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Journal of Sport and Health Science 2019年第6期8卷 595-600页

作者： Mickael Campo Stéphane Champely Andrew MLane Elisabeth Rosnet claude ferrand Benoit Louvet SPMS(EA 4180) UBFCDijon 21078France Laboratory for Vulnerabilities and Innovation in Sport(L-VIS EA 7428)University of Lyon 1Villeurbanne 69622France Institute of Sport Faculty of EducationHealth and Well-beingUniversity of WolverhamptonWs13BDUK Faculty of Sport Sciences Universitéde Reims Champagne-ArdenneReims 51096France Research Team of Psychology of Ages of Life(EA 2114) University Francois RabelaisTours 37041France CETAPS(EA 3832) Normandie UniversitéMont Saint Aignan 76821France

Purpose:This study investigated emotion-performance relationships in rugby *** identified which emotions rugby players experienced and the extent to which these emotions were associated with performance,considering how emotions unfold over the course of a game,and whether the game was played at home or ***:Data were gathered from 22 professional male rugby union players using auto-confrontation interviews to help identify situations within games when players experienced intense *** assessed the intensity of emotions experienced before each discrete performance and therefore could assess the emotion-performance relationship within a ***:Players identified experiencing intense emotions at 189 *** in rugby union rated the quality of each performance at these 189 time-points on a visual analog scale.A Linear Mixed Effects model to investigate emotion-performance relationships found additive effects of game location,game time,and emotions on individual ***:Results showed 7 different pre-performance emotions,with high anxiety and anger associating with poor *** research should continue to investigate emotion-performance relationships during performance using video-assisted recall and use a measure of performance that has face validity for players and coaches alike.

关键词： Emotion Game location Game time Linear Mixed Effects model Multilevel analysis Performance assessment Team sport

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Numerical Investigation of Flutter Stability in Subsonic Space Turbine Blisk with Emphasis on Cut-on/Cut-off Modes and Interblade Phase Angles

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Journal of Thermal Science 2012年第6期21卷 492-499页

作者： Hakim Ferria Pascal ferrand Franois Pacull Stéphane Aubert Laboratoire de Mécanique des Fluides et d'Acoustique CNRS UMR 5509 Université de LyonUniversité Claude Bernard Lyon 1INSA Lyon 36avenue Guy de Collongue69134 EcullyFrance Fluorem 64 chemin des Mouilles69134 EcullyFrance

The so-called blisks,*** bladed disks,are characterized by very low viscous material damping and make the flutter prediction much more *** that framework,a two-dimensional numerical study of a space turbine blisk featuring complex deformation of blades and high eigenfrequency(>40kHz)is *** simulations are based on unsteady Reynolds Averaged Navier Stokes computations linearized in the frequency domain and consist in the superposition of an unsteady linear(in time)pressure field,generated by a harmonic perturbation,upon a steady nonlinear(in space)*** aerodynamic damping coefficient is calculated over a range of nodal diameters,and the blades are predicted aeroelastically ***,violent changes occur and are rather critical since sudden and large deviations in stability *** that context,the nature of the waves propagating from the cascade are *** an approach provides fundamental knowledge about the perturbations which can either propagate to the far-field(cut-on mode)or decay(cut-off mode).It is expected that the ability of the flow to damp or to amplify the blade motion is strongly affected by the way unsteady perturbations are transferred from the cascade to the *** nature of the waves are first assessed from the aforementioned linearized results,then they are evaluated analytically and finally compared.A good agreement is found despite the strong assumptions of the analytical *** results show a clear correlation between the cut-on/cut-off conditions and *** least stable configuration corresponds to cut-off mode at the inlet and no wave at the *** outgoing waves from the cascade,the blade is prone to be less stable:the energy from the blades vibration is necessarily dissipated or sent out by the cascade.

关键词： subsonic flutter LRANS blisk cut-on/cut-off mode interblade phase angle nodal diameter.

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Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation

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World Journal of Gastroenterology 2014年第21期20卷 6560-6572页

作者： Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud Clermont Université UMR1071 Inserm/Ud’Auvergne and INRA USC201863000 Clermont-FerrandFrance Centre Hospitalier Universitaire 63000 Clermont-FerrandFrance

AIM: To provide further insight into the characterization of mucosa-associated Escherichia coli (E. coli) isolated from the colonic mucosa of cancer patients.

关键词： B2 Escherichia coli Carcinoembryonic antigen-related cell adhesion molecule 6 Cell proliferation Colon cancer Polyketide synthase genomic island

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Chicken Anatomical Composition Prediction in Madagascar： Indigenous Race and Starbro Strain

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Journal of Environmental Science and Engineering(A) 2016年第3期5卷 156-162页

作者： Isabelle Herisoa Hantanirina Rivo Nirina Rabearimisa Jean de Neupomuscene Rakotozandriny claude Mazel Department of Animal Science Graduate School of Agronomics Sciences University of Antananarivo Antananarivo 175Madagascar Modeling and Optimization Systems Laboratory Blaise Pascal University/CNRS Clermont-Ferrand Ⅱ Campus Cezeaux 10125France

Consumer requirement evolution in time necessitates a good control on product features. The present study aims at providing a better knowledge about the different broiler body composition characteristics found in Madagascar poultry farms. Data about 8,262 heads of indigenous race or Starbro strain chickens, raised in a suburban setting have been collected. At the end of the raising cycle, measurements by individual weighing of the animal anatomical composition were performed. The results showed that chicken live weight variation depends upon liver, thigh, wing, breast and abdominal fat weight variation. Chicken age at slaughtering doesn＇t have any effect on the variable. The derived multilinear regressions make up relevant simulations on observed data due to their significance （p 〈 1‰） and present some satisfactory statistical estimate indices, especially with a steady adjusted R^2 value.

关键词： Poultry indigenous race Starbro broiler strain anatomical composition prediction model Madagascar.

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Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice

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World Journal of Gastroenterology 2022年第48期28卷 6935-6949页

作者： Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Bouleté Charlène Guérin Wafa Bahlouli David Vaudry Jean claude do Rego Jean-Nicolas Cornu Anne-Marie Leroi Moïse Coëffier Mathieu Meleine Guillaume Gourcerol Nutrition Gut and Brain Unit(Inserm U1073)Institute for Research and Innovation in BiomedicineUniversitéde Rouen NormandieRouen 76000France Department of Gastroenterology and Hepatology UniversitéCatholique de LouvainCHU UCL NamurYvoir 5530Belgium Department of Physiology CHU RouenUniversitéde Rouen NormandieRouen 76031France Department of Urology CHU RouenUniversitéde Rouen NormandieRouen 76000France Inserm UMR 1245Team Epigenetics and Pathophysiology of Neurodevelopmental DisordersUniversitéde Rouen NormandieRouen 76000France Behavioural Analysis Platform(SCAC) HeRacLeS Inserm US51-CNRS UAR2026Institute for Research and Innovation in BiomedicineUniversitéde Rouen NormandieRouen 76000France Department of Nutrition CHU RouenUniversitéde Rouen NormandieRouen 76000France Inserm U1107 NeuroDolClermont Auvergne UniversityClermont-Ferrand 63000France

BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral *** pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the *** precise pathophysiology remains poorly *** To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms *** Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane *** sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal ***,used as a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used as a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using *** fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal *** expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western *** Visceral hypersensitivity to colorectal distension was observed after the intravesical injection of acetic acid vs saline(P<0.0001).This effect started 1 h post-injection and lasted up to 7 d *** increased permeability or inflammation was shown in the bladder or colon 7 d *** hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(P<0.0001).In green fluorescent protein on the fractalkine receptor-positive mice,intravesical acetic acid injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(P<0.0001).NK1 receptor and MAPK-p38 levels were increased in the spinal cord up to 7 d after

关键词： Cross-organ sensitization MAPK-p38 Microglia NK1 receptor Pain Visceral hypersensitivity

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Patatin-like PLA<sub>2</sub>with cytotoxicity against mammalian and plant tumour cells

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Advances in Biological Chemistry 2013年第5期3卷 485-500页

作者： Bernard Griffaut Eric Debiton Marie-Josèphe Galmier Ana Mustel Jean-claude Madelmont Gérard Ledoigt Clermont Université UMR 547 INRA-Université PIAF Université Blaise-Pascal Campus des Cézeaux Aubière Cedex France Clermont Université UMR 547 INRA-Université PIAF Université Blaise-Pascal Campus des Cézeaux Aubière Cedex France Clermont Université Université d’Auvergne Imagerie Moléculaire et Thérapie Vectorisée BP Clermont-Ferrand France Clermont Université Université d’Auvergne Imagerie Moléculaire et Thérapie Vectorisée BP Clermont-Ferrand France Inserm UMR 990 IMTV Clermont-Ferrand France

Plants can respond to traumatism by synthesis and secretion of defence molecules. Wound-healing and desiccation stress of pieces of potato tuber parenchyma (Solanum tuberosum) promoted the secretion of a patatin-like phospholipase A2, PLA2 (EC.3.***.1.4.) that displayed cytotoxic activity against tumour cells. The potato secretion product, an oligomeric form of patatin-like protein, was shown to contain several isoforms of PLA2 polypeptides and to be associated with other proteins, including Kunitz-type protease inhibitors. Patatin-like protein secretion was inhibited by vanadate. Secreted patatin-like proteins displayed specific features, such as extracellular function and low molecular weights, mainly 36 to 40 kDa. The 36-kDa polypeptide sequence was related to iPLA2α. Polypeptide spots of secreted patatin-like protein exhibited a nucleotide-binding consensus motif, GGGIKG that has been described in iPLA2 gene family. The cytotoxic agent caused cell death of plant crown-gall induced by Agrobacterium tumefaciens, and inhibited B16 cell proliferation, but at the same concentration did not display any toxicity against non-transformed cells. PLA2 enzyme activity was required for cytotoxicity against B16 melanoma cells. A model for such a specific activity against tumour cells is discussed in connection with asymmetric phospholipid patterns of cell membranes. In conclusion, secreted patatin-like PLA2 (e-patatin) may represent a novel therapeutic target for the development of new agents against cancer.

关键词： Cytotoxicity Patatin Phospholipase A2

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Monoterpene hydrocarbons,major components of the dried leaves essential oils of five species of the genus Eucalyptus from Cote d’Ivoire

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Natural Science 2012年第2期4卷 106-111页

作者： Kanko Coffi Kone Soleymane Ramiarantsoa Harisolo Tue Bi Balo Chalchat Jean claude Chalard Pierre Figueredo Gilles Ahibo-Coffy Antoine Laboratoire de Chimie Organique Biologique Unite de Formation et de Recherche des Sciences des Structures de la Matiere et de Tecnhologie(UFR SSMT)Universite de Cocody-AbidjanAbidjanCote d’Ivoire Laboratoire de Chimie Organique Structurale UFR SSMTUniversite de Cocody-AbidjanAbidjanCote d’Ivoire Laboratoire de Chimie des Heterocycles et des Glucides Chimie des Huiles Essentielles Universite Blaise PascalClermont FerrandFrance

The chemical composition of the essential oils obtained from the dried leaves of five species of the genus Eucalyptus (E. camaldulensis, E. de-glupta, E. grandis, E. torelliana, E. urophylla) growing in C?te d’Ivoire, was analyzed by means of GC and GC/MS. The density and the refractive index were measured. The major components of all these oils are: α-pinene, β-pinene, α-phellandrene, limonene, γ-terpinene, p-cymene and β-caryo-phyllene. The particularity of these oils is their monoterpene hydrocarbons major components.

关键词： Eucalyptus Camaldulensis E.Deglupta E.Grandis E.Torelliana E.Urophylla Essential Oil Monoterpene Hydrocarbons Density Refractive Index

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麻醉中肌肉松弛药与逆转剂应用指南—法国麻醉与重症监测治疗学会(SFAR 2020)

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中华麻醉学杂志 2022年第7期42卷 771-793页

作者： Benoît Plaud Christophe Baillard Jean-Louis Bourgain Gaëlle Bouroche Laetitia Desplanque Jean-Michel Devys Dominique Fletcher Thomas Fuchs-Buder Gilles Lebuffe claude Meistelman Cyrus Motamed Julien Raft Frédérique Servin Didier Sirieix Karem Slim Lionel Velly Franck Verdonk Bertrand Debaene 巴黎大学巴黎公共援助医院麻醉和重症监护科圣路易医院巴黎75010法国巴黎大学巴黎公共援助医院麻醉和重症监护科科钦医院皇家港巴黎75014法国古斯塔夫-鲁西研究所麻醉科犹太城94800法国里昂贝拉尔中心麻醉科里昂69008法国巴黎公共援助医院麻醉和重症监护科克劳德·贝尔纳德医院巴黎75877法国罗斯柴尔德基金会医院麻醉和重症监护科巴黎75019法国凡尔赛-伊夫林地区圣康坦大学巴黎公共援助医院安布鲁瓦兹·帕雷医院麻醉科布洛涅-比扬古92100法国洛林大学南锡大学中心医院麻醉和重症监护科南锡地区54511法国里尔大学赫里兹医院麻醉和重症监护科里尔59037法国洛林癌症研究所麻醉科南锡地区54519法国 Marzet-Navarre集团综合医院麻醉科波城64000法国奥弗涅大学消化和肝胆外科埃斯坦医院克莱蒙费朗63100法国艾克斯-马赛大学蒂莫内医院麻醉和重症监护科马赛13385法国索邦大学圣安托万医院巴黎75012法国普瓦提埃大学麻醉和重症监护科普瓦提埃大学中心医院普瓦提埃86021法国

目的为更新1999年法国共识"麻醉中肌肉松弛药与逆转剂的应用"特召集16名专家成立共识委员会。编写开始时宣布庄重的利益声明与分歧监督原则,并在编写过程中予以执行,本指南编写全过程不依赖任何商业资助。所有作者均需遵循推荐分级的评... 详细信息

目的为更新1999年法国共识"麻醉中肌肉松弛药与逆转剂的应用"特召集16名专家成立共识委员会。编写开始时宣布庄重的利益声明与分歧监督原则,并在编写过程中予以执行,本指南编写全过程不依赖任何商业资助。所有作者均需遵循推荐分级的评价、制定与评估系统的原则(Grading of Recommendations,Assessment,Development and Evaluation,GRADE?),以评估这些推荐意见的证据质量,规避基于低质量证据做出强推荐的可能性。故有少数推荐意见仍未分等级。方法专家组的讨论主要集中在以下8个问题:(1)在无面罩通气困难标准的情况下,是否有必要在注射肌肉松弛药前检查面罩通气的可行性?面罩通气是否有必要使用肌肉松弛药?(2)为便于气管插管是否有必要使用肌肉松弛药?(3)是否有必要使用肌肉松弛药以便于声门上气道装置的置入及管理相关并发症?(4)是否有必要应用神经肌肉阻滞监测来进行气道管理?(5)是否有必要应用肌肉松弛药以利于手术的进行?如有必要,是哪种手术?(6)术中是否有必要监测神经肌肉阻滞程度?(7)防治肌肉松弛药残留阻滞作用的策略是什么?(8)在特殊人群中(如电休克治疗、肥胖、儿童、神经肌肉疾病、肝/肾功能衰竭、老年患者)使用肌肉松弛药和逆转剂的适应证及注意事项是什么?所有问题都采用研究对象、干预、对照和预后(Population,Intervention,Comparison and Outcome,PICO)模型中的临床问题予以阐明,并生成证据档案,最后采用GRADE?系统评估文献分析的结果并进行推荐。结果SFAR指南专家组提出了31项关于麻醉中应用肌肉松弛药与逆转剂的推荐意见。在这些推荐意见中,有11项是属于强推荐(GRADE 1±),有20项是属于弱推荐(GRADE 2±),有5项应用GRADE?系统无法给出推荐意见,其中2个问题生成了专家意见。经过2轮讨论和1次修订后,所有指南和方案都获得了专家组的一致同意。结论关于麻醉中应用肌肉松弛药与逆转剂的多项强推荐意见,专家间意见基本一致。SFAR推荐在整个麻醉过程中使用神经肌肉功能监测仪来监测神经肌肉阻滞程度。

关键词：肌肉松弛药逆转剂神经肌肉监测专家指南更新

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