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Upper e.o.hageal sphincter abnormalities are strongly predictive.o. treatment response in patients with achalasia

World Journal of Clinical Cases 2014年第9期2卷 448-454页

作者： Simon C Mathews Maria Ciarleglio Yamile Haito Chavez John o clarke ellen Stein Bani Chander Roland Department of Medicine Johns Hopkins University School of MedicineBaltimore MD 21224 United States School of Public Health Yale UniversityNew Haven CT 06520 United States Division of Gastroente.o.ogy and Hepatology Johns Hopkins University School of MedicineBaltimore MD 21224 United States

AIM: To investigate the relationship between upper e.o.hageal sphincter abnormalities achalasia treatment MeTHoDS: We performed a retrospective study of 41 consecutive patients referred for high re.o.ution e.o.hageal manometry with a final manometric diagnosis of achalasia. Patients were sub-divided by presence.o. absence.o. Upper e.o.hageal sphincter(UeS) abnormality, and clinical and manometric profiles were *** between UeS abnormality and sub-type(i.e.,hypertensive, hypotensive.o. impaired relaxation) and a number of variables, including qualitative treatment response, achalasia sub-type, co-morbid medical illness,psychiatric illness, surgical history, dominant presentingsymptom, treatment type, age and gender were also ***: Among all 41 patients, 24(58.54%) had a UeS abnormality present. There were no significant differences between the groups in terms of age, gender or any other clinical or de.o.raphic profiles. Among those with UeS abnormalities, the majority were either hypertensive(41.67%) or had impaired relaxation(37.5%) as compared to hypotensive(20.83%), although this did not reach statistical significance(P = 0.42). There was no specific association between treatment response and treatment type received; however, there was a significant association between UeS abnormalities and treatment response. In patients with achalasia and concomitant UeS abnormalities, 87.5% had poor treatment response, while.o.ly 12.5% had favorable response. In contrast, in patients with achalasia and no UeS abnormalities, the majority(78.57%) had good treatment response, as compared to 21.43% with poor treatment response(P = 0.0001). After controlling for achalasia sub-type, those with UeS abnormality had 26 times greater odds of poor treatment response than those with no UeS abnormality(P = 0.009). Similarly, after controlling for treatment type, those with UeS abnormality had 13.9 times greater odds of poor treatment response compared to those w

关键词： Upper e.o.hageal sphincter Achalasia Motility Dysphagia e.o.hageal disorders

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c-myb对胚胎干细胞体外造血分化及定型的影响

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第三军医大学学报 2005年第6期27卷 485-489页

作者：陈洁平 De.o.ah clarke Constanze Bonifer 第三军医大学西南医院血液内科重庆400038 Molecular Medicine Unit St. James's University Hospital University of Leeds

目的　通过体外胚胎干细胞培养体系对eS细胞进行c- myb等位基因打靶,建立c -myb+ +及c -myb eS细胞模型的基础上,探讨转录因子c- myb在造血定型和分化中的作用。方法　通过体外eS细胞去除LIF半固体介质eBs的造血分化体系,采用... 详细信息

目的　通过体外胚胎干细胞培养体系对eS细胞进行c- myb等位基因打靶,建立c -myb+ +及c -myb eS细胞模型的基础上,探讨转录因子c- myb在造血定型和分化中的作用。方法　通过体外eS细胞去除LIF半固体介质eBs的造血分化体系,采用甲基纤维素克隆形成分析和real timePCR观察c- myb+ +及c -myb eS细胞,比较分析其不同分化过程及阶段中造血各系形成和相关基因表达变化。结果　c -myb+ +及c -myb eS胚胎体(eBs)大小及形态相似,c -myb+ +eSeBs形成显著多于c -myb 。c -myb+ +组CFU- e出现在第6天,高峰为第8天;c- myb 组也有相似的改变,但其 CFU- e数目少于c -myb+ +。c -myb+ +组CFU- M高峰为第7天;c- myb 也有相似的改变,但其CFU- M数目高于c- myb+ +。c -myb+ +CFU -GM出现在第7天,高峰为第12天,而c -myb 未见CFU -GM形成。real timePCR分析显示,c -myb 及 c- myb+ +β globin,zeta globin,Lys,C- fms基因表达无显著变化。结论　低水平的c -myb不影响祖细胞的扩增,但影响其终末分化。低水平的c -myb表达在造血定型中对红系的发育具有一定的影响,而对巨噬细胞的发育成熟无明显影响。 c -myb的表达水平对造血分化相关基因的表达没有明显的影响。

关键词： c-myb 胚胎干细胞分化造血定型

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Comparison of open and closed hyperthermic intraperitoneal che.o.herapy: Results from the United States hyperthermic intraperitoneal che.o.herapy collaborative

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World Journal of Gastrointestinal oncology 2020年第7期12卷 756-767页

作者： Jennifer L Leiting Jordan M Cloyd Ahmed Ahmed Keith Fournier Andrew J Lee Sophie Dessureault Seth Felder Jula Veerapong Joel M Baumgartner Callisia clarke Harveshp Mogal Charles A Staley Mohammad Y Zaidi Sameer H Patel Syed A Ahmad Ryan J Hendrix Laura Lambert Daniel e Abbott Courtney Pokrzywa Mustafa Raoof Christopher J LaRocca Fabian M Johnston Jonathan Greer Travis e Grotz Division of Hepatobiliary and Pancreas Surgery Mayo ClinicRochesterMN 55901United States Division of Surgical oncology Department of SurgeryThe Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Surgical oncology University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastrointestinal oncology Moffitt Cancer CenterDepartment of Oncologic SciencesMorsani College of MedicineTampaFL 33612United States Division of Surgical oncology Department of SurgeryUniversity of CaliforniaSan DiegoCA 92093United States Division of Surgical oncology Department of SurgeryMedical College of WisconsinMilwaukeeWI 53226United States Division of Surgical oncology Winship Cancer InstituteEmory UniversityAtlantaGA 30322United States Department of Surgery University of Cincinnati College of MedicineCincinnatiOH 45267United States Division of Surgical oncology Department of SurgeryUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Peritoneal Surface Malignancy Program Section of Surgical oncology Huntsman Cancer InstituteUniversity of UtahSalt Lake CityUT 84112United States Division of Surgical oncology Department of SurgeryUniversity of WisconsinMadisonWI 53792United States Christopher La Rocca Division of Surgical OncologyDepartment of SurgeryCity of Hope National Medical CenterDuarteCA 91010United States Department of Surgery Johns Hopkins UniversityBaltimoreMD 21287United States

BACKGRoUND Cytoreductive surgery(CRS)with hyperthermic intraperitoneal che.o.herapy(HIPeC)for peritoneal carcinomatosis can be performed in two ways:open or closed abdominal *** To evaluate the impact of HIPeC method on post-operative and long-term survival *** Patients undergoing CRS with HIPeC from 2000-2017 were identified in the United States HIPeC collaborative ***-operative,recurrence,and overall survival outcomes were compared between those who received open vs closed *** of the 1812 patients undergoing curative-intent CRS and HIPeC,372(21%)patients underwent open HIPeC and 1440(79%)underwent closed *** was no difference in re.o.eration or severe complications between the two *** HIPeC had higher rates of 90-d readmission while.o.en HIPeC had a higher rate.o. 90-d *** multi-variable analysis,closed HIPeC technique was not a significant predictor for overall survival(hazards ratio:0.75,95%confidence interval:0.51-1.10,P=0.14)or recurrence-free survival(hazards ratio:1.39,95%confidence interval:1.00-1.93,P=0.05)in the entire *** findings remained consistent in the appendiceal and the colorectal *** In this multi-institutional analysis,the HIPeC method was not independently associated with relevant post-operative.o. long-term *** technique may be left to the discretion of the.o.erating surgeon.

关键词： Mucinous appendiceal carcinoma Cytoreductive surgery Multi-institutional

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关于面向新建议书的进展情况报告——来自国际放射防护委员会的通讯

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辐射防护 2001年第4期21卷 193-200页

作者： Roger H clarke 胡遵素国际放射防护委员会单位不详

致电离辐射在医学和工业中使用的百年历史 ,从一开始就有了需要保护人类使之防御与照射有关的危害的忠告。在这整个时期 ,防护标准发生的演变 ,既反映了对照射的生物效应的科学认识 ,也反映了适用的社会标准与伦理标准。目前 ,ICRP主委... 详细信息

致电离辐射在医学和工业中使用的百年历史 ,从一开始就有了需要保护人类使之防御与照射有关的危害的忠告。在这整个时期 ,防护标准发生的演变 ,既反映了对照射的生物效应的科学认识 ,也反映了适用的社会标准与伦理标准。目前 ,ICRP主委员会正在考虑一个经过修改的简单方法 ,该方法基于一种面向个人的哲理 ,意味着委员会可能从过去强调的面向社会准则上做出转变。最初的建议通过 IRPA散发 ,并公开发表在 1999年 6月的《放射防护杂志 (Journal of RadiologicalProtection)上。委员会在收到意见和 IRPA 10大会评论的基础上 ,开始拟定下一建议书。本文阐述了在准备下一建议书时所涉及的问题 ,指出了委员会拟遵循的过程。委员会希望在未来的几年内将会有持续不断的争论。

关键词：国际放射防护委员会电离辐射防护建议书生物效应辐射剂量

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雌二醇对动情间期切除卵巢母羊黄体生成激素脉冲分泌的抑制作用

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中华内分泌代谢杂志 1990年第3期6卷 163-165页

作者：李江源 I.J.clarke 中国人民解放军总医院内分泌科澳大利亚亨利王子医院医学研究中心

12只动情间期母羊切除卵巢后,根据随机皮下植入或不植入e_2而分为二组。通过颈静脉插管每5～10分钟采血一次,连续8～9小时,分离血浆作LH放免测定。实验组的平均LH基础分泌水平和LH脉冲幅高比对照组显著减低,LH脉冲频率无明显改变。LH的... 详细信息

12只动情间期母羊切除卵巢后,根据随机皮下植入或不植入e_2而分为二组。通过颈静脉插管每5～10分钟采血一次,连续8～9小时,分离血浆作LH放免测定。实验组的平均LH基础分泌水平和LH脉冲幅高比对照组显著减低,LH脉冲频率无明显改变。LH的平均基础分泌水平和脉冲幅高显著相关。本研究表明,植入e_2抑制垂体LH的分泌,其作用可能主要是抑制LH对GnRH的反应,因此,作用部位是在垂体水平。LH基础分泌水平的下降,亦可能是e_2的抑制作用所致。

关键词：雌二酶黄体生成激素脉冲分泌

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The Digital Age.o. Campus Maps on Mobile Devices

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Journal of Computer and Communications 2016年第7期4卷 22-30页

作者： Fan Wu Dwayne clarke Jian Jiang Asif Baba Sherman Buford Computer Science Department Tuskegee University Tuskegee USA Police Department Tuskegee University Tuskegee USA

Deve.o.ing mobile applications have always been a rising topic in the technology world. With the recent deve.o.ment in technology, mobile applications play an important role in various applications throughout the world. Mobile applications are constantly e.o.ving. There are several ongoing research and deve.o.ments in both industry and academia. In this paper, we present the design and implementation of a mobile application that creates an electronic map or e-map application for the campus of Tuskegee University. The goals for this mobile application are to make the campus map easier and user-friendly for parents, visitors, and students using mobile devices. With this mobile application, the users will be able to search and find campus buildings, as well as give feedback on the application to eliminate the need for paper documentation.

关键词： Mobile Application Mobile Device e-Map

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现代中国人群形成与分化的形态证据--中国与非洲和欧洲人群头骨非测量特征分析

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人类学学报 2011年第3期30卷 250-264页

作者：刘武吴秀杰邢松 Victoria GIBBoN Ronald clarke 中国科学院古脊椎动物与古人类研究所中国科学院脊椎动物进化系统学重点实验室北京100044 中国科学院研究生院北京100049 Purdue University West Lafayette USA University of the Witwatersrand Johannesburg South Africa

现代人群形成与分化导致生活在世界不同地区的人类形成了具有明显体质特征差别的人群(或种族)。对更新世末期及全新世以来不同地理区域近代和现代人群体质特征差别、相互亲缘关系的分析是现代人群形成与分化研究的重要组成部分。本文通... 详细信息

现代人群形成与分化导致生活在世界不同地区的人类形成了具有明显体质特征差别的人群(或种族)。对更新世末期及全新世以来不同地理区域近代和现代人群体质特征差别、相互亲缘关系的分析是现代人群形成与分化研究的重要组成部分。本文通过对21项头骨非测量特征在近代和现代中国人群,以及现代非洲和欧洲人群共330例标本的出现率和表现特点的观察和数据分析,发现绝大多数特征的出现率或表现特点在三个人群间都具有不同程度的差异,有些特征在人群间的差异甚至非常明显。与非洲及欧洲人群相比,现代中国人头骨总体显得纤细,眉弓、角圆枕、颧三角、颧结节等反映头骨粗壮程度的特征在现代中国人群的发育明显弱于非洲和欧洲人群。此外,现代中国人群还具有一些明显不同于非洲和欧洲人群的头骨非测量特征,包括锐利的眶外下缘、相对平坦的眉间鼻根点、较圆隆的颅侧壁、平坦的顶孔人字区、深弧形的上颌颧突下缘,梯形和左右不一的鼻额-额颌缝走向等。采用判别分析可以将67.0%—79.5%的标本正确地判别归入其原来所属的组群。其中对中国人群的正确判别率分别达到70.4%和82.9%。个体标本分布显示非洲人群表现较大的分散性,而中国和欧洲人群样本的分布明显密集集中,提示中国和欧洲人群似乎具有更多的衍生性特征。本研究还发现多数在人群间差别显著的头骨非测量特征与头骨粗壮程度有关,作者对相关的问题进行了分析探讨。

关键词：头骨非测量特征现代中国人群现代非洲人群现代欧洲人群

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Spatial and Temporal Patterns of In Situ Sea Surface Temperatures within the Gulf of Mexico from 1901-2010

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American Journal of Climate Change 2016年第3期5卷 314-343页

作者： Jason Allard John V. clarke III Barry D. Keim Department of Physics Astronomy & Geosciences Valdosta State University Valdosta GA USA Department of Geography and Anthropology Louisiana State University Baton Rouge LA USA

This work examines the spatial and temporal patterns of seasonal sea surface temperatures (SSTs) across the Gulf of Mexico (GoM) for the period 1901-2010. The extended Re.o.structed Sea Surface Temperature, version 4 (eRSST.v4), dataset was selected for this study over other re.o.structions because.o. its 2° × 2° grid cell spatial re.o.ution, its recent update to adjust for known biases in SST observations, and its ability to be compared to other in situ studies of GoM SSTs. The monthly eRSST.v4 data were averaged seasonally for each year and grid cell in the GoM. Seasonal SST trends were then calculated for each grid cell with varying start dates (e.g., 1901-2010, 1911- 2010) to account for nonlinear SST changes over the study period. Results indicate that the GoM SSTs closely resemble those.o. global annual temperature trends: SSTs warmed from 1901 to ~1940, followed by a period with little trend or a slight cooling until the mid-1970s, and then a warming afterwards through 2010. The spatial patterns and magnitudes of SST changes, however, varied by season and location within the GoM. The spatial patterns involved gradients with latitudinal and/or longitudinal components: a southwest-northeast (warmer-cooler) gradient in winter, an east-west (warmer-cooler) gradient in spring and fall, and a northwest-southeast (warmer-cooler) gradient in summer. The magnitude.o. SST changes tended to be largest in summer, followed by spring, fall, and winter. The long-term (1901-2010) SST trends were significant throughout the GoM in summer and fall, but only significant towards the southwestern GoM in winter and spring. These results have implications in discussion of climate change and its impacts on tropical activity in the GoM Basin.

关键词： Sea Surface Temperature Gulf of Mexico Temperature Re.o.structions Temperature Variability

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Adverse Wear in MoM Hip-Arthroplasty Related to the Production of Metal Fragments at Impingement Sites

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open Journal of orthopedics 2018年第10期8卷 381-412页

作者： T. K. Donaldson e. J. Smith A. Koutalos A. John J. Y. Lazennec I. C. clarke empire.o.thopedics Colton CA USA Department of orthopaedics University of Bristol Bristol England Department of orthopaedics University Hospital of Larissa Larissa Greece Department of orthopaedics University of Cardiff and Vale NHS Trust Wales England Department of orthopedic and Trauma Surgery La Pitié-Salpêtrière Hospital University of Paris Paris France Department of orthopaedics Loma Linda University Medical Center Loma Linda CA USA

Metal on metal (MoM) bearings were reintroduced as resurfacing arthroplasty (RA) for the younger, more active patient and were later incorporated into total hip arthroplasty (THA). early results were encouraging. However, recent publications identified adverse tissue responses to metal debris, such that the majority of MoM designs have been abandoned due to the increase in cobalt-chromium (CoCr) debris and associated metal ions. Re.o.ts of MoM THA cited risks that included acetabular cups with high-inclination angles, i.e. “edge-loading”, and “trunnionosis”. Hip impingement was also a cited risk in one MoM study, with “type-IV” wear noted to be a sliding/impaction type.o. wear, characterized by deep scratches. Sliding/impaction wear mechanisms produced at impingement are not well represented in current MoM literature. There.o.e, our objective in this review was to consolidate evidence for impingement risks. We hypothesize that hip impingement and subluxation with metal-backed acetabular cups can trigger wear mechanisms that result in, 1) fe.o.al-neck notching, 2) release.o. large metal particles, 3) production of uniquely large scratches, defined as “microgrooves” on heads and cups, 4) formation of “polar” and “basal” microgrooves precisely aligning with cup profiles during impingement, and 5) equatorial microgrooves relate to soft-tissue sites of impingement. Relevant risk scenarios were evaluated and included hip impingement in both sitting and standing postures, head subluxation, wear patterns defining in-vivo component positions, and evidence for circulating metal fragments. The study relied on mapping of wear patterns to deduce in-vivo positioning of devices and relied on surrogate fe.o.al stems of the same brand to simulate neck-cup impingement. eoS imaging techniques were used to analyze functional-sitting and functional-standing postures and prove existence.o. hip impingement sites in patients. The study identified 8-risk scenarios for wear damage.o. MoM bea

关键词： Resurfacing Arthroplasty MoM

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兽医毒物学

兽医毒物学

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1984年

作者：（英）克拉克（e.G.C.clarke）（英）克拉克（M.L.clarke）王建元等译

来源：汇雅图书（南通市图书馆... 评论

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