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A systematic review of salivary biomarkers in Parkinson's disease

Neural Regeneration Research 2024年第12期19卷 2613-2625页

作者： Maria Ilenia De Bartolo Daniele Belvisi Romina Mancinelli Matteo Costanzo claudia caturano Giorgio Leodori Alfredo Berardelli Giovanni Fabbrini Giorgio Vivacqua IRCCS Neuromed PozzilliItaly Department of Human Neurosciences Sapienza University of RomeRomeItaly Department of Anatomical HistologicalForensic Medicine and Orthopedics SciencesSapienza University of RomeRomeItaly Department of Experimental Morphology and Microscopy-Integrated Research Center(PRAAB)-Campus Biomedico University of Rome RomeItaly

The search fo r reliable and easily accessible biomarkers in Parkinson's disease is receiving a growing emphasis,to detect neurodegeneration from the prodromal phase and to enforce disease-modifying *** the need for non-invasively accessible biomarke rs,the majo rity of the studies have pointed to cerebrospinal fluid or peripheral biopsies biomarkers,which require invasive collection *** represents an easily accessible biofluid and an incredibly wide source of molecular *** the present study,after presenting the morphological and biological bases for looking at saliva in the search of biomarkers for Parkinson's disease,we systematically reviewed the results achieved so far in the saliva of different cohorts of Parkinson's disease patients.A comprehensive literature search on PubMed and SCOPUS led to the discovery of *** screening and exclusion,34 relevant articles were derived fo r systematic ***-synuclein,the histopathological hallmark of Parkinson's disease,has been the most investigated Parkinson's disease biomarker in saliva,with oligomeric alphasynuclein consistently found increased in Parkinson's disease patients in comparison to healthy controls,while conflicting results have been reported regarding the levels of total alpha-synuclein and phosphorylated alpha-synuclein,and few studies described an increased oligomeric alpha-synuclein/total alpha-synuclein ratio in Parkinson's *** alpha-synuclein,other biomarkers to rgeting diffe rent molecular pathways have been explored in the saliva of Parkinson's disease patients:total tau,phosphorylated tau,amyloid-β1-42(pathological protein aggregation biomarkers);DJ-1,heme-oxygenase-l,metabolites(alte red energy homeostasis biomarkers);MAPLC-3beta(aberrant proteostasis biomarker);cortisol,tumor necrosis factor-alpha(inflammation biomarkers);DNA methylation,miRNA(DNA/RNA defects biomarkers);acetylcholinesterase activity(synaptic and neuronal network

关键词： alpha-synuclein amyloid-beta autophagy DJ-1 neurodegeneration neuroinflammation Parkinson's disease salivary biomarkers tau

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Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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Crystal structure evolution of complex metal aluminum hydrides upon hydrogen release

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Journal of Energy Chemistry 2020年第3期29卷 133-143页

作者： claudia Weidenthaler Max-Planck-Institut für Kohlenforschung 45470 Mülheim an der RuhrGermany

Complex aluminum hydrides have been widely studied as potential hydrogen storage materials but also,for some time now, for electrochemical applications. This review summarizes the crystal structures of alkali and alkaline earth aluminum hydrides and correlates structure properties with physical and chemical properties of the hydride compounds. The crystal structures of the alkali metal aluminum hydrides change significantly during the stepwise dehydrogenation. The general pathway follows a transformation of structures built of isolated [AlH4]- tetrahedra to structures built of isolated [Al H6]3- *** crystal structure relations in the group of alkaline earth metal aluminum hydrides are much more complicated than those of the alkali metal aluminum hydrides. The structures of the alkaline earth metal aluminum hydrides consist of isolated tetrahedra but the intermediate structures exhibit chains of cornershared octahedra. The coordination numbers within the alkali metal group increase with cation sizes which goes along with an increase of the decomposition temperatures of the primary hydrides. Alkaline earth metal hydrides have higher coordination numbers but decompose at slightly lower temperatures than their alkali metal counterparts. The decomposition pathways of alkaline metal aluminum hydrides have not been studied in all cases and require future research.

关键词： Complex aluminum hydrides Hydrogen storage Crystal structure

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HOMOGENIZATION RESULTS FOR ENZYME CATALYZED REACTIONS THROUGH POROUS MEDIA

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Acta Mathematica Scientia 2009年第1期29卷 74-82页

作者： claudia Timofte Department of Mathematics Faculty of Physics University of BucharestP.O. Box MG-11

The aim of this article is to study the effective behavior of the solution of a nonlinear problem arising in the modelling of enzyme catalyzed reactions through the exterior of a domain containing periodically distributed reactive solid obstacles,with period ε.The asymptotic behavior of the solution of such a problem is governed by a new elliptic boundary-value problem,with an extra zero-order term that captures the effect of the enzymatic reactions.

关键词： Homogenization enzyme reactive flows Michaelis-Menten mechanism

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Adult mammalian neurogenesis and motivated behaviors

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Integrative Zoology 2018年第6期13卷 655-672页

作者： claudia JORGENSEN Behavioral Science Department Utah Valley UniversityOremUtahUSA

Adult neurogenesis continues to captivate the curiosity of the scientific community;and researchers seem to have a particular interest in identifying the functional implications of such *** the majority of research focuses on the association between adult neurogenesis and learning and memory(including spatial learning associated with hippocampal neurogenesis and olfactory discrimination associated with neurogenesis in the olfactory system),the following review will explore the link to motivated *** particular,goal-directed behaviors such as sociosexual,parental,aggressive,as well as depression-and anxiety-like behaviors and their reciprocal association to adult neurogenesis will be *** review will detail research in humans and other mammalian ***,the potential mechanisms underlying these neurogenic alterations will be ***,the review will conclude with a discussion on the functional significance of these newly generated cells in mediating goal-directed behaviors.

关键词： adult neurogenesis aggression anxiety depression reproduction

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Improving Scalability of Cloud Monitoring Through PCA-Based Clustering of Virtual Machines

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Journal of Computer Science & Technology 2014年第1期29卷 38-52页

作者： claudia Canali Riccardo Lancellotti IEEE Department of Information Engineering University of Modena and Reggio Emilia ACM

Cloud computing has recently emerged as a leading paradigm to allow customers to run their applications in virtualized large-scale data centers. Existing solutions for monitoring and management of these infrastructures consider virtual machines （VMs） as independent entities with their own characteristics. However, these approaches suffer from scalability issues due to the increasing number of VMs in modern cloud data centers. We claim that scalability issues can bc addressed by leveraging the similarity among VMs behavior in terms of resource usage patterns. In this paper we propose an automated methodology to cluster VMs starting from the usage of multiple resources, assuming no knowledge of the services executed on them. The innovative contribution of the proposed methodology is the use of the statistical technique known as principal component analysis （PCA） to automatically select the most relevant information to cluster similar VMs. We apply the methodology to two case studies, a virtualized testbed and a real enterprise data center. In both case studies, the automatic data selection based on PCA allows us to achieve high performance, with a percentage of correctly clustered VMs between 80% and 100% even for short time series （1 day） of monitored data. Furthermore, we estimate the potential reduction in the amount of collected data to demonstrate how our proposal may address the scalability issues related to monitoring and management in cloud computing data centers.

关键词： cloud computing resource monitoring principal component analysis k-means clustering

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Tuning two-dimensional electron and hole gases at LaInO_(3)/BaSnO_(3) interfaces by polar distortions,termination,and thickness

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npj Computational Materials 2021年第1期7卷 1584-1591页

作者： Wahib Aggoune claudia Draxl Institut für Physik and IRIS Adlershof Humboldt-Universität zu Berlin12489 BerlinGermany

Two-dimensional electron gases(2DEG),arising due to quantum confinement at interfaces between transparent conducting oxides,have received tremendous attention in view of electronic ***,we explore the potential of interfaces formed by two lattice-matched wide-gap oxides of emerging interest,i.e.,the polar,orthorhombic perovskite LaInO_(3)and the nonpolar,cubic perovskite BaSnO_(3),employing first-principles *** find that the polar discontinuity at the interface is mainly compensated by electronic relaxation through charge transfer from the LaInO_(3)to the BaSnO_(3)*** leads to the formation of a 2DEG hosted by the highly dispersive Sn-s-derived conduction band and a 2D hole gas of O-p character,strongly localized inside LaInO_(3).We rationalize how polar distortions,termination,thickness,and dimensionality of the system(periodic or non-periodic)can be exploited in view of tailoring the 2DEG characteristics,and why this material is superior to the most studied prototype LaAlO_(3)/SrTiO_(3).

关键词： termination gases distortion

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PHASE PORTRAITS OF THE LESLIE-GOWER SYSTEM

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Acta Mathematica Scientia 2022年第5期42卷 1734-1742页

作者： Jaume LLIBRE claudia VALLS Departament de Matematiques Universitat Autonoma de Barcelona08193BellaterraBarcelonaCataloniaSpain Departamento de Matematica Instituto Superior TecnicoUniversidade de LisboaAu.Rovisco Pais 1049-001LisboaPortugal

In this paper we characterize the phase portraits of the Leslie-Gower model for competition among *** give the complete description of their phase portraits in the Poincarédisc(i.e.,in the compactification of R^(2) adding the circle S1 of the infinity)modulo topological *** is well-known that the equilibrium point of the Leslie-Gower model in the interior of the positive quadrant is a global attractor in this open quadrant,and in this paper we characterize where the orbits attracted by this equilibrium born.

关键词： predator-prey models Leslie-Gower system Poincare compactification global phaseportraits

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Genotoxicity biomarkers in aquatic bioindicators

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Current Zoology 2014年第2期60卷 273-284页

作者： claudia BOLOGNESI Silvia CIRILLO Environmental Carcinogenesis Unit IRCCS Azienda Ospedaliera Universitaria San Martino- IST Istituto Nazionale Ricerca sulCancro L.go Rosanna Benzi 10 Genova Italy

Pollution of the aquatic environment is an ever-growing problem, as waters are the ultimate sink for the large number of xenobiotics from multiple sources. DNA damaging agents have a significant ecological relevance since they are implicated in many pathological processes and exert effects beyond that of individual being active through following generations. A large number of methods have been applied to evaluate genotoxic damage in different aquatic species. Comet assay, as method for de- tecting DNA alterations, and micronucleus test, as an index of chromosomal damage are the most widely applied and validated methods in field studies. These methods were applied in different vertebrate and invertebrate aquatic species, but only mollusk and fish species have been employed in routine biomonitoring programs. Mussels, due to their widely geographical distribution and the suitability for caging represent the bioindicator of choice in field studies. Mytilus species is the most used marine mussel. The use of fish is limited to specific geographic areas. The present review mainly focuses on the application of comet assay and micronucleus test in mussels. A number of biomonitoring studies in mussels, using comet assay or micronucleus test, revealed exposure to different classes of genotoxic compounds with a good discrimination power. The different evidence from the two as- says, reflects different biological mechanisms for the two genetic endpoints, DNA damage and chromosomal damage, suggesting their combined application in the field. Different endogenous and exogenous factors have been shown to modulate the genotoxic responses in mussels, acting as confounding factors in environmental monitoring. The use of standardized protocol for caging, sampling and genotoxity evaluation is critical in biomonitoring studies. The use of a multimarker approach coupling genotoxicity biomarkers with physiological and biochemical factors allows to have a complete picture of the environmenta

关键词： Aquatic animals Genotoxicity Bioindicator Biomarker Micronucleus test Comet assay Bivalve Mussel

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Liouvillian and Analytic Integrability of the Quadratic Vector Fields Having an Invariant Ellipse

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Acta Mathematica Sinica,English Series 2014年第3期30卷 453-466页

作者： Jaume LLIBRE claudia VALLS Departament de Matemàtiques Universitat Autònoma de Barcelona Departamento de Matemtica Instituto Superior TcnicoUniversidade Tcnica de Lisboa

We characterize the Liouvillian and analytic integrability of the quadratic polynomial vector fields in R2 having an invariant *** precisely,a quadratic system having an invariant ellipse can be written into the form x=x2＋y2-1＋y（ax＋by＋c）,y=x（ax＋by＋c）,and the ellipse becomes x2＋y2=*** prove that（i） this quadratic system is analytic integrable if and only if a=0;（ii） if x2＋y2=1 is a periodic orbit,then this quadratic system is Liouvillian integrable if and only if x2＋y2=1 is not a limit cycle;and（iii） if x2＋y2=1 is not a periodic orbit,then this quadratic system is Liouvilian integrable if and only if a=0.

关键词： Liouvillian integrability quadratic planar polynomial vector fields invariant ellipse

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