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Newton-科学世界 2005年第2期 42-46页

作者： Patrizia Giongo giacomo Nazzaro 赵吉才

关于人体生物钟的最新消息：那些夜猫子的时间过得比较慢；面对于那些早起者来说，不只白天来得早，时间过得也快。研究人员还发现，足球射门和减肥都有一个最佳时刻。

关键词：足球射门生理节律消息研究人员人体生物钟时刻减肥白天发现

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Non-Conventional MRI Techniques as an Alternative Role to the Clinical diagnosis in Alzheimer’s disease

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Health 2014年第19期6卷 2712-2723页

作者： Elisabetta Giugni Rita Vadalà Francesca Romana Pezzella Giuseppe Bomboi Stefano Galletti giacomo Luccichenti Carmela Colica Orietta Picconi Stefano Bastianello European Biomedical Foundation Onlus Rome Italy IRCCS Santa Lucia Foundation Rome Italy Stroke Unit AOS Camillo-Forlanini Hospital Rome Italy Neurology Unit—II Faculty of Medicine—“Sapienza” University of Rome Rome Italy CNR—ISN—UOS Pharmacology Roccelletta di Borgia Catanzaro Italy Opera S.r.l. Genova Italy Department of Brain and Behavioral Sciences University of Pavia Pavia Italy

Improved methods for early diagnosis and non-invasive surrogates for the diagnosis of disease severity in Alzheimer’s disease (AD) are becoming the new challenge. Dementia can now be accurately determined through clinical evaluation, cognitive screening, basic laboratory evaluation and structural imaging. Magnetic resonance (MRI) techniques are being evaluated as possible surrogate measures to monitor disease progression. The purpose of this work is to correlate the results of combined advanced MR techniques with neuropsychological performance in order to identify a sensible and sensitive imaging approach to quantify neurodegenerative disease progression. One of the most relevant evidences in our study is the degeneration of the fibers of the corpus callosum in the pathogenesis of cognitive disorders in AD patients, as demonstrated by the relationship between altered neuropsychological tests and reduced FA (Fractional Anisotrophy) values of the corpus callosum in such patients. This data is also integrated by the evidence of anatomic reduction of the total volume of the corpus callosum assessed by FreeSurfer, thus supporting the hypothesis that the “brain disconnects” play a key role in the pathogenesis of AD. Statistical evaluation of regression consisting in the identification of different numerical coefficients that are multiplied by the thickness of the right fusiform value or by the volume of left inferoparietal region and left middle-temporal region, allows us to obtain the predictive numeric value of the related neuropsychological test. Combination of non-conventional magnetic resonance imaging, including morphometry, spectroscopy, MD (mean diffusivity) and FA evaluation, could be an alternative to clinic in the evaluation of neurodegeneration in AD.

关键词： Alzheimer’s disease (AD) Non Conventional MRI Technique MRI Reproducible Marker

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世界标准日祝词国际标准促进和平和繁荣

船舶标准化与质量 2000年第5期 2-3页

作者： Mathias Funfschilling giacomo Elias Yoshio Utsumi IEC ISO ITU

在技术、经济和各种国际关系以前所未有的速度发展和变化的今天,人类对稳定有着强烈的渴求。人类一方面不断地探索、创造和发展世界,另一方面又希望世界更加有序、更加和平和繁荣。在这个表面上相互矛盾的环境中,人类几乎永远需要一个... 详细信息

在技术、经济和各种国际关系以前所未有的速度发展和变化的今天,人类对稳定有着强烈的渴求。人类一方面不断地探索、创造和发展世界,另一方面又希望世界更加有序、更加和平和繁荣。在这个表面上相互矛盾的环境中,人类几乎永远需要一个众人皆知的起始点,一些"程序规则",及一个共同的基准以衡量进步、满意度和成就。从哲学或理性的范畴来说,共同的基准和程序规则在理论上是指那些可以被社会各界人士所接受和应用的道德或伦理标准。而在科学技术领域以及绝大多数的工业、商业和经济领

关键词：程序规则 IEC 协商一致

Huge Congenital Thymic Cyst with Microscopic Thymoma

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World Journal of Cardiovascular Surgery 2013年第3期3卷 111-113页

作者： Alberto Terminella giacomo Cusumano Ignazio Vasta Rosalia Giarlotta Salvatore Bellofiore Carmelo Riscica Lizzio Salvatore Saita Maria D’Arrigo Department of Histopathology “Vittorio Emanuele—Policlinico” Hospital Catania Italy division of General Thoracic Surgery “Vittorio Emanuele—Policlinico” Hospital Catania Italy

The congenital thymic cysts are rare. They have a congenital origin and they are benign. The differential diagnosis of acquired cysts, cystic thymoma and thymic malignancies in cystic degeneration can be particularly difficult. Rarely, they assume clinical relevance for the appearance of symptoms of compression, more typical of malignant lesions, and the association with thymoma was reported in very few cases in literature. For all these features, treatment strategy remains controversial and in particular surgical approach. We report a case of a huge symptomatic congenital thymic cyst, surgically removed with histological finding of microscopic thymoma.

关键词： Thymic Cystis Thymoma Mediastinal Tumor Surgery

Myocarditis Associated with Coronavirus disease 2019 (COVID-19) in a Pediatric Patient

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Advances in Infectious diseases 2020年第3期10卷 226-232页

作者： Filippo M. Salvini Valentina Giuli Elisabetta F. Stacul Chiara Moretti Alessandra Corato Sara Santacesaria Gabriele Vignati Costantino De giacomo division of Pediatrics Niguarda Hospital Milan Italy division of Pediatric Cardiology Niguarda Hospital Milan Italy

Viral infection is one of the most important causes of myocarditis both in adult and pediatric age. We describe acute myocarditis due to SARS-CoV-2 infection in an otherwise healthy 12-years-old Caucasian boy. He was admitted because of a history of 2 days of fever, dry cough, diarrhea, abdominal pain and fatigue. In spite of a family history of COVID-19 patient strict contact, a first nasopharyngeal swab for SARS-CoV-2 RNA resulted negative. After 4 days, his clinical condition evolved, with the onset of interstitial pneumonia, as documented by chest tomography and tachycardia. Blood analysis showed an NTproBNP and TnT increasing, transthoracic echocardiography revealed normal left ventricle (LV) dimension, altered myocardial texture, diffuse hypokinesis and impaired left ventricular function. A nasopharyngeal swab tested positive for SARS-CoV-2 infection at day 6 after admission. Heart failure conventional treatment associated with heparin, glucocorticoids and Remdesivir were administered with progressive improvement of clinical and instrumental conditions. No residual heart damage was documented during the following 3 monthes cardiological outpatient follow-up. Although COVID-19 infection has a milder course of disease in children than in adults, severe forms of the disease may occur and myocarditis should be carefully considered in the pediatric age.

关键词： Coronavirus disease 19 Children Myocarditis Remdesivir

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国际标准促进和平与繁荣

术语标准化与信息技术 2000年第3期 4-5页

作者： Mathias Fü nfschilling giacomo Elias Yoshio Utsumi

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慢性肝病的血小板减少症：来自移植患者的经验

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传染病网络动态 2007年第12期 27-29页

作者： giacomo Laffi 董培玲（编译）杨月（审校）

晚期肝硬化病人止血障碍，原因复杂，其中血小板减少症是一常见表现。这一现象的发病机制很复杂，脾的血池储存、血小板的消耗增加和／或产生减少被认为是发病因素。采用放射性同位素示踪标记血小板的动力学研究显示血小板汇集增加、平... 详细信息

晚期肝硬化病人止血障碍，原因复杂，其中血小板减少症是一常见表现。这一现象的发病机制很复杂，脾的血池储存、血小板的消耗增加和／或产生减少被认为是发病因素。采用放射性同位素示踪标记血小板的动力学研究显示血小板汇集增加、平均血小板寿命下降。而且发现轻度肝硬化患者平均血小板计数几乎正常，因为骨髓产生血小板较正常情况增加两倍。几项研究证实这一假说：当肝脏功能进行性衰竭时，TPO（血小板生成因子）合成减少导致对骨髓刺激不当，低血小板血症随之发生。

关键词：血小板减少症慢性肝病血小板生成因子移植放射性同位素肝硬化病人血小板计数肝硬化患者

Feasibility of en bloc thulium laser enucleation of the prostate in a large case series. Are results enhanced by experience?

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Asian Journal of Urology 2019年第4期6卷 339-345页

作者： Giovanni Saredi giacomo Maria Pirola Francesca Ambrosini Simone Barbieri Lorenzo Berti Andrea Pacchetti Domenico Iovino Giuseppe Ietto Letizia Libassi Giulio Carcano Department of Urology Ospedale di Circolo e Fondazione MacchiVareseItaly Department of Urology Usl Toscana Sud EstSan Donato HospitalArezzoItaly Centro Cardiologico Monzino IRCCSMilanItaly Department of Urology University of GenovaGenovaItaly Department of Surgery University of InsubriaVareseItaly

Objective:To provide the first large single-operator case series of patients who undergo“en bloc”thulium laser enucleation of the prostate(ThuLEP)and to demonstrate an improvement in enucleation efficacy with ***:We prospectively evaluated a cohort of patients with symptomatic benign prostatic hyperplasia(BPH)who underwent“en bloc”ThuLEP between May 2015 and November *** between dependent variables(delivered energy and operating time)and independent variables(adenoma volume and experience)were estimated with regression *** experience was calculated as the time interval between the date of the first operation of the series and the date of the operation being ***:A total of 100 patients were registered for the *** operative time was 56.5 min(interquartile range[IQR]:40-85 min).Median enucleation time was 17.4 min(IQR:15-21.5 min).Median enucleation index(enucleation time per adenoma gram)was 0.3 min/g(0.2-0.3 min/g).The overall operative time is not influenced by experience,but we registered a significant trend towards a reduction in the total amount of energy delivered energy normalized per adenoma gram(p=0.0148).Conclusion:We believe that further attention is needed for these new“en bloc”prostatic enucleation techniques,which can facilitate some surgical steps,leading to a widespread use of laser technology for BPH surgical treatment.

关键词： Benign prostatic hyperplasia Endoscopic enucleation of the prostate Laser surgery Thulium laser enucleation of the prostate

全新约翰迪尔5R系列,更舒适、更高效、更紧凑

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农业机械 2017年第2期 51-51页

作者： giacomo di Paola 吴昱

2016年11月9—13日，第42届意大利国际农业及园林机械展览会（EIMA International 2016）在意大利博洛尼亚成功举办。展会上，不少企业发布了新产品，EIMA展会刊《Mw》将这些新产品汇集成册，对受邀观众发放。

关键词：约翰迪尔舒适紧凑园林机械博洛尼亚意大利展览会展会

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direct-acting antivirals and hepatocellular carcinoma occurrence and recurrence in hepatitis C virus-related liver cirrhosis: fact or fiction

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Hepatoma Research 2018年第11期4卷 16-31页

作者： Alberto Zanetto Sarah Shalaby Alberto Ferrarese Chiara Becchetti Salvatore Sciarrone giacomo Germani Marco Senzolo Martina Gambato Francesco Paolo Russo Patrizia Burra Multivisceral Transplant Unit Department of SurgeryOncology and GastroenterologyPadua University HospitalPadua 35128Italy

Since the widespread adoption of new direct-acting antiviral agents (DAAs), the approach to hepatitis C virus (HCV) infection has changed profoundly as almost all patients can be cured regardless of the stage of their liver disease. On the other hand, there are a few conflicting reports on the risk of hepatocellular carcinoma (HCC) occurring and recurring in patients given DAA-based therapy. The present review focuses on the latest and most relevant literature providing evidence on the occurrence and recurrence of HCC after HCV antiviral treatment with the new DAAs. Retaining the distinction between HCC occurrence and recurrence, we also discuss its patterns of presentation and speculate on the possible pathogenic mechanisms. We offer our personal viewpoints on this important issue, which has kept clinicians second-guessing in real-world clinical practice, when dealing with HCV eradication in the setting of advanced liver disease in this interferon-free era.

关键词： Hepatitis C virus direct-acting antiviral agent occurrence recurrence hepatocellular carcinoma and liver cirrhosis