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On the Darboux Integrability of the Hindmarsh–Rose Burster

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Acta Mathematica Sinica,English Series 2018年第6期34卷 947-958页

作者： Jaume LLIBRE claudia VALLS Departament de Matematiques Universitat Autonoma de Barcelona 08193 BeUaterra Barcelona Catalonia Spain Departamento de Matematica Instituto Superior TecnicoUniversidade Tecnica de Lisboa Av. Rovisco Pals 1049-001 Lisboa Portugal

We study the Hindmarsh-Rose burster which can be described by the differential system x^·=y-x^3＋bx^2＋I-z,y^·=1-5x^2-y,z^·=μ（s（x-x0）-z）where b, I, μ, s, x0 are parameters. We characterize all its invariant algebraic surfaces and all its exponential factors for all values of the parameters. We also characterize its Darboux integrability in function of the parameters. These characterizations allow to study the global dynamics of the system when such invariant algebraic surfaces exist.

关键词： Polynomial integrability rational integrability Darboux polynomials Darboux first integrals invariant algebraic surfaces exponential factors Hindmarsh Rose burster

Clinical Research on Acupuncture-Concepts and Guidance on Efficacy and Effectiveness Research

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Chinese Journal of Integrative Medicine 2011年第2期17卷 166-172页

作者： claudia M Witt Institute for Social Medicine Epidemiology and Health EconomicsCharite University Medical Center10098 BerlinGermany

Over the last few years a number of large acupuncture trials have been carried out in western countries. The following article draws on the experience from these recent large-scale trials on acupuncture to outline the way randomized trials could be used to answer questions on efficacy, effectiveness and efficiency. It will provide guidance, firstly on the underlying concepts of both efficacy and effectiveness and secondly on designing both types of trials. In addition, the controversy over specific and non-specific effects of acupuncture, emerging from the results of the above-mentioned trials, will be highlighted. Suggestions for future clinical research on acupuncture include： greater reflection on the complex approach of Chinese medicine, and transparent and detailed reporting according to CONSORT and STRICTA guidelines. The current data on acupuncture point-specific effects do indeed have relevance, however for valid decision-making on acupuncture, further clinical trials on effectiveness and cost-effectiveness are required to provide realistic benefit estimates for future health care.

关键词： acupuncture efficacy effectiveness randomized controlled trial randomized pragmatic trial

Geomechanical design of a room and rib pillar granite mine

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Journal of University of Science and Technology Beijing 2008年第2期15卷 97-103页

作者： Daniele Peila claudia Guardini Sebastiano Pelizza Tunnelling Underground Space Center Department of EnvironmentLand and Geotechnology Engineering Politecnico di Torino Tunnelling Underground Space Center Department of EnvironmentLand and Geotechnology EngineeringPolitecnico di TorinoTorinoItaly

The geomechanical and stability design of an underground granite mine located in Canal San Bovo （Trento district, Northeastern Italy） was described. The exploitation of the granite, which is used in the ceramic industry, was carried out by the rooms and rib pillars method. The rooms are 12 m wide while the pillars are 11 m wide and they cross the main discontinuity set of the rock mass in the perpendicular direction. To verify the stability condition of an underground mine, it is necessary to carry out the calcula- tions that are able to check both the local and global stability of the rock mass. In the studied example, this approach has been applied with the development of analytical and numerical parametric analyses and it has permitted to get the best orientation and to design the size of rooms and pillars.

关键词： mining room and pillar rock mechanics stability analysis

Microglia-oligodendrocyte intercellular communication: role of extracellular vesicle lipids in functional signalling

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Neural Regeneration Research 2021年第6期16卷 1194-1195页

作者： Alice Gualerzi Marta Lombardi claudia Verderio IRCCS Fondazione Don Carlo Gnocchi MilanItaly CNR Institute of Neuroscience MilanItaly

The term microglia refers to the group of resident brain immune-cells that are responsible,mainly,for the immune response and the homeostasis of the *** monocyte-derived macrophages that infiltrate the brain,microglia are longlived cells which arise exclusively from the embryonic yolk sac(Stratoulias et al.,2019).Impairment in microglia functions is at the basis for the development of multiple brain diseases,including multiple sclerosis and neurodegenerative *** the last decade,the number of research articles and reviews dealing with the role of microglia in the pathogenesis of brain disorders has exponentially increased.

关键词： al. homeostasis diseases

An easy,accurate and efficient procedure to create forest fire risk maps using the SEXTANTE plugin Modeler

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Journal of Forestry Research 2016年第6期27卷 1361-1372页

作者： Lia Duarte Ana claudia Teododo Earth Sciences Institute(ICT) University of PortoRua Campo Alegre4169-007 PortoPortugal Department of Geosciences Environment and Land PlanningFaculty of SciencesUniversity of PortoRua Campo Alegre4169-007 PortoPortugal

To prevent, detect, and protect against forest fires, forest personnel need to define rules for determining forest fire risk. In Portugal, all municipalities must annually produce forest fire risk （FFR） maps. To produce more reliable FFR maps more easily, we developed an open source model using the Modeler plugin of SEXTANTE in the program QGIS version 2.0 Dufour. The model provides all the maps involved in the FFR model （susceptibility map, hazard map, vulnerability map, economic value map, and potential loss map） and was produced according to Portuguese Forest Authority＇s （AFN, Autoridade Florestal Nacional） rules for determining the FFR. This model was tested for the Portuguese municipality Santa Maria da Feira, where 40 % of the total municipality area falls in the category ＂very high＂ or ＂high＂ fire risk. The ＂very high＂ fire risk area is mainly classified as broad-leaved forest and has the steepest slopes （〉15 %）. The distance of burned areas to roads was also analyzed; the proportion of burned areas increased with increasing distance to the main roads. In addition, 92.6 % of the ＂high＂ and ＂very high＂ risk zones were located in areas with lower elevation. These results confirmed that forest fire is strongly influenced not only by environmental factors but also by anthropogenic factors. The procedure implemented here was compared with our open source application already available in QGIS and also to the same procedure implemented in GIS pro- prietary software. Although the results were obviously the same, the model developed here presents several advan- tages over the other two approaches. Besides being faster, it is easy to change the model parameters according to user needs （i.e., to the rules of different countries）, and can be modified and adapted to other variables and other areas to create risk maps for different natural phenomena （e.g., floods, earthquakes, landslides）. The model is easy to use and to create risk and hazard maps rapidly in a free, open

关键词： Forest fire risk (FFR) maps SEXTANTE Modeler. QGIS Open source

Deformation at low and high stress-loading rates

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Geoscience Frontiers 2019年第1期10卷 43-54页

作者： claudia A.Trepmann Lina Seybold Department of Earth and Environmental Sciences Ludwig-Maximilians University

In an extensional shear zone in the Talea Ori, Crete, quartz veins occur in high-pressure low-temperature metamorphic sediments at sites of dilation along shear band boundaries, kink band boundaries and boudin necks. Bent elongate grains grown epitactically from the host rock with abundant fluid inclusion trails parallel to the vein wall indicate vein formation by crack-seal increments during dissolutionprecipitation creep of the host rock. The presence of sutured high-angle grain boundaries and subgrains shows that temperatures were sufficiently high for recovery and strain-induced grain boundary migration, i.e. higher than 300 -350℃, close to peak metamorphic conditions. The generally low amount of strain accumulated by dislocation creep in quartz of the host rock and most veins indicates low bulk stress conditions of a few tens of MPa on a long term. The time scale of stress-loading to cause cyclic cracking and sealing is assumed to be lower than the Maxwell relaxation time of the metasediments undergoing dissolution-precipitation creep at high strain rates(10^(-10) s^(-1) to 10^(-9) s^(-1)), which is on the order of hundred years. In contrast, some veins discordant or concordant to the foliation show heterogeneous quartz microstructures with micro-shear zones, sub-basal deformation lamellae, shortwavelength undulatory extinction and recrystallized grains restricted to high strain zones. These microstructures indicate dislocation glide-controlled crystal-plastic deformation(low-temperature plasticity) at transient high stresses of a few hundred MPa with subsequent recovery and strain-induced grain boundary migration at relaxing stresses and temperatures of at least 300 -350℃. High differential stresses in rocks at greenschist-facies conditions that relieve stress by creep on the long term, requires fast stress-loading rates, presumably by seismic activity in the overlying upper crust. The time scale for stress loading is controlled by the duration of the slip eve

关键词： High-stress crystal plasticity Crack-seal Seismic cycle Stress-loading rates Talea Ori Crete

Mechanisms of intrahepatic triglyceride accumulation

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World Journal of Gastroenterology 2016年第4期22卷 1664-1673页

作者： claudia Ress Susanne Kaser Department of Internal Medicine I Medical University Innsbruck6020 InnsbruckAustria Christian Doppler Laboratory of Metabolic Crosstalk Department of Internal Medicine 1Medical University Innsbruck6020 InnsbruckAustria

Hepatic steatosis defined as lipid accumulation in hepatocytes is very frequently found in adults and obese adolescents in the Western World. Etiologically, obesity and associated insulin resistance or excess alcohol intake are the most frequent causes of hepatic steatosis. However, steatosis also often occurs with chronic hepatitis C virus(HCV) infection and is also found in rare but potentially life-threatening liver diseases of pregnancy. Clinical significance and outcome of hepatic triglyceride accumulation are highly dependent on etiology and histological pattern of steatosis. This review summarizes current concepts of pathophysiology of common causes of hepatic steatosis, including non-alcoholic fatty liver disease(NAFLD), alcoholic fatty liver disease, chronic HCV infections, drug-induced forms of hepatic steatosis, and acute fatty liver of pregnancy. Regarding the pathophysiology of NAFLD, this work focuses on the close correlation between insulin resistance and hepatic triglyceride accumulation, highlighting the potential harmful effects of systemic insulin resistance on hepatic metabolism of fatty acids on the one side and the role of lipid intermediates on insulin signalling on the other side. Current studies on lipid droplet morphogenesis have identified novel candidate proteins and enzymes in NAFLD.

关键词： Steatosis Lipid accumulation Fatty acids Insulin resistance Triglycerides

Telomere and telomerase in chronic liver disease and hepatocarcinoma

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World Journal of Gastroenterology 2014年第20期20卷 6287-6292页

作者： Lucia Carulli claudia Anzivino Department of Biomedical Metabolic and Neural Sciences. University of Modena and Reggio Emilia 41126 Modena Italy

The pathogenesis of liver cirrhosis is not completely *** in the majority of patients,the risk factors may be identified in B and C viral hepatitis,alcohol intake,drugs or fatty liver disease,there is a small percentage of patients with no apparent risk *** addition,the evolution of chronic liver disease is highly heterogeneous from one patient to *** patient with identical risk factors,some rapidly progress to cirrhosis and hepatocellular carcinoma(HCC)whereas others have a benign ***,a genetic predisposition may contribute to the development of cirrhosis and *** supporting the role of genetic factors as a risk for cirrhosis has been accumulating during the past *** addition to the results from epidemiological studies,polymorphisms studies and data on twins,the concept of telomere shortening as a genetic risk factor for chronic liver disease and HCC has been *** we review the literature on telomerase mutations,telomere shortening and liver disease including hepatocellular carcinoma.

关键词： Chromosomes Telomere Telomerase Liver-cirrhosis Hepatocarcinoma

A Numerical Study of Quantum Decoherence

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Communications in Computational Physics 2012年第6期12卷 85-108页

作者： Riccardo Adami claudia Negulescu Dipartimento di Matematica e Applicazioni Universita di Milano Bicoccavia R.Cozzi5320125 MilanoItaly CMI/LATP(UMR 6632) Universit´e de Provence39rue Joliot Curie13453 Marseille Cedex 13France

The present paper provides a numerical investigation of the decoherence effect induced on a quantum heavy particle by the scattering with a light *** time dependent two-particle Schr¨odinger equation is solved by means of a time-splitting *** damping undergone by the non-diagonal terms of the heavy particle density matrix is estimated numerically,as well as the error in the Joos-Zeh approximation formula.

关键词： Quantum mechanics Schr¨odinger equation heavy-light particle scattering interference decoherence numerical discretization numerical analysis splitting scheme