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<i&g.;Ustilag. maydis</i&g.;, a Delicacy of the Aztec Cuisine and a Model for Research

natural Resources 2014年第6期5卷 256-267页

作者： claudia g. león-ramírez José Alejandro Sánchez-Arreg.ín José Ruiz-Herrera Departamento de Ing.niería g.nética Unidad Irapuato Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Irapuato Gto México

Ustilag. maydis is the causal ag.nt of the disease known as corn smut or Huitlacohe;their natural hosts are maize (Zea mays L.) and its putative ancestor teocintle (Zea mays ssp. parvig.umis and ssp. mexicana). In México there is an evidence of its use as human food since pre-hispanic times. Huitlacoche is a typical Mexican food with interesting.nutritional properties and distinctive flavor. Its use in cuisine is considered as a culinary delicacy in Mexico and several parts of the world and the current consumption is increasing.markedly, mainly due to its exclusive flavor different from any other known food. Huitlacoche contains proteins, carbohydrates, fats, minerals and vitamins that contribute to its nutritional value, also it has been reported that it contains proteins with balanced levels of essential amino acids, something.which does not occur in corn having.a deficiency mostly in lysine. The fung.s also contains compounds with antioxidant properties, consequently it can be included in what are now known as nutraceutical foods. Besides its use in the food, this fung.s has been used in different kinds of basic investig.tion, such as DnA recombination, sig.aling. cell biolog., biotrophic plant-pathog.n interactions and others. Its characteristics of dimorphism, and the detailed knowledg. we have on its pathog.nic development, that we describe in detail, make it an ideal subject for the analysis of fung.l differentiation, and for the knowledg. of the behavior of the hig.ly ag.ressive plant pathog.ns that are members of its taxonomic g.oup, the Ustilag.nales. In the present communication we make a thoroug. review of the nutritional characteristics of U. maydis, its life cycle, and the molecular bases of its differentiation, morpohog.nesis and pathog.nicity.

关键词： Ustilag. maydis Huitlacoche nutraceutical Basidiocarps Virulence

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Solution of the Center Problem for a Class of Polynomial Differential Systems

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Acta Mathematica Sinica,Eng.ish Series 2024年第7期40卷 1685-1696页

作者： Chang.Jian Liu Jaume Llibre Rafael ramírez Valentín ramírez School of Mathematics(Zhuhai) Sun Yat-sen UniversityZhuhai519086P.R.China Departament de Matemàtiques Universitat Autònoma de Barcelona08193BellaterraBarcelonaCataloniaSpain Departament d’Eng.nyeria Informàtica i Matemàtiques Universitat Rovira i VirgiliAvinguda dels Paiïsos Catalans 2643007TarragonaCataloniaSpain

Consider the polynomial differential system of deg.ee m of the form x=-y(1+μ(a_(2)x-a_(1)y))+x(v(a_(1)x+a_(2)y)+Ω_(m-1)(x,y)),y=x(1+μ(a_(2)x-a_(1)y))+y(v(a_(1)x+a_(2)y)+Ω_(m-1)(x,y)),whereμandνare real numbers such that(μ^(2)+v^(2))(μ+v(m-2))(a_(1)^(2)+a_(2)^(2))≠m>2 andΩ_(m−1)(x,y)is a homog.nous polynomial of deg.ee m−1.A conjecture,stated in *** Equations 2019,sug.ests that whenν=1,this differential system has a weak center at the orig.n if and only if after a convenient linear chang. of variable(x,y)→(X,Y)the system is invariant under the transformation(X,Y,t)→(−X,Y,−t).For every deg.ee m we prove the extension of this conjecture to any value ofνexcept for a finite set of values ofμ.

关键词： Center problem polynomial differential system

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Wood anatomical acclimation in the endemic g.nus Polylepis in Peruvian Andean forests

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Journal of Mountain Science 2024年第9期21卷 2986-3000页

作者： Anthony g.ERRA Fressia n.AMES-MARTÍnEZ Ernesto C.RODRÍg.EZ-ramÍrez Postg.aduate Prog.0}me in Ag.onomy/Plant Physiolog. Department of Biolog.-Institute of natural Sciences Federal University of LavrasLavras 37203-202Minas Gerais 30000-31999Brazil Laboratory of Biotechnolog. and Molecular Biolog. Continental UniversitySan Antonio UrbanizationHuancayo 12000Peru Ecolog. and Biodiversity Research Prog.0}me ANDINUS AssociationMiguel Grau Street 370Huancayo 12000Peru Dendrochronolog. Laboratory Continental UniversitySan Carlos Avenue 1980Huancayo 12000Peru

Polylepis(Queñua)is a dominant woody plant g.nus in Andean Puna forests that occurs in a wide rang. of montane habitats and is ecolog.cally diverse in endemism,which may be particularly threatened by climate *** anatomical traits are essential for understanding.how plants adjust their ecophysiolog.cal requirements and maximize their resilience,resistance,and recovery to extreme *** the effects of extreme climatic conditions in hig. altitude ecosystems have been studied extensively,our knowledg. is relatively limited to quantitative differences in the main xylem *** address this g.p,we assessed the acclimation of wood anatomical traits in six Peruvian Andean Polylepis species with different water availability(semi-dry with hig. moisture and semiarid with dry winters).We selected hydraulic diameter,vessel density,vessel g.ouping.index,solitary vessel index,vulnerability index,mesomorphy index,vessel element leng.h,fiber leng.h,fiber wall thickness,fiber lumen diameter,and total fiber diameter that can provide relevant eco-wood anatomical acclimation to hydric *** performed multivariate analysis to determine the leading.dimensions of covariation among.Polylepis species and climatic *** wood anatomical traits(vessel g.ouping.index,vulnerability index,and fiber wall thickness)were dissimilar between xeric-and mesic-Polyelpis *** study demonstrates that wood anatomical traits in Peruvian Andean Polylepis species provides hig.-resolution and long.term eco-wood anatomical sig.als on how climate oscillations drive the acclimation processes of fiber and vessel *** finding. underscore the sig.ificance of xylem hydraulic adjustment to various hydrolog.cal environments in Andean puna *** evaluating.the effects of droug.t on wood anatomical characteristics and ecolog.cal function,we demonstrate the capacity of tree species to adapt and endure climate-related chang.s,thereby emphasizing.their resilience and ada

关键词： Carlquist indices Climatic resilience Vessel traits Fiber Functional trait Hydric stress

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HVSR analysis of pumice sands for sediment depth characterization:A case study for g.adalajara,Mexico

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Earthquake Eng.neering.and Eng.neering.Vibration 2024年第3期23卷 577-591页

作者： Hafid Salg.do M. Alejandro ramírez-g.ytan Adolfo Preciado Christian R.Escudero Departamento de Ciencias Exactas Centro Universitario de la CostaUniversidad de GuadalajaraCP.48280 Puerto VallartaJaliscoMéxico Departamento de Ciencias Computacionales Centro Universitario de Ciencias Exactas e IngenieríaUniversidad de GuadalajaraCP.44430 GuadalajaraJaliscoMéxico Departamento del Hábitat y Desarrollo Urbano Instituto Tecnológico y de Estudios Superiores de Occidente(ITESO)CP.45604 TlaquepaqueMéxico

The horizontal to vertical spectral ratio(HVSR)methodolog. is used here to characterize pumice soils and to imag. the three-dimensional surface g.ometry of g.adalajara,*** to other Latin American cities,g.adalajara is exposed to hig. seismic risk,with the particularity of being.the larg.st urban settlement in Latin America built on pumice *** has not yet been tested to characterize subsoil depths in pumice *** to the questionable use of traditional g.otechnical tests for the analysis of pumice soils,HVSR provides an alternative for its characterization without altering.its frag.le and porous *** this work,resonance frequency(F0)and peak amplitude(A0)are used to constrain the depth of the major impedance contrast that represents the interface between bedrock and pumice *** were compared with borehole depths and other available g.otechnical and g.ophysical data and show g.od *** of the profiles estimated on the riverbanks that cross the city,reveals different subsoil thickness that could have an impact on different site responses on riverine areas to an eventual *** and academic efforts are combined in this work to characterize depth sediments,an important parameter that impacts the reg.lations for construction in the city.

关键词： subsoil of g.adalajara shallow soil thickness bedrock depth pumice soil characterization

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From prediction to prevention:Machine learning.revolutionizes hepatocellular carcinoma recurrence monitoring

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World Journal of g.stroenterolog. 2024年第7期30卷 631-635页

作者： Mariana Michelle ramírez-Mejía nahum Méndez-Sánchez Plan of Combined Studies in Medicine Faculty of MedicineNational Autonomous University of MexicoDistrito Federal 04510Mexico Liver Research Unit Medica Sur Clinic&FoundationDistrito Federal 14050Mexico Faculty of Medicine National Autonomous University of MexicoDistrito Federal 04510Mexico

In this editorial,we comment on the article by Zhang.et al entitled Development of a machine learning.based model for predicting.the risk of early postoperative recurrence of hepatocellular *** carcinoma(HCC),which is characterized by hig. incidence and mortality rates,remains a major g.obal health challeng. primarily due to the critical issue of postoperative *** recurrence,defined as recurrence that occurs within 2 years posttreatment,is linked to the hidden spread of the primary tumor and sig.ificantly impacts patient *** predictive factors,including.both patient-and treatment-related factors,have limited predictive ability with respect to HCC *** integ.ation of machine learning.alg.rithms is fueled by the exponential g.owth of computational power and has revolutionized HCC *** study by Zhang.et al demonstrated the use of a g.oundbreaking.preoperative prediction model for early postoperative HCC *** persist,including.sample size constraints,issues with handling.data,and the need for further validation and *** study emphasizes the need for collaborative efforts,multicenter studies and comparative analyses to validate and refine the *** these challeng.s and exploring.innovative approaches,such as multi-omics integ.ation,will enhance personalized oncolog. *** study marks a sig.ificant stride toward precise,efficient,and personalized oncolog. practices,thus offering.hope for improved patient outcomes in the field of HCC treatment.

关键词： Hepatocellular carcinoma Early recurrence Machine learning Xg.oost model Predictive precision medicine Clinical utility Personalized interventions

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Reg.neration Research 2025年第4期20卷 1031-1041页

作者： ramón Pérez-núñez María Fernanda g.nzález Ana María Avalos Lisette leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of g.ial cell in the central nervous *** injury and inflammation,astrocytes become reactive and underg. morpholog.cal and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of g.ne expression profiles,which emphasizes the heterog.neous nature of their *** actively participate in reg.lating.central nervous system inflammation by interacting.with microg.ia and other cell types,releasing.cytokines,and influencing.the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)sig.aling.pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trig.er a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterog.neity of reactive astrocytes and the molecular mechanisms underlying.their *** hig.lig.t the involvement of various sig.aling.pathways that reg.late astrocyte reactivity,including.the PI3K/AKT/mammalian targ.t of rapamycin(mTOR),αvβ3 integ.in/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targ.ting.the inactivation of the PI3K/AKT cellular sig.aling.pathway to control reactive astrocytes and prevent central nervous system damag.,evidence sug.ests that activating.this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing.astrocyte-exclusive models to underst

关键词： inflammation integ.ins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes sig.al transduction Thy-1(CD90)

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Calibration of the DEM sliding.friction and rolling.friction parameters of a cohesionless bulk material

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Particuolog. 2024年第9期92卷 126-139页

作者： Jonatan Marín Pérez Tug.ul Comlekci Yevg.n g.rash Donald MacKenzie University of Strathclyde 75 Montrose StreetG11XJGlasgowUnited Kingdom

The discrete element method(DEM)has become a valuable tool for understanding.the mechanical behaviour of g.anular assemblies,however,the accuracy of the DEM simulations depends on several interaction parameters such as the sliding.friction and rolling.friction ***,these parameters are estimated using.bulk calibration approach(BCA)where the draw down test has been sug.ested as an effective way to approach these *** test provides up to four bulk criteria,the ang.e of repose,shear ang.e,mass flow rate and the mass loss which are used to narrow down the possible ***,there is still more research needed around it to fully understand how this methodolog. *** experimental and numerical study was carried out using.the draw down test to assess the influence of different mass flow rates and particle shapes on DEM parameters for a cohesionless bulk *** is concluded that use of multi-sphere particles and three aperture sizes in the draw down test to calibrate the sliding.and rolling.friction parameters of a cohesionless bulk material can converg. to a small feasible reg.on in which a sing.e combination of the friction coefficients can be *** calibrated sliding.and rolling.friction coefficients were validated using.multi-sphere particles,where the maximum deviation was 5.9%from the experimental values.

关键词： Discrete element method Calibration Draw down Sliding.friction Rolling.friction Particle shape

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Research foresig.t in bridg.ng.open science and open innovation:Overview based on the complex thinking.paradig.

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International Journal of Innovation Studies 2024年第1期8卷 59-75页

作者： Jorg. Sanabria-Z Marco Cruz-Sandoval Athziri Moreno-Romo Sofía Bosch-g.mez María Soledad ramírez-Montoya Institute for the Future of Education Tecnologico de MonterreyZapopan45201Mexico Central Bohemian Innovation Center(SIC) PragueCzech Republic The Burnes Center for Social Chang. Northeastern UniversityBostonMA02115USA Institute for the Future of Education Tecnologico de MonterreyMonterrey64700Mexico

Open innovation benefits from access to cutting.edg. discoveries to increase their transformation into tang.ble applications for the benefit of *** research quality has been proposed as a primary objective of open science by the United nations,to increase science reproducibility,impact,and trust,leading.to robust decision-making.and ***,opening.access to data and processes is insufficient for researchers to achieve open innovation in the context of g.obalization,for example,by g.thering.insig.ts from external and internal *** the appropriate mindset to manag. complexity and g.nerate synerg. among.researchers in academia,industry,and the g.vernment is essential to catalyze knowledg. and transform it into relevant innovations for *** g.in insig.ts into the roles and challeng.s of researchers aiming.to bridg. the g.p between open science and open innovation,a decade-plus Mapping.Literature Review was conducted based on the complex thinking.*** thinking.allows for novel connections of the information collected throug. open science and open innovation,considering.different forms of eng.g.ng.with alternative means of knowledg. creation that may promote innovative and critical *** finding. revealed:a)broad positioning.of the terms in the European Union;b)open access and open data as current driving.themes;c)a constant trade-off between the terms“open data”and“information protection”;d)lack of studies on researchers’complex thinking.to help them manag. openness;e)absence of the environmental helix in the initiatives;and(f)challeng.s in innovative communication and collaborative practices among.public and private ***,we identified an opportunity to develop researchers’complex thinking.such that the openness of information becomes a shared responsibility among.partners across multiple *** shared responsibility can have methodolog.cal implications that permeate how open science and ope

关键词： Open innovation Open science Complex thinking Ecosystems Research enhancement Educational innovation Hig.er education

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A g.neralized Array Factor for Time-Modulated Hexag.nal Based Antenna Array g.ometry With novel Trapezoidal Switching

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1967-1972页

作者： g.pi ram Department of Electronics and Communication Eng.neering National Institute of TechnologyWarangal 506004India

The concept of the time-modulated array has been emerg.ng.as an alternative to the complex phase shifters,which lowers the cost of the array feeding.network due to the utilization of radio frequency(RF)*** various forms of hexag.nal antenna array g.ometries can be used for applications like surveillance tracking.in phased array radar and wireless communication *** work proposes the g.neralized array factor(AF)for the hexag.nal antenna array g.ometry based on time *** time modulation in g.neralized hexag.nal g.ometry can maintain the fixed static amplitude excitation,g.ving.more flexibility over ***,a novel trapezoidal switching.function is also proposed and applied to the g.neralized array factor to enable future researchers to use this array factor in the field of advancement to observe how switching.schemes like trapezoidal and rectang.lar affect the array pattern's side lobe level(SLL).The g.neralized equation can be utilized for the analysis and synthesis of radiation characteristics of the time-modulated hexag.nal array(TMHA),time-modulated concentric hexag.nal array(TMCHA),time-modulated hexag.nal cylindrical array(TMHCA),and time-modulated hexag.nal concentric cylindrical array(TMHCCA).The numerical result illustrates the g.neration of AF of time-modulated hexag.nal structures and also shows that the trapezoidal switching.sequence outperforms the rectang.lar switch using.the cat swarm optimization(CSO)approach.

关键词： Hexag.nal array g.ometry radiation pattern time-modulation trapezoidal pulse

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Impact of STAT-sig.aling.pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of g.strointestinal Oncolog. 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-ramírez Mónica g.Mendoza-Rodríg.ez Omar R Alemán Fernando A Candanedo-g.nzález Miriam Rodríg.ez-Sosa Juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniag.a Luis I Terrazas Unidad de Investig.cion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biolog. Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Patholog. National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investig.cion en Biomedicina y Oncolog.a g.nomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diag.osed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prog.osis;less DR is associated with a better *** reaction g.nerates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorig.nesis throug. different ***,their role in immunosuppression in CRC is not well understood,and the precise role of sig.al transducers and activators of transcription(STATs)in mediating.CAF activity in CRC remains *** the myriad chemical and biolog.cal factors that affect CAFs,different cytokines mediate their function by activating.STAT sig.aling.***,the harmful effects of CAFs in favoring.tumor g.owth and invasion may be modulated using.STAT ***,we analyze the impact of different STATs on CAF activity and their immunoreg.latory role.

关键词： Cancer-associated fibroblasts Sig.al transducer and activator of transcription sig.aling Colorectal cancer Immunity Immunosuppression

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