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Sex differences in the risk of retinopathy of prematurity:a systematic review,frequentist and Bayesian meta‑analysis,and meta‑regression

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World Journal of Pediatrics 2024年第4期20卷 340-352页

作者： Tamara M.Hundscheid Silvia Gulden Mohamad F.Almutairi František Bartoš giacomo Cavallaro Eduardo Villamor division of Neonatology Department of PediatricsMosaKids Children’s HospitalMaastricht University Medical Center(MUMC+)School for Oncology and Reproduction(GROW)Maastricht UniversityP.Debyelaan 25.P.O.Box 58006202 AZ MaastrichtThe Netherlands Neonatal Intensive Care Unit Sant’Anna HospitalComoItaly Department of Psychology University of Amsterdam1001 NK AmsterdamThe Netherlands Neonatal Intensive Care Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly

Background Retinopathy of prematurity(ROP)is generally considered to be more frequent in males than in ***,it is not known whether sex differences in ROP affect all degrees of the condition,are global and have changed as neonatology has *** aimed to conduct a systematic review and meta-analysis of studies addressing sex differences in the risk of developing *** PubMed/MEDLINE and Embase databases were *** frequentist,random-effects risk ratio(RR)and 95%confidence interval(CI)were *** model averaged(BMA)meta-analysis was used to calculate the Bayes factors(BFs).The BF10 is the ratio of the probability of the data under the alternative hypothesis(H1)over the probability of the data under the null hypothesis(H0).Results We included 205 studies(867,252 infants).Frequentist meta-analysis showed a positive association between male sex and severe ROP(113 studies,RR=1.14,95%CI=1.07–1.22)but no association with any ROP(144 studies,RR=1.00,95%CI=0.96–1.03).BMA showed extreme evidence in favor of H1 for severe ROP(BF10=71,174)and strong evidence in favor of H0 for any ROP(BF10=0.05).The association between male sex and severe ROP remained stable over time and was present only in cohorts from countries with a high or high-middle sociodemographic *** Our study confirms the presence of a male disadvantage in severe ROP but not in less severe forms of the *** are variations in the sex differences in ROP,depending on geographical location and sociodemographic level of the countries.

关键词： Oxidative stress Retinopathy of prematurity Sex characteristics

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Rare shear-type fracture of the talar head in a thirteen-year-old child—Is this a transitional fracture:A case report and review of the literature

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World Journal of Orthopedics 2021年第5期12卷 329-337页

作者： Luca Monestier giacomo Riva Luca Faoro Michele Francesco Surace Orthopedic and Trauma Unit ASST Sette LaghiVarese 21100Italy Residency Program in Orthopedics and Trauma University of InsubriaVarese 21100Italy Department of Biotechnology and Life Sciences University of InsubriaVarese 21020Italy

BACKGROUND Talar fractures are exceedingly rare in *** are very few studies on the clinical aspects,the long-term outcomes and the appropriate treatment of these fractures in pediatric *** mechanism of trauma consists of the application of a sudden dorsiflexion force on a fully plantar-flexed *** mechanism,symptoms and imaging of injuries of the talar head are similar to transitional fractures that are normally described at the distal epiphysis of the tibia:the so-called transitional fracture is defined as an epiphyseal injury when the growth plate has already started to *** SUMMARY A thirteen-year-old girl reported a high-energy trauma to her right foot,due to falling from her horse.X-rays at the Emergency Department were *** of persistent pain,the patient was assessed by an orthopedic surgeon after two weeks and computed tomography scans revealed a misdiagnosed displaced shear-type fracture of the talar ***,surgical open reduction and fixation with two headless screws was *** girl was assessed regularly,and plain films at follow-up revealed complete healing of the *** six months after surgery,the patient returned to pre-injury sport activities reporting no *** Injuries of the talar head in childhood should be considered as transitional *** reduction with internal fixation aims to reduce malalignment and *** tomography scans are recommended in these cases.

关键词： Head Talus Transitional fracture Child Surgical treatment Case report

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Comment on:“A review on radiofrequency,microwave and high-intensity focused ultrasound ablations for hepatocellular carcinoma with cirrhosis”

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 640-642页

作者： Michele Finotti Maurizio Romano Marco Brizzolari Michele Scopelliti giacomo Zanus 4th Surgery Unit Regional Hospital TrevisoUniversity of PaduaDipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche(DISCOG)PaduaItaly Baylor Scott&White Annette C.and Harold C.Simmons Transplant Institute Baylor University MedicalDallasTXUSA

We read with great interest the published article of Cheung et al.(1)on Hepatobiliary Surgery and *** authors provided a comprehensive review and critical evaluation of the three main locoregional ablation(LRA)techniques for liver cancer:radiofrequency(RFA),microwave(MWA),and high-intensity focused ultrasound ablations(HIFU).The focus of the paper is on their application to patients affected by hepatocellular carcinoma(HCC)in the context of end-stage liver disease.

关键词： hepatocellular Surgery al.

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Operative link for gastritis assessment vs operative link on intestinal metaplasia assessment

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World Journal of Gastroenterology 2011年第41期17卷 4596-4601页

作者： Massimo Rugge Matteo Fassan Marco Pizzi Fabio Farinati giacomo Carlo Sturniolo Mario Plebani David Y Graham Surgical Pathology and Cytopathology Unit Department of Diagnostic Medical Sciences and Special TherapiesUniversity of Padova Istituto Oncologico del Veneto IOV-IRCCS Department of Gastroenterology and Surgical Sciences Gastroenterology UnitUniversity of Padova Department of diagnostic Medical Sciences and Special Therapies Clinical Chemistry UnitUniversity of Padova digestive disease division Baylor College of MedicineVeterans Administration Hospital

AIM:To compare the reliability of gastritis staging sys-tems in ranking gastritis-associated cancer risk in a large series of consecutive ***:Gastric mucosal atrophy is the precancer-ous condition in which intestinal-type gastric cancer(GC)most frequently *** operative link for gas-tritis assessment(OLGA)staging system ranks the GC risk according to both the topography and the severity of gastric atrophy(as assessed histologically on the ba-sis of the Sydney protocol for gastric mucosal biopsy).Both cross-sectional and long-term follow-up trials have consistently associated OLGA stages Ⅲ-Ⅳ with a higher risk of GC.A recently-proposed modification of the OLGA staging system(OLGIM)basically incorporates the OLGA frame,but replaces the atrophy score with an assessment of intestinal metaplasia(IM)alone.A series of 4552 consecutive biopsy sets(2007-2009)was re-trieved and reassessed according to both the OLGA and the OLGIM staging systems.A set of at least 5 biopsy samples was available for all the cases ***:In 4460 of 4552 cases(98.0%),both the high-risk stages(Ⅲ + Ⅳ)and the low-risk stages(0 +Ⅰ + Ⅱ)were assessed applying the OLGA and OL-GIM *** the 243 OLGA high-risk stages,14(5.8%)were down-staged to a low risk using *** 67(1.5%)incidentally-found neoplastic lesions(intraepithelial or invasive)were consistently associated with high-risk stages,as assessed by both OLGA and OLGIM(P < 0.001 for both).Two of 34 intestinal-type GCs coexisting with a high-risk OLGA stage(stage Ⅲ)were associated with a low-risk OLGIM stage(stage Ⅱ).CONCLUSION:Gastritis staging systems(both OLGA and OLGIM)convey prognostically important informa-tion on the gastritis-associated cancer *** of its clinical impact,the stage of gastritis should be included as a conclusive message in the gastritis histol-ogy *** it focuses on IM alone,OLGIM staging is less sensitive than OLGA staging in the identif ication of patients at high r

关键词： Gastritis Staging Atrophic gastritis Intestinal metaplasia Operative link for gastritis assessment Operative link on intestinal metaplasia assessment

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Modern blepharoplasty:From bench to bedside

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World Journal of Clinical Cases 2023年第8期11卷 1719-1729页

作者： Giovanni Miotti Marco Zeppieri giacomo Pederzani Carlo Salati Pier Camillo Parodi Department of Medical Surgical and Health SciencesPlastic and Reconstructive Surgery UnitUniversity of TriesteTrieste 34123Italy Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

The demand for procedures aiming to rejuvenate the upper third part of the face and the periocular region has increased in the past several *** is one of the most frequently performed procedures worldwide to *** is currently the first choice in order to achieve permanent and effective results;however,it is burdened by potential surgical complications feared by *** is an increasing trend in individuals to request less invasive,non-surgical,effective,and safe procedures for eyelid *** aim of this minireview is to present a brief overview of non-surgical blepharoplasty techniques that have been reported in the literature in the past 10 *** modern techniques that provide a rejuvenation of the entire area have been *** less invasive methods have been proposed in the current literature and in modern-day routine clinical *** fillers are a commonly chosen option for providing enhanced aesthetic results,especially considering that volume loss can be one of the main underlying causes of facial and periorbital *** acid use may be considered when the problem is represented by periorbital excess fat *** simultaneous excess and loss of elasticity of the skin can be assessed with techniques such as lasers and plasma ***,techniques such as platelet-rich plasma injections and the insertion of twisted polydioxanone threads are emerging as viable methods to rejuvenate the periorbital region.

关键词： Non-surgical blepharoplasty Laser treatment Dermatochalasis Aesthetic Non-invasive procedures Hyaluronic acid Plasma exeresis Eyelids

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Dynamical changes in hydration water accompanying lysozyme thermal denaturation

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Frontiers of physics 2015年第5期10卷 35-41页

作者： Francesco Mallamace Carmelo Corsaro Domenico Mallamace Nicola Cicero Sebastiano Vasi giacomo Dugo H. Eugene Stanley CNR-IPCF Messina Istituto per i Processi Chimico-Fisici Viale F. Stagno D'Alcontres 37 98158 Messina Italy dipartimento di Fisica e Scienze della Terra Universitd di Messina Viale F. Stagno D'Alcontres 31 98166 Messina Italy Center for Polymer Studies and Department of Physics Boston University Boston MA 02215 USA dipartimento di Scienze dell'Ambiente della Sicurezza del Territorio degli Alimenti e della Salute Universita di Messina Viale F. Stagno d'Alcontres 31 98166 Messina Italy

We study the dynanfics of the first hydration shell of lysozyme to determine the role of hydra- tion water that accompanies lysozyme thermal denaturation. We use nuclear magnetic resonance spectroscopy to investigate both the translational and rotational contributions. Data on proton self-diffusion and reorentational correlation time indicate that the kinetics of the lysozyme fold- ing/unfolding process is controlled by the dynamics of the water molecules in the first hydration shell. When the hydration water dynamics change, because of the weakening of the hydrogen bond network, the three-dimensional structure of the lysozyme is lost and denaturation is triggered. Our data indicates that at temperatures above approximately 315 K, water behaves as a simple liquid and is no longer a good solvent.

关键词： lysozyme unfolding hydration water NMR correlation time solvent dynamics

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A-site phase segregation in mixed cation perovskite

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Materials Reports(Energy) 2021年第4期1卷 3-21页

作者： Lang Liu Jiuzhou Lu Hao Wang Zhenhua Cui giacomo Giorgi Yang Bai Qi Chen Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications MIIT Key Laboratory for Low-dimensional Quantum Structure and DevicesExperimental Center of Advanced MaterialsSchool of Materials Science&EngineeringBeijing Institute of TechnologyBeijing100081PR China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081PR China Chaotic Matter Science Research Center Department of MaterialsMetallurgy and ChemistryJiangxi University of Science and TechnologyGanzhou341000PR China Beijing Institute of Technology Chongqing Innovation Center Chongqing401120PR China Department of Civil&Environmental Engineering(diCA) Universita degli Studi di PerugiaVia G.Duranti 9306125PerugiaItaly CNR-SCITEC 06123PerugiaItaly

Mixed cation strategy greatly benefits the enhancement of device performance and chemical ***,adverse impact also accompanies the mixed cation system *** brings the compositional instability,wherein the homogeneous film is likely to segregate into multi-phases during the fabrication and ageing process,thus resulting in the efficiency reduction of perovskite solar cells(PSCs)*** review focuses on the cation induced phase segregation,and elucidates the segregation mechanisms from the perspectives of film formation and ageing process,***,the influence of cation segregation on device performance and operational stability are *** based on these understandings,viable strategies are proposed for the design of phase-stable mixed composition halide perovskites and for suppressing segregation to benefit its development towards commercial applications.

关键词： Photovoltaic Perovskite Mixed cation Phase segregation Stability

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Onlife Migrants and digital *** for a Sociology of digital Migrations

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Sociology Study 2021年第3期11卷 102-111页

作者： giacomo Buoncompagni University of Macerata MacerataItaly

Migration is a global phenomenon and can present different characteristics and trends,as well as multiple reasons for its origin,linked for example to political,economic,war,climatic or cultural *** discourse on migrants is often fuelled by prejudices and stereotypes with sometimes important consequences,such as episodes of misinformation or verbal violence,transmitted in digital format,with a high percentage of sharing and ***,scientific literature in the social sciences is still scarce,as is the attention of institutions and media to the“digital dimension”of the migration *** new electronic-digital media are increasingly interconnected environments used to build and share information,also in the field of ***,it is necessary to scientifically investigate this aspect and to know the languages and communication modes of“digital migrants”(cybermigrants),in order to manage technological risks and their new virtual identities,beyond any form of *** is the term coined by philosopher Luciano Floridi to represent the new human condition in the digital age.A dimension that can also be identified in the migration phenomenon:migrants are not only the subject of journalistic narratives,but they live connectedly and actively participate in the spaces of the *** these reasons,and others that will be presented here,through the study and analysis of the international literature,we would like to try to think of a new social science:the“sociology of digital migrations”.

关键词： cybermigration digital media identity technological risk multiculturalism surveillance

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Colonoscopic evaluation of hematochezia in low and average risk patients for colorectal cancer:A prospective study

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World Journal of Gastroenterology 2006年第45期12卷 7304-7308页

作者： Puglisi Carlo Russo Francesco Paolo Barbera Carmelo Incarbone Salvatore Aprile Giuseppe Bonanno giacomo Russo Antonio Cattedra di Gastroenterologia Università di Catania Azienda Ospedaliero Universitaria Policlinico-Catania Italy

AIM: To relate the endoscopic findings in patients with hematochezia with regard to age in “low and average risk” for colorectal cancer (CRC) and to localize signifi cant lesions in order to identify patients who need sigmoidoscopy or total colonoscopy. METHODS: This prospective study was performed in an open access GI endoscopy unit. Out of 4322 consecutive patients undergoing colonoscopy, 918 reported hema- tochezia. The fi nal study group comprized 180 patients aged below 45 and 237 over 45. Main exclusion criteria were a 1st-degree family history of colorectal carcinoma, patients reporting blood mixed with stools and/or pro- gressive colonic symptoms, or patients who had under- gone colon surgery for neoplastic lesions. RESULTS: Total colonoscopy could be performed in 96% of patients. Abnormal findings were observed in 34.3% of the younger and in 65.7% of the older ones. Findings were the presence of polyps in the distal colon (n = 2) and IBD in the proximal colon (n = 29) in the group of the younger patients, and polyps (n = 15), IBD (n = 13), and carcinoma (n = 6, 4 of the lesions were located proximal to the splenic flexure) in the elderly. Our f indings suggest that the diagnostic potential of total colonoscopy in patients younger than 45 referring scant hematochezia, is not mandatory. By exploring only the distal tract of the colon we have misdiagnosed two cases of IBD located in the ascending colon. In this group of patients additional risk factors must be identifi ed before performing a total colonoscopy. Regarding the patients older than 45 yr, the exploration of the distal colon would have led to our overlooking a carcinoma, two neoplastic polyps and one IBD located in the proximal colon. CONCLUSION: Young patients with scant hematochezia but without risk factors for neoplasia do not need a totalcolonoscopy, whereas is mandatory performing a total colonoscopy in older patients even in the presence of anal pathology.

关键词： Hematochezia Colonoscopy Neoplasia Colonic neoplasia

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Inflammatory bowel disease in the dog:differences and similarities with humans

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World Journal of Gastroenterology 2010年第9期16卷 1050-1056页

作者： Matteo Cerquetella Andrea Spaterna Fulvio Laus Beniamino Tesei giacomo Rossi Elisabetta Antonelli Vincenzo Villanacci Gabrio Bassotti School of Medical Veterinary Sciences University of CamerinoVia Circonvallazione Gastroenterology and Hepatology Section Department of Clinical and Experimental MedicineSanta Maria della Misericordia Hospital 2nd Department of Pathology Spedali Civili of BresciaPiazza Spedali Civili

Inflammatory bowel diseases (IBD) represent important chronic conditions affecting the gastrointestinal tract in ***,similar disorders are found in several animal species and the IBD affecting dogs are particularly *** are encompassed by an umbrella of probably several different entities with common symptoms,some of which seem to share striking similarities with human *** review will focus on the actual knowledge of IBD in dogs,and attempt to identify differences and similarities with human IBD conditions.

关键词： Colitis Dog Inflammatory bowel diseases

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