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Diabetic kidney disease in pediatric patients: A current review

World Journal of Diabetes 2022年第8期13卷 587-599页

作者： Carmen Muntean Iuliana Magdalena Starcea claudia Banescu Department of Pediatrics I “George Emil Palade”University of MedicinePharmacySciences and Technology of Târgu MuresTârgu Mures 540142Romania Department of IVth Pediatrics University of Medicine and Pharmacy“Grigore T.Popa”Iasi 700115Romania Center for Advanced Medical and Pharmaceutical Research University of MedicinePharmacySciences and Technology of Târgu MureșMureșTârgu Mures 540142Romania

In the last decades,a significant increase in the incidence of diabetic kidney disease(DKD)was observed concomitant with rising diabetes mellitus(DM)*** disease associated with DM in children and adolescents is represented by persistent albuminuria,arterial hypertension,progressive decline in estimated glomerular filtration rate to end-stage renal disease and increased cardiovascular and all-cause morbidity and mortality of these *** medical practice,the common and still the“gold standard”marker for prediction and detection of diabetic kidney involvement in pediatric diabetes is represented by microalbuminuria screening even if it has low specificity to detect early stages of *** are some known limitations in albuminuria value as a predictor biomarker for DKD,as not all diabetic children with microalbuminuria or macroalbuminuria will develop end-stage renal *** tubular damage occurs before the glomerular injury,tubular biomarkers are superior to the glomerular ***,they may serve for early detection of DKD in both type 1 DM and type 2 *** and new biomarkers to identify diabetic children and adolescents at risk of renal complications at an early stage as well as renoprotective strategies are necessary to delay the progression of kidney disease to end-stage kidney *** biomarkers and therapeutic strategies are discussed as timely diagnosis and therapy are critical in the pediatric diabetic population.

关键词： Diabetes Kidney disease Biomarkers Microalbuminuria Therapy Children

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chemokine/chemokine receptor pair CC L20/CC R6 in humancolorectal malignancy:An overview

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World Journal of Gastroenterology 2016年第2期22卷 833-841页

作者： Vilma Oliveira Frick claudia Rubie Ulrich Keilholz Pirus Ghadjar Department of General- Visceral-Vascular-and Pediatric SurgeryUniversity of the Saarland66421 Homburg/SaarGermany CharitéComprehensive Cancer Center CharitéUniversitätsmedizin BerlinCampus CharitéMitte10117 BerlinGermany Department of Radiation Oncology CharitéUniversitätsmedizin Berlin13353 BerlinGermany

Chemokines belong to a superfamily of small, cytokinelike proteins, which induce multiple physiological functions, particularly cytoskeletal rearrangement and compartment-specific migration through their interaction with G-protein-coupled receptors. Chemokines and their receptors have been widely acknowledged as essential and selective mediators in leukocyte migration in inflammatory response. It is now established that the chemokine/chemokine receptor system is also used by cancer cells to direct lymphatic and haematogenous spreading and additionally has an impact on the site of metastatic growth of different tumours. In recent years an increasing number of studies have drawn attention to CC-chemokine cysteine motif chemokine ligand 20(CCL20) and its physiological sole receptor CCR6 to play a role in the onset, development and metastatic spread of various gastrointestinal cancer entities. Among various cancer types CCR6 was also demonstrated to be significantly overexpressed in colorectal cancer(CRC) and stimulation by its physiological ligand CCL20 has been reported to promote CRC cell proliferation and migration in vitro. Further, the CCL20/CCR6 system apparently plays a role in the organ-selective liver metastasis of CRC. Here we review the literature on expression patterns of CCL20 and CCR6 and their physiological interactions as well as the currently presumed role of CCL20 and CCR6 in the formation of CRC and the development of liver metastasis, providing a potential basis for novel treatment strategies.

关键词： Chemokine/chemokine receptor pair CCR6 Chemokine ligand 20 Colorectal cancer Metastasis Liver

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The carbon fluxes in different successional stages:modelling the dynamics of tropical montane forests in South Ecuador

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Forest Ecosystems 2017年第2期4卷 143-153页

作者： sebastian paulick claudia dislich jürgen homeier rico fischer andreas huth Department of Ecological Modelling Helmholtz Centre for Environmental Research-UFZPermoserstr1504318 LeipzigGermany Georg-August-University Gottingen Plant EcologyUntere KarspOle 237073 GottingenGermany University of Osnabriick Institute of Environmental Systems ResearchBarbarastr1249076 OsnabruckGermany iDiv German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-LeipzigDeutscher Platz 5e04103 LeipzigGermany

Background： Tropical forests play an important role in the global carbon（C） ***, tropical montane forests have been studied less than tropical lowland forests, and their role in carbon storage is not well *** forests are highly endangered due to logging, land-use and climate *** objective was to analyse how the carbon balance changes during forest ***： In this study, we used a method to estimate local carbon balances that combined forest inventory data with process-based forest *** utilised such a forest model to study the carbon balance of a tropical montane forest in South Ecuador, comparing two topographical slope positions（ravines and lower slopes vs upper slopes and ridges）.Results： The simulation results showed that the forest acts as a carbon sink with a maximum net ecosystem exchange（NEE） of 9.3 Mg C？（ha？yr）-1during its early successional stage（0–100 years）.In the late successional stage, the simulated NEE fluctuated around zero and had a variation of 0.77 Mg C？（ha？yr）–*** simulated variability of the NEE was within the range of the field *** discovered several forest attributes（e.g., basal area or the relative amount of pioneer trees） that can serve as predictors for NEE for young forest stands（0–100 years） but not for those in the late successional stage（500–1,000 years）.In case of young forest stands these correlations are high, especially between stand basal area and ***： In this study, we used an Ecuadorian study site as an example of how to successfully link a forest model with forest inventory data, for estimating stem-diameter distributions, biomass and aboveground net primary *** conclude, this study shows that process-based forest models can be used to investigate the carbon balance of tropical montane *** this model it is possible to find hidden relationships between forest attributes and forest carbon *** relationships promote a better understandin

关键词： Forest model Tropical montane forest Forest succession Carbon balance Forest productivity FORMIND

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Reproducible Research Publication Workflow:A Canonical Workflow Framework and FAIR Digital Object Approach to Quality Research Output

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Data Intelligence 2022年第2期4卷 306-319页

作者： Limor Peer claudia Biniossek Dirk Betz Thu-Mai Christian Institution for Social and Policy Studies Yale UniversityConnecticut 06520USA Center for Empirical Research in Economics and Behavioral Sciences(CEREB) University of ErfurtThuringen 99089Germany Odum Institute for Research in Social Science University of North Carolina SystemNorth Carolina 27514-3916USA

In this paper we present the Reproducible Research Publication Workflow(RRPW)as an example of how generic canonical workflows can be applied to a specific *** RRPW includes essential steps between submission and final publication of the manuscript and the research artefacts(i.e.,data,code,etc.)that underlie the scholarly claims in the manuscript.A key aspect of the RRPW is the inclusion of artefact review and metadata creation as part of the publication *** paper discusses a formalized technical structure around a set of canonical steps which helps codify and standardize the process for researchers,curators,and *** proposed application of canonical workflows can help achieve the goals of improved transparency and reproducibility,increase FAIR compliance of all research artefacts at all steps,and facilitate better exchange of annotated and machine-readable metadata.

关键词： FAIR research output FAIR Digital Objects Reproducible research Research compendium Compendium publication workflow Data quality review

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Topographic effects observed at Amatrice hill during the 2016-2017 Central Italy seismic sequence

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Earthquake Engineering and Engineering Vibration 2021年第1期20卷 63-78页

作者： Gerardo Grelle Laura Bonito Maresca Rosalba Silvia Iacurto claudia Madiai Paola Revellino Giuseppe Sappa Department of Civil Building and Environmental EngineeringSapienza University of RomeItaly Department of Sciences and Technologies University of SannioItaly Department of Civil and Environmental Engineering University of FlorenceItaly

The estimate of seismic site effects by experimental approaches is based on different assumptions aimed at simplifying the complex actual site conditions and related ***,the reliability of the results can increase if the experimental data is focused on quite strong seismic sequences and the on-site acquisition of a large number of signals is deemed strategic for the assessment of the expected *** on these considerations,the ground motion at the Red Zone sector of Amatrice hill,violently struck by the 2016-2017 Central Italy seismic sequence,was analyzed via an observational approach.A large set of weak motions(moment magnitude Mw 2.5-3.9)was analyzed in this study by means of standard(SSR)and horizontal to vertical(HVSR)spectral ratio *** results from the experimental analysis of the site effects by using weak motion and noise signals show a significant amplification at the top of Amatrice hill with a remarkable polarization of the motion and changes in spectral shapes according to the topographic setting of the relief.

关键词： topographic effects standard spectra ratio(SSR) horizontal and vertical spectral ratio(HVSR) directional effects

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Isolation, Characterization And Identification of Probiotic Bacteria from Chinese Soft-shell Turtle(Trionyx Sinensis)

Isolation, Characterization And Identification of Probiotic ...

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作者： claudia Rodrighero Maia 宁波大学

学位级别：硕士

中华鳖是中国和东南亚国家养殖最为普遍的养殖鳖种,中国是世界中华鳖养殖产量最高的国家,中华鳖养殖年产量达7000吨,全国有各类龟鳖养殖场数千个,重要分成在长江以南各省。随着中华鳖集约化养殖的快速发展,养殖中华鳖各类疾病发生频繁,... 详细信息

中华鳖是中国和东南亚国家养殖最为普遍的养殖鳖种,中国是世界中华鳖养殖产量最高的国家,中华鳖养殖年产量达7000吨,全国有各类龟鳖养殖场数千个,重要分成在长江以南各省。随着中华鳖集约化养殖的快速发展,养殖中华鳖各类疾病发生频繁,主要包括气单胞菌、爱德华菌、变形杆菌等各类细菌。抗生素由于存在诱发耐药性等种类弊病,在水产上的使用受到诸种限制。近年来,各类有益微生物制剂作为疾病控制和预防的替代手段,日益受到重视。本文拟从养殖中华鳖体内分离和鉴定天然栖息的有益菌,以期为中华鳖疾病防控提供新的途径。从养殖中华鳖中分离到73株不同菌株,用嗜水气单胞菌ATCC 7966和BSK10作为指示菌,用于筛选抗病原菌的颉抗菌。共分离到18株对气单胞菌有明显抑菌效果的菌株,对嗜水气单胞菌的抑菌圈大于6mm,用纸片法测定阳性菌培养上清的抑菌力,抑菌圈均为6 mm以上(纸片直径4mm)。对18个阳性菌株用16s r RNA通用引物进行了PCR克隆,经序列分析,鉴定了上述菌株,共分到假单胞菌杆菌(Pseudomonas sp)、黄杆菌(Flavobacterium sp)、紫色杆菌(Janthinobacterium sp.)、波单胞菌(Brevundimonas vesicularis)、芽孢杆菌(Bacillus sp),滕黄微球菌(Micrococcus luteus)、,梭菌(Clostridiales bacterium)、微球菌(Micrococcaceae bacterium)、肠球菌(Enterococcus sp)、土壤杆菌(Agrobacterium sp)、金黄杆菌(Chryseobacterium sp)等。上述有抑菌活性菌株中,有17株可在营养肉汤中快速生长,20小时的菌浓度可达105-108 CFU.m L-1,表明这些菌株适合大量培养,具备规模化培养和作为生产应用的可能性。这些从中华鳖体内分离的天然栖息菌有望作为中华鳖养殖中的有益菌使用,提高中华鳖养殖健康水平、减少病害发生、提高免疫力。此外,从中华鳖体内分离到蜡样微球菌(Micrococcus cereus),该菌对革兰阳性菌和阴性菌均有较强的抑菌力,计划对该菌进行进一步研究,并摸索蜡样微球菌在中华鳖室内和养殖疾病防控中应用条件。.

关键词：中华鳖有益菌筛选 16srRNA 鉴定

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Residual feed intake divergence during the preweaning period is associated with unique hindgut microbiome and metabolome profiles in neonatal Holstein heifer calves

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Journal of Animal Science and Biotechnology 2020年第2期11卷 453-467页

作者： Ahmed Elolimy Abdulrahman Alharthi Mohamed Zeineldin claudia Parys Juan J.Loor Mammalian NutriPhysioGenomics Department of Animal SciencesUniversity of IllinoisUrbanaILUSA Department of Animal Sciences University of IllinoisUrbanaILUSA Department of Animal Production National Research CentreDokkiGizaEgypt Carl R.Woese Institute for Genomic Biology University of IllinoisUrbanaIllinoisUSA Department of Animal Medicine College of Veterinary MedicineBenha UniversityBenhaEgypt Evonik Nutrition&Care GmbH Hanau-WolfgangGermany Division of Nutritional Sciences Illinois Informatics InstituteUniversity of IllinoisUrbanaILUSA

Background:Recent studies underscored that divergence in residual feed intake(RFI)in mature beef and dairy cattle is associated with changes in ruminal microbiome and metabolome profiles which may contribute,at least in part,to better feed *** the rumen in neonatal calves during the preweaning period is underdeveloped until close to weaning,they rely on hindgut microbial fermentation to breakdown undigested diet *** leads to production of key metabolites such as volatile fatty acids(VFA),amino acids,and vitamins that could potentially be absorbed in the hind-gut and help drive growth and *** RFI divergence in neonatal calves is associated with changes in hindgut microbial communities and metabolites is largely ***,the objective of the current study was to determine differences in hindgut microbiome and metabolome in neonatal Holstein heifer calves retrospectively-grouped based on feed efficiency as mostefficient(M-eff)or least-efficient(L-eff)calves using RFI divergence during the preweaning ***:Twenty-six Holstein heifer calves received 3.8 L of first-milking colostrum from their respective dams within 6 h after *** were housed in individual outdoor hutches bedded with straw,fed twice daily with a milk replacer,and had ad libitum access to a starter grain mix from birth to weaning at 42 d of *** were classified into M-eff[n=13;RFI coefficient=−5.72±0.94 kg DMI(milk replacer+starter grain)/d]and L-eff[n=13;RFI coefficient=5.61±0.94 kg DMI(milk replacer+starter grain)/d]based on a linear regression model including the combined starter grain mix and milk replacer DMI,average daily gain(ADG),and metabolic body weight(MBW).A deep sterile rectal swab exposed only to the rectum was collected immediately at birth before colostrum feeding(i.e.,d 0),and fecal samples at d 14,28,and 42(prior to weaning)for microbiome and untargeted metabolome analyses using 16S rRNA gene sequencing and LC-MS.M

关键词： Feed efficiency Gut Metabolomics Microbiota Neonates Newborn Preweaning RFI

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Weighted Best Local Approximation

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Analysis in Theory and Applications 2016年第1期32卷 355-372页

作者： Segio Favier claudia Ridolfi Instituto de Matematica Aplicada San Luis Conicet and Universidad Nacional de San Luis Ejercito de los Andes 950 San Luis Argentina

In this survey the notion of a balanced best multipoint local approximation is fully exposed since they were treated in the LP spaces and recent results in Orlicz spaces. The notion of balanced point, introduced by Ch... 详细信息

关键词： Best Local approximation multipoint approximation balanced neighborhood

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Complexation of As(Ⅲ)by phosphonate ligands in aqueous fluids:Thermodynamic behavior,chemical binding forms and sequestering abilities

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Journal of Environmental Sciences 2020年第8期32卷 100-110页

作者： Donatella Chillè Donatella Aiello Giuseppa Ida Grasso Ottavia Giuffrè Anna Napoli Carmelo Sgarlata claudia Foti Dipartimento di Scienze Chimiche BiologicheFarmaceutiche ed AmbientaliUniversitàdi MessinaViale F.Stagno d’Alcontres 3198166 MessinaItaly Dipartimento di Chimica e Tecnologie Chimiche Universitàdella CalabriaVia P.Bucci87036 Arcavacata di Rende(CS)Italy Dipartimento di Scienze Chimiche Universitàdegli Studi di CataniaViale A.Doria 695125 CataniaItaly

In recent years,the contamination of water by arsenic reached alarming levels in many countries of the world,attracting the interest of many researchers engaged in testing methodologies able to remove this harmful *** important aspect that must be taken into consideration is the possibility to find arsenic in different chemical forms which could require different approaches for its *** this aim,a speciation analysis appears to be crucial for better understanding the behavior of arsenic species in aqueous solutions,especially in presence of compounds with marked chelating *** can be identified as good sequestering agents and,at this purpose,this manuscript intends to investigate the interaction of As(Ⅲ)with three phosphonic acids derived from nitrilotriacetic acid(NTA)by replacements of one(N-(Phosphonomethyl)iminodiacetic acid,NTAP),two(N,N-Bis-(phosphonomethyl)glycine,NTA2P)and three(Nitrilotri(methylphosphonic acid),NTA3P)carboxylic groups with the same number of phosphonate *** in-depth potentiometric and calorimetric investigation allowed to determine speciation models featured by simple ML,MLH i and ML(OH)species.A complete thermodynamic characterization of the systems is reported together with the definition of coordination mode by mass spectrometry *** the light of the speciation models,the possibility of using these ligands in arsenic removal techniques was assessed by determining the pL 0.5(the concentration of ligand able to remove the 50%of metal ion present in trace).All ligands show a good sequestering ability,in particular under the conditions of fresh water,following the trend NTA3P>NTA2P>NTAP.

关键词： Phosphonate ligands Arsenic Thermodynamic interaction parameters Sequestering ability

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Seroconversion of HBsAG coincides with hepatitis A superinfection: A case report

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World Journal of Clinical Cases 2020年第9期8卷 1651-1655页

作者： claudia Beisel Marylyn M Addo Julian Schulze zur Wiesch Department of Internal Medicine Division of Infectious DiseaseUniversity Medical Center Hamburg-EppendorfHamburg 20251Germany German Center for Infection Research Hamburg 20251Germany

BACKGROUND Hepatitis B virus(HBV)is a hepatotropic virus that can cause acute and chronic liver *** to the world health organization 257 million people are infected with chronic HBV infection ***-infection with other hepadnaviruses,including hepatitis A virus(HAV),hepatitis C virus,hepatitis D virus,and hepatitis E virus is associated with increased risk of acute liver failure in patients with chronic *** SUMMARY Here,we report a case of a 47-year old male patient with HBV-related compensated Child A cirrhosis,who presented with general fatigue,malaise and laboratory signs of acute *** the patient was regularly seen at a specialized university liver unit,the HAV vaccination status was *** HAV super-infection was diagnosed by positive serological and polymerase chain reaction *** acute HAV super-infection,spontaneous HBsAg elimination and development of an anti-HBs titer were *** This case illustrates the importance of carefully checking the vaccination *** our patient,unspecific immunological responses to HAV led to functional cure of HBV.

关键词： Chronic hepatitis B infection Liver cirrhosis Acute hepatitis A infection HBsAg clearance Functional cure Case report

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