 20125Italy Department of chemistry Wayne State UniversityDetroitMichigan 48202USA CNR-IMEM Parco Area delle Scienze 37/AParma 43124Italy

Taking the full advantage of the conformal growth characterizing atomic layer deposition(ALD),the possibility to grow Co thin films,with thickness from several tens down to few nanometers on top of a granular topological insulator(TI)Sb2Tes film,exhibiting a quite high surface roughness(2-5 nm),was *** study the Co growth on the Sb2Tes substrate,we performed simultaneous Co depositions also on sputtered Pt substrates for *** conducted a thorough chemical-structural characterization of the Co/Sb2Tes and Co/Pt heterostructures,confirming for both cases,not only an excellent conformality,but also the structural continuity of the Co layers.X-ray diffraction(XRD)and high-resolution transmission electron microscope(HRTEM)analyses evidenced that Co on Sb2Te3 grows preferentially oriented along the[0oe]direction,following the underlying rhombohedric ***,Co crystallizes in a cubic phase oriented along the[111]direction when deposited on *** work shows that,in case of deposition of crystalline materials,the ALD surface selectivity and conformality can be extended to the definition of local epitaxy,where in-plane ordering of the crystal structure and mosaicity of the developed crystallized grains are dictated by the underlying ***,a highly sharp and chemically-pure Co/Sb2Tes interface was evidenced,which is promising for the application of this growth process for spintronics.

关键词： atomic layer deposition X-ray diffraction Co-fcc Co-hep antimony telluride metal organic chemical vapor deposition spintronics

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Crystal structure evolution of complex metal aluminum hydrides upon hydrogen release

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Journal of Energy Chemistry 2020年第3期29卷 133-143页

作者： claudia Weidenthaler Max-Planck-Institut für Kohlenforschung 45470 Mülheim an der RuhrGermany

Complex aluminum hydrides have been widely studied as potential hydrogen storage materials but also,for some time now, for electrochemical applications. This review summarizes the crystal structures of alkali and alkaline earth aluminum hydrides and correlates structure properties with physical and chemical properties of the hydride compounds. The crystal structures of the alkali metal aluminum hydrides change significantly during the stepwise dehydrogenation. The general pathway follows a transformation of structures built of isolated [AlH4]- tetrahedra to structures built of isolated [Al H6]3- *** crystal structure relations in the group of alkaline earth metal aluminum hydrides are much more complicated than those of the alkali metal aluminum hydrides. The structures of the alkaline earth metal aluminum hydrides consist of isolated tetrahedra but the intermediate structures exhibit chains of cornershared octahedra. The coordination numbers within the alkali metal group increase with cation sizes which goes along with an increase of the decomposition temperatures of the primary hydrides. Alkaline earth metal hydrides have higher coordination numbers but decompose at slightly lower temperatures than their alkali metal counterparts. The decomposition pathways of alkaline metal aluminum hydrides have not been studied in all cases and require future research.

关键词： Complex aluminum hydrides Hydrogen storage Crystal structure

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Hepatitis B virus and hepatitis C virus dual infection

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World Journal of Gastroenterology 2014年第40期20卷 14559-14567页

作者： Gaia Caccamo Francesca Saffioti Giovanni raimondo Division of Clinical and Molecular Hepatology Department of Internal Medicine University Hospital of Messina 98124 Messina Italy

Hepatitis B virus(HBV)and hepatitis C virus(HCV)share common mode of transmission and both are able to induce a chronic *** HBV/HCV chronic coinfection is a fairly frequent occurrence,especially in high endemic areas and among individuals at high risk of parenterally transmitted *** intracellular interplay between HBV and HCV has not yet been sufficiently clarified,also due to the lack of a proper in vitro cellular *** evaluation of serum HBV DNA and HCV RNA amounts has revealed that complex virological profiles may be present in coinfected *** HBV/HCV infection has been associated to a severe course of the liver disease and to a high risk of developing hepatocellular *** the clinical importance,solid evidence and clear guidelines for treatment of this special population are still *** review summarizes the available data on the virological and clinical features as well as the therapeutic options of the dual HBV/HCV infection,and highlights the aspects that need to be better clarified.

关键词： Hepatitis B virus/hepatitis C virus coinfection Chronic hepatitis Viral interaction Cirrhosis Hepatocellular carcinoma Antiviral therapy

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Vibro-acoustic characteristics of multifunctional carbon fiber reinforced panel

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Defence Technology（防务技术） 2023年第6期24卷 129-139页

作者： Liberata Guadagno Marialuigia raimondo Luigi Vertuccio Giuseppina Barra Maurizio Arena Massimo Viscardi Department of Industrial Engineering University of SalernoVia Giovanni Paolo II13284084FiscianoSAItaly Department of Engineering University of Campania“Luigi Vanvitelli”Via Roma 29I-81031AversaItaly Department of Industrial Engineering Aerospace SectionUniversity of Naples“Federico Ⅱ”Via Claudio 2180125NaplesItaly

This paper deals with the assessment of vibro-acoustic properties of a multifunctional carbon fiber reinfo rced panel manu factured by bulk infu sion,a modified resin film infusion *** components of the epoxy resin were chosen to contrast the electrical insulating property and poor flame resistance of the epoxy resins impregnating carbon woven *** confer electrical conductivity to the resin a percentage of 0.5 wt%of Multi-Wall Carbon Nanotubes(MWCNTs)was dispersed in the resin,whereas to increase flame resistance a percentage of 5 wt%of Glycidil Polyhedral Oligomeric Silsesquioxanes(GPOSS)was solubilized in the epoxy ***,as hardener agents,a mixture of 4,4’-DiaminoDiphenyl Sulfone(DDS)(53.4 wt%)and Bis(3-Aminophenyl)Methyl Phosphine Oxide(BAMPO)(46.7 wt%)was *** values of the electrical conductivity were found satisfactory enough,being4.02×10^(-2)S/m for the multifunctional resin and 1.39×10^(4)S/m for the in-plane conductivity of the panel,whereas the Limiting Oxygen Index(LOI)value of the multifunctional resin was found to increase from 27%to 36%.Considering these promising results,an experimental assessment of the vibro-acoustic properties of the manufactured multifunctional panel was also *** panel was tested mainly to evaluate its low-frequency vibration damping and sound insulation *** manufactured panel demonstrated an improved efficiency if compared to a baseline configuration,presenting almost the double modal damping and a gain of 10 dB on the global noise reduction.

关键词： Composite materials Electrical properties Damping Tunneling atomic force microscopy(TUNA) Vibro-acoustic properties

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HOMOGENIZATION RESULTS FOR ENZYME CATALYZED REACTIONS THROUGH POROUS MEDIA

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Acta Mathematica Scientia 2009年第1期29卷 74-82页

作者： claudia Timofte Department of Mathematics Faculty of Physics University of BucharestP.O. Box MG-11

The aim of this article is to study the effective behavior of the solution of a nonlinear problem arising in the modelling of enzyme catalyzed reactions through the exterior of a domain containing periodically distributed reactive solid obstacles,with period ε.The asymptotic behavior of the solution of such a problem is governed by a new elliptic boundary-value problem,with an extra zero-order term that captures the effect of the enzymatic reactions.

关键词： Homogenization enzyme reactive flows Michaelis-Menten mechanism

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Adult mammalian neurogenesis and motivated behaviors

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Integrative Zoology 2018年第6期13卷 655-672页

作者： claudia JORGENSEN Behavioral Science Department Utah Valley UniversityOremUtahUSA

Adult neurogenesis continues to captivate the curiosity of the scientific community;and researchers seem to have a particular interest in identifying the functional implications of such *** the majority of research focuses on the association between adult neurogenesis and learning and memory(including spatial learning associated with hippocampal neurogenesis and olfactory discrimination associated with neurogenesis in the olfactory system),the following review will explore the link to motivated *** particular,goal-directed behaviors such as sociosexual,parental,aggressive,as well as depression-and anxiety-like behaviors and their reciprocal association to adult neurogenesis will be *** review will detail research in humans and other mammalian ***,the potential mechanisms underlying these neurogenic alterations will be ***,the review will conclude with a discussion on the functional significance of these newly generated cells in mediating goal-directed behaviors.

关键词： adult neurogenesis aggression anxiety depression reproduction

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Timescales of geological processes: Preface

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Geoscience Frontiers 2019年第1期10卷 1-3页

作者： Andrew Putnis Christopher J.Spencer Tom raimondo The Institute for Geoscience Research School of Earth and Planetary Science Curtin University School of Natural and Built Environments University of South Australia

*** One of the major challenges in Geoscience is to understand how the formation and evolution of the Earth System are governed by timescales-that is,how the various geological processes that continue to contribute to its present-day structure and composition operated in the deep *** traditional view of such processes refers to events that occur at immense spatial scales and over hundreds of millions of years,constrained in most cases by the ages of rocks determined using isotopic dating methods or the fossil ***,the modern view of geological processes has increasingly acknowledged that their durations can be significantly shorter than previously thought possible,or indeed detectable without recent analytical *** are a prime example of rapid,high energy and episodic events that have a profound effect on subsequent processes such as metamorphism,fluid transport,and ore formation e the evidence of which is written in microstructures,compositional zoning,and P-T *** studies have also revealed that the reaction rates between fluids and rocks can be extremely rapid relative to geological *** has led to the notion that geological processes are not necessarily continuous over millions of years but may,in fact,be sporadic,with long periods where essentially no reactions take place punctuated by periods of intense activity.

关键词： In Preface Timescales of geological processes

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Improving Scalability of Cloud Monitoring Through PCA-Based Clustering of Virtual Machines

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Journal of Computer Science & Technology 2014年第1期29卷 38-52页

作者： claudia Canali Riccardo Lancellotti IEEE Department of Information Engineering University of Modena and Reggio Emilia ACM

Cloud computing has recently emerged as a leading paradigm to allow customers to run their applications in virtualized large-scale data centers. Existing solutions for monitoring and management of these infrastructures consider virtual machines （VMs） as independent entities with their own characteristics. However, these approaches suffer from scalability issues due to the increasing number of VMs in modern cloud data centers. We claim that scalability issues can bc addressed by leveraging the similarity among VMs behavior in terms of resource usage patterns. In this paper we propose an automated methodology to cluster VMs starting from the usage of multiple resources, assuming no knowledge of the services executed on them. The innovative contribution of the proposed methodology is the use of the statistical technique known as principal component analysis （PCA） to automatically select the most relevant information to cluster similar VMs. We apply the methodology to two case studies, a virtualized testbed and a real enterprise data center. In both case studies, the automatic data selection based on PCA allows us to achieve high performance, with a percentage of correctly clustered VMs between 80% and 100% even for short time series （1 day） of monitored data. Furthermore, we estimate the potential reduction in the amount of collected data to demonstrate how our proposal may address the scalability issues related to monitoring and management in cloud computing data centers.

关键词： cloud computing resource monitoring principal component analysis k-means clustering

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