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Analysis of YouTube^(TM) videos related to bowel preparation for colonoscopy

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World Journal of Gastrointestinal endoscopy 2014年第9期6卷 432-435页

作者： Corey Hannah Basch Grace clarke Hillyer Rachel Reeves Charles e Basch Department of Public Health William Paterson University Department of epidemiology Mailman School of Public Health Columbia University Department of Health and Behavior Studies Teachers College Columbia University

AIM: To examine YouTubeTM videos about bowel preparation procedure to better understand the quality of this information on the Internet. MeTHoDS: YouTubeTM videos related to colonoscopy preparation were identified during the winter of 2014; only those with ≥ 5000 views were selected for analysis(n = 280). Creator of the video, length, date posted, whether the video was based upon personal experience, and theme was re.o.ded. Bivariate analysis was conducted to examine differences between consumers vs healthcare professionals-created videos. ReSULTS: Most videos were based on personal experience. Half were created by consumers and 34% were ≥ 4.5 min long. Healthcare professional videos were viewed more.o.ten(> 19400, 59.4% vs 40.8%,P = 0.037, for healthcare professional and consumer, respectively) and more.o.ten focused on the purgative type and completing the preparation. Consumer videos received more comments(> 10 comments, 62.2% vs 42.7%, P = 0.001) and more.o.ten emphasized the palatability of the purgative, disgust, and hunger during the procedure. Content of colonoscopy bowel preparation YouTube? videos is influenced by who creates the video and may affect views on colon cancer screening. CoNCLUSIoN: The impact of perspectives on the quality of health-related information found on the Internet requires further examination.

关键词： colonoscopy professional screening created emphasized winter Colon worse cance.o.s preparing

丙型肝炎病毒干扰素敏感决定区基因“盒”的研究

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中华医学杂志 2001年第1期81卷 61-62页

作者：李刚 Jenny L Craigen Lynda Tussey eric DAD’Souza Tony R Carroll 姚集鲁 Berwyn e clarke 中山医科大学附属第三医院传染病科广州510630 Glaxowellco meMedicines Research Centre Glaxowellco

目前公认对丙型肝炎治疗有效的药物是干扰素，其最终疗效亦只有20%左右。影响干扰素疗效的因素是多方面的［1］，其中位于丙型肝炎病毒(HCV)非结构蛋白NS5A的第2209至2248位氨基酸序列与干扰素疗效密切相关，该区域称为干扰素敏感决定区... 详细信息

目前公认对丙型肝炎治疗有效的药物是干扰素，其最终疗效亦只有20%左右。影响干扰素疗效的因素是多方面的［1］，其中位于丙型肝炎病毒(HCV)非结构蛋白NS5A的第2209至2248位氨基酸序列与干扰素疗效密切相关，该区域称为干扰素敏感决定区(ISDR)［2，3］。

关键词：丙型肝炎病毒干扰素药物敏感性治疗

降e大调第三交响曲：op.55“英雄”：op.55 'e.o.ca'

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2006年

作者：贝多芬(Ludwig van Beethoven)[作曲] 克拉克(Richard clarke)编订

并列题名：Symphony No.3 in e major/ es-dur

ISBN: (纸本)7540438002

并列题名：Symphony No.3 in e major/ es-dur

关键词：交响曲

来源：畅想之星图书光盘版（南... 评论

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风湿性疾病的负担

国际内科双语杂志（中英文） 2007年第3期7卷 23-25,53-55页

作者： Alexandra M clarke De.o.ah P M Symmons 杨宏梅（译）顾瑞金（校）曼彻斯特大学关节炎研究运动流行病学单位工作的研究助理和博士学生英国曼彻斯特大学风温病学和肌肉骨骼流行病学教授不详

肌肉骨骼病是个人、社会和公共医疗卫生服务的主要负担。全科医师诊疗的大部分新发肌肉骨骼病是自限性疾病如软组织风湿病、慢性广泛疼痛和关节痛。骨关节炎的新发病例比类风湿性关节炎多10倍。肌肉骨骼病的患病更常见于女性，并趋向于... 详细信息

肌肉骨骼病是个人、社会和公共医疗卫生服务的主要负担。全科医师诊疗的大部分新发肌肉骨骼病是自限性疾病如软组织风湿病、慢性广泛疼痛和关节痛。骨关节炎的新发病例比类风湿性关节炎多10倍。肌肉骨骼病的患病更常见于女性，并趋向于随年龄而增长。全科医师诊疗的几乎1／10都是肌肉骨骼系统疾病。患病率将有可能随着预期寿命的延长而持续升高。随之将导致卫生专家工作量的增加和更多的公共医疗卫生服务的负担。用于肌肉骨骼病的费用包括付给公共医疗卫生服务和社会的费用及间接费用。在英国，所有残疾救济金费用中排在第五位的是肌肉骨骼系统疾病。类风湿性关节炎患者每年每位的费用总计达￡7000，而髋和膝的置换费用平均为￡5000。肌肉骨骼病的危险因素包括年龄和性别。有些肌肉骨骼病的患病率可因种族、生活方式的因素和遗传倾向性而异。患肌肉骨骼病的主要后果是慢性疼痛和残障。肌肉骨骼病的负担极大。这些疾病对公共医疗卫生服务和社会的影响将随预期寿命的延长而持续增长。

关键词：流行病学肌肉骨骼风湿致病率患病率发病率死产率残障费用危险因素

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肺癌全基因组测序

国际病理科学与临床杂志 2013年第4期33卷 277-285页

作者： Marissa Daniels Felicia Goh Casey M. Wright Krishna B. Sriram Vandana Relan Belinda e. clarke edwina e. Duhig Rayleen V. Bowman Ian A Yang Kwun M. Fong 孙岚何建行 Thoracic Research Laboratory Department of Thoracic Medicine The Prince Charles Hospital UQ Thoracic Research Centre School of Medicine The University of Queensland Pathology Queensland Department of Anatomical PathologyThe Prince Charles Hospital 重庆市璧山县人民医院肿瘤科重庆402760 广州医学院第一附属医院心胸外科广州510120 广州呼吸疾病研究所广州510120

肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为"下一代测序技术"的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。... 详细信息

肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为"下一代测序技术"的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免"无辜"患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。

关键词：高通量核苷酸测序 DNA序列分析肺肿瘤非小细胞肺癌小细胞肺癌

Search for the rare decays W^(+)→D_(s)^(+)γ and Z→D^(0)γ at LHCb

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中国物理C:英文版 2023年第9期47卷 14-26页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan Beteta F.Abudinén T.Ackernley B.Adeva M.Adinolfi P.Adlarson H.Afsharnia C.Agapopoulou C.A.Aidala Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albe.o.Z.Aliouche P.Alvarez Cartelle R.Amalric S.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso e.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza Leite M.Barbetti R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Be.o.s I.Be.o. I.Belyaev G.Benane G.Bencivenni e.Ben-Haim A.Berezhnoy *** *** Andres D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.P.Blago T.Blake F.Blanc J.e.Blank S.Blusk D.Bobulska J.A.Boelhauve.o.Boente Garcia T.Boettcher A.Boldyrev C.S.Bolognani R.Bolzonella N.Bondar F.Borgato S.Borghi M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo J.Brown D.Brundu A.Buonaura L.Buonincontri A.T.Burke C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti L.Carus A.Casais Vidal R.Caspary G.Casse M.Cattaneo G.Cavalle.o.V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.e.L.clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan e.Cognera Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High energy Physics Tsinghua UniversityBeijingChina Institute.o. High energy Physics(IHeP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute.o. Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHe Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Ge.o.a GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHCb experiment at a centre.o.-mass energy of 13TeV,corresponding to an integrated luminosity of 2.0fb−*** significant signal is observed for either decay mode and upper limits on their branching fractions are set using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization *** upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,*** is the first re.o.ted search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.

关键词： W/Z boson rare decay upper limit of branching fraction

An Instrument Variable Model of the Impact of Financing Decisions on Performance.o. Small Businesses in Australia＇s Pre-global Financial Crisis

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Journal of Modern Accounting and Auditing 2012年第7期8卷 1052-1065页

作者： LI Yongqiang Anona Armstrong Andrew clarke Victoria University Melbourne Australia

Firm level empirical research on the impact of financing decisions on small business performance is scarce in the Australian context. This study adopts an instrument variable (IV) approach to analyze the impact of financing decisions, in particular, equity or debt are.o.tained, on the performance.o. small businesses by using the panel data from Australian Bureau of Statistics (ABS) Business Longitudinal Database (BLD) 2004-2005, 2005-2006, and 2006-2007. Performance variables, i. e., sales and expenditure, are used as dependent variables. equity and debt obtained are used as independent variables (or known as treatments). IV includes size.o. the business, age.o. the business, number of locations, and industry division etc.. The results from IV modeling outperformed those.o.tained from oLS (ordinary Least Squares). Findings include: (1) financing has significantly positive impacts on the performance.o. small businesses in Australia; (2) equity and debt financing are used as alternatives, comparatively, equity financing is preferred; (3) capital purchases are largely funded by debt financing, while non-capital purchases and salary expenses are funded by equity financing; and (4) equity financing is more.o.ten used by firms with increasing capital purchases and declining non-capital purchases, while debt financing is used by firms with the.o.posite trends. The paper concludes with a discussion of the limitations of this research and future research"s directions.

关键词：股权融资澳大利亚小型企业金融危机 V模型决策性能工具

新型10价肺炎球菌结合疫苗候选物在冈比亚人群中的安全性和免疫原性研究

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微生物学免疫学进展 2020年第5期48卷 38-38页

作者：王建文(摘译) 焦磊 clarke e(审校) 不详

当前肺炎球菌结合疫苗(PCV)产量不足,需要一种能提供和已上市的PCVs保护能力相当或者更高产的PCV。印度血清研究所有限公司优化生产效率后的PCV候选疫苗(SIIPL-PCV)具有这一潜力,该疫苗针对的是非洲和亚洲最流行的致病血清型。作者研究... 详细信息

当前肺炎球菌结合疫苗(PCV)产量不足,需要一种能提供和已上市的PCVs保护能力相当或者更高产的PCV。印度血清研究所有限公司优化生产效率后的PCV候选疫苗(SIIPL-PCV)具有这一潜力,该疫苗针对的是非洲和亚洲最流行的致病血清型。作者研究了SIIPL-PCV在冈比亚成年人、幼儿和婴儿中的安全性、耐受性和免疫原性。

关键词：肺炎球菌结合疫苗候选疫苗免疫原性 PCV 优化生产耐受性安全性 SII

Diagnosis of gastrointestinal bleeding: A practical guide for clinicians

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World Journal of Gastrointestinal Pathophysiology 2014年第4期5卷 467-478页

作者： Bong Sik Matthew Kim Bob T Li Alexander engel Jaswinder S Samra Stephen clarke Ian D Norton Angela e Li Department of Gastroente.o.ogy Royal North Shore Hospital St Leonards NSW 2065 Sydney Australia Department of Medical oncology Royal North Shore Hospital St Leonards NSW 2065 Sydney Australia Sydney Medical School University of Sydney Camperdown NSW 2050 Sydney Australia Department of Colorectal Surgery Royal North Shore Hospital St Leonards NSW 2065 Sydney Australia Department of Gastrointestinal Surgery Royal North Shore Hospital St Leonards NSW 2065 Sydney Australia Australian School of Advanced Medicine Macquarie University North Ryde NSW 2109 Sydney Australia

Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute.o. overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the.o.erall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians.

关键词： Gastrointestinal he.o.rhage Diagnostic techniques endoscopy Colonoscopy Capsule endoscopy ente.o.copy Computed tomography Angiography