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Utilizing the ultrasensitive Schistosoma up-converting phosphor lateral flow circulating anodic antigen(UCP-LF CAA)assay for sample pooling-strategies

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Infectious Diseases of Poverty 2017年第1期6卷 1379-1391页

作者： Paul L.A.M.Corstjens Pytsje T.Hoekstra claudia j.de dood Govert j.van Dam department of Molecular Cell Biology Leiden University Medical CenterP.O.Box 96002300RCLeidenThe Netherlands department of Parasitology Leiden University Medical CenterP.O.Box 96002300RCLeidenThe Netherlands

Background:Methodological applications of the high sensitivity genus-specific Schistosoma CAA strip test,allowing detection of single worm active infections(ultimate sensitivity),are discussed for efficient utilization in sample pooling *** relevant cost reduction,pooling of samples rather than individual testing can provide valuable data for large scale mapping,surveillance,and ***:The laboratory-based CAA strip test utilizes luminescent quantitative up-converting phosphor(UCP)reporter particles and a rapid user-friendly lateral flow(LF)assay *** test includes a sample preparation step that permits virtually unlimited sample concentration with urine,reaching ultimate sensitivity(single worm detection)at 100%*** facilitates testing large urine pools from many individuals with minimal loss of sensitivity and *** test determines the average CAA level of the individuals in the pool thus indicating overall worm burden and *** requiring test results at the individual level,smaller pools need to be analysed with the pool-size based on expected prevalence or when unknown,on the average CAA level of a larger group;CAA negative pools do not require individual test results and thus reduce the number of ***:Straightforward pooling strategies indicate that at sub-population level the CAA strip test is an efficient assay for general mapping,identification of hotspots,determination of stratified infection levels,and accurate monitoring of mass drug administrations(MDA).At the individual level,the number of tests can be reduced *** low endemic settings as the pool size can be increased as opposed to prevalence ***:At the sub-population level,average CAA concentrations determined in urine pools can be an appropriate measure indicating worm *** strategies allowing this type of large scale testing are feasible with the various CAA strip test formats and do not affect sens

关键词： Schistosomiasis Diagnostics Sample pooling Mass drug administration Circulating anodic antigen Lateral flow Strip test Up-converting reporter particle UCP-LF CAA

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Selecting accurate post-elimination monitoring tools to prevent reemergence of urogenital schistosomiasis in Morocco:a pilot study

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Infectious Diseases of Poverty 2017年第1期6卷 664-672页

作者： Abdelaali Balahbib Fatima Amarir Paul L.A.M.Corstjens claudia jde dood Govert jvan Dam Amina Hajli Meryem Belhaddad Bouchra El Mansouri Abderrahim Sadak Mohamed Rhajaouim El Bachir Adlaoui National Reference Laboratory for Schistosomiasis and Malacology National Institute of HygieneAgdalRabatMorocco Faculty of Science Laboratory of Zoology and General BiologyAgdalRabatMorocco Laboratory of Parasitology and Malacology Institute of Nursing Professions and Health TechniquesCasablancaMorocco department of Molecular Cell Biology Leiden University Medical CenterLeidenThe Netherlands department of Parasitology Leiden University Medical CenterLeidenThe Netherlands

Background:After alleged stop of transmission of schistosomiasis and further down the line in post elimination settings,sensitive tools are required to monitor infection status to prevent potential *** Rahala,where transmission cycle of Schistosoma haematobium is interrupted since 2004 but where 30%of snails are still infected by ***,potential human *** infection can’t be *** methods based on egg-counts do not provide the required sensitivity,antibody or antigen assays are envisaged as the most appropriate tools for this type of ***:In this pilot study,the performances of three assays were compared:two commercially available antibody tests(ELISA and haemagglutination format)indicating exposure,and an antigen test(lateral flow strip format)demonstrating active *** 37 recruited study participants resided in Rahala(Akka,province Tata,Morocco).Participants had been diagnosed and cured from schistosomiasis in the period between 1983 and *** 2015 these asymptomatic participants provided fresh clinical samples(blood and urine)for analysis with the aforementioned diagnostics ***:No eggs were identified in the urine of the 37 *** haemagglutination test indicated 6 antibody positives whereas the ELISA indicated 28 antibody positives,one indecisive and one false *** and haemagglutination results matched for 18 individuals,amongst which 5 out of 6 haemagglutination *** the antigen test(performed on paired serum and urine samples),serum from two participants(cured 21 and 32 years ago)indicated the presence of low levels of the highly specific Schistosoma circulating anodic antigen(CAA),demonstrating low worm level infections(less than 5 pg/ml corresponding to probably single worm pair).One tested also CAA positive with *** indicated the presence of human anti-Schistosoma antibodies in these two CAA positive cases,haemagglutination results were ***:To pre

关键词： Schistosomiasis Transmission stop Elimination Monitoring Antibody test Antigen test Circulating Anodic Antigen(CAA) Active infection

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癌症诊断的进展

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国外医学（肿瘤学分册） 1990年第5期17卷 287-289页

作者： dood GD 孙玉荣

近年来,诊断性成像随着电子计算机和电子学的研究进展,取得了丰富的经验。通过这些技术的应用,可望对肿瘤诊断、分析程期和病人预后方面有重要的作用。在处理癌症病人时,成像过程必须考虑肿瘤的特征,包括大体形态学和自然病史。由于技... 详细信息

近年来,诊断性成像随着电子计算机和电子学的研究进展,取得了丰富的经验。通过这些技术的应用,可望对肿瘤诊断、分析程期和病人预后方面有重要的作用。在处理癌症病人时,成像过程必须考虑肿瘤的特征,包括大体形态学和自然病史。由于技术日趋精细,发现肿瘤的微蔓延和对周围结构的影响,在制定治疗方案中,已表现出明显的重要性。磁共振成像磁共振成像(MRI)已成为一种可接受的临床技术。目前,临床磁共振成像取决于激发带正电荷的氢原子核。一个氢的质子。

关键词：癌症诊断

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提高聚氯乙烯的户外耐候性

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电线电缆 1987年第4期 34-35页

作者： dood S. Darr ,吴曾权

在硬质和软质聚氯乙烯塑料中,加入无机稳定剂氧化锌.能提高其耐紫外线老化性能,防止由此而引起的老化降解.如果氧化锌和二氧化钛并用.在户外使用时可取得更令人满意的效果.

关键词：聚氯乙烯稳定剂大气老化试验

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