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Expression of juvenile hormone acid O-methyltransferase and juvenile hormone synthesis in Blattella germanica

Insect Science 2018年第5期25卷 787-796页

作者： claudia V. Dominguez Jose L. Maestro Institute of Evolutionary Biology CSIC-Universitat Pompeu Fabra Barcelona Spain

Juvenile hormone （JH）, a sesquiterpenoid synthetized by the insect corpora allata （CA）, plays critical roles in metamorphosis and reproduction. Penultimate or last step of JH synthesis is catalyzed by juvenile hormone acid O-methyltransferase （JHAMT）. Here we report the cloning and expression analysis of the JHAMT orthologue in the cockroach, Blattella germanica （L.）（BgJHAMT）. BgJHAMT is mainly expressed in CA, with only expression traces in ovary. Three different isoforms, differing in the 3＇-UTR sequence, were identified. Isoform A shows between 35 and 65 times higher expression than B and C in CA from penultimate nymphal instar and adult females. RNAi-triggered knock down of BgJHAMT produces a dramatic reduction of JH synthesis, concomitant with a decrease of fat body viteUogenin expression and basal follicle length. BgJHAMT mRNA levels in CA of females along the gonadotrophic cycle parallel, with a slight advancement, JH synthesis profile. BgJHAMT mRNA levels were reduced in starved females and in females in which we reduced nutritional signaling by knocking down insulin receptor and target of rapamycin （TOR）. Results show that conditions that modify JH synthesis in adult B. germanica females show parallel changes of BgJHAMT mRNA levels and that the JH-specifie branch of the JH synthesis pathway is regulated in the same way as the mevalonate branch. Furthermore, we demonstrate that nutrition and its signaling through the insulin receptor and TOR pathways are essential for activating BgJHAMT expression, which suggests that this enzyme can be a checkpoint for the regulation of JH production in relation to nutritional status.

关键词： Blattella germanica corpora allata JHAMT juvenile hormone nutritionalsignaling

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Palynostratigraphy of the Zorritas Formation, Antofagasta region, Chile： Insights on the Devonian]Carboniferous boundary in western Gondwana

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Geoscience Frontiers 2017年第3期8卷 493-506页

作者： claudia V. Rubinstein Elodie Petus Hans Niemeyer IANIGLA CCT-CONICET Mendoza Av. Ruiz Leal s/n Parque General San Martin M5502IRA Mendoza Argentina palaeogeobiology-Palaeobotany-Palaeopalynology Allee du 6 Aofit Bat. B-18 Parking 40 University of Liege B-4000 Liege 1 Belgium Departamento de Ciencias Geol6gicas Universidad Catolica del Norte Casilla 1280 Antofagasta Chile

The Middle Member of the Zorritas Formation in the Antofagasta region of northern Chile, yielded terrestrial and marine palynomorph assemblages which span the Devonian/Carboniferous boundary. The assemblages show a clear predominance of terrestrial palynomorphs with 70 miospore species, 18 marine phytoplankton species, two non-marine algae and one chitinozoan species, all coming from 15 productive levels. Palynomorphs are poorly preserved and most of them are reworked. Three palyno- logical associations are recognized based on miospores. These are assigned to the Tournaisian-Visean, Tournaisian and probable latest Famennian. Age assignments are discussed in the frame of the spore zonal schemes established for Euramerica and western Gondwana. The stratigraphical distribution of spores allows the identification of the probable position of the Devonian/Carboniferous boundary within the Zorritas Formation. This system boundary is proposed for the first time in Palaeozoic sedimentary rocks of northern Chile. The presence of Gondwanan typical miospore species indicates affinities with this palaeocontinent even though the Tournaisian and Tournaisian-Viseao miospore associations sup- port the cosmopolitanism already suggested for the early Carboniferous flora. The significant number of reworked palynomorphs together with the sedimentological analysis of the studied sections, suggest that these deposits were severely impacted by the climatic change and major sea level fluctuations. Similar conditions were recorded in coeval western Gondwana basins.

关键词： Miospores Phytoplankton Devonian/Carboniferous boundary Western Gondwana Chile

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Using risk-benefit analysis to control Salmonella in chicken meat

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Food Quality and Safety 2021年第4期5卷 375-387页

作者： Eduardo Cesar Tondo claudia Titze Hessel Gonçalves Department of Food Science Institute of Food Science and Technology of the Federal University of Rio Grande do Sul-ICTA/UFRGSPorto AlegreRSBrazil

We have created a risk-benefit analysis(RBA)model to assist in food safety decision-making by analyzing Salmonella control in Brazilian chicken ***,we described the issues in a risk profile and used a 5x5 matrix to rank the risks associated with *** then classified the magnitude of benefits and costs of control measures using another ***,we verified the beneficial effects of recommended control measures using Quantitative Microbiological Risk Assessment(QMRA).The RBA classified Salmonella contamination as risk 6,indicating that control measures should be taken in the short and medium *** also recommended the adoption of biosecurity measures on farms to reduce the prevalence of Salmonella in birds,better control of carcass washings and chiller tank management,and information placement on packages and campaigns to raise the awareness of the population about the need to control Salmonella contamination before *** the other hand,it did not recommend better controls at scalding and *** confirmed the beneficial effects of the recommended control *** example,as Salmonella prevalence in poultry increased from 4.04 per cent to 50 per cent,the risk of infection per serving also increased from 0.0080 to *** better controls in washings and chiller tank management did not affect the risk of infection,it reduced Salmonella counts on *** assume that the presence of Salmonella on carcasses was due to improper thermal processing or cross-contamination,which increased the risk from 0.0080 to *** RBA demonstrated the logic involved in the adoption of control measures,and this can be helpful in the risk management of food safety issues.

关键词： Risk management risk perception food safety

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Hypoxia,angiogenesis and liver fibrogenesis in the progression of chronic liver diseases

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World Journal of Gastroenterology 2010年第3期16卷 281-288页

作者： claudia Paternostro Ezio David Erica Novo Maurizio Parola Department of Experimental Medicine and Oncology Interuniversity Centre for Hepatic PathophysiologyUniversity of Torino Department of Pathology San Giovanni Battista Hospital

Angiogenesis is a dynamic,hypoxia-stimulated and growth factor-dependent process,and is currently referred to as the formation of new vessels from preexisting blood *** and clinical studies have unequivocally reported that hepatic angiogenesis,irrespective of aetiology,occurs in conditions of chronic liver diseases(CLDs) characterized by perpetuation of cell injury and death,inflammatory response and progressive *** and related changes in liver vascular architecture,that in turn concur to increase vascular resistance and portal hypertension and to decrease parenchymal perfusion,have been proposed to favour fibrogenic progression of the disease towards the end-point of ***,hepatic angiogenesis has also been proposed to modulate the genesis of portal-systemic shunts and increase splanchnic blood flow,thus potentially affecting complications of *** angiogenesis is also crucial for the growth and progression of hepatocellular *** literature has identified a number of cellular and molecular mechanisms governing the cross-talk between angiogenesis and fibrogenesis,with a specifi c emphasis on the crucial role of hypoxic conditions and hepatic stellate cells,particularly when activated to the myofibroblast-like *** anti-angiogenic therapy has been proven to be effective in limiting the progression of CLDs in animal *** a clinical point of view,anti-angiogenic therapy is currently emerging as a new pharmacologic intervention in patients with advanced fibrosis and cirrhosis.

关键词： Chronic liver diseases Hepatic myofi broblasts Hypoxia Liver angiogenesis Liver fi brogenesis

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*** volcano high-resolution topography:airborne LiDAR modelling validated by GPS data

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International Journal of Digital Earth 2016年第7期9卷 710-732页

作者： Marina Bisson claudia Spinetti Marco Neri Alessandro Bonforte Istituto Nazionale di Geofisica e Vulcanologia via della Faggiola 32PisaItaly Istituto Nazionale di Geofisica e Vulcanologia Centro Nazionale Terremotivia di Vigna MurataRomeItaly Istituto Nazionale di Geofisica e Vulcanologia Sezione di CataniaOsservatorio EtneoPiazza RomaCataniaItaly

High-resolution digital topography is essential for land management and planning in any type of territory as well as the reproduction of the Earth surface in a geocoded digital format that allows several Digital Earth *** a volcanic environment,Digital Elevation Models are a valid reference for multi-temporal analyses aimed to observe frequent changes of a volcano edifice and for the relative detailed morphological and structural *** the first time,a DTM(Digital Terrain Model)and a DSM(Digital Surface Model)covering the entire *** volcano(Italy)derived from the same airborne Light Detection and Ranging(LiDAR)are here *** than 250 million 3D LiDAR points have been processed to distinguish ground elements from natural and anthropic *** end product is the highly accurate representation of *** landscape(DSM)and ground topography(DTM)dated *** models have a high spatial resolution of 2 m and cover an area of 620 *** DTM has been validated by GPS ground control *** vertical accuracy has been evaluated,resulting in a root-mean-square-error of±0.24 *** DTM is available as electronic supplement and represents a valid support for various scientific studies.

关键词： Airborne LiDAR GPS DEM Mt.Etna

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PI3K/mTOR mediate mitogen-dependent HDAC1 phosphorylation in breast cancer:a novel regulation of estrogen receptor expression

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分子细胞生物学报:英文版 2015年第2期7卷 132-142页

作者： Simona Citro claudia Miccolo Laura Meloni Susanna Chiocca Department of Experimental Oncology European Institute of OncologyIFOM-IEO Campusvia Adamello 1620139 MilanItaly Department for Molecular Biomedical Research Technologiepark Zwijnaarde927 VIB west9052 GhentBelgium

Histone deacetylase 1(HDAC1)is an important epigenetic controller involvedin transcriptional regulation throughmodification of chromatin *** and epigenetic changes and deregulation of signal transduction pathways have been implicated in the development of breast *** of estrogen receptor a(ERa)expression is one of the mechanisms behind the acquisition of endocrine *** and increased hormone and growth factor receptor signaling in breast cancer cells contribute to resistance to endocrine *** HDACs and the PI3K/mTOR signaling pathway are becoming promising targets in breast cancer,reversing also acquired hormone *** we show how mitogens,activating the PI3K/mTOR pathway,trigger the phosphorylation of HDAC1 in breast cancer cells,which is completely dependent on the activity of the p70 S6 kinase(S6K1).Our findings show that S6K1,overexpressed in many breast cancers,controls HDAC1-dependent transcriptional regulation of ERa levels upon mitogenic stimuli,controlling HDAC1 recruitment to the ERa ***,cell treatment with both mTOR and HDACs inhibitors shows an additive effect in inhibiting breast cancer *** confirms the novel cross-talk between the HDAC1 and PI3K pathways with clinical implications towards the treatment of this malignant disease.

关键词： breast cancer estrogen receptor HDAC1/mTOR/PI3K/S6K1

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A Novel Intermediary Framework for Dynamic Edge Service Composition

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Journal of Computer Science & Technology 2012年第2期27卷 281-297页

作者： claudia Canali Michele Colajanni Delfina Malandrino Vittorio Scarano Raffaele Spinelli Department of Information Engineering University of Modena and Reggio Emilia Department of Computer Science University of Salerno

Multimedia content,user mobility and heterogeneous client devices require novel systems that are able to support ubiquitous access to the Web *** this scenario,solutions that combine flexibility,efficiency and scalability in offering edge services for ubiquitous access are *** propose an original intermediary framework,namely Scalable Intermediary Software Infrastructure （SISI）,which is able to dynamically compose edge services on the basis of user preferences and device *** SISI framework exploits a per-user profiling mechanism,where each user can initially set his/her personal preferences through a simple Web interface,and the system is then able to compose at run-time the necessary *** basic framework can be enriched through new edge services that can be easily implemented through a programming model based on APIs and internal *** experiments demonstrate that flexibility and edge service composition do not affect the system *** show that this framework is able to chain multiple edge services and to guarantee stable performance.

关键词： ubiquitous Web edge service intermediary framework service flow performance

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Early-onset colorectal cancer:Current insights and future directions

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 230-241页

作者： claudia Wing-Kwan Wu Rashid N Lui Division of Gastroenterology and Hepatology Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong KongChina Department of Clinical Oncology The Chinese University of Hong KongHong KongChina

Early-onset colorectal cancer(EOCRC)has seen an alarming rise worldwide over the past two *** reason for this global trend is poorly *** appears to have its own unique clinical and molecular features when compared with late-onset colorectal *** patients appear to have more distal or rectal disease,a more advanced stage of disease at presentation,and more unfavorable histological *** risk factors for EOCRC is the first step in mitigating the rising burden of this *** we summarize several noteworthy biological factors and environmental exposures that are postulated to be responsible *** can hopefully translate in clinical practice to the development of better risk stratification tool for identifying highrisk individuals for early colorectal cancer screening,and identifying areas needed for further research to curb this rising trend.

关键词： Early-onset colorectal cancer Young-onset colorectal cancer Risk factors Environmental exposures Microbiome Genetics

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Traumatic fatal cerebral hemorrhage in an old patient with a history of multiple sclerosis under dabigatran： a case report and review of the literature

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Journal of Geriatric Cardiology 2015年第1期12卷 83-87页

作者： claudia Stollberger Andreas Ulram Adam Bastovansky Josef Finsterer Hospital Rudolfstiftung Juehgasse 25 A-1030 Vienna Austria

One disadvantage of direct anticoagulant drug is the lack of an antidote, which may become relevant in patients with traumatic brain in- jury. A 77-years old man with atrial fibrillation and syncope received dabigatran despite recurrent falls. Due to a ground-level-fall, he suffered from subarachnoidal and intraparenchymal hemorrhages, subdural hematoma and brain edema with a midline shift. Despite osteoelast/c trepanation and hematoma-evacuation he remained comatose and died seven days later without regaining consciousness. Most probably, decreased dabigatran clearance due to increased age might have contributed to the fatal course. We suggest withholding anticoagulant therapy in patients with unexplained falls. If anticoagulant therapy is deemed necessary, vitamin-K-antagonists with their potential for laboratory monitoring and reversal of anticoagulant activity should be preferred.

关键词： Cerebral hemorrhage Anticoagulation Dabigatran Atrial fibrillation

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Characterization of nucleohistone and nucleoprotamine components in the mature human sperm nucleus

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Asian Journal of Andrology 2008年第4期10卷 535-541页

作者： Yan Li claudia Lalancette David Miller Stephen A. Krawetz Center for Molecular Medicine and Genetics Wayne State University School of Medicine Wayne 48201 MI USA Department of Obstetrics and Gynecology Wayne State University School of Medicine Wayne 48201 MI USA Reproduction and Early Development Group University of Leeds Institute of Genetics Health and Therapeutics Leeds LS29JT UK Institute for Scientific Computing Wayne State University Wayne 48201 MI USA

Aim： To simultaneously determine the localization of histones and protamines within human sperm nuclei. Methods： Immunofluorescence of the core histones and protamines and fluorescence in situ hybridization of the telomere region of chromosome 16 was assessed in decondensed human sperm nuclei. Results： Immunofluorescent localization of histones, protamine 1 （PRM1） and protamine 2 （PRM2） along with fluorescence in situ hybridization localization of chromosome 16 telomeric sequences revealed a discrete distribution in sperm nuclei. Histones localized to the posterior ring region （i.e. the sperm nuclear annulus）, whereas PRM1 and PRM2 appeared to be dispersed throughout the entire nucleus. Conclusion： The co-localization of the human core sperm histones with the telomeric regions of chromosome 16 is consistent with the reorganization of specific non-protamine regions into a less compacted state.

关键词： human sperm nucleus histone protamine telomere

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