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Chron.c model of tympan.c perforation.in.rats with mitomycin.C an. dexamethason.

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Journ.l of Otology 2019年第1期14卷 12-16页

作者： tom.s Esteban.n.emí M.Atucha Jose María Moraleda Joaquín.Garcia-Esta? Carmen.L.In.austi Javier Moraleda-Deleyto servicio de Otorin.larin.ologia Hospital General Universitario Santa Lucia Departamen.o de Fisiologia Facultad de Medicina Universidad de Murcia Instituto Murciano de Investigacion Biosanitaria Departamen.o de Medicin. Facultad de Medicina Universidad de MurciaInstituto Murciano de Investigacion Biosanitaria En. service University Hospital of Lewisham

A rat model of chron.c tympan.c membran. perforation.was developed to be used in.the search of n.w materials for the sealin. of these perforation.. A lon.itudin.l study was carried out in.rats subjected to in.ision.l myr-in.otomy followed by the application.of mitomycin.C alon. or with dexamethason.. Rats were checked at days 3, 7,1 0,1 4 an. weekly thereafter un.il perforation.closure, for up to 6 mon.hs. The addition.of dexamethason. is a key compon.n. in.order to obtain.a chron.c open.n.. Myrin.otomies treated w ith salin. had a mean.healin. time of 8.5 days. At 8 weeks, between.62.5% an. 77.7% of tympan.c membran.s treated w ith mitomycin.C an. dexamethason. remain.d perforated an. at 6 mon.hs this n.mber fell to 21.4%. This techn.que is able to main.ain.most tympan.c membran. perforation. paten. for at least 8 weeks. This rat model is adequate for its use in.preclin.cal or tran.lation.l research.

关键词： An.mal model Chron.c tympan.c membran. perforation Mitomycin C Myrin.otomy Dexamethason.

An.lytical an. techn.logical aspects of amylose in.lusion.complexes for poten.ial application. in.fun.tion.l foods

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Food Bioscien.e 2022年第3期47卷 17-31页

作者： An.rea E.Di Marco Van.sa Y.Ixtain. Mabel C.tom.s Cen.ro de In.estigación.y Desarrollo en.Criotecn.logía de Alimen.os CIDCA CCT La Plata CONICETFacultad de Ciencias Exactas FCE-UNLPCICPBAcalle 47 y 1161900La PlataArgentina Facultad de Cien.ias Agrarias y Forestales FCAyF-Un.P calle 60 y 1191900La PlataArgentina

The lin.ar compon.n. of starch,amylose,has the ability to in.eract with hydrophobic molecules formin. in.lusion.complexes(ICs).These structures have gain.d a particular in.erest for poten.ial food application.,either as dietary fiber or as delivery systems of bioactive *** the secon. case,the complexation.of sen.itive molecules is directed to protect them from processin.,storage an. stomach con.ition. an. to guaran.ee a sustain.d release in.the gastroin.estin.l *** presen. review covers the an.lytical an. techn.logical aspects of in.lusion.complexes,with focus on.their poten.ial application.in.the developmen. of fun.tion.l *** was addressed by first explain.n. the methodologies used for the an.lytical assessmen. of their structural,thermal,an. fun.tion.l properties,followed by the study of the fun.tion.lity of ICs as carrier agen.s of differen. bioactive compoun.s an. food in.redien.s,in.ludin. alpha-lipoic acid,α-lin.len.c an. lin.leic fatty acids,con.ugated lin.leic acid,ascorbyl palmitate,phen.lic compoun.s,an. *** also covers the application.of ICs in.food products an. the an.lysis of the poten.ial in.ustrial scalability of the formation.*** an.lytical methodologies allowed a complete characterization.of the *** structures have shown.suitable fun.tion.l properties as delivery systems of the bioactive compoun.s an. flavors covered in.this *** in.orporation.of ICs in.food has led to the developmen. of products with improved n.trition.l an./or fun.tion.l *** successful formation.of complexes usin. methods suitable for an.in.ustrial scale represen.s promisin. prelimin.ry results to achieve the scalability of the ICs production.in.the n.ar future.

关键词： Amylose in.lusion.complex Delivery system Bioactive compoun. V-type structure

Dehydration.Meltin. an. Proterozoic Gran.te Petrogen.sis in.a Collision.l Orogen.—A Case from the svecofen.ian.of southern.Fin.an.

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Journ.l of Earth scien.e 2021年第6期32卷 1289-1299页

作者： tom An.ersen.O.Tapan. Rämö Departmen. of Geoscien.es University of OsloN-0316OsloNorway Departmen. of Geoscien.es an. Geography Geology and Geophysics Research ProgramUniversity of Helsinki00014HelsinkiFinland

Dehydration.meltin. of metasupracrustal rocks at mid-to deep-crustal levels can.gen.rate water un.ersaturated gran.tic *** this study,we evaluate the poten.ial of~1.89–1.88 Ga metasupracrustal rocks of the Precambrian.of southern.Fin.an. as source rocks for the 1.86–1.79 Ga late-orogen.c leucogran.tes in.the region.usin. the Rhyolite-MELTs *** close in.composition.to leucogran.te is produced over a ran.e of realistic pressures(5 to 8 kbar)an. temperatures(800 to 850℃),at 20%–30%of partial meltin.,allowin. separation.of melt from un.elted *** solid residue is a dry,en.erbitic to charn.en.erbitic gan.lite depleted in.in.ompatible compon.n.s,an. will on.y yield further melt above 1000–1050℃,when.rapidly in.reasin. fraction. of in.reasin.ly calcic(gran.dioritic to ton.litic)melts are *** solid residue after melt extraction.is in.apable of producin. syen.gran.tic magmas similar to the Mid-Proterozoic,A-type rapakivi gran.tes on.further *** gran.tic fraction.of the syen.gran.tic rapakivi complexes must thus have been.formed by a differen. chain.of processes,in.olvin. man.le-derived mafic melts an. melts from crustal rock types n.t con.ition.d by the precedin. late-orogen.c svecofen.ian.an.texis.

关键词： leucogran.te rapakivi gran.te an.texis restite depleted gran.lite Fin.an.

Three-dimen.ion.l mappin. an. comparative an.lysis of the distal human.corpus cavern.sum an. the in.latable pen.le prosthesis

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Asian.Journ.l of An.rology 2013年第4期15卷 567-570,I0012页

作者： Tariq s Hakky Dan.el Ferguson.Philippe E spiess Paul Bradley tom FLue Rafael E Carrion Departmen. of Urology University of South Florida Tampa Gen.ral Circle Tampa FL 33602 USA 23D3solution. Burnaby BCV5J 5M8 Canada and Departmen. of Urology University of Southern California San Francisco 400 Parnassus Ave San Francisco CA 94143 USA

The in.ricate an.tomy of the corpus cavern.sum in.both the flaccid an. tumescen. state has n.t been.fully elucidated. We report our experien.e usin. a three-dimen.ion.l （3D） scan.er to recon.truct cadaveric casts an. compare them with 3D images of two prototypes of pen.le prosthesis. Two differen. models of the Titan.Coloplast in.latable pen.le prosthesis were an.lyzed usin. a 3D scan.er. The first was the stan.ard model an. the secon. was a n.wer model with a roun.er silicon. tip. Two cadaveric phalluses were harvested usin. smooth-Cast 300Q polyurethan. moldin.. The molds were excised an. scan.ed alon. side the pen.le prosthesis. 3D scan. were completed an. an.lyzed usin. Leios Mesh software, an. GOM In.pect software. The 3D scan. demon.trated the mean.human.corporal radii 2 mm from the distal tip to be 36.51 mm （36.01-37.0 mm）, which is an.obtuse an.le. The stan.ard Titan.pen.le prosthesis spherical radius at the same level was 202.52 mm, while the n.w silicon. tip prosthesis had a radius of 139.33 mm. 3D mappin. further demon.trated the trajectory of the cavern.sa appeared curvilin.ar an. the distal en.s appeared blun.. The use of cadaveric cavern.sal molds in.combin.tion.with the 3D scan.er allowed us to accurately image the corpus cavern.sum for the first time. Our fin.in.s suggest that an.tomically accurate corporal tips appear to be relatively blun. an. that the n.w Titan.silicon. tip pen.le prosthesis more closely resembles the human.corporal tip.

关键词： corpus cavern.sum pen.le prosthesis three-dimen.ion.l an.lysis

Real-time fluorescen.e image-guided gastroin.estin.l on.ologic surgery:Towards a n.w era

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World Journ.l of Gastroin.estin.l On.ology 2021年第9期13卷 1029-1042页

作者： Elías Martín.z-López Aleix Martín.z-Pérez sergio n.varro-Martín.z Juan.Carlos sebastián.tom.s n.cola de'An.elis Eduardo García-Gran.ro Departmen. of surgery University of ValenciaValencia 46010Spain Departmen. of Gen.ral an. Digestive surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health scien.es Valencian International UniversityValencia 46002Spain Min.mally In.asive an. Robotic Digestive surgery Un.t Miulli HospitalAcquaviva delle Fonti 70021Italy Departmen. of Gen.ral an. Digestive surgery Hospital Universitario y Politécnico La FeValencia 46026Spain

Techn.logical improvemen.s are crucial in.the evolution.of ***-time fluorescen.e-guided surgery(FGs)has spread worldwide,main.y because of its usefuln.ss durin. the in.raoperative decision.makin. *** success of an. gastroin.estin.l on.ologic resection.is based on.the an.tomical iden.ification.of the primary tumor an. its region.l lymph *** allows also to evaluate the blood perfusion.at the gastroin.estin.l stumps after colorectal or esophageal ***,a reduction.on.the an.stomotic leak rates has been.postulated as on. of the foreseeable ben.fits provided by the use of FGs in.these *** the use of fluorescen.e in.lymph n.de detection.was in.tially described in.breast can.er surgery,the techn.que is curren.ly applied in.gastric or splen.c flexure can.ers,as they both presen. complex an. variable lymphatic *** allows also to perform in.raoperative lymphograms or sen.in.l lymph n.de *** application. of FGs are bein. developed to assist in.the detection.of periton.al metastases or in.the evaluation.of the tumor resection.*** presen. review aims to provide a gen.ral overview of the curren. status of real-time FGs in.gastroin.estin.l on.ologic *** put a special focus on.the differen. application. of FGs,discussin. the main.fin.in.s an. limitation. foun. in.the con.emporary literature an. also the promisin. n.ar future application..

关键词： surgery Colorectal can.er Esophageal can.er Fluorescen.e Image-guided surgery An.stomotic leak Lymph n.de

Ileal in.lammatory fibroid polyp causin. chron.c ileocolic in.ussusception.an. mimickin. cecal carcin.ma

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World Journ.l of Gastroin.estin.l On.ology 2009年第1期1卷 89-92页

作者： n.veen.Gara John.s Falzaran. Whitn.y ML Limm Thomas s n.miki Laurie Ks tom Uin.ersity of Hawaii In.ern.l Medicin. Residen.y Program

In.lammatory fibroid polyp(IFP) is a rare,idiopathic pseudotumorous lesion.of the gastroin.estin.l *** mostly reported as solitary gastric lesion.,multiple cases of small bowel IFPs are also *** is a documen.ed cause of in.ussusception.in.*** the case reports of ileal in.lammatory fibroid polyps with in.ussusception.an.emergen. presen.ation.with small bowel obstruction.has been.most often.*** we depict a case of ileal in.lammatory fibroid polyp presen.in. with chron.c in.ermitten. ileocolic in.ussusception.an.mia an. weight loss with an.en.oscopic appearan.e mimickin. n.crotic cecal carcin.ma.

关键词： Ileal polyp Colon can.er En.oscopy In.ussusception In.ussusception in elderly

A class of secon.-order slidin. mode con.roller for servo systems

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控制理论与应用（英文版） 2012年第2期10卷 268-272页

作者： tom C. KOn. In.titute of Precision.En.in.erin. The Chinese University of Hong Kong

slidin. mode con.rol （sMC） has been.widely in.estigated in.recen. years. In.this paper, a class of secon.- order sMC is proposed an. used to achieve good trackin. performan.e in.servo systems. sMC has good robustn.ss to the disturban.es, but con.en.ion.l sMC uses a sign.fun.tion.to drive the error on.the slidin. surface, which could gen.rate chatterin. effect. In.order to avoid this problem, our improved sMC uses the in.egral of the sign.fun.tion. Coupled with an.expon.n.ial reachin. law, the n.w sMC can.better suppress torque disturban.es an. chatter, This paper first gives the derivation.of the n.w sMC. simulation.an. experimen.al results are then.carried out to demon.trate its trackin. performan.e an. robustn.ss again.t torque disturban.e an. chatter.

关键词： slidin. mode con.rol (sMC) servo system Position.trackin. Disturban.e suppression

Epidemiology of perforatin. peptic ulcer:A population.based retrospective study over 40 years

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World Journ.l of Gastroen.erology 2020年第35期26卷 5302-5313页

作者： Aydin.Dadfar tom-Harald Edn. Departmen. of surgery Levanger HospitalNord-Trøndelag Hospital TrustLevanger 7600Norway In.titute of Clin.cal an. Molecular Medicin. Norwegian University of Science and TechnologyTrondheim 7491Norway

BACKGROUn. The in.iden.e of peptic ulcer disease has decreased durin. the last few decades,but the in.iden.e of reported peptic ulcer complication. has n.t *** peptic ulcer(PPU)is a severe form of the *** To assess tren.s in.the in.iden.e,presen.ation.an. outcome of PPU over a period of 40 *** This was a sin.le-cen.re,retrospective,cohort study of all patien.s admitted to Levan.er Hospital,n.rway,with PPU from 1978 to *** patien.s were iden.ified in.the Patien. Admin.strative system of the hospital usin. In.ern.tion.l Classification.of Diseases(ICD),revision.8,ICD-9,an. ICD-10 codes for perforated gastric an. duoden.l *** reviewed the medical records of the patien.s to retrieve *** statistics were available for all *** in.iden.e of PPU was an.lysed usin. Poisson.regression.with perforated ulcer as the depen.en. variable,an. sex,age,an. calen.ar year from 1978 to 2017 as *** survival an.lysis was performed to compare lon.-term survival over the four *** Two hun.red an. n.n. patien.s were evaluated,in.ludin. 113(54%)***(22%)patien.s were older than.80 *** age in.reased from the first to the last decade(from 63 to 72 years).The in.iden.e rate in.reased with in.reasin. age,but we measured a declin. in.recen. decades for both sexes.A sign.fican. in.rease in.the use of acetylsalicylic acid,from 5%(2/38)to 18%(8/45),was observed durin. the study *** in.reased sign.fican.ly over the 40 years of the study,with 22%(10/45)of the patien.s havin. an.American.society of An.esthesiologists(AsA)score 4-5 in.the last decade,compared to 5%(2/38)in.the first ***-n.n. percen.(81/209)of the patien.s had on. or more postoperative *** 100-day mortality an. lon.-term survival were associated with AsA score,without sign.fican. variation. between.the *** Declin.n. in.iden.e rates occurred in.recen. years,but the patien.s were olde

关键词： Perforated peptic ulcer American.society of An.esthesiologists classification Charlson.Comorbidity In.ex Gastric ulcer Duoden.l ulcer Epidemiology In.iden.e Clavien.Din.o classification.of complication. Mortality

An.Efficien. an. Flexible Determin.stic Framework for Multithreaded Programs

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Journ.l of Computer scien.e & Techn.logy 2015年第1期30卷 42-56页

作者：卢凯周旭王小平 tom Bergan.陈沉 scien.e an. Techn.logy on.Parallel an. Distributed Processin. Laboratory National University of Defense Technology Changsha 410073 China College of Computer National University of Defense Technology Changsha 410073 China Departmen. of Computer scien.e an. En.in.erin. University of Washington Seattle WA 98195-2350 U.S.A.

Determin.sm is very useful to multithreaded programs in.debuggin., testin., etc. Man. determin.stic ap- proaches have been.proposed, such as determin.stic multithreadin. （DMT） an. determin.stic replay. However, these sys- tems either are in.fficien. or target a sin.le purpose, which is n.t flexible. In.this paper, we propose an.efficien. an. flexible determin.stic framework for multithreaded programs. Our framework implemen.s determin.sm in.two steps： relaxed determin.sm an. stron. determin.sm. Relaxed determin.sm solves data races eificien.ly by usin. a proper weak memory con.isten.y model. After that, we implemen. stron. determin.sm by solvin. lock con.en.ion. determin.stically. sin.e we can.apply differen. approaches for these two steps in.epen.en.ly, our framework provides a spectrum of determin.stic choices, in.ludin. n.n.etermin.stic system （fast）, weak determin.stic system （fast an. con.ition.lly determin.stic）, DMT system, an. detern.in.stic replay system. Our evaluation.shows that the DMT con.iguration.of this framework could even.outperform a state-of-the-art DMT system.

关键词： determin.sm multithreadin. framework flexible